556 results on '"Blocking (radio)"'
Search Results
2. Network Support for IP Trace Back Model in Wireless Sensor Networks Using Quantum Annealing Method
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N. Arulanand and Madhumitha Kulandaivel
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Guard (information security) ,Network packet ,Computer science ,Blocking (radio) ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Denial-of-service attack ,Computer Science Applications ,Bandwidth (computing) ,The Internet ,Electrical and Electronic Engineering ,business ,Wireless sensor network ,Ingress router ,Computer network - Abstract
Distributed Denial-Of-Service (DDoS) attacks are one of the all the more difficult security issues on the Internet today. They can without much of a stretch, fumes the assets of the potential Victims. The issue is much more extreme since the aggressors regularly produce their IP delivers to shroud their character. The current guard mechanism against DDoS attacks, the attack traffic will be filtered at the victim’s side. For this situa- tion, regardless of whether the attacking traffic is filtered by the victim, the attacker may achieve the objective of blocking access to the victim’s bandwidth. IP-Trace back ap- proaches enable the victim to trace back to the wellspring of an attack and they will not be able to minimize the attack when the attack is in progress. Hence is to minimize the quan- tity of malicious packets entering into the network we put forth a quantum annealing technique to identify and alleviate the DDoS attack. The attack messages are minimized by utilizing client puzzle as a part of the ingress router; the path fingerprint is used at the egress side. Simulation studies prove that the proposed mechanism is optimally successful in recognizing and mitigating the DDoS attacks.
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- 2021
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3. Queueing based spectrum management in cognitive radio networks with retrial and heterogeneous service classes
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Shruti Goel and Rakhee Kulshrestha
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Queueing theory ,Cognitive radio ,General Computer Science ,Handover ,business.industry ,Computer science ,Blocking (radio) ,Quality of service ,Throughput ,business ,Spectrum management ,Radio spectrum ,Computer network - Abstract
Cognitive radio is an emerging technology, aimed at efficient use of the scarce radio spectrum. In cognitive radio networks (CRNs), spectrum licensed to the primary users (PUs) is shared by the secondary users (SUs) which affects the performance of the network. This paper proposes a novel spectrum management scheme for CRNs, where heterogeneous secondary real-time and non-real time users compete for the available channels with primary users and utilize two types of buffers under the probability retrial policy. To enhance the quality of service (QoS) for the secondary users (SUs), spectrum handoff and call buffering strategies with retrial policy are employed jointly so that SUs that would otherwise be blocked or forcibly dropped could be queued and possibly served later. The whole system is modeled using a multi-dimensional continuous-time Markov chain (CTMC) and accordingly, the QoS performance metrics are derived. Numerical results are presented which illustrate that the provision of queues under the proposed retrial policy increases overall network resource utilization and throughput while decreasing blocking and dropping probabilities.
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- 2021
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4. Analysis of double-frequency jitter on time-delayed oscillators networks and perturbations adjustment in clock
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Diego Paolo Ferruzzo Correa, Roger Oliva Felix, Átila Madureira Bueno, José Manoel Balthazar, Universidade Estadual Paulista (UNESP), and Universidade Federal do ABC (UFABC)
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Blocking (radio) ,Computer science ,Local oscillator ,General Physics and Astronomy ,Time signal ,Synchronizing ,Topology ,Phase detector ,Synchronization ,Phase-locked loop ,Hardware_INTEGRATEDCIRCUITS ,General Materials Science ,Physical and Theoretical Chemistry ,Jitter - Abstract
Made available in DSpace on 2022-05-01T06:31:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 The delay in signal transmission for oscillator networks influences in the synchronization, getting oscillatory behavior. The synchronization occurs by the phase-locked loops (PLL), synchronizing the local oscillator with a reference phase and frequency. The oscillators are implemented in data and telecommunications communication systems, as elements (nodes) for distribution of time signals (clock). In the work is implementated the time signal distribution network, with three nodes, in order to establish a common time base, with adjustment of disturbance in clock. The phase detection process generates a periodic oscillation called double-frequency jitter (DFJ). The DFJ is inevitable, appearing even with the PLL operating in the blocking range. Therefore, this work aims to study the effect of the double frequency oscillation on a network with signal transmission delay, its influence on the synchronous states of network, and the performance of oscillators to recover the common time base of clock, when disturbed. Institute of Sciente and Technology São Paulo State University-UNESP, Av. Três de Março 511 Fedeal University of ABC-UFABC, R. Arcturus 3 School of Engineering São Paulo State University-UNESP, Av. Eng. Luís Edmundo Carrijo Coube, 14-01 Institute of Sciente and Technology São Paulo State University-UNESP, Av. Três de Março 511 School of Engineering São Paulo State University-UNESP, Av. Eng. Luís Edmundo Carrijo Coube, 14-01
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- 2021
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5. Detection of power swing and blocking the distance relay using the variance calculation of the current sampled data
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Behrooz Taheri, Milad Faghihlou, and Sirus Salehimehr
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Signal processing ,Noise (signal processing) ,Blocking (radio) ,Computer science ,Applied Mathematics ,Swing ,Parallel ,Signal ,Power (physics) ,law.invention ,Relay ,law ,Control theory ,Electrical and Electronic Engineering - Abstract
Power swings appear as a result of sudden addition or removal of heavy loads, switching, cutoff of a parallel line, and reclosing. These swings can affect the protective zones of distance relays, causing them to malfunction and erroneously cut off healthy lines from the grid. This paper proposes a new solution for detecting power swings and preventing this malfunction based on the variance of data sampled from the current signal. The lack of any signal processing phase in the proposed solution makes it computationally light and thus suitable for implementation in distance relays. In addition, the method's performance is not affected by the presence of noise in the sampled signal. The method is able to detect power swings of stable, unstable, and multi-mode variety. In comparison with some of the latest works in the field of power swing detection as well as conventional methods, it is demonstrated that the method outperforms them in terms of response time, the ability to detect different varieties of the power swing, and the ability to detect different varieties of faults that may occur simultaneously with a power swing.
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- 2021
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6. Global trends in the occurrence and characteristics of blocking anticyclones using Şen innovative trend analysis
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Bahtiyar Efe and Anthony R. Lupo
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Trend analysis ,Atmospheric Science ,Blocking (radio) ,Northern Hemisphere ,Environmental science ,Atmospheric sciences ,Block (meteorology) ,Southern Hemisphere - Abstract
Atmospheric blocking plays an important role in modulating mid-latitude weather, in particular in the Northern Hemisphere (NH). Trend analysis of atmospheric blocking for both hemispheres by using Sen’s Innovative Trend Analysis (ITA) is performed in this study. The blocking data archived in the University of Missouri covers the period of 1968–2019 for the NH and 1970–2019 for the Southern Hemisphere is used in the study. Block occurrence, duration and blocking intensity (BI) is analysed by classifying the NH (and SH) into three groups according to the preferred blocking locations: Atlantic, Pacific and Continental (Atlantic, Pacific and Indian). In the NH, blocking intensity showed mixed results. It showed a decreasing trend for the entire hemisphere and Atlantic Region, whilst a different trend was shown for different BI clusters. For blocking numbers and duration, the entire hemisphere and regions showed increasing trends. These increasing trend values were also statistically significant. In the SH, blocking intensity showed a decreasing trend for low clusters, whilst medium and high cluster increased for the entire hemisphere. Block duration showed an increasing trend for the entire SH. Block numbers showed increasing trends, except for one point in the low cluster. Blocking characteristics showed different trends for different preferred blocking locations. Increasing trends of blocking numbers for the overall SH and Pacific region are statistically significant at 95% level. Increasing trends of blocking duration for the overall SH, Atlantic and Pacific region are statistically significant at 90%, 95% and 95% level, respectively.
