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Europe must increasingly deal with the harmful impacts of climate change, regardless of its success in reducing emissions. These impacts have significant cross-border effects and threaten to deepen existing divisions. Cooperation on adaptation, which is mostly seen as requiring local or regional efforts, may be useful, but the role of the European Union is ill-defined. This article gives an overview of how climate change might transform Europe and how it might affect people and the economy. It also discusses on what grounds adaptation policies should be pursued at the EU level. The article argues that a stronger adaptation governance framework would benefit adaptation efforts and formulates three ideas to strengthen adaptation. The first is a three-layered governance framework based on intensive cooperation to establish binding adaptation plans. Second is an EU-level insurance scheme against damages from climate change, with the size of national contributions tied to the achievement of targets in adaptation plans. The final suggestion is to increase ex ante adaptation funding by targeting more spending under EU regional and agricultural policies specifically to adaptation in the most vulnerable regions.

In the COVID-19 pandemic, governments have, among other measures,1,2 mandated the use of COVID certificates to prove vaccination, recovery, or a recent negative test, and have required them to access shops, restaurants, schools, universities, or workplaces.3 While arguments for and against COVID certificates have focused on reducing transmission and ethical concerns,4,5 the incentive effect of COVID certificates on vaccine uptake, health outcomes, and the economy has not yet been investigated. To estimate this effect, we construct counterfactuals based on innovation diffusion theory6 for France, Germany, and Italy. We estimate that the announcement of COVID certificates during summer 2021 led to increased vaccine uptake in France of 13.0 (95% CI 9.7–14.9) percentage points (p.p.) of the total population up to the end of the year, in Germany 6.2 (2.6–6.9) p.p., and in Italy 9.7 (5.4–12.3) p.p. Further, this averted an additional 3,979 (3,453–4,298) deaths in France, 1,133 (-312–1,358) in Germany, and 1,331 (502–1,794) in Italy; and prevented gross domestic product (GDP) losses of €6.0 (5.9–6.1) billion in France, €1.4 (1.3–1.5) billion in Germany, and €2.1 (2.0–2.2) billion in Italy. Notably, the application of COVID certificates substantially reduced the pressure on intensive care units (ICUs) and, in France, averted occupancy levels being exceeded where prior lockdowns were instated. Varying government communication efforts and restrictions associated with COVID certificates may explain country differences, such as the smaller effect in Germany. Overall, our findings are more sizeable than predicted.7 This analysis may help inform decisions about when and how to employ COVID certificates to increase vaccine uptake and thus avoid stringent interventions, such as closures, curfews, and lockdowns, with major social and economic consequences.

The purpose of this study was to report several novel classification systems for intra-articular lesions observed during hip arthroscopy, and to quantify the interrater reliability of both these novel systems and existing classifications of intra-articular lesions when tested by a group of high-volume hip arthroscopists. Five hip arthroscopists deliberated over shortcomings in current classification systems and developed several novel grading systems with particular effort made to capture factors important to the treatment and outcomes of hip arthroscopy for labral injury. A video learning module describing the classifications was then developed from the video archive of surgeries performed by the senior author and reviewed by study participants. Following review of the module, a pilot study was completed using five randomly selected videos, after which participating surgeons met once more to discuss points of disagreement and to seek clarification. The final video collection for testing reliability was composed of 29 videos selected with the intent of capturing all sublevels of each classification scheme. Study participants recorded their assessments using each classification scheme, and interrater reliability was calculated by a study participant not involved in grading. The average kappa coefficients for the classification schemes ranged from 0.38 to 0.54, with the interrater reliability of all classification schemes except labral degeneration qualifying as moderate. The percent of cases with absolute agreement ranged from 17.2% to 51.7% across the classification systems. Even among a group of high-volume hip arthroscopists who engaged in several discussions about the proposed classification schemes, grades were found to have at best moderate interrater reliability. Moderate interrater reliability is demonstrated for novel grading systems for describing labral tear complexity, labral bruising, labral size, and extent of synovitis, and fair reliability is demonstrated for labral degeneration. Further development and refinement of multifactorial grading systems for describing labral injury are indicated. Evaluating the multifactorial nature of intra-articular lesions in the hip is an important part of intraoperative decision-making and defining reliable classifications for intra-articular lesions is a critical first step towards developing generalizable criteria for guiding treatment type. Level III.

