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In a subduction zone, the volcanic arc marks the location where magma, generated via flux melting in the mantle wedge, migrates through the crust and erupts. While the location of deep magma broadly defines the arc position, here we argue that crustal structures, identified in geophysical data from the Washington Cascades magmatic arc, are equally important in controlling magma ascent and defining the spatial distribution and compositional variability of erupted material. As imaged by a three-dimensional resistivity model, a broad lower-crustal mush zone containing 3–10% interconnected melt underlies this segment of the arc, interpreted to episodically feed upper-crustal magmatic systems and drive eruptions. Mount St Helens is fed by melt channelled around a mid-Tertiary batholith also imaged in the resistivity model and supported by potential–field data. Regionally, volcanism and seismicity are almost exclusive of the batholith, while at Mount St Helens, along its margin, the ascent of viscous felsic melt is enabled by deep-seated metasedimentary rocks. Both the anomalous forearc location and composition of St Helens magmas are products of this zone of localized extension along the batholith margin. This work is a compelling example of inherited structural control on local stress state and magmatism. Crustal structures are as important as deep mantle melting in controlling magma ascent and the composition and distribution of erupted material, according to 3D resistivity modelling, geophysical data and the distribution of Quaternary volcanism.

Background An epigenetic field of cancer susceptibility exists for prostate cancer (PC) that gives rise to multifocal disease in the peripheral prostate. In previous work, genome-wide DNA methylation profiling identified altered regions in the normal prostate tissue of men with PC. In the current multicenter study, we examined the predictive strength of a panel of loci to detect cancer presence and grade in patients with negative biopsy tissue. Results Four centers contributed benign prostate biopsy tissues blocks from 129 subjects that were either tumor associated (TA, Grade Group [GG] ≥ 2, n = 77) or non-tumor associated (NTA, n = 52). Biopsies were analyzed using pyrosequencing for DNA methylation encompassing CpG loci near CAV1, EVX1, FGF1, NCR2, PLA2G16, and SPAG4 and methylation differences were detected within all gene regions (p < 0.05). A multiplex regression model for biomarker performance incorporating a gene combination discriminated TA from NTA tissues (area under the curve [AUC] 0.747, p = 0.004). A multiplex model incorporating all the above genes and clinical information (PSA, age) identified patients with GG ≥ 2 PC (AUC 0.815, p < 0.0001). In patients with cancer, increased variation in gene methylation levels occurs between biopsies across the prostate. Conclusions A widespread epigenetic field defect is utilized to detect GG ≥ 2 PC in patients with histologically negative biopsies. These alterations in non-tumor cells display increased heterogeneity of methylation extent and are spatially distant from tumor foci. These findings have the potential to decrease the need for repeated prostate biopsy.

There is a remarkable difference between the maximum temperature of black smoker effluent (350 degrees C-400 degrees C) and the temperature of the solidifying magma which heats it (approximately 1,200 degrees C). It has been suspected for some time that the nonlinear thermodynamic properties of water might be responsible for this discrepancy. Here, we translate this hypothesis into a physical model, by examining the internal temperature structure of convection cells in a porous medium. We demonstrate that, at pressures appropriate to seafloor crust, plumes of pure water form naturally at approximately 400 degrees C for any heat source with temperature greater than approximately 500 degrees C. Higher temperatures are confined to a boundary layer at the base of the convection cell, where the flow is horizontal. The phenomenon is explained analytically using the thermodynamic properties of water, and is illustrated by numerical simulations. Our model predicts the existence of the high-temperature 'reaction zone' found in ophiolites and suggests that vent temperatures will remain steady as magma chambers solidify and cool.

Geophysical Inverse Theory. By Robert L. Parker R. L.. Princeton University Press: 1994. Pp. 386. £30r $39.50.