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- 2022
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7. On Effects of Spinning Moments on Wheeled Vehicle Skidding
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A. V. Vlakhova and A. P. Novoderova
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Statistics and Probability ,Blocking (radio) ,Applied Mathematics ,General Mathematics ,010102 general mathematics ,Mechanics ,Physics::Classical Physics ,Coulomb friction ,01 natural sciences ,010305 fluids & plasmas ,Computer Science::Robotics ,Reference plane ,Axle ,0103 physical sciences ,0101 mathematics ,Spinning ,Slipping ,Mathematics - Abstract
We give a mathematical description of the initial stage of both axles skidding for a wheeled vehicle on a bend that arises in the case of blocking or slipping of wheels of one of its axles. It is shown that within the framework of Zhuravlev’s model of friction, which takes into account the moments of spinning friction (they appear as a result of interaction of the wheels with the reference plane), the vehicle skidding is less than for the Coulomb friction model.
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- 2021
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8. Atmospheric blocking events in the North Atlantic: trends and links to climate anomalies and teleconnections
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Philippe Gachon, Hussein Wazneh, Bruno Tremblay, Anne de Vernal, and René Laprise
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Atmospheric Science ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,Lag ,Northern Hemisphere ,010502 geochemistry & geophysics ,01 natural sciences ,Latitude ,Extreme weather ,North Atlantic oscillation ,Climatology ,Atlantic multidecadal oscillation ,Environmental science ,0105 earth and related environmental sciences ,Teleconnection - Abstract
Atmospheric blockings are generally associated with large-scale high-pressure systems that interrupt west-to-east atmospheric flow in mid and high latitudes. Blockings cause several days of quasi-stationary weather conditions, and therefore can result in monthly or seasonal climate anomalies and extreme weather events on the affected regions. In this paper, the long-term coupled CERA-20C reanalysis data from 1901 to 2010 are used to evaluate the links between blocking events over the North Atlantic north of 35° N, and atmospheric and oceanic modes of climate variability on decadal time scales. This study indicates more frequent and longer lasting blocking events than previous studies using other reanalyses products. A strong relationship was found between North Atlantic blocking events and North Atlantic Oscillation (NAO), Atlantic Multidecadal Oscillation (AMO) and Baffin Island–West Atlantic (BWA) indices, in fall, winter and spring. More blocking events occur during the negative phases of the NAO index and positive phases of the BWA mode. In some situations, the BWA patterns provide clearer links with the North Atlantic blocking occurrence than with the NAO alone. The correlation between the synchronous occurrences of AMO and blocking is generally weak, although it does increase for a lag of about 6–10 years. Convergent cross mapping (CCM) furthermore demonstrates a significant two-way causal effect between blocking occurrences and the NAO and BWA indices. Finally, while we find no significant trends in blocking frequencies over the last 110 years in the Northern Hemisphere, these events become longer lasting in summer and fall, and more intense in spring in the North Atlantic.
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- 2021
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9. Parallel Switch Configuration for High Voltage DC Switching to Secure PV Power System Safety
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Jung-Hyun Yun, Gi-Ju Sun, and Min-Woo Cheon
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Materials science ,business.industry ,Blocking (radio) ,020209 energy ,Electrical engineering ,High voltage ,02 engineering and technology ,Insulated-gate bipolar transistor ,021001 nanoscience & nanotechnology ,Electronic, Optical and Magnetic Materials ,law.invention ,Relay ,law ,Heat generation ,Hardware_INTEGRATEDCIRCUITS ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Low voltage ,Electronic circuit ,Voltage - Abstract
The photovoltaic power generation system for input blocking was manufactured to be used for blocking control by separately manufacturing two circuits of DC 180[V] PV strings for smooth experimentation. By attaching the circuit proposed in this study to the separately fabricated circuit input part, interruption and input were repeated, and the presence or absence of an arc and the magnitude of the voltage applied to the cut-off circuit were analyzed. It was possible to suppress constant heat generation by using a relay with a low switching voltage at all times, and offset the high voltage with a low voltage of 2[V] with a parallel type IGBT only when blocking was necessary. By attaching a parallel type IGBT, arc generation could be eliminated, and a safe and efficient cut-off circuit could be constructed.
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- 2021
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10. A step-by-step guide home
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Kiah Hardcastle
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business.industry ,Computer science ,Blocking (radio) ,General Neuroscience ,Path (graph theory) ,business ,Neuroscience ,Computer network - Abstract
Shamash et al. probe the navigational strategies mice use as they escape from a threat. By systematically placing and removing obstacles blocking their initial path, the authors find evidence that mice memorize intermediate ‘subgoal’ locations to find their way home.
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- 2021
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11. Context-adaptive blocking for protecting personal information exposed to social multimedia content
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Seok-Woo Jang and Byeongtae Ahn
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Computer Networks and Communications ,Blocking (radio) ,business.industry ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,020207 software engineering ,Context (language use) ,Image processing ,02 engineering and technology ,Object (computer science) ,Upload ,Hardware and Architecture ,0202 electrical engineering, electronic engineering, information engineering ,Media Technology ,Computer vision ,Artificial intelligence ,Social multimedia ,Line (text file) ,business ,Personally identifiable information ,Software - Abstract
With the development of many devices that support high-speed wired and wireless Internet, it has been universalized to upload and download various kinds of social multimedia information. However, image data including sensitive personal information are easily exposed to Internet users. In this study, the algorithm is introduced to make it possible to exclude background regions from various types of input color images, to robustly detect the target regions including personal information, and then effectively protect the detected target regions through context-adaptative blocking. In this study, the background regions are first excluded from input color images, and then only the target regions including personal information are robustly segmented on the basis of human skin color. Subsequently, the detected target regions are effectively blocked in the way of selecting regional blurring adaptively in line with surrounding situations, and therefore it is possible to prevent personal information from being exposed. The experimental result of this study reveals that the proposed method robustly blocks the target object regions including personal information of input images in line with surrounding situations. The algorithm proposed in this study is expected to be applied practically to many fields associated with image processing, such as video surveillance, video monitoring, and target object covering.
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- 2020
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12. Extreme temperatures linked to the atmospheric blocking events in Turkey between 1977 and 2016
- Author
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Ali Deniz, Anthony R. Lupo, and Bahtiyar Efe
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021110 strategic, defence & security studies ,Atmospheric Science ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,0211 other engineering and technologies ,02 engineering and technology ,Cooling effect ,Block (meteorology) ,01 natural sciences ,Summer season ,Animal science ,Earth and Planetary Sciences (miscellaneous) ,Environmental science ,Frequency distribution ,Winter season ,0105 earth and related environmental sciences ,Water Science and Technology - Abstract
Extreme maximum (Tx) and extreme minimum temperature (Tn) frequency distributions during summer and winter for blocked conditions were analyzed within Turkey during the period from 1977 to 2016 by using observational data. The Tx (0.5–0.8%) and Tn (0.4–2.0%) frequencies vary between these values for the entire period during summer. However, Tx varies between 0.0 and 1.0, while Tn varies between 0.8 and 2.4 during winter. It is quite clear that atmospheric blocking has a greater cooling effect during winter. The maximum values for Tx and Tn are observed when the block center located within the easternmost sector impacting Turkey for summer. The maximum Tx frequency is observed in association with blocking in the westernmost sector, and the maximum Tn frequency is observed with blocking in the easternmost sector impacting Turkey during the winter season. Block intensity has almost no impact on Tx frequency although it has enhancing effect on Tn frequency during the summer. For winter, block intensity has a decreasing effect on both the maximum Tn and maximum Tx. The maximum Tx and Tn values increase with the block size for the summer. During the winter, the maximum Tx frequency decreases with the increase in the size of a blocking event; however, the greatest Tn frequency is observed within the 0°–30° E sector and lowest within the 30° E–60° E sector. The block duration has an enhancing influence on the maximum Tx value, while maximum Tn is observed during short-duration events and a minimum is observed during moderate-duration events during the summer season. For the winter season, the block duration has a decreasing effect for Tx frequencies and increasing effect for Tn.
