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Your search keyword '"Benedito, Rui"' showing total 16 results
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16 results on '"Benedito, Rui"'

1. Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate

Author

Thambyrajah, Roshana, primary, Maqueda, Maria, additional, Neo, Wen Hao, additional, Imbach, Kathleen, additional, Guillén, Yolanda, additional, Grases, Daniela, additional, Fadlullah, Zaki, additional, Gambera, Stefano, additional, Matteini, Francesca, additional, Wang, Xiaonan, additional, Calero-Nieto, Fernando J., additional, Esteller, Manel, additional, Florian, Maria Carolina, additional, Porta, Eduard, additional, Benedito, Rui, additional, Göttgens, Berthold, additional, Lacaud, Georges, additional, Espinosa, Lluis, additional, and Bigas, Anna, additional

Published
2024
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2. Incongruence between transcriptional and vascular pathophysiological cell states

Author

Fernández-Chacón, Macarena, primary, Mühleder, Severin, additional, Regano, Alvaro, additional, Garcia-Ortega, Lourdes, additional, Rocha, Susana F., additional, Torroja, Carlos, additional, Sanchez-Muñoz, Maria S., additional, Lytvyn, Mariya, additional, Casquero-Garcia, Verónica, additional, De Andrés-Laguillo, Macarena, additional, Muhl, Lars, additional, Orlich, Michael M., additional, Gaengel, Konstantin, additional, Camafeita, Emilio, additional, Vázquez, Jesús, additional, Benguría, Alberto, additional, Iruela-Arispe, M. Luisa, additional, Dopazo, Ana, additional, Sánchez-Cabo, Fátima, additional, Carter, Hannah, additional, and Benedito, Rui, additional

Published
2023
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3. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Author

Bernier-Latmani, Jeremiah, primary, Cisarovsky, Christophe, additional, Mahfoud, Samantha, additional, Ragusa, Simone, additional, Dupanloup, Isabelle, additional, Barras, David, additional, Renevey, François, additional, Nassiri, Sina, additional, Anderle, Pascale, additional, Squadrito, Mario Leonardo, additional, Siegert, Stefanie, additional, Davanture, Suzel, additional, González-Loyola, Alejandra, additional, Fournier, Nadine, additional, Luther, Sanjiv A., additional, Benedito, Rui, additional, Valet, Philippe, additional, Zhou, Bin, additional, De Palma, Michele, additional, Delorenzi, Mauro, additional, Sempoux, Christine, additional, and Petrova, Tatiana V., additional

Published
2022
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4. Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

Author

Mühleder, Severin, Fernández-Chacón, Macarena, Garcia-Gonzalez, Irene, Benedito, Rui, FWF Austrian Science Fund, Fundación La Caixa, European Research Council, Centro Nacional de Investigaciones Cardiovasculares Carlos III (España), Ministerio de Economía, Industria y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), and Fundación ProCNIC

Subjects
Senescence, Aging, Cell cycle checkpoint, Vascular differentiation, Angiogenesis, Endothelial cells, medicine.medical_treatment, Neovascularization, Physiologic, Review, Disease, Biology, Cell-cycle arrest, Regenerative medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Cell Movement, Neoplasms, medicine, Humans, Molecular Biology, Cell Proliferation, 030304 developmental biology, Feedback, Physiological, Pharmacology, 0303 health sciences, Neovascularization, Pathologic, Cell growth, Growth factor, Endothelial Cells, Cell Biology, Cell biology, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Malformations, Molecular Medicine, Signal transduction, Sprouting, Signal Transduction
Abstract

Therapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The general view is that an increase in vascular growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. However, several recent studies showed that an increase in mitogenic stimuli can also lead to the arrest of angiogenesis. This is due to the existence of intrinsic signaling feedback loops and cell cycle checkpoints that work in synchrony to maintain a balance between endothelial proliferation and sprouting. This balance is tightly and effectively regulated during tissue growth and is often deregulated or impaired in disease. Most therapeutic strategies used so far to promote vascular growth simply increase mitogenic stimuli, without taking into account its deleterious effects on this balance and on vascular cells. Here, we review the main findings on the mechanisms controlling physiological vascular sprouting, proliferation, and senescence and how those mechanisms are often deregulated in acquired or congenital cardiovascular disease leading to a diverse range of pathologies. We also discuss alternative approaches to increase the effectiveness of pro-angiogenic therapies in cardiovascular regenerative medicine. Severin Mühleder was funded by the Austrian Science Fund (FWF) project J4358. Macarena Fernández-Chacón and Irene Garcia-Gonzalez were supported by PhD fellowships from Fundación La Caixa (CX_E-2015-01 and CX-SO-16-1, respectively). Rui Benedito was funded by the European Research Council (ERC-2014-StG—638028), the Centro Nacional de Investigaciones Cardiovasculares (CNIC), and by the Ministerio de Economia, Industria y Competitividad (MEIC: SAF2013-44329-P, SAF2017-89299-P, and RYC-2013-13209). The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades (MCNU) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Sí

