1. Allogeneic stem cell transplantation for older advanced MDS patients: improved survival with young unrelated donor in comparison with HLA-identical siblings
- Author
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Kroger, N., Zabelina, T., Wreede, L. de, Berger, J., Alchalby, H., Biezen, A. van, Milpied, N., Volin, L., Mohty, M., Leblond, V., Blaise, D., Finke, J., Schaap, N., Robin, M., Witte, T. de, and European Grp Blood Marrow Transpla
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,donor selection ,Human leukocyte antigen ,Gastroenterology ,Young Adult ,HLA Antigens ,Translational research [ONCOL 3] ,allogeneic stem cell transplantation ,unrelated donor ,Internal medicine ,MDS ,Humans ,Transplantation, Homologous ,Medicine ,Young adult ,Sibling ,Survival rate ,Aged ,donor age ,Donor selection ,business.industry ,Siblings ,Hazard ratio ,Translational research Immune Regulation [ONCOL 3] ,Hematology ,Middle Aged ,Prognosis ,Confidence interval ,Surgery ,Survival Rate ,Transplantation ,Oncology ,Myelodysplastic Syndromes ,Female ,Neoplasm Recurrence, Local ,Unrelated Donors ,business ,Follow-Up Studies ,Stem Cell Transplantation - Abstract
Contains fulltext : 117578.pdf (Publisher’s version ) (Closed access) We investigated whether a young human leukocyte antigen (HLA)-matched unrelated donor (MUD) should be preferred as donor to an HLA-identical sibling (MRD) for older patients with myelodysplastic syndrome (MDS) (>/=50 years) who underwent allogeneic stem cell transplantation (AHSCT). Outcomes of 719 MDS patients with a median age of 58 years (range, 50-73 years) who received AHSCT from related (n=555) or unrelated (n=164) donors between 1999 and 2008 and reported to the European Group for Blood and Marrow Transplantation were analyzed. The median donor age of the MRD was 56 years (range: 35-78), in contrast to 34 years (range: 19-64) for the MUDs. Influence of donor's age on survival was not observed for MRD (hazard ratio (HR): 1.01 (95% confidence interval (CI): 0.99-1.02), P=0.2), but there was a significant impact of MUD's age on outcome (HR: 1.03 (95% CI: 1.01-1.06); P=0.02). Transplantation from younger MUDs (30 years): 40% vs 33% vs 24% (P=0.04). In a multivariate analysis, AHSCT from young MUD (
- Published
- 2012