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Start Over Author "Ai-nan Zhou" Publisher springer science and business media llc
1 results on '"Ai-nan Zhou"'

1. Quantitative Study of Impurities in Enzalutamide and Identification, Isolation, Characterization of Its Four Degradation Products Using HPLC, Semi-preparative LC, LC/ESI–MS and NMR Analyses

Author

Jianqi Li, Gengli Duan, Lejun Ruan, and Ai-Nan Zhou

Subjects
Chromatography, 010401 analytical chemistry, Organic Chemistry, Clinical Biochemistry, Lc esi ms, Mass spectrometry, 01 natural sciences, Biochemistry, High-performance liquid chromatography, 0104 chemical sciences, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Impurity, 030220 oncology & carcinogenesis, Degradation (geology), Enzalutamide
Abstract

Enzalutamide was recently approved for the treatment of castration-resistant prostate cancer. In this study, the related substances in enzalutamide bulk substance were analyzed qualitatively and quantitatively. Four degradation products (Oxi, A9, P1 and P2) of enzalutamide were isolated using semi-preparative liquid chromatography and characterized using nuclear magnetic resonance and mass spectrometry. In addition, two reversed-phase liquid chromatography methods were developed for quantification of 13 potential impurities and the main constituent, respectively. These two methods were validated and applied during the impurity studies and quality control analysis of the laboratory-prepared samples of enzalutamide.

Published
2018
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