1. Effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluids on angiogenesis-related proteins in patients undergoing peritoneal dialysis
- Author
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Ikutaro Furuno, Yutaka Otsuji, Masaru Araki, Yasushi Oginosawa, Kazutoshi Nakazono, Akihiro Kuma, Yuki Tsuda, Masahito Tamura, Hiromichi Ueno, Masaharu Kataoka, Hiroyuki Morimoto, Emi Hasegawa, Kenya Sanada, Yoichi Ueta, and Tetsu Miyamoto
- Subjects
Nephrology ,medicine.medical_specialty ,Biocompatibility ,Angiogenesis ,Urology ,medicine.medical_treatment ,Bicarbonate ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Pharmacology ,Peritoneal dialysis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,In patient ,Transplantation ,Oncogene ,business.industry ,Growth-related oncogene ,Biocompatible material ,Diseases of the genitourinary system. Urology ,Bicarbonate/lactate-buffered neutral peritoneal dialysis fluid ,chemistry ,Chemokine ,RC870-923 ,business - Abstract
Background In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary to improve the biocompatibility of peritoneal dialysis fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected to be improved biocompatible. This study evaluated the biocompatibility of B/L-PDFs by analysis on the profile of angiogenesis-related proteins in drained dialysate of patients undergoing PD. Methods Concentrations of 20 angiogenesis-related proteins in the dialysate were semi-quantitatively determined using a RayBio® Human Angiogenesis Antibody Array and were compared between B/L-PDFs and conventional lactate-buffered neutral PDFs (L-PDFs). Results The expression of growth-related oncogene (GRO α/β/γ), which belongs to the CXC chemokine family, decreased significantly after use of the B/L-PDFs compared to the L-PDFs (P = 0.03). The number of the proteins with lower level in the B/L-PDFs compared with L-PDFs was significantly negatively correlated with the PD duration (Spearman ρ = − 0.81, P = 0.004). Conclusion This study suggested that B/L-PDFs are more biocompatible than conventional PDFs.
- Published
- 2021