5 results on '"Antonio De Leo"'
Search Results
2. Multifocal Fibrosing Thyroiditis: an Under-recognized Mimicker of Papillary Thyroid Carcinoma
- Author
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Agnese Orsatti, Antonio De Leo, Federico Chiarucci, Giulia Simoncini, Nadia Cremonini, Adele Fornelli, Luca Amorosa, Thais Maloberti, Dario de Biase, and Giovanni Tallini
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Adult ,Male ,Thyroiditis ,Hyperplasia ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Hashimoto Disease ,General Medicine ,Middle Aged ,Carcinoma, Papillary ,Pathology and Forensic Medicine ,Young Adult ,Endocrinology ,Thyroid Cancer, Papillary ,Humans ,Female ,Thyroid Neoplasms ,Aged - Abstract
Multifocal fibrosing thyroiditis (MFT) is an enigmatic entity, characterized by multiple fibrotic scar-like lesions with a paucicellular fibrotic center surrounded by a cellular peripheral area with reactive-appearing follicular cell atypia and variable chronic inflammation. Although poorly recognized and likely underreported in surgical pathology, the entity is considered rare with only 65 cases to date–including the current one reported to expand on the preoperative findings of this under-recognized entity. The average age of the patients is 46.8 years (range 15–71 years), 94% are female, with female to male ratio of 15:1. Individual MFT lesions typically have a superficial location. The average number of fibrotic lesions is 15.4 (range 2–51 per MFT case). Their average size is 3.1 mm (range 0.4–15.1). MFT is a disorder of diseased thyroids, typically found postoperatively in glands removed for other reasons, such as chronic lymphocytic/Hashimoto thyroiditis (32.3%), follicular nodular disease (nodular hyperplasia) (30.1%), hyperthyroidism/diffuse hyperplasia (Graves disease) (9.2%). Intriguing is the association with papillary thyroid carcinoma–present in 38.5% of MFT cases, and particularly with sub-centimetric and multifocal papillary thyroid carcinoma, with which MFT can be confused. Cases where MFT is the only thyroid pathology (7.7%) can be preoperatively mistaken for papillary thyroid carcinoma, due to worrisome ultrasound (US) and cytologic features, both of which are here documented for the first time as a component of this article. Wider recognition of MFT and of its cytologic and ultrasound features at preoperative evaluation may reduce unnecessary thyroidectomies.
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- 2022
3. Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy
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Ivan Corazza, Roberto Manfredi, Christoph Dickmans, Claudio Denitto, Paolo Emilio Orlandi, Enrico Giampieri, Caterina Maggioli, Giovanni Tallini, Antonio De Leo, Sirio Fiorino, Elio Jovine, Michela Visani, Francesco Del Forno, Paolo Leandri, Claudio Gallo, Michele Cammarosano, Maddalena Zippi, Thomas Brand, Francesco Miceli, Giorgia Acquaviva, Elisa Fogacci, Roberto Jovine, Sergio Sabbatani, Michele Battilana, Dario de Biase, Francesca Travasoni Loffredo, Wandong Hong, Renzo Moretti, Fiorino, Sirio, Gallo, Claudio, Zippi, Maddalena, Sabbatani, Sergio, Manfredi, Roberto, Moretti, Renzo, Fogacci, Elisa, Maggioli, Caterina, Travasoni Loffredo, Francesca, Giampieri, Enrico, Corazza, Ivan, Dickmans, Christoph, Denitto, Claudio, Cammarosano, Michele, Battilana, Michele, Orlandi, Paolo Emilio, Del Forno, Francesco, Miceli, Francesco, Visani, Michela, Acquaviva, Giorgia, De Leo, Antonio, Leandri, Paolo, Hong, Wandong, Brand, Thoma, Tallini, Giovanni, Jovine, Elio, Jovine, Roberto, and de Biase, Dario
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Aging ,ARDS ,medicine.medical_specialty ,Pneumonia, Viral ,Review ,Ascorbic Acid ,medicine.disease_cause ,Proinflammatory cytokine ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,CoV-2 ,Epidemiology ,Humans ,Vitamin E ,Medicine ,030212 general & internal medicine ,Vitamin D ,Vitamin A ,Pandemics ,Pathological ,Aged ,030304 developmental biology ,Coronavirus ,SARS ,0303 health sciences ,SARS-CoV-2 ,business.industry ,COVID-19 ,Vitamins ,medicine.disease ,Ageing ,Cytokine release syndrome ,Immunology ,Cytokines ,Th17 Cells ,Therapeutic strategy ,Geriatrics and Gerontology ,Coronavirus Infections ,business ,Cytokine storm - Abstract
Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a “public health emergency of international concern”. A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins. Methods We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function. Results SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection. Conclusions Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.
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- 2020
4. Correction to: 34th European Congress of Pathology - Abstracts
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Antonio De Leo
- Subjects
Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine - Published
- 2022
5. Abstracts
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Ilya Dolgushin, David Harrison, Antonio De Leo, Ilya Mikhailov, Peter Caie, Piotr Donizy, Fatima El agy, Rafal Matkowski, Maciej Kaczorowski, Pavel G Malkov, Ines P. Nearchou, Vladislav Tiurin, Małgorzata Pieniążek, Nina Oleynikova, AGNIESZKA HAŁOŃ, Georgios Androutsopoulos, Olga Kharlova, and Paulo Teixeira
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medicine.medical_specialty ,business.industry ,medicine ,Cell Biology ,General Medicine ,Angiomatosis ,Kasabach–Merritt syndrome ,medicine.disease ,business ,Molecular Biology ,Dermatology ,Pathology and Forensic Medicine - Published
- 2018
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