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- 2020
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13. Fast Blocking Effect of Gallamine on LCC Channels: Analysis Using a Truncated Kinetic Scheme
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O. V. Lunko and O. O. Lun’ko
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0301 basic medicine ,Physiology ,Blocking (radio) ,Chemistry ,General Neuroscience ,Kinetic scheme ,Blocking effect ,Ion current ,Kinetic energy ,Molecular physics ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Amplitude ,Reaction rate constant ,Modulation ,030217 neurology & neurosurgery - Abstract
Modulation of Large-conductance cationic (LCC) channel currents through the inner nuclear membrane of rat Purkinje neurons by gallamine was estimated using analysis of the amplitude histograms. A kinetic scheme consisting of one open state and one blocked state of the channel was used. The search for optimal kinetic parameters of the truncated model was performed for the analysis of the blocking effect. The estimated rate constants of blocking and unblocking by 100 μM gallamine at –40 mV were 17880 ± ± 975 and 12790 ± 922, respectively. The obtained data show that gallamine is a fast blocker of the above channels; blocking is accompanied by ion current fluctuations suitable for the analysis using the two-state model if contribution of the events formed by intrinsic ion channel activity can be neglected.
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- 2020
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14. Evaluation of the Relationship between Blocking Patterns and Duration of Spring Frost Waves: The Case of Iran
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Gholamreaza Barati, Mohammad Moradi, and Farzaneh Jafari Hombari
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Average duration ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,Spring season ,Cold air ,Geopotential height ,010502 geochemistry & geophysics ,01 natural sciences ,eye diseases ,Duration (music) ,Climatology ,Frost ,Slow speed ,Environmental science ,0105 earth and related environmental sciences - Abstract
In order to evaluate the effects of blocking patterns on the duration of frost waves across Iran, the minimum daily temperatures of 60 weather stations were collected from 20 March 1968 to 21 June 2014. The findings, which were obtained based on the distribution tables of reported temperatures and their frequency variation graphs, resulted in identifying 114 frost waves. We obtained the daily weather maps at 500 hPa from NCEP/NCAR during the peak days of durable frosts, and it was revealed that the formation of low pressures over 20°-70°E and the dominant southwest-northeast troughs at 500 hPa facilitated the influx of cold air from both eastern Europe and central Siberia toward Iran, leading to the average frost duration of 12.4 days. Furthermore, low-pressure centers appeared in a dipole pattern in northern Iran over Caspian Sea and created durable frosts with an average duration of 15.4 days. The effect of omega shaped pattern of the geopotential height on durable frosts demonstrated a sharp difference with two recent patterns leading to the frost occurrence with a 13.3-day duration averagely. Additionally, the slow speed of cold western currents in the rex type of blocking from 30° to 50°N caused durable frosts of 14.3 days. Also, we found a specific reduction in the frequency of blocking patterns, which has occurred in the past four decades. Mostly, the blocking and non-blocking patterns cause long- and short-duration frosts over Iran, respectively.
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- 2020
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15. Novel flexible HVDC transmission converter station topology with DC fault blocking capability
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Qunhai Huo, Jingyuan Yin, Guoen Cao, Peng Wang, Guo Xinming, Jin Zhu, and Tongzhen Wei
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Transmission (telecommunications) ,Control and Systems Engineering ,Blocking (radio) ,Computer science ,Power electronics ,Topology (electrical circuits) ,Electrical and Electronic Engineering ,Network topology ,Topology ,Fault (power engineering) ,DC-BUS ,Block (data storage) - Abstract
The conventional half-bridge submodule (HBSM)-based multilevel modular converter (MMC) cannot block DC faults. To solve this problem, a novel flexible overhead-line high-voltage direct current (HVDC) transmission converter station topology is proposed in this study, which provides DC fault blocking capability. By adding blocking submodules (SMs) onto the positive and negative DC buses of a conventional HBSM converter station, a rapid fault current blocking can be achieved in the case of a DC bus short circuit. The DC fault blocking principle of the proposed topology and the rapid fault blocking capability of the blocking SM are analyzed. The quantity of required major components is also calculated. In addition, the IGBT, the system loss and the control complexity quantities are comprehensively compared with those of existing topologies. The validity of the proposed topology is demonstrated based on simulation and experimental studies.
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- 2020
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16. Synthesis and Comparative Inotropic Effects of Several Isoquinoline Alkaloids
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Sh. S. Khushmatov, A. Sh. Saidov, Valentina I. Vinogradova, I. Z. Zhumaev, and Sh. N. Zhurakulov
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Pharmacology ,Inotrope ,010405 organic chemistry ,Blocking (radio) ,Chemistry ,Free base ,01 natural sciences ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Drug Discovery ,Muscarinic acetylcholine receptor ,Isoquinoline - Abstract
Compounds 3a [1-(3′,4′-methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline] and 3b [1-(6′-bromo-3′,4′-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline] demonstrated dose-dependent (5-75 μM) negative inotropic effects. Compound 5 [1,3-bis-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin- 1-yl)propane] demonstrated a two-phase inotropic effect. The experimental results and a literature analysis suggested that the negative inotropic effects of the tested compounds (3a, 3b, 5) could be due to their influences on the [Ca2+]i concentration through blocking of cardiomyocyte Na+- and Ca2+-channels. The positive inotropic effect of free base 5 could be related to modulation of cardiomyocyte muscarinic receptor activity.
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- 2020
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17. Performance analysis of secondary users under heterogeneous licensed spectrum environment in cognitive radio ad hoc networks
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Anand Jee, Wasim Arif, and Shanidul Hoque
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Markov chain ,business.industry ,Wireless ad hoc network ,Blocking (radio) ,Computer science ,020206 networking & telecommunications ,Throughput ,02 engineering and technology ,Spectrum management ,Cognitive radio ,Handover ,0202 electrical engineering, electronic engineering, information engineering ,sort ,020201 artificial intelligence & image processing ,Electrical and Electronic Engineering ,business ,Computer network - Abstract
Cognitive radio (CR) is a hopeful technology to sort out spectrum scarcity and underutilization problem in ad hoc networks. With the help of cognitive radio technology, unlicensed users can efficiently utilize the unused part of heterogeneous licensed spectrum. In this article, we present a three-dimensional (3D) Markov chain analysis for spectrum management scheme under heterogeneous licensed bands of two different licensed spectrum pools in cognitive radio ad hoc networks. We present the concept of interpool and intrapool spectrum handoff in the proposed model and derive blocking probability, dropping probability, non-completion probability, and throughput to estimate the performance of the secondary users under heterogeneous licensed spectrum environment. The impact of secondary users dynamic along with the primary users’ activity model on the performance measuring metrics in terms of blocking probability, dropping probability, non-completion probability, and throughput for three different cases is also investigated. The proposed model offers significant improvement in the performance of secondary users under heterogeneous licensed spectrum environment in a CR ad hoc network.
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- 2020
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18. Exosome-mediated miR-7-5p delivery enhances the anticancer effect of Everolimus via blocking MNK/eIF4E axis in non-small cell lung cancer
- Author
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Haihua Wang, Jiadi Luo, Jinwu Peng, Sile Liu, Yuting Zhan, Yue Ning, Yang Yang, Hongmei Zheng, Jian Ma, Qiuyuan Wen, Songqing Fan, Weiyuan Wang, and Hongjing Zang
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Cancer Research ,Lung Neoplasms ,Immunology ,Exosomes ,Exosome ,Cellular and Molecular Neuroscience ,Carcinoma, Non-Small-Cell Lung ,Cell Line, Tumor ,medicine ,Humans ,Everolimus ,Lung cancer ,Cell Proliferation ,Mitogen-Activated Protein Kinase Kinases ,QH573-671 ,Chemistry ,Blocking (radio) ,TOR Serine-Threonine Kinases ,EIF4E ,Cell Biology ,medicine.disease ,MicroRNAs ,Eukaryotic Initiation Factor-4E ,Cancer research ,Non small cell ,Cytology ,medicine.drug - Abstract
Background Everolimus is a kind of mTOR inhibitors. Activated mitogen-activated protein kinase interacting kinases/eukaryotic translation initiation factor 4E (MNK/eIF4E) axis plays a crucial role in resistance to Everolimus in non-small cell lung cancer (NSCLC). Typically, eIF4E phosphorylation increased by mTOR inhibitors was mainly mediated by MNKs. But the mechanisms are poorly understood. Recently, extensive reprogramming of miRNA profiles has also been found after long-term mTOR inhibitor exposing. Our previous studies have confirmed that tumor suppressor miR-7-5p was decreased in A549 cells after treatment with Everolimus. Exactly, MNK1 is the target of miR-7-5p. Here, we investigated the biological functions and potential molecular mechanisms of miR-7-5p in the NSCLC undergoing treatment with Everolimus. Methods miR-7-5p level and expression of main markers of MNK/eIF4E axis were evaluated by qRT-PCR, western blot, in situ hybridization, and immunohistochemistry on NSCLC cell lines and human NSCLC samples. Proliferation, migration and invasion of NSCLC cells in culture were explored by Colony formation, CCK-8, Wound healing and Transwell assays. NSCLC cell tumorigenicity was assessed by xenotransplants in nude mice. Targeted binding of miR-7-5p to MNK1 was confirmed by the Dual-luciferase reporter assay. And the isolation and identification of exosomes were investigated by Invitrogen™ Total Exosome RNA Isolation Kit, western blot, transmission electron microscopy and Zetasizer Nano ZS90 instrument. Results Everolimus targeted mTORC1 inducing NSCLC cells to secrete miR-7-5p-loaded exosomes in Rab27A and Rab27B dependent manners. Loss of intracellular miR-7-5p induced phosphorylation of MNK/eIF4E axis, but supplement of extra exosomal miR-7-5p could reverse it. Of note, both lower expression of miR-7-5p and elevated MNK1 protein were associated with poor prognosis of NSCLC. Both endogenous miR-7-5p and exo-miR-7-5p enhanced the therapeutic efficacy of Everolimus through inhibiting the proliferation, migration, and metastasis of NSCLC in vitro and vivo. Combination of miR-7-5p with Everolimus induced apoptosis to exhibit a synergistic anticancer therapeutic efficacy via dual abrogation of MNK/eIF4E and mTOR in NSCLC. Conclusion Everolimus decreases the intracellular miR-7-5p levels through release of miR-7-5p loaded exosomes from NSCLC cells in Rab27A and Rab27B dependent manners. Either endogenous miR-7-5p or exo-miR-7-5p combined with Everolimus can enhance the anticancer efficacy via targeting MNK/eIF4E axis and mTOR. Therefore, exosome-mediated miR-7-5p delivery combined with Everolimus may be considered as a promising novel combined therapeutic strategy for NSCLC.
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- 2022
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19. Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein–ACE2 interaction
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ChangDong Lin, MengYa Yuan, Y. Wan, Yue Li, Cui Liu, ZhaoYuan Liu, and JianFeng Chen
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,medicine.drug_class ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,Translational immunology ,Antibodies, Viral ,Monoclonal antibody ,Correspondence ,medicine ,Humans ,Immunology and Allergy ,Antibodies, Blocking ,SARS-CoV-2 ,Chemistry ,Blocking (radio) ,HEK 293 cells ,High-throughput screening ,Spike Protein ,Virology ,HEK293 Cells ,Infectious Diseases ,Spike Glycoprotein, Coronavirus ,Angiotensin-Converting Enzyme 2 ,Infection ,Single-Chain Antibodies - Published
- 2021
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20. Design and simulation of reverse-blocking Schottky-drain AlN/AlGaN HEMTs with drain field plate
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Zhang Weihang, Qing Tang, Yinhe Wu, Jincheng Zhang, Zhihong Liu, Zhao-Xi Wu, Dujun Zhao, Zhongyang Li, Chao Duan, Qing Yang, Yue Hao, Shenglei Zhao, Wang Zhongxu, and Bo Mei
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Materials science ,General Computer Science ,Passivation ,business.industry ,Blocking (radio) ,Electric field ,Optoelectronics ,Schottky diode ,business ,Mole fraction ,Septic drain field ,Voltage - Abstract
In this paper, Schottky-drain reverse-blocking AlN/AlGaN HEMTs with drain field plate (FP) have been investigated by Silvaco-ATLAS tools. For HEMTs without FP, with the increase of Al mole fraction in AlGaN channel from 0 to 0.5, the reverse-blocking voltage increases from −158 V to −720 V. By using the drain field plate technique, a second electric field peak is introduced and the reverse-blocking voltage can be improved. Combined with the optimization of the SiN passivation thickness, optimal electric field management can be achieved to obtain the highest reverse-blocking voltage devices. Since HEMTs with different Al mole fractions possess different critical electric field values, the optimal SiN thickness are varied. With the increase of the Al mole fraction from 0 to 0.5, the reverse-blocking voltage increases from −510 V to −4500 V for HEMTs using drain FP and optimal SiN passivation thickness, and a high power figure-of-merit of 1.171 GW/cm2 is achieved. AlGaN channel HEMTs with Al mole fraction demonstrate great potential for power applications.
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- 2021
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21. Contention resolution in dense WDM-PON networks by incorporating fiber temporal delay approach
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Shippu Sachdeva, Jagjit Malhotra, and Manoj Kumar
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Computer science ,Blocking (radio) ,Data_CODINGANDINFORMATIONTHEORY ,Division (mathematics) ,Passive optical network ,Multiplexing ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Wavelength ,Control theory ,Wavelength-division multiplexing ,Electronic engineering ,Channel spacing ,Electrical and Electronic Engineering - Abstract
With the propelling high capacity demands, passive optical networks (PONs) are getting extra consideration nowadays. Problem: Burst blocking in wavelength division multiplexed (WDM) PON system increase with the contention period > burst time. Motivation: In the absence of optical random memory in optical communication networks, contention resolution using temporal delays is prominent work and can be accomplished using Fiber temporal delay paths. Burst blocking becomes high in the network at larger contention period such as time between two bursts is larger. Methods: Therefore, in this work, a 40 Gbps × 10 WDM channels based PON system with 50 GHz channel spacing over 20 km is investigated by incorporating switches, switch controller, buffers and Fiber temporal delay paths to decrease the bursts blocking in the system. In order to assign delay to bursts, an algorithm is proposed and calculated amount of delay are assigned to demanding wavelengths for bursts which inturn decrease the blocking. Analysis: Proposed WDM-PON system is simulated in the simulation tool and investigated for different FTD delays, burst loss probability, burst arrival rate, buffering delay and performance is also analyzed in terms of log BER. Results: Bursts blocking probability increases with the increase in burst arrival rate, lesser buffering delays, and more no. of input ports. Further investigation reveals that higher extinction ratios can provide better log BER.
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- 2021
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22. Is blocking with Articaine better than Lidocaine?
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Emily McIlvanna
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Lidocaine ,Blocking (radio) ,business.industry ,Anesthesia ,Materials Chemistry ,medicine ,Articaine ,business ,medicine.drug - Published
- 2020
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23. Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors
- Author
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Matthew P.H. Gardner, Megan Lozzi, Chun Yun Chang, Mihaela D. Iordanova, Etienne J. P. Maes, Alexandra A Usypchuk, Geoffrey Schoenbaum, and Melissa J. Sharpe
- Subjects
0301 basic medicine ,Computer science ,Dopamine ,Optogenetics ,Article ,03 medical and health sciences ,0302 clinical medicine ,Reward ,medicine ,Animals ,Rats, Long-Evans ,Blocking (radio) ,Dopaminergic Neurons ,General Neuroscience ,Association Learning ,Brain ,Function (mathematics) ,Rats ,Shunting ,030104 developmental biology ,Conditioning, Operant ,Conditioning ,Cues ,Rats, Transgenic ,Temporal difference learning ,Neuroscience ,psychological phenomena and processes ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Reward-evoked dopamine transients are well established as prediction errors. However, the central tenet of temporal difference accounts—that similar transients evoked by reward-predictive cues also function as errors—remains untested. In the present communication we addressed this by showing that optogenetically shunting dopamine activity at the start of a reward-predicting cue prevents second-order conditioning without affecting blocking. These results indicate that cue-evoked transients function as temporal-difference prediction errors rather than reward predictions. Maes et al. use second-order conditioning, blocking and optogenetic inhibition to show that cue-evoked dopamine transients function as temporal-difference prediction errors rather than reward predictions.
- Published
- 2020
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24. Wave-Breaking Features of Blocking over Central Siberia and Its Impacts on the Precipitation Trend over Southeastern Lake Baikal
- Author
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Dorina Chyi, Zuowei Xie, Pinwen Guo, Huijun Wang, and Ning Shi
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,Rossby wave ,010502 geochemistry & geophysics ,01 natural sciences ,Anticyclone ,Climatology ,Middle latitudes ,Ridge (meteorology) ,Clockwise ,Precipitation ,Trough (meteorology) ,Geology ,0105 earth and related environmental sciences - Abstract
Precipitation over southeastern Lake Baikal features a significant decreasing trend in July and August over 1979-2018 and is closely related to blocking occurrence over central Siberia (45°–70°N, 75°–115°E). This study investigates the formation and maintenance of anticyclonic and cyclonic wave-breaking (AWB and CWB) blocking events and their climate impacts on precipitation in the southeastern Lake Baikal area. Both AWB and CWB blocking events are characterized by a cold trough deepening from the sub-Arctic region and a ridge amplifying toward its north over central Siberia, as well as an evident Rossby wave train over midlatitude Eurasia. For AWB blocking events, the ridge and trough pair tilts clockwise and the wave train exhibits a zonal distribution. In contrast, ridge and trough pair associated with CWB blocking events leans anticlockwise with larger-scale, meridional, and more anisotropic signatures. Moreover, the incoming Rossby wave energy associated with CWB blocking events is more evident than for AWB blocking events. Therefore, CWB blocking events are more persistent. AWB blocking events produce more extensive and persistent precipitation over the southeastern Lake Baikal area than CWB blocking events, in which moderate above-normal rainfall is seen in the decaying periods of blockings. A significant decreasing trend is found in terms of AWB blocking occurrence over central Siberia, which may contribute to the downward trend of precipitation over southeastern Lake Baikal.
- Published
- 2019
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25. Australian blocking impacts on ocean surface waves
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Mark Hemer, Andrew G. Marshall, and Kathleen L. McInnes
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Atmospheric Science ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,Northern Hemisphere ,Forcing (mathematics) ,010502 geochemistry & geophysics ,01 natural sciences ,Wave model ,Surface wave ,Climatology ,Wind wave ,Environmental science ,Hindcast ,Significant wave height ,Physics::Atmospheric and Oceanic Physics ,0105 earth and related environmental sciences - Abstract
We assess the impact of split-flow blocking in the Australian region on global ocean wind waves using 30 years of high-resolution wave data from the CAWCR wave model hindcast. Statistically significant anomalies in significant wave height (Hs), peak wave period (Tp) and zonal wave energy flux (CgE) are found to covary with local variations in surface zonal wind induced by blocking at 140° E. Strong negative anomalies in these wave fields highlight the role of blocking in promoting calm wave conditions around the Australian coast. A relatively weak but notable remote signal also appears in the Northern Hemisphere extratropics, suggesting a link to the Australian region via tropical forcing. The occurrence of daily low (below the 5th percentile) and high (above the 95th percentile) wave conditions also varies contemporaneously with blocking at 140° E. Considering the ability of global circulation model forecasts to skilfully predict the blocking index out to at least 2 weeks lead time, our results point to blocking as a possible source of predictable wind-wave variability from sub-weekly to seasonal timescales.
- Published
- 2019
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26. Climatologies of blocking highs detected by a unified Eddy-ABS approach
- Author
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Ping Liu
- Subjects
Atmospheric Science ,Percentile ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,Zonal and meridional ,Seasonality ,010502 geochemistry & geophysics ,medicine.disease ,Geodesy ,01 natural sciences ,Latitude ,Normal distribution ,Climatology ,medicine ,Longitude ,Geographic coordinate system ,Geology ,0105 earth and related environmental sciences - Abstract
Typical blocking indices in longitude or both longitude and latitude are compared to demonstrate: (1) the central blocking latitude (CBL) should be any of 40–80° N; (2) reversals of meridional gradients in absolute fields (ABS) about specified CBLs or in combination with time anomalies exceeding a threshold missed blocking patterns or misidentified non-blocking structures. Blocking highs are identified by a new Eddy-ABS index. A large-scale high is represented by a local maximum of zonal eddy anomalies, its immediately surrounding points and subsequent contiguous grids with decreasing anomalies but exceeding the 75th percentile. A high with any ABS reversal is an instantaneous blocking (IB). Maximum overlapping IBs become quasi-stationary when moving less than 10° longitudes per day. Four and more quasi-stationary IBs form a blocking event (BE). This unified index has identified IBs and BEs at vertical levels in the Northern (NH) and Southern Hemispheres (SH) during different seasons. In the NH, BEs exhibit strong seasonality, geographical preference and quasi-barotropicity. The lifetime, maximum intensity, impact area, and moving speed have a log-linear, log-normal, log-normal, and normal distribution, respectively. These features occur similarly in the SH, except for very small occurrences at 200 hPa in JJA and a normal distribution for the maximum intensity. Properties other than the moving speed significantly correlate with the maximum intensity in both hemispheres. The missing and misidentification issues are reasonably well resolved by this new index.
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- 2019
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27. Plasmon Based Cellulose Nano Fibril–PVA Film for Effective Ultra Violet Radiation Blocking
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Jasmine Jose, Rani Abraham, Jeyaprabha Balasubramanian, Vinoy Thomas, J. C. Thomas, M. S. Latha, Titu Thomas, Prakash Periakaruppan, and Archana Raj
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Vinyl alcohol ,Fabrication ,Materials science ,Blocking (radio) ,Nanochemistry ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Nano ,medicine ,General Materials Science ,Cellulose ,0210 nano-technology ,Plasmon ,Ultraviolet - Abstract
Recent years have witnessed significant interest in biodegradable and transparent ultraviolet (UV) protecting films from renewable resources. In the present paper, preparation, characterization and evaluation of UV radiation blocking capability of transparent and flexible cellulose nano fibril (CNF)–poly vinyl alcohol (PVA) films are described. Synthesized films exhibited good transparency in the visible region and UV blocking ability. Addition of plasmonic silver (~ 22 nm) to the films lead to complete blocking of UV radiations. Synthesized films were highly stable for a long exposure to intense sunlight. The defined methods show a straightforward procedure for the fabrication of environment friendly UV-radiation blocking films for industrial/commercial/textile applications.
- Published
- 2019
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28. Examination of a relationship between atmospheric blocking and seismic events in the Middle East using a new seismo-climatic index
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Friedemann Freund and Mohammad Reza Mansouri Daneshvar
- Subjects
010506 paleontology ,Climatic index ,Blocking (radio) ,Magnitude (mathematics) ,Geology ,Crust ,Limiting ,Induced seismicity ,010502 geochemistry & geophysics ,01 natural sciences ,Cyclogenesis ,Seismology ,0105 earth and related environmental sciences - Abstract
This study statistically examines the role of atmospheric blocking as a precursor of major seismic events. Atmospheric blocking archive and earthquake databases for the Middle East region are compiled for 2000–2013. Correlations between atmospheric blocking events and seismicity are examined based on defined seismo-climatic index (SCI) based on variations of earthquake frequency and magnitude before and after blocking events. Limiting the SCI index to values > 6, 16 out of 26 major earthquakes (M > 6), i.e. 62%, are shown to have occurred within 14 days after blocking events over their respective epicentral regions. The correlation between blocking events and subsequent seismicity falls into a range of 0.694–0.803. Additional blocking-related atmospheric anomalies such as cyclogenesis, cloud coverage, and anomalous rainfall prior to major earthquakes can be understood as processes that take place in the Earth’s crust and at the ground-to-air interface as a result of the stress activation of positive hole charge carriers at depth, in the hypocentral rock volume, and their rapid migration to the Earth’s surface. Hence, atmospheric blocking events in a seismically active region may be categorized as an earthquake precursory phenomenon.
- Published
- 2019
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29. The role of latent heating in atmospheric blocking dynamics: a global climatology
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Daniel Steinfeld and Stephan Pfahl
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Atmospheric Science ,010504 meteorology & atmospheric sciences ,Advection ,Blocking (radio) ,Baroclinity ,010502 geochemistry & geophysics ,01 natural sciences ,Eddy ,Anticyclone ,Climatology ,Extratropical cyclone ,Environmental science ,Outflow ,Tropopause ,0105 earth and related environmental sciences - Abstract
Atmospheric blocking represents an important aspect of the mid-latitude weather variability, but the different processes contributing to its formation and maintenance are not yet fully understood. This study investigates the role that diabatic processes, in particular the release of latent heating in strongly ascending airstreams, play in the dynamics and spatio-temporal variability of blocking in a detailed 38-year global climatological analysis. The results show that the formation and (re-)intensification of blocking are often preceded by latent heating connected to upstream baroclinic developments. While the importance of latent heating varies considerably between individual blocking events and different regions, in particular between ocean and continents, latent heating is generally most important during onset and in more intense and larger blocks. The episodic nature of latent heating during the blocking life cycle, associated with a series of transient cyclones approaching the blocking, can contribute to both the high- (fast onset and fluctuation in intensity and size) and low-frequency (maintenance and quasi-stationarity during maturation phase) properties of blocking anticyclones and provide the required flow amplification in addition to dry-dynamical interaction between synoptic eddies and blocking. This amplification results from a combination of the direct injection of anticyclonic air into the upper-troposphere within cross-isentropic ascending airstreams, setting up large-scale anticyclonic PV anomalies, and the advection of PV by the enhanced divergent outflow at the tropopause (indirect effect). This divergent outflow on the western flank of the blocking anticyclone interacts with the upper-level PV gradient and leads to a westward amplification of the ridge, diminishing the tendency for dissipation and the eastward advection by the background flow, thus contributing to blocking stationarity. Taking into account such diabatic mechanisms in blocking dynamics will be important to improve predictions of blocking and assess future changes in the extratropical large-scale circulation.
- Published
- 2019
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30. Performance Analysis of Fractional Guard Channel Scheme with Buffer for Cellular Mobile Networks
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Rakhee Kulshrestha, Madhu Jain, and Shruti
- Subjects
Scheme (programming language) ,Computer simulation ,business.industry ,Computer science ,Blocking (radio) ,Quality of service ,SIGNAL (programming language) ,General Physics and Astronomy ,Handover ,Key (cryptography) ,business ,computer ,Computer network ,Communication channel ,computer.programming_language - Abstract
In this paper, we have developed an efficient channel assignment scheme using fractional guard channel for utilizing the limited radio recourses efficiently and seamlessly by providing buffer for good-quality signal calls to improve the quality of service. Two models are proposed to prioritize good-quality handoff calls over poor-quality calls. The expressions for blocking probability, call dropped probability of handoff calls, utilization of channels and buffer are obtained for a cellular radio network. Numerical simulation results for both the models illustrate the impact of different parameters on the key performance measures.
- Published
- 2019
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31. How Valuable are Patent Blocking Strategies?
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Katrin Hussinger, Dirk Czarnitzki, and Bart Leten
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Organizational Behavior and Human Resource Management ,Economics and Econometrics ,Blocking (radio) ,Strategy and Management ,05 social sciences ,Offensive ,Competitor analysis ,Product (business) ,Order (exchange) ,Management of Technology and Innovation ,0502 economics and business ,Value (economics) ,Business ,050207 economics ,Market value ,Industrial organization ,050205 econometrics ,Block (data storage) - Abstract
Firms use patents for blocking competitors’ innovation activities. Offensive blocking is a practice whereby firms patent alternatives of a focal invention preempting technological substitutes produced by competitors. Defensive blocking entails the creation of patent portfolios that block technologies in order to increase competitors’ willingness to trade patents. This paper examines the private value of both patent blocking strategies with the use of a novel measure of the offensive and defensive “blocking power” of patent portfolios. We show that both strategies increase firms’ market value. In discrete (complex) product industries, however, only offensive (defensive) patent blocking is associated with higher value.
- Published
- 2019
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32. The relationship between atmospheric blocking and precipitation changes in Turkey between 1977 and 2016
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Anthony R. Lupo, Bahtiyar Efe, and Ali Deniz
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Atmospheric Science ,La Niña ,El Niño Southern Oscillation ,Animal science ,urogenital system ,Blocking (radio) ,Mean value ,Positive relationship ,Precipitation ,Winter season ,Biology ,reproductive and urinary physiology ,Precipitation frequency - Abstract
The relationship between blocking events and mean precipitation frequency (MPF) was investigated in this work for Turkey during 1977–2016. The overall MPF for the examined stations during blocked days (nonblocked days) fluctuated between 0.15 and 0.43 (0.12 and 0.38). The ratio of MPF during the blocked days to nonblocked days ranges between 12 and 38%. During the winter season, the country has higher MPF values during blocked days. The greatest ratio of MPF values during blocked days to nonblocked days is observed in summer due to smaller values of MPF occurring during this season overall. Higher MPF occurs when the event center was located between 0o and 30o E (mean 0.27, range 0.17–0.51). There is no relationship between blocking duration and MPF for all seasons. There is a positive relationship between blocking intensity and MPF during summer (CC = 0.35, significant at the 95% level) and fall (CC = 0.43, significant at the 95% level). The relationship between blocking longitudinal extent and MPF is significant at the 95% confidence level during the summer and fall seasons with correlation coefficients of 0.29 and 0.25, respectively. A composite of the 10 blocking events associated with the largest MPF demonstrated that there is moist advection via westerly flow into Turkey in all seasons. During winter, a greater proportion of these events is observed during the La Nina phase of El Nino Southern Oscillation, but during El Nino in spring and summer. For the blocking case study (31 October to 5 November 2009) associated with the largest MPF, the mean value across the country was 0.73. The mean total precipitation during this period was 63.4 mm.
- Published
- 2019
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33. CO2 microbubble colloidal gas aphrons for EOR application: the generation using porous filter, diameter size analysis and gas blocking impact on sweep efficiency
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Ferian Anggara, Mochammad Andy Natawijaya, and Yuichi Sugai
- Subjects
Blocking (radio) ,020209 energy ,lcsh:QE420-499 ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Microbubble ,Colloidal Gas Aphrons ,Tertiary recovery ,Filter (aquarium) ,lcsh:Petrology ,Solvent ,General Energy ,020401 chemical engineering ,Chemical engineering ,Surface-area-to-volume ratio ,Colloidal gas aphrons ,lcsh:TP690-692.5 ,CO2 EOR ,0202 electrical engineering, electronic engineering, information engineering ,Microbubbles ,0204 chemical engineering ,Porous medium ,Porosity ,lcsh:Petroleum refining. Petroleum products - Abstract
The CO2 is regarded to be an excellent solvent for miscible flooding. However, it is still facing a main problem which is the high mobility. Microbubbles with their unique characters offer some advantages for CO2 EOR application. Different pore throat size filters were used to generate different dominant sizes of microbubbles that were injected into sandpacks under tertiary condition. Microscopic analysis was carried out to visualize the presence, stability and behavior of microbubbles inside the solution and porous media. The microbubbles with a dominant size of 10–50 µm showed additional 26.38% of oil recovery, showing their advantages over a larger dominant size of microbubbles up to 5.28% of oil recovery. The injection with larger microbubbles with a dominant size of 70–150 µm showed 27.5% of higher injection pressure than with a smaller dominant size of microbubbles, showing their advantage in gas blocking ability. In the heterogeneous porous media experiment, the recovery volume ratio between low- and high-permeability sandpacks was increased from 1:57 during water flooding to 1:4 during the CO2 microbubble injection with 74.65% of additional recovery from a low-permeability zone, showing the microbubble gas blocking capability to change the flow pattern inside heterogeneous porous media.
- Published
- 2019
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34. Multimodal approach for multimedia injurious contents blocking
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Seok-Woo Jang and Byeongtae Ahn
- Subjects
Multimedia ,Computer Networks and Communications ,Computer science ,Blocking (radio) ,020207 software engineering ,02 engineering and technology ,computer.software_genre ,Hardware and Architecture ,0202 electrical engineering, electronic engineering, information engineering ,Media Technology ,Multimedia information systems ,Computer communication networks ,computer ,Software - Abstract
Due to the development of IT technology, harmful multimedia contents are spreading out. In addition, obscene and violent contents have a negative impact on children. Therefore, in this paper, we propose a multimodal approach for blocking obscene and violent video contents. Within this approach, there are two modules each detects obsceneness and violence. In the obsceneness module, there is a model that detects obsceneness based on adult and racy score. In the violence module, there are two models for detecting violence: one is the blood detection model using RGB region and the other is motion extraction model for observation that violent actions have larger magnitude and direction change. Through result of these three models, this approach judges whether or not the content is harmful. This can contribute to the blocking obscene and violent contents that are distributed indiscriminately.
- Published
- 2019
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35. PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion
- Author
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Claudia Waskow, Robert A.J. Oostendorp, Christine Dierks, Anna Lena Illert, Alina Rudorf, Anabel Zwick, Claudius Klein, Marie Follo, Justus Duyster, Sandra Kissel, Ralph Wäsch, Sandra Pennisi, Dietmar Pfeifer, Sarah Decker, Tony Andreas Müller, and Benjamin Rister
- Subjects
Cancer Research ,Mobilization ,Blocking (radio) ,Plerixafor ,PIM1 ,Hematology ,Pharmacology ,Biology ,CXCR4 ,Oncology ,Downregulation and upregulation ,medicine ,Secretion ,Receptor ,medicine.drug - Published
- 2019
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36. Detection of power swing and fault occurring simultaneously with power swing using instantaneous frequency
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Farzad Razavi, Mohammad Parpaei, Behrooz Taheri, and Sirus Salehimehr
- Subjects
Economics and Econometrics ,Computer science ,Blocking (radio) ,020209 energy ,020208 electrical & electronic engineering ,02 engineering and technology ,Swing ,Fault (power engineering) ,Instantaneous phase ,Power (physics) ,law.invention ,Electric power system ,General Energy ,Electric power transmission ,Control theory ,Relay ,law ,Modeling and Simulation ,0202 electrical engineering, electronic engineering, information engineering - Abstract
Energy transmission lines play a more important role in power transferring from producer to consumers. Energy transmission lines should be protected from the fault and the faults should be cleared as soon as possible time. Distance relays due to their simplicity application are widely used for protection of power transmission lines. When a power swing occurs in the power system the distance relay may mal-operate during this phenomenon. In order to prevent this, the power swing blocking function is used in distance relays. In this paper, a new method based on the rate of change of the instantaneous frequency is proposed. This method has been tested practically in a standard two-area network and its applicability for detection of different types of faults is presented. One of the features of this method is low computing and simplicity in implementation, independent of network type, unnecessarily complicated setting, high impedance fault detection, and unstable power swing detection. Also, the proposed method is compared with the conventional industrial method and it has been shown that the proposed method has better performance.
- Published
- 2019
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- View/download PDF
37. Correction To: Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein–ACE2 interaction
- Author
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ChangDong Lin, Yuebin Zhang, Jing Liu, ZhaoYuan Liu, Li Y, Guohui Li, Yue Li, Chenjian Gu, JianFeng Chen, and Xia Mu
- Subjects
Drug ,Cancer Research ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,QH301-705.5 ,Blocking (radio) ,Chemistry ,media_common.quotation_subject ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Spike Protein ,Ceftazidime ,Virology ,In vitro ,Genetics ,medicine ,Medicine ,Biology (General) ,media_common ,medicine.drug - Published
- 2021
- Full Text
- View/download PDF
38. Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1
- Author
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Yuanyu Huang, Ziyue Li, Ge Yang, Liping Zhao, Feng Qu, Irfan Mohammed, Yongxiang Zhao, Wei Wei, Haihua Xiao, and Weisheng Guo
- Subjects
Cancer Research ,2019-20 coronavirus outbreak ,Letter ,Coronavirus disease 2019 (COVID-19) ,QH301-705.5 ,Aptamer ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Protein domain ,Therapeutics ,Antiviral Agents ,Neutralization ,Protein Domains ,Genetics ,Humans ,Biology (General) ,Nucleic-acid therapeutics ,Molecular medicine ,SARS-CoV-2 ,Chemistry ,Blocking (radio) ,COVID-19 ,Spike Protein ,Aptamers, Nucleotide ,Virology ,COVID-19 Drug Treatment ,Drug screening ,Spike Glycoprotein, Coronavirus ,Medicine ,Infectious diseases - Published
- 2021
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39. Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein–ACE2 interaction
- Author
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Yuebin Zhang, Xia Mu, Yue Li, ZhaoYuan Liu, Chenjian Gu, JianFeng Chen, Li Y, Guohui Li, ChangDong Lin, and Jing Liu
- Subjects
Drug ,Cancer Research ,Letter ,QH301-705.5 ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,media_common.quotation_subject ,Ceftazidime ,Cell Line ,Genetics ,medicine ,Humans ,Biology (General) ,media_common ,SARS-CoV-2 ,Chemistry ,Blocking (radio) ,COVID-19 ,Correction ,Spike Protein ,Virology ,In vitro ,COVID-19 Drug Treatment ,Drug screening ,Cell culture ,Spike Glycoprotein, Coronavirus ,Angiotensin-converting enzyme 2 ,Medicine ,Angiotensin-Converting Enzyme 2 ,Structural biology ,Infection ,medicine.drug - Published
- 2021
- Full Text
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40. Correction to: Isorhamnetin protects against cardiac hypertrophy through blocking PI3K–AKT pathway
- Author
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Lili Xiao, Yanzhou Zhang, Rui Yao, Lu Gao, Dianhong Zhang, Binbin Du, Leiming Wu, Zheng Wang, Zhen Huang, and Yuzhou Liu
- Subjects
Chemistry ,business.industry ,Blocking (radio) ,Clinical Biochemistry ,Cell Biology ,General Medicine ,chemistry.chemical_compound ,Text mining ,Cardiac hypertrophy ,Cancer research ,business ,Molecular Biology ,PI3K/AKT/mTOR pathway ,Isorhamnetin - Published
- 2021
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41. Can Cytokine Blocking Prevent Depression in COVID-19 Survivors?
- Author
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Fabio Ciceri, Giulio Cavalli, Francesco Benedetti, Mario Gennaro Mazza, Patrizia Rovere-Querini, Lorenzo Dagna, Benedetti, F., Mazza, M., Cavalli, G., Ciceri, F., Dagna, L., and Rovere-Querini, P.
- Subjects
Adult ,Male ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,medicine.medical_treatment ,Immunology ,Neuroscience (miscellaneous) ,Humans ,Medicine ,Immunology and Allergy ,Survivors ,Letter to the Editor ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Psychiatric Status Rating Scales ,Pharmacology ,Depression ,Blocking (radio) ,business.industry ,Disease progression ,COVID-19 ,Middle Aged ,Cytokine ,Psychiatric status rating scales ,Disease Progression ,Cytokines ,Female ,Cytokine Release Syndrome ,business - Published
- 2020
- Full Text
- View/download PDF
42. Correction to: Models of displacement and blocking force of ionic-polymer metal composites based on actuation mechanism
- Author
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Aifen Tian, Xixi Wang, Xining Zhang, Liang Yang, and Dongsheng Zhang
- Subjects
Mechanism (engineering) ,Ionic polymer–metal composites ,chemistry.chemical_compound ,Materials science ,chemistry ,Blocking (radio) ,General Engineering ,General Materials Science ,General Chemistry ,Composite material ,Displacement (fluid) - Published
- 2020
- Full Text
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43. Analysis of a PPLN-based cSFG/DFG wavelength conversion for capacities beyond 100 Gb/s
- Author
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Rahman Nouroozi, Amin Babazadeh, and Elaheh Bazouband
- Subjects
Lithium niobate ,Physics::Optics ,02 engineering and technology ,01 natural sciences ,law.invention ,010309 optics ,chemistry.chemical_compound ,Channel capacity ,law ,Wavelength-division multiplexing ,0103 physical sciences ,Electrical and Electronic Engineering ,Physics ,business.industry ,Blocking (radio) ,021001 nanoscience & nanotechnology ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Wavelength ,chemistry ,Modulation ,Optoelectronics ,0210 nano-technology ,business ,Waveguide ,Quadrature amplitude modulation - Abstract
Wavelength division multiplexing-based networks suffer from blocking probability due to wavelength contention resolution. Such a problem can even be worth when the advanced coherently modulation formats such as M-array quadrature amplitude modulation is used to increase the channel capacity beyond 100 Gbit/s. This paper presents theoretical study of cascaded sum frequency generation and difference frequency generation based tunable wavelength conversion in a periodically poled lithium niobate waveguide as a trivial solution to the wavelength blocking problem when advanced signal modulation formats are considered. It is shown numerically that wavelength conversion of single channel up to 1 Tbit/s would be possible with a 3 cm long wavelength converter.
- Published
- 2020
- Full Text
- View/download PDF
44. Blocking information on COVID-19 can fuel the spread of misinformation
- Author
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Heidi J. Larson
- Subjects
2019-20 coronavirus outbreak ,Multidisciplinary ,020205 medical informatics ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Blocking (radio) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Internet privacy ,02 engineering and technology ,03 medical and health sciences ,0302 clinical medicine ,0202 electrical engineering, electronic engineering, information engineering ,Viral therapy ,Confidentiality ,030212 general & internal medicine ,Business ,Misinformation ,Coronavirus Infections - Abstract
Governments need to think twice before they suppress messages related to COVID-19. Governments need to think twice before they suppress messages related to COVID-19.
- Published
- 2020
- Full Text
- View/download PDF
45. A blocking diagnosis method and its application in the blocking system over Europe in the Summer of 2010
- Author
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H. M. Hasanean, Y. Y. Hafez, and M. A. Hussein
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,Blocking (radio) ,Human life ,0207 environmental engineering ,Northern Hemisphere ,Geopotential height ,02 engineering and technology ,01 natural sciences ,Atmospheric research ,Summer season ,Climatology ,Environmental science ,020701 environmental engineering ,0105 earth and related environmental sciences - Abstract
The blocking phenomenon has received considerable attention from many researchers due to its impact on weather and human life. This paper aims to provide a new blocking definition with applicability to observations. The daily National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis data for the Northern Hemisphere of geopotential height at a level of 500 hPa during the summer season of 2010 was used in this study. Additionally, observations for several meteorological variables over the Northern Hemisphere, including Europe, through that period were collected and analyzed. By applying the new blocking definition over the Northern Hemisphere, three blocking events persisted over Europe for a duration of 5, 17 and 36 days. The exact total days of blocking events that persisted over Europe was 58 days in the summer of 2010. Moreover, during the blocking events in the summer of 2010 abnormal weather conditions, extremely hot, dry and increased pressure over Europe observed.
- Published
- 2020
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- View/download PDF
46. The electrical properties enhance of BEP laminate employing HBP blocking by hexanoic acid
- Author
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Ling Weng, Lizhu Liu, Xiaorui Zhang, and Zilong Wang
- Subjects
Permittivity ,Hexanoic acid ,Moisture absorption ,Materials science ,Blocking (radio) ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Volume (thermodynamics) ,chemistry ,Electrical resistivity and conductivity ,Dielectric loss ,Electrical and Electronic Engineering ,Composite material ,0210 nano-technology ,Fire retardant - Abstract
A laminate aimed to be used in high frequency CCL is prepared by introducing free volume into employing adding HBP blocking by hexanoic acid (HBP-C6). The effects of HBP-C6 on the electrical properties is analyzed. The results indicated the permittivity (Dk) of laminated is 4.03 and the dielectric loss (Df) is 0.00018 at the frequency of 107 Hz, when the HBP-C6 content is 15 wt%. The breakdown strength of the laminate is 28.62 kV/mm, the volume resistivity of composites is 3.25 × 1014 Ω m, which shows a good insulation property. The mechanical, moisture absorption rate, peel strength and flame retardant results also give the application possibility on high frequency CCL.
- Published
- 2018
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- View/download PDF
47. LaSa: Location Aware Wireless Security Access Control for IoT Systems
- Author
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Lei Wang, Linlin Guo, Bingxian Lu, Jialin Liu, Wei Zhou, Myeong-Hun Jeong, Guangjie Han, and Shaowen Wang
- Subjects
Computer Networks and Communications ,Computer science ,Blocking (radio) ,business.industry ,Wireless network ,RSS ,020206 networking & telecommunications ,Access control ,02 engineering and technology ,computer.file_format ,Crowdsourcing ,Wireless security ,Identification (information) ,Hardware and Architecture ,Channel state information ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,business ,computer ,Software ,Information Systems ,Computer network - Abstract
IoT (Internet of Things) security has become a severe yet not well solved problem attracting increasing research attention as well as industrial concerns. Location-based access control approaches, such as Wi-Fi geo-fencing, promise to fulfill the needs of preventing unauthorized access to IoT systems. We propose a crowdsourcing method for location aware security access control, namely LaSa, which is able to confine wireless network access inside certain physical areas only using a single commercial Access Point (AP). Specifically, LaSa detects whether a user enters or exits a room by discovering and recognizing the unique signal patterns. It combines the Received Signal Strength (RSS), Channel State Information (CSI), and coarse Angle of Arrival (AoA) data to improve the accuracy of user classification for accessing the wireless network. Real-world experimental results show that LaSa can achieve a 97.0% accuracy of identification of unauthorized users while maintaining a low false blocking rate of authorized users as low as 3.3%. LaSa is designed to be straightforward for integration with commercial APs and deployment to home and business Wi-Fi environments.
- Published
- 2018
- Full Text
- View/download PDF
48. Neuromuscular Blocking Drugs and Postoperative Pulmonary Complications
- Author
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Jesse M. Ehrenfeld and Letha Mathews
- Subjects
medicine.medical_specialty ,business.industry ,Blocking (radio) ,Neuromuscular transmission ,Retrospective cohort study ,Surgical procedures ,Neuromuscular Blocking Agents ,Appropriate use ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,030202 anesthesiology ,Anesthesiology ,Anesthesia ,Medicine ,030212 general & internal medicine ,business - Abstract
The purpose of this chapter is to provide a brief review of the literature around the relationship between the use of neuromuscular blocking drugs and subsequent postoperative pulmonary complications. A recent series of retrospective studies evaluating the use of neuromuscular blocking agents and postoperative complications have demonstrated growing evidence for a clear relationship between the use of the agents and downstream complications. The frequency of postoperative respiratory problems seems to be mitigated to some degree through the appropriate use of reversal agents. Care should be exercised when administering neuromuscular blocking agents during surgical procedures. Appropriate monitoring of neuromuscular transmission should be used along with a strategy to provide adequate reversal at the end of the surgical procedure.
- Published
- 2018
- Full Text
- View/download PDF
49. Getting the Inside Dope on Ketamine's Mysterious Ability to Rapidly Relieve Depression
- Author
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Simon Makin
- Subjects
Brain region ,Blocking (radio) ,business.industry ,medicine ,Antidepressant ,Ketamine ,General Medicine ,business ,Neuroscience ,Depression (differential diagnoses) ,medicine.drug - Abstract
The notorious party drug may act as an antidepressant by blocking neural bursts in a little-understood brain region that may drive depression
- Published
- 2018
- Full Text
- View/download PDF
50. An efficient scheduling algorithm using queuing system to minimize starvation of non-real-time secondary users in Cognitive Radio Network
- Author
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N. Suganthi and S. Meenakshi
- Subjects
Queue management system ,Computer Networks and Communications ,business.industry ,Wireless network ,Blocking (radio) ,Computer science ,Quality of service ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Non real time ,020302 automobile design & engineering ,020206 networking & telecommunications ,02 engineering and technology ,Scheduling (computing) ,Cognitive radio ,0203 mechanical engineering ,0202 electrical engineering, electronic engineering, information engineering ,business ,Software ,Computer network ,Communication channel - Abstract
Cognitive Radio Network is an emerging popular wireless network, designed for efficient spectrum utilization. It enables unlicensed users to access the unused portion of the licensed spectrum opportunistically. The major challenge is to share the unused portion of the spectrum efficiently to the unlicensed users. Channel aggregation is an interesting approach by which channels can be grouped and allocated to unlicensed users. A combined Round Robin Priority (RRP) scheduling algorithm is proposed by which the starvation of low priority SUs are minimized and QoS parameters are better compared to the traditional static and dynamic channel aggregation method. Fuzzy Inference System is used to evaluate the priority of the Secondary User. The QoS parameters utilized for comparison are spectrum utilization, capacity of the secondary network, delay, blocking probability and forced termination probability.
- Published
- 2018
- Full Text
- View/download PDF
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