1. The small heat shock protein, HSPB6, in muscle function and disease
- Author
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Charles R. Flynn, Michael R. Sheller, Padmini Komalavilas, Catherine M. Dreiza, Luciana B. Lopes, Elizabeth J. Furnish, Christopher C. Smoke, and Colleen M. Brophy
- Subjects
Phosphopeptides ,medicine.medical_specialty ,Mini Review ,Molecular Sequence Data ,Disease ,Biology ,Biochemistry ,Heat shock protein ,Internal medicine ,medicine ,Animals ,Humans ,HSP20 Heat-Shock Proteins ,Amino Acid Sequence ,Muscle, Skeletal ,Peptide sequence ,Hyperplasia ,Myocardium ,Cardiac muscle ,Skeletal muscle ,Muscle, Smooth ,Cell Biology ,Subarachnoid Hemorrhage ,Asthma ,Rats ,Cell biology ,medicine.anatomical_structure ,Endocrinology ,Signal transduction ,ITGA7 ,Function (biology) ,Signal Transduction - Abstract
The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.
- Published
- 2009
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