The purpose of the current study was to establish a risk stratification for hip injury by presenting the classification of sports among adolescent athletes undergoing hip arthroscopy. A multicentre registry was queried to examine the incidence of adolescent athletes undergoing hip arthroscopy. Patients were identified and grouped according to their sport-specific risk classification (level I–III). Chi-square analysis was performed to determine the relationship of classification of sport and gender in adolescent athletes to hip arthroscopy. A second chi-square analysis was performed to determine the relationship of classification of sport and number of sports the adolescent athlete was participating in prior to arthroscopic hip surgery. A total of 297 adolescent athletes were included in the study with 129 (43.4%) participating in level I sports compared with 84 (28.3%) in level II and 84(28.3%) in level III sports. Chi-square testing demonstrated a significant effect on gender and sport classification, X2 (2, N = 297) = 31.18, p

If the three biggest economies agree a carbon tax on imports, it will catalyse climate action globally. If the three biggest economies agree a carbon tax on imports, it will catalyse climate action globally.

Cell-based, mathematical modeling of collective cell behavior has become a prominent tool in developmental biology. Cell-based models represent individual cells as single particles or as sets of interconnected particles, and predict the collective cell behavior that follows from a set of interaction rules. In particular, vertex-based models are a popular tool for studying the mechanics of confluent, epithelial cell layers. They represent the junctions between three (or sometimes more) cells in confluent tissues as point particles, connected using structural elements that represent the cell boundaries. A disadvantage of these models is that cell-cell interfaces are represented as straight lines. This is a suitable simplification for epithelial tissues, where the interfaces are typically under tension, but this simplification may not be appropriate for mesenchymal tissues or tissues that are under compression, such that the cell-cell boundaries can buckle. In this paper we introduce a variant of VMs in which this and two other limitations of VMs have been resolved. The new model can also be seen as on off-the-lattice generalization of the Cellular Potts Model. It is an extension of the open-source package VirtualLeaf, which was initially developed to simulate plant tissue morphogenesis where cells do not move relative to one another. The present extension of VirtualLeaf introduces a new rule for cell-cell shear or sliding, from which T1 and T2 transitions emerge naturally, allowing application of VirtualLeaf to problems of animal development. We show that the updated VirtualLeaf yields different results than the traditional vertex-based models for differential-adhesion-driven cell sorting and for the neighborhood topology of soft cellular networks., Comment: 28 pages, 4 figures; accepted for publication in Bulletin of Mathematical Biology

Background Opioid use disorder (OUD) is associated with substantial morbidity and mortality for women, especially during the perinatal period. Opioid overdose has become a significant cause of maternal death in the United States, with rates highest in the immediate postpartum year. While pregnancy is a time of high motivation for healthcare engagement, unique challenges exist for pregnant women with OUD seeking both substance use treatment and maternity care, including managing change after birth. How women successfully navigate these barriers, engage in treatment, and abstain from substance use during pregnancy and postpartum is poorly understood. The aim of this study is to explore the experiences of postpartum women with OUD who successfully engaged in both substance use treatment and maternity care during pregnancy, to understand factors contributing to their ability to access care and social support. Methods We conducted semi-structured, in-depth interviews with postpartum women in sustained recovery (n = 10) engaged in a substance use treatment program in northern New England. Interviews were analyzed using grounded theory methodology. Results Despite multiple barriers, women identified pregnancy as a change point from which they were able to develop self-efficacy and exercise agency in seeking care. A shift in internal motivation enabled women to disclose need for OUD treatment to maternity care providers, a profoundly significant moment. Concurrently, women developed a new capacity for self-care, demonstrated through managing relationships with providers and family members, and overcoming logistical challenges which had previously seemed overwhelming. This transformation was also expressed in making decisions based on pregnancy risk, engaging with and caring for others, and providing peer support. Women developed resilience through the interaction of inner motivation and their ability to positively utilize or transform external factors. Conclusions Complex interactions occurred between individual-level changes in treatment motivation due to pregnancy, emerging self-efficacy in accessing resources, and engagement with clinicians and peers. This transformative process was identified by women as a key factor in entering recovery during pregnancy and sustaining it postpartum. Clinicians and policymakers should target the provision of services which promote resilience in pregnant women with OUD.

