Search

Your search keyword '"Botte, V."' showing total 8 results
Start Over Author "Botte, V." Publisher springer science and business media llc
8 results on '"Botte, V."'

8. TrkA and TrkC neurotrophin receptor-like proteins in the lizard gut

Author

C. Lamanna, P. de Girolamo, Castaldo L, Virgilio Botte, J.A. Vega, Carla Lucini, Lucini, Carla, DE GIROLAMO, Paolo, Lamanna, C, Botte, V, Vega, Ja, Castaldo, Luciana, Lamanna, C., Botte, V., and Vega, J. A.

Subjects
Male, animal structures, Histology, Enteroendocrine Cells, Blotting, Western, Enteroendocrine cell, Receptors, Nerve Growth Factor, Tropomyosin receptor kinase B, Tropomyosin receptor kinase A, Biology, Receptor, Nerve Growth Factor, Tropomyosin receptor kinase C, Pathology and Forensic Medicine, Intestine, Small, Animals, Low-affinity nerve growth factor receptor, Receptor, trkC, Tissue Distribution, Intestine, Large, Nerve Growth Factors, Intestinal Mucosa, Receptor, trkA, Receptor, Phylogeny, Neurons, Stomach, Receptor Protein-Tyrosine Kinases, Lizards, Cell Biology, Protein-Tyrosine Kinases, Immunohistochemistry, Molecular biology, nervous system, Gastric Mucosa, Trk receptor, embryonic structures, biology.protein, Female, Neurotrophin
Abstract

The tyrosine kinase proteins (Trk), encoded by the trk family of proto-oncogenes, mediate, in mammals, the action of neurotrophins, a family of growth factors acting on the development and maintenance of the nervous system. Neurotrophins and their specific receptors, TrkA, TrkB and TrkC, seem to be phylogenetically well preserved but, in reptiles, data regarding the occurrence of Trk-like proteins are very scarce, especially in non-nervous organs. Western blot analysis demonstrated that the lizard gut contains TrkA- and TrkC-like, but not TrkB-like, proteins. Consistently, TrkA- and TrkC-like immunoreactivity were both observed in neurons of the anterior intestine, whereas endocrine cells of the stomach and anterior intestine only displayed TrkA-like immunoreactivity. These results demonstrate for the first time the occurrence of Trk-like proteins in non-neuronal tissues of reptilians and provide further evidence for the evolutionary preservation of the molecular mass and cell distribution of Trk neurotrophin receptor-like proteins in the gut of vertebrates.

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results