1. Immunomodulating functions of human leukocyte antigen-G and its role in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
- Author
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Ya Gao, Xiaoyin Bu, Jinman Zhong, Weiru Li, Shengchun Cai, and Bao-Hong Ping
- Subjects
medicine.medical_specialty ,Immune regulation ,medicine.medical_treatment ,Graft vs Host Disease ,chemical and pharmacologic phenomena ,Review Article ,Hematopoietic stem cell transplantation ,Human leukocyte antigen ,Disease ,Transplantation tolerance ,Graft-versus-host disease ,Immune tolerance ,Immunomodulation ,Immune system ,immune system diseases ,Internal medicine ,MHC class I ,medicine ,Animals ,Humans ,Transplantation, Homologous ,HLA-G Antigens ,Hematology ,biology ,business.industry ,Hematopoietic Stem Cell Transplantation ,General Medicine ,medicine.disease ,Human leukocyte antigen-G ,surgical procedures, operative ,Allogeneic hematopoietic stem cell transplantation ,Immunology ,biology.protein ,business - Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapeutic strategy to treat several hematological malignancies and non-hematological malignancies. However, graft-versus-host disease (GVHD) is a frequent and serious transplant-related complication which dramatically restrains the curative effect of allo-HSCT and a significant cause of morbidity and mortality in allogeneic HCT recipients. Effective prevention of GVHD mainly depends on the induction of peripheral immune tolerance. Human leukocyte antigen-G (HLA-G) is a non-classical MHC class I molecule with a strong immunosuppressive function, which plays a prominent role in immune tolerance. HLA-G triggers different reactions depending on the activation state of the immune cells and system. It also exerts a long-term immune tolerance mechanism by inducing regulatory cells. In this present review, we demonstrate the immunomodulatory properties of human leukocyte antigen-G and highlight the role of HLA-G as an immune regulator of GVHD. Furthermore, HLA-G could also serve as a good predictor of GVHD and represent a new therapeutic target for GVHD.
- Published
- 2021
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