Published
2020

5. Angiocrine polyamine production regulates adiposity

Author

Monelli, Erika, primary, Villacampa, Pilar, additional, Zabala-Letona, Amaia, additional, Martinez-Romero, Anabel, additional, Llena, Judith, additional, Beiroa, Daniel, additional, Gouveia, Leonor, additional, Chivite, Iñigo, additional, Zagmutt, Sebastián, additional, Gama-Perez, Pau, additional, Osorio-Conles, Oscar, additional, Muixi, Laia, additional, Martinez-Gonzalez, Ainara, additional, Castillo, Sandra D., additional, Martín-Martín, Natalia, additional, Castel, Pau, additional, Valcarcel-Jimenez, Lorea, additional, Garcia-Gonzalez, Irene, additional, Villena, Josep A., additional, Fernandez-Ruiz, Sonia, additional, Serra, Dolors, additional, Herrero, Laura, additional, Benedito, Rui, additional, Garcia-Roves, Pablo, additional, Vidal, Josep, additional, Cohen, Paul, additional, Nogueiras, Rubén, additional, Claret, Marc, additional, Carracedo, Arkaitz, additional, and Graupera, Mariona, additional

Published
2022
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8. Arterialization requires the timely suppression of cell growth

Author

Luo, Wen, primary, Garcia-Gonzalez, Irene, additional, Fernández-Chacón, Macarena, additional, Casquero-Garcia, Verónica, additional, Sanchez-Muñoz, Maria S., additional, Mühleder, Severin, additional, Garcia-Ortega, Lourdes, additional, Andrade, Jorge, additional, Potente, Michael, additional, and Benedito, Rui, additional

Published
2020
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9. Publisher Correction: High mitogenic stimulation arrests angiogenesis

Author

Pontes-Quero, Samuel, primary, Fernández-Chacón, Macarena, additional, Luo, Wen, additional, Lunella, Federica Francesca, additional, Casquero-Garcia, Verónica, additional, Garcia-Gonzalez, Irene, additional, Hermoso, Ana, additional, Rocha, Susana F., additional, Bansal, Mayank, additional, and Benedito, Rui, additional

Published
2019
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11. High mitogenic stimulation arrests angiogenesis

Author

Pontes-Quero, Samuel, primary, Fernández-Chacón, Macarena, additional, Luo, Wen, additional, Lunella, Federica Francesca, additional, Casquero-Garcia, Verónica, additional, Garcia-Gonzalez, Irene, additional, Hermoso, Ana, additional, Rocha, Susana F., additional, Bansal, Mayank, additional, and Benedito, Rui, additional

Published
2019
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12. Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception

Author

Bicker, Frank, primary, Vasic, Verica, additional, Horta, Guilherme, additional, Ortega, Felipe, additional, Nolte, Hendrik, additional, Kavyanifar, Atria, additional, Keller, Stefanie, additional, Stankovic, Nevenka Dudvarski, additional, Harter, Patrick N., additional, Benedito, Rui, additional, Lutz, Beat, additional, Bäuerle, Tobias, additional, Hartwig, Jens, additional, Baumgart, Jan, additional, Krüger, Marcus, additional, Radyushkin, Konstantin, additional, Alberi, Lavinia, additional, Berninger, Benedikt, additional, and Schmidt, Mirko H. H., additional

Published
2017
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13. Sequential Notch activation regulates ventricular chamber development

Author

D’Amato, Gaetano, primary, Luxán, Guillermo, additional, del Monte-Nieto, Gonzalo, additional, Martínez-Poveda, Beatriz, additional, Torroja, Carlos, additional, Walter, Wencke, additional, Bochter, Matthew S., additional, Benedito, Rui, additional, Cole, Susan, additional, Martinez, Fernando, additional, Hadjantonakis, Anna-Katerina, additional, Uemura, Akiyoshi, additional, Jiménez-Borreguero, Luis J., additional, and de la Pompa, José Luis, additional

Published
2015
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