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20 results on '"Cavadino, Alana"'

3. An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)

Author

Donegan, Carina Joy, primary, Daldegan-Bueno, Dimitri, additional, Sumner, Rachael, additional, Menkes, David, additional, Evans, William, additional, Hoeh, Nicholas, additional, Sundram, Frederick, additional, Reynolds, Lisa, additional, Ponton, Rhys, additional, Cavadino, Alana, additional, Smith, Todd, additional, Roop, Partha, additional, Allen, Nathan, additional, Abeysinghe, Binu, additional, Svirskis, Darren, additional, Forsyth, Anna, additional, Bansal, Mahima, additional, and Muthukumaraswamy, Suresh, additional

Published
2023
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11. Signal Detection in EUROmediCAT: Identification and Evaluation of Medication–Congenital Anomaly Associations and Use of VigiBase as a Complementary Source of Reference

Author

Cavadino, Alana, primary, Sandberg, Lovisa, additional, Öhman, Inger, additional, Bergvall, Tomas, additional, Star, Kristina, additional, Dolk, Helen, additional, Loane, Maria, additional, Addor, Marie-Claude, additional, Barisic, Ingeborg, additional, Cavero-Carbonell, Clara, additional, Garne, Ester, additional, Gatt, Miriam, additional, Khoshnood, Babak, additional, Klungsøyr, Kari, additional, Latos-Bielenska, Anna, additional, Lelong, Nathalie, additional, Lutke, Reneé, additional, Materna-Kiryluk, Anna, additional, Nelen, Vera, additional, Nevill, Amanda, additional, O’Mahony, Mary, additional, Mokoroa, Olatz, additional, Pierini, Anna, additional, Randrianaivo, Hanitra, additional, Rissmann, Anke, additional, Tucker, David, additional, Wiesel, Awi, additional, Yevtushok, Lyubov, additional, and Morris, Joan K, additional

Published
2021
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14. Evaluating the effects of an exercise program (Staying UpRight) for older adults in long-term care on rates of falls: study protocol for a randomised controlled trial

Author

Taylor, Lynne, primary, Parsons, John, additional, Taylor, Denise, additional, Binns, Elizabeth, additional, Lord, Sue, additional, Edlin, Richard, additional, Rochester, Lynn, additional, Del Din, Silvia, additional, Klenk, Jochen, additional, Buckley, Christopher, additional, Cavadino, Alana, additional, Moyes, Simon A., additional, and Kerse, Ngaire, additional

Published
2020
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15. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Author

Jiang, Xia, O'Reilly, Paul F, Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J Brent, Dupuis, Josée, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A, Albanes, Demetrius, Lutsey, Pamela L, Yao, Lu, Tang, Weihong, Econs, Michael J, Wallaschofski, Henri, Völzke, Henry, Zhou, Ang, Power, Chris, McCarthy, Mark I, Michos, Erin D, Boerwinkle, Eric, Weinstein, Stephanie J, Freedman, Neal D, Huang, Wen-Yi, Van Schoor, Natasja M, Van Der Velde, Nathalie, Groot, Lisette CPGM De, Enneman, Anke, Cupples, L Adrienne, Booth, Sarah L, Vasan, Ramachandran S, Liu, Ching-Ti, Zhou, Yanhua, Ripatti, Samuli, Ohlsson, Claes, Vandenput, Liesbeth, Lorentzon, Mattias, Eriksson, Johan G, Shea, M Kyla, Houston, Denise K, Kritchevsky, Stephen B, Liu, Yongmei, Lohman, Kurt K, Ferrucci, Luigi, Peacock, Munro, Gieger, Christian, Beekman, Marian, Slagboom, Eline, Deelen, Joris, Heemst, Diana Van, Kleber, Marcus E, März, Winfried, De Boer, Ian H, Wood, Alexis C, Rotter, Jerome I, Rich, Stephen S, Robinson-Cohen, Cassianne, Den Heijer, Martin, Jarvelin, Marjo-Riitta, Cavadino, Alana, Joshi, Peter K, Wilson, James F, Hayward, Caroline, Lind, Lars, Michaëlsson, Karl, Trompet, Stella, Zillikens, M Carola, Uitterlinden, Andre G, Rivadeneira, Fernando, Broer, Linda, Zgaga, Lina, Campbell, Harry, Theodoratou, Evropi, Farrington, Susan M, Timofeeva, Maria, Dunlop, Malcolm G, Valdes, Ana M, Tikkanen, Emmi, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Raitakari, Olli T, Mikkilä, Vera, Ikram, M Arfan, Sattar, Naveed, Jukema, J Wouter, Wareham, Nicholas J, Langenberg, Claudia, Forouhi, Nita G, Gundersen, Thomas E, Khaw, Kay-Tee, Butterworth, Adam S, Danesh, John, Spector, Timothy, Wang, Thomas J, Hyppönen, Elina, Kraft, Peter, and Kiel, Douglas P

Subjects
Cohort Studies, Male, Vesicular Transport Proteins, Humans, Female, Vitamin D, Polymorphism, Single Nucleotide, White People, Amidohydrolases, Autoimmune Diseases, Genome-Wide Association Study
Abstract

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC23A, and P = 1.9×10-14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.

Published
2018
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17. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Author

Jiang, Xia, primary, O’Reilly, Paul F., additional, Aschard, Hugues, additional, Hsu, Yi-Hsiang, additional, Richards, J. Brent, additional, Dupuis, Josée, additional, Ingelsson, Erik, additional, Karasik, David, additional, Pilz, Stefan, additional, Berry, Diane, additional, Kestenbaum, Bryan, additional, Zheng, Jusheng, additional, Luan, Jianan, additional, Sofianopoulou, Eleni, additional, Streeten, Elizabeth A., additional, Albanes, Demetrius, additional, Lutsey, Pamela L., additional, Yao, Lu, additional, Tang, Weihong, additional, Econs, Michael J., additional, Wallaschofski, Henri, additional, Völzke, Henry, additional, Zhou, Ang, additional, Power, Chris, additional, McCarthy, Mark I., additional, Michos, Erin D., additional, Boerwinkle, Eric, additional, Weinstein, Stephanie J., additional, Freedman, Neal D., additional, Huang, Wen-Yi, additional, Van Schoor, Natasja M., additional, van der Velde, Nathalie, additional, Groot, Lisette C. P. G. M. de, additional, Enneman, Anke, additional, Cupples, L. Adrienne, additional, Booth, Sarah L., additional, Vasan, Ramachandran S., additional, Liu, Ching-Ti, additional, Zhou, Yanhua, additional, Ripatti, Samuli, additional, Ohlsson, Claes, additional, Vandenput, Liesbeth, additional, Lorentzon, Mattias, additional, Eriksson, Johan G., additional, Shea, M. Kyla, additional, Houston, Denise K., additional, Kritchevsky, Stephen B., additional, Liu, Yongmei, additional, Lohman, Kurt K., additional, Ferrucci, Luigi, additional, Peacock, Munro, additional, Gieger, Christian, additional, Beekman, Marian, additional, Slagboom, Eline, additional, Deelen, Joris, additional, Heemst, Diana van, additional, Kleber, Marcus E., additional, März, Winfried, additional, de Boer, Ian H., additional, Wood, Alexis C., additional, Rotter, Jerome I., additional, Rich, Stephen S., additional, Robinson-Cohen, Cassianne, additional, den Heijer, Martin, additional, Jarvelin, Marjo-Riitta, additional, Cavadino, Alana, additional, Joshi, Peter K., additional, Wilson, James F., additional, Hayward, Caroline, additional, Lind, Lars, additional, Michaëlsson, Karl, additional, Trompet, Stella, additional, Zillikens, M. Carola, additional, Uitterlinden, Andre G., additional, Rivadeneira, Fernando, additional, Broer, Linda, additional, Zgaga, Lina, additional, Campbell, Harry, additional, Theodoratou, Evropi, additional, Farrington, Susan M., additional, Timofeeva, Maria, additional, Dunlop, Malcolm G., additional, Valdes, Ana M., additional, Tikkanen, Emmi, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo-Pekka, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, Mikkilä, Vera, additional, Ikram, M. Arfan, additional, Sattar, Naveed, additional, Jukema, J. Wouter, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Forouhi, Nita G., additional, Gundersen, Thomas E., additional, Khaw, Kay-Tee, additional, Butterworth, Adam S., additional, Danesh, John, additional, Spector, Timothy, additional, Wang, Thomas J., additional, Hyppönen, Elina, additional, Kraft, Peter, additional, and Kiel, Douglas P., additional

Published
2018
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18. Vitamin D and cognitive function: A Mendelian randomisation study

Author

Maddock, Jane, primary, Zhou, Ang, additional, Cavadino, Alana, additional, Kuźma, Elżbieta, additional, Bao, Yanchun, additional, Smart, Melissa C., additional, Saum, Kai-Uwe, additional, Schöttker, Ben, additional, Engmann, Jorgen, additional, Kjærgaard, Marie, additional, Karhunen, Ville, additional, Zhan, Yiqiang, additional, Lehtimäki, Terho, additional, Rovio, Suvi P., additional, Byberg, Liisa, additional, Lahti, Jari, additional, Marques-Vidal, Pedro, additional, Sen, Abhijit, additional, Perna, Laura, additional, Schirmer, Henrik, additional, Singh-Manoux, Archana, additional, Auvinen, Juha, additional, Hutri-Kähönen, Nina, additional, Kähönen, Mika, additional, Kilander, Lena, additional, Räikkönen, Katri, additional, Melhus, Håkan, additional, Ingelsson, Erik, additional, Guessous, Idris, additional, Petrovic, Katja E, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Vollenweider, Peter, additional, Lind, Lars, additional, Eriksson, Johan G., additional, Michaëlsson, Karl, additional, Raitakari, Olli T., additional, Hägg, Sara, additional, Pedersen, Nancy L., additional, Herzig, Karl-Heinz, additional, Järvelin, Marjo-Riitta, additional, Veijola, