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16 results on '"Aries, Marcel"'

1. A Comprehensive Perspective on Intracranial Pressure Monitoring and Individualized Management in Neurocritical Care: Results of a Survey with Global Experts

Author

Brasil, Sérgio, primary, Godoy, Daniel Agustín, additional, Videtta, Walter, additional, Rubiano, Andrés Mariano, additional, Solla, Davi, additional, Taccone, Fabio Silvio, additional, Robba, Chiara, additional, Rasulo, Frank, additional, Aries, Marcel, additional, Smielewski, Peter, additional, Meyfroidt, Geert, additional, Battaglini, Denise, additional, Hirzallah, Mohammad I., additional, Amorim, Robson, additional, Sampaio, Gisele, additional, Moulin, Fabiano, additional, Deana, Cristian, additional, Picetti, Edoardo, additional, Kolias, Angelos, additional, Hutchinson, Peter, additional, Hawryluk, Gregory W., additional, Czosnyka, Marek, additional, Panerai, Ronney B., additional, Shutter, Lori A., additional, Park, Soojin, additional, Rynkowski, Carla, additional, Paranhos, Jorge, additional, Silva, Thiago H. S., additional, Malbouisson, Luiz M. S., additional, and Paiva, Wellingson S., additional

Published
2024
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2. Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study

Author

Gomez, Alwyn, primary, Froese, Logan, additional, Griesdale, Donald, additional, Thelin, Eric P., additional, Raj, Rahul, additional, van Iperenburg, Levi, additional, Tas, Jeanette, additional, Aries, Marcel, additional, Stein, Kevin Y., additional, Gallagher, Clare, additional, Bernard, Francis, additional, Kramer, Andreas H., additional, and Zeiler, Frederick A., additional

Published
2024
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3. Cerebral autoregulation derived blood pressure targets in elective neurosurgery

Author

Beqiri, Erta, primary, García-Orellana, Marta, additional, Politi, Anna, additional, Zeiler, Frederick A., additional, Placek, Michal M., additional, Fàbregas, Neus, additional, Tas, Jeanette, additional, De Sloovere, Veerle, additional, Czosnyka, Marek, additional, Aries, Marcel, additional, Valero, Ricard, additional, de Riva, Nicolás, additional, and Smielewski, Peter, additional

Published
2024
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5. Towards autoregulation-oriented management after traumatic brain injury: increasing the reliability and stability of the CPPopt algorithm

Author

Beqiri, Erta, Ercole, Ari, Aries, Marcel JH, Placek, Michal M, Tas, Jeanette, Czosnyka, Marek, Stocchetti, Nino, Smielewski, Peter, CENTER-TBI High Resolution (HR ICU) Sub-Study Participants and Investigators, Ercole, Ari [0000-0001-8350-8093], and Apollo - University of Cambridge Repository

Subjects
CPPopt, Cerebral autoregulation, Traumatic brain injury, Multiwindow weighted approach, Reliability, Stability
Abstract

PURPOSE: CPPopt denotes a Cerebral Perfusion Pressure (CPP) value at which the Pressure-Reactivity index, reflecting the global state of Cerebral Autoregulation, is best preserved. CPPopt has been investigated as a potential dynamically individualised CPP target in traumatic brain injury patients admitted in intensive care unit. The prospective bedside use of the concept requires ensured safety and reliability of the CPP recommended targets based on the automatically-generated CPPopt. We aimed to: Increase stability and reliability of the CPPopt automated algorithm by fine-tuning; perform outcome validation of the adjusted algorithm in a multi-centre TBI cohort. METHODS: ICM + software was used to derive CPPopt and fine-tune the algorithm. Parameters for improvement of the algorithm were selected based on qualitative and quantitative assessment of stability and reliability metrics. Patients enrolled in the Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI) high-resolution cohort were included for retrospective validation. Yield and stability of the new algorithm were compared to the previous algorithm using Mann-U test. Area under the curves for mortality prediction at 6 months were compared with the DeLong Test. RESULTS: CPPopt showed higher stability (p

Published
2023

6. Cerebrovascular pressure reactivity and brain tissue oxygen monitoring provide complementary information regarding the lower and upper limits of cerebral blood flow control in traumatic brain injury: a CAnadian High Resolution-TBI (CAHR-TBI) cohort study

Author

Gomez, Alwyn, primary, Sekhon, Mypinder, additional, Griesdale, Donald, additional, Froese, Logan, additional, Yang, Eleen, additional, Thelin, Eric P., additional, Raj, Rahul, additional, Aries, Marcel, additional, Gallagher, Clare, additional, Bernard, Francis, additional, Kramer, Andreas H., additional, and Zeiler, Frederick A., additional

Published
2022
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8. Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis

Author

Zeiler, Frederick A, Ercole, Ari, Beqiri, Erta, Cabeleira, Manuel, Aries, Marcel, Zoerle, Tommaso, Carbonara, Marco, Stocchetti, Nino, Smielewski, Peter, Czosnyka, Marek, Menon, David K, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants And Investigators, Zeiler, Frederick A [0000-0003-1737-0510], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Critical Care, Therapeutic intensity, hemic and immune systems, chemical and pharmacologic phenomena, PRx, TIL, Middle Aged, Cohort Studies, Young Adult, Treatment Outcome, Cerebrovascular Circulation, TBI, Brain Injuries, Traumatic, Humans, Cerebrovascular reactivity, Arterial Pressure, Female, Intracranial Hypertension, Aged, Retrospective Studies
Abstract

BACKGROUND: Impaired cerebrovascular reactivity in adult traumatic brain injury (TBI) is known to be associated with poor outcome. However, there has yet to be an analysis of the association between the comprehensively assessed intracranial hypertension therapeutic intensity level (TIL) and cerebrovascular reactivity. METHODS: Using the Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI) high-resolution intensive care unit (ICU) cohort, we derived pressure reactivity index (PRx) as the moving correlation coefficient between slow-wave in ICP and mean arterial pressure, updated every minute. Mean daily PRx, and daily % time above PRx of 0 were calculated for the first 7 days of injury and ICU stay. This data was linked with the daily TIL-Intermediate scores, including total and individual treatment sub-scores. Daily mean PRx variable values were compared for each TIL treatment score via mean, standard deviation, and the Mann U test (Bonferroni correction for multiple comparisons). General fixed effects and mixed effects models for total TIL versus PRx were created to display the relation between TIL and cerebrovascular reactivity. RESULTS: A total of 249 patients with 1230 ICU days of high frequency physiology matched with daily TIL, were assessed. Total TIL was unrelated to daily PRx. Most TIL sub-scores failed to display a significant relationship with the PRx variables. Mild hyperventilation (p < 0.0001), mild hypothermia (p = 0.0001), high levels of sedation for ICP control (p = 0.0001), and use vasopressors for CPP management (p < 0.0001) were found to be associated with only a modest decrease in mean daily PRx or % time with PRx above 0. CONCLUSIONS: Cerebrovascular reactivity remains relatively independent of intracranial hypertension therapeutic intensity, suggesting inadequacy of current TBI therapies in modulating impaired autoregulation. These findings support the need for investigation into the molecular mechanisms involved, or individualized physiologic targets (ICP, CPP, or Co2) in order to treat dysautoregulation actively.

Published
2019

14. Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study

Author

Dias, Celeste, primary, Silva, Maria João, additional, Pereira, Eduarda, additional, Monteiro, Elisabete, additional, Maia, Isabel, additional, Barbosa, Silvina, additional, Silva, Sofia, additional, Honrado, Teresa, additional, Cerejo, António, additional, Aries, Marcel J. H., additional, Smielewski, Peter, additional, Paiva, José-Artur, additional, and Czosnyka, Marek, additional

Published
2015
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