The EU is a relatively open economy and has benefited from the global multilateral system. We argue that the EU should defend its strategic interests with three steps. First, it should collaborate with partners around the world in defence of multilateralism. Second, it should establish deeper economic relations with emerging economies. Collaboration in support of the Paris agreement is also essential. Third, the EU must be reformed to increase its external credibility. The Singapore ruling has offered a useful clarification on trade policy. Addressing internal imbalances would also increase external credibility. Finally, strengthening Europe's social model would provide a counter model to protectionist temptations.

This article discusses the impedance method in the forward calculation in magnetic induction tomography (MIT). Magnetic field and eddy current distributions were obtained numerically for a sphere in the field of a coil and were compared with an analytical model. Additionally, numerical and experimental results for phase sensitivity in MIT were obtained and compared for a cylindrical object in a planar array of sensors. The results showed that the impedance method provides results that agree very well with reality in the frequency range from 100 kHz to 20 MHz and for low conductivity objects (10 S/m or less). This opens the possibility of using this numerical approach in image reconstruction in MIT.

To compare the lithium-thermal double indicator dilution (Li-thermal), indocyanine green-thermal double indicator dilution (ICG-thermal), single thermal indicator dilution (single-thermal) and gravimetric techniques of extravascular lung water volume (EVLW) measurement in porcine models of acute lung injury.Two animal models designed to invoke a systemic inflammatory response.Laboratory study.A total of 12 immature Deutsches Landschwein pigs.Extravascular lung water volume was measured at four time points using Li-thermal, ICG-thermal and single-thermal techniques. Measurements were performed using existing technology according to manufacturer's instructions. Post-mortem gravimetric EVLW measurements were performed by measuring wet and dry mass of lung tissue. Measurements were compared using the Bland-Altman method. Data are presented as mean (SD).Data were collected in 12 animals and comparison between all 4 techniques was possible in 10 animals. EVLW measured by gravimetry was 9.2 (+/-3.0)ml kg(-1). When compared to gravimetry, both Li-thermal and ICG-thermal techniques showed minimal bias but wide limits of agreement (LOA) [Li-thermal: bias -1.8 ml kg(-1) (LOA +/- 13.1); ICG-thermal bias -1.0 ml kg(-1) (LOA +/- 6.6)]. Comparison between the single-thermal and gravimetric methods identified both considerable bias and wide LOA [+8.5 ml kg(-1) (LOA +/- 14.5)].Clinically significant differences between EVLW measurements obtained with the gravimetric method and three in vivo indicator dilution techniques were identified. While none of the techniques could be considered ideal, the ICG-thermal method appeared more reliable than either the Li-thermal or single thermal techniques. Further research is required to determine whether the accuracy of the prototype Li-thermal technique can be improved.

We investigate the effect of fiscal institutions such as the strength of the finance minister in the budget process and deficits on interest rate spreads of Eurozone countries. Deficits significantly increase risk premia measured by relative swap spreads. The effect of deficits is significantly lower under EMU. This effect partly results from neglecting the role of fiscal institutions. After controlling for institutional changes, fiscal policy remains a significant determinant of risk premia in EMU. Better institutions are connected with lower risk premia. Furthermore deficits matter less for risk premia in countries with better institutions. Markets acknowledge that better institutions reduce fiscal difficulties rendering the monitoring of annual developments less important.

Stem cells are defined by their unique capacity for self-renewal and multilineage differentiation. Stem cells have been obtained from multiple extramedullary tissues. Recently, a population of progenitor cells have been identified in the endometrium. However, multilineage differentiation of endometrial stem cells has not been reported. Endometrial tissue was obtained from reproductive-aged women undergoing surgery for benign disease, from which monolayer endometrial stromal cell (ESC), myometrial, fibroid, fallopian tube, and uterosacral ligament tissue cultures were generated. Once confluent, cells were trypsinized and centrifuged in conical tubes to form a cell pellet. Cell pellets were cultured in a defined chondrogenic media (CM) containing dexamethasone and transforming growth factor (TGF)-beta2 or TGF-beta 3 for 3 to 21 days. Samples were analyzed for markers of human articular cartilage, including sulfated glycosaminoglycans and expression of type II collagen. ESC pellets cultured in CM were found to contain cells that resemble chondrocytes. These cells expressed sulfated glycosaminoglycans and type II collagen typical of human articular cartilage. Myometrial, fibroid, fallopian tube, and uterosacral ligament cells were unable to undergo chondrogenic differentiation using the pellet culture method. Cells derived from the endometrium were able to differentiate into a heterologous cell type: chondrocytes, thus demonstrating the presence of multipotent stem cells. Endometrium is a potential source of multipotent stem cells.

While there are studies that focus specifically on hate crimes, especially anti-lesbian, gay, bisexual, and/or transgender motivated violence, little research has been done to examine the role that law enforcement officials play in responding to crimes related to the Gay/Lesbian/Bisexual/Transgender (GLBT) community. This study, therefore, attempts to do just that. Using traditional content-analysis techniques, we examine 1,896 incident reports that were collected by a GLBT advocacy group in Minnesota, between 1990 and 2000, to begin to understand the range of police responses in relation to the GLBT community. Results indicate that while police conduct improved, negative responses and behaviors on the part of law enforcement officials outnumbered positive responses. The most common complaint by Helpline callers was inadequate response by the police; there were also numerous callers indicating that they were further victimized at the hands of the law enforcement officials. The data suggest a continued need for the education of law enforcement officials regarding issues facing the GLBT community, advocacy for victims of crime who are many times reluctant to report an incident to the police and increased attention to issues of oversight and accountability for officers who are responding to calls for help from the GLBT community.

Foreign direct investment is of increasing importance in the European Union. This paper estimates the effect of taxes on foreign direct investment (FDI) flows and on three sub-components of these flows for the countries of the enlarged European Union. The model in the spirit of gravity equations robustly explains FDI flows between the 25 member states. Sample selection needs to be addressed in the estimation. We show that the different subcomponents of FDI should and indeed do react differently to taxes. After controlling for unobserved country characteristics and common time effects, the top statutory corporate tax rate of both, source and host country, turn insignificant for total FDI and investment into equity. However, high source country taxes clearly increase the probability of firms to re-invest profits abroad and lower the percentage of debt financed FDI. This might reflect profit re-allocation to avoid taxes. Market size factors have the expected signs.

Despite substantial evidence that fish oil-derived (n-3) polyunsaturated fatty acids (PUFA) may protect against cardiovascular disease, the effects of supplements containing (n-3) PUFA on the skeletal system are unknown. Here we investigated how a diet supplemented with 10 g/100 g fish oil affected tibial cortical morphology and mechanical properties in weanling rabbits. Rabbits were subdivided into a normal control (n = 10), a fish oil (n = 20), and a pair-fed (n = 20) group. The pair-fed group was energy restricted to match average body mass of the fish oil group. At completion of the 40 day dietary intervention, control rabbits were significantly heavier than the other two groups. Comparison between control and pair-fed rabbits revealed that energy restriction alone (30%) did not induce significant changes in tibial middiaphyseal morphology, but tibial longitudinal growth was significantly impaired. Most tibial mechanical properties were significantly degraded by energy restriction. Fish oil-supplemented rabbits had significantly smaller middiaphyseal areal properties and shorter tibiae than pair-fed rabbits. Tibial structural properties were significantly reduced in fish oil-fed rabbits, but tibial stress at the proportional limit (material property) was not significantly affected. Our data suggest that 10% fish oil supplementation in the presence of modest vitamin E supplementation can have detrimental effects on the skeleton of rapidly growing rabbits.

There are many computational vision techniques that fundamentally rely upon assumptions about the nature of diffuse reflection from object surfaces consisting of commonly occurring nonmetallic materials. Probably the most prevalent assumption made about diffuse reflection by computer vision researchers is that its reflected radiance distribution is described by the Lambertian model, whether the surface is rough or smooth. While computationally and mathematically a relatively simple model, in physical reality the Lambertian model is deficient in accurately describing the reflected radiance distribution for both rough and smooth nonmetallic surfaces. Recently, in computer vision diffuse reflectance models have been proposed separately for rough, and, smooth nonconducting dielectric surfaces each of these models accurately predicting salient non-Lambertian phenomena that have important bearing on computer vision methods relying upon assumptions about diffuse reflection. Together these reflectance models are complementary in their respective applicability to rough and smooth surfaces. A unified treatment is presented here detailing important deviations from Lambertian behavior for both rough and smooth surfaces. Some speculation is given as to how these separate diffuse reflectance models may be combined.

A robust and accurate polarization phase-based technique for material classification is presented. The novelty of this technique is three-fold in (i) its theoretical development, (ii) application, and, (iii) experimental implementation. The concept of phase of polarization of a light wave is introduced to computer vision for discrimination between materials according to their intrinsic electrical conductivity, such as distinguishing conducting metals, and poorly conducting dielectrics. Previous work has used intensity, color and polarization component ratios. This new method is based on the physical principle that metals retard orthogonal components of light upon reflection while dielectrics do not. This method has significant complementary advantages with respect to existing techniques, is computationally efficient, and can be easily implemented with existing imaging technology. Experiments for real circuit board inspection, nonconductive and conductive glass, and, outdoor object recognition have been performed to demonstrate its accuracy and potential capabilities.

The relationship between soil acidity and polyamine (putrescine, spermidine, spermine) concentrations in roots was evaluated and compared to (1) nodule numbers in common beans and (2) tannin concentrations in roots. Six Phaseolus vulgaris cultivars were grown in pots in a greenhouse in soil at pH 4.5 or 5.5 and inoculated with Rhizobium leguminosarum bv. phaseoli strains. At pH 4.5 nodule numbers were strongly reduced but polyamine concentrations were 50% higher than at pH 5.5. At both pH levels putrescine and spermidine were the dominant polyamines, while the concentration of spermine was less than half of the other two. There was also a cultivar effect on the polyamine concentration, but this was much less pronounced than the pH effect. By 22 days after planting the uninoculated control plants had about 13% lower levels of polyamines than the inoculated plants. The concentrations of putrescine, spermidine, and spermine were negatively correlated with nodule numbers, but positively correlated with the root tannin content. There were no significant correlations with either root or plant dry weight.

The uv laser-ablation behavior of various oxide ceramics (Al2O3, MgO, ZrO2) has been studied using different wavelengths (248 nm, 308 nm) and pulse durations (30 ns, 500 fs). Time-resolved absorption measurements of the sample and the ablation plume during ablation were performed. Using sub-ps pulses the ablation threshold fluence is generally lower than for ns pulses; the ablation rate is higher in the whole investigated fluence range up to 20 J/cm2. The study of the morphology of the ablation structures and the results of the absorption experiments lead to the conclusion that different ablation mechanisms are involved. Using ns pulses “plasma mediated ablation” is dominating, whereas in the fs case the process is controlled by multi-photon absorption enabling microstructuring of the material.

The dependence of the ablation rate of various materials on the laser spot diameter on the sample surface has been investigated. The experiments have been performed with excimer lasers at the wavelengths 193, 248 and 308 nm. Polymers, aluminum oxide ceramics, and glasses have been ablated under vacuum and ambient atmosphere conditions. In general, all materials show a more or less pronounced increase of the ablation rate with decreasing spot diameter in the range of 10–200 μm if pulses with nanosecond pulse durations are applied. For ultrashort pulses (500 fs) at 248 nm this diameter dependence is not observed. The expansion of the ablation plume over areas of different size seems to be the main reason for this effect.

Six Rhizobium leguminosarum bv. phaseoli strains (Ciat 151, Ciat 895, Ciat 899, CE3, H2C, Kim5s) were tested for nodule occupancy in different bean cultivars at two field sites (one fertile, one acid tropical soil) and in the greenhouse. The effects of several environmental factors such as low pH, high temperature, Al and Mn toxicity, iron deficiency, bean tannins, and bean phytoalexins were tested in vitro. Strain Kim5s was competitive under all tested conditions while strains CE3 and H2C had consistently low nodule occupancy levels. Strain Ciat 151 was superior to the other inoculant strains in the acid soil but competed poorly in the fertile soil. Strain Ciat 895 was more competitive in the fertile soil. There was a decline in nodule occupancy for all strains tested from the first trifoliate leaf stage to the pod-filling stage. No plant genotype effect on nodule occupancy was observed. There were significant (P

We observe that resonant ionization plays a dominant role in the multiphoton ionization (MPI) of xenon at wavelengths around 600 nm, irrespective of the detuning of multiples of the photon energy from excited states of the undisturbed atom. Angular distributions of energy resolved photoelectrons allow to identify excited states which are strongly ac-Stark shifted in the intense laser field and which serve as intermediate resonances in MPI processes. Angular distributions measured at different wavelengths show that the ac-Stark shift of excited states can be larger than the photon energyhω. Our results support the model proposed by Freeman et al.

The PulseCO pressure waveform algorithm is used for both LiDCO™plus and LiDCOrapid hemodynamic monitors to estimate cardiac output (CO). The accuracy of this CO estimate is achieved by comparing (calibrating) the PulseCO with a known CO, for example from the lithium dilution or LiDCO which scales the software algorithm and reduces the bias to the actual CO [1]. This calibration/scaling factor (CF) is patient specific and should not significantly change over a period of a few days as it reflects the patient's aortic capacitance.

One of the advantages which projects in musical computation have over computing projects in other humanities disciplines is the previous existence of a rather good notational system for the description of the subject matter at hand. Music notation is fairly compact, is visually suggestive of the material it represents, and is easily read and written. More remarkably, the musician is able to perform music in "real time" from the musical score. Music notation as we have it today has been evolving for upwards of 3000 years and assumed a form prototypical of its current form some 350 years ago. It was then logical, when certain applications in musical computing arose, to attempt to devise an adequate encoding language which represented musical notation. A number of such languages have been designed, reviewed in books by Lincoln (1970), Brook (1970), and Heckmann (1967), and some of them are still used today. One such language is known as DARMS (Digital Alternate Representation of Musical Scores), which was devised by Professor Stefan Bauer-Mengelberg of the IBM Corporation, to form the input stage of a musical printing process. The history of its development is discussed by Erickson (1975), and its syntax, described in Erickson (1976) and in Erickson and Wolff (in press), will provide examples to follow. The virtues of music notation are predicated upon certain information-processing characteristics of the human perceptual and cognitive apparatus, which exceed those of state-of-the-art computer programs. It is these capacities which permit the high level of complexity found in musical notation. To adequately interpret muscial scores, we must make syntactic and semantic decisions in processing serial information, based on broad left and/or right contexts. We are required to resolve formally ambiguous cases, and to be conversant in a number of "dialects" of musical notation

The interaction of hydrogen atoms with strong laser fields at intensities up to some 1013 W cm−2 was studied experimentally at the wavelengths λ=355 nm, 532 nm and 1064 nm. The ion yield, the energy spectrum of the photoelectrons and their angular distributions were measured. The angular distributions at λ=355 nm and λ=532 nm provide a sensitive test for theoretical calculations. Comparison with the calculations available shows that perturbation theory with proper inclusion of atomic structure yields results which agree with experiment. Intensity dependent changes of angular distributions at λ=532 nm are observed, which indicate that at 1013 W cm−2 higher order processes become noticable. At λ=1064 nm the situation is more complicated, experimentally as well as theoretically. Intensities of some 1013 W cm−2 are necessary to observe ionization. Strong distortions of the atomic structure can be expected. Presently only qualitative aspects of the angular distributions can be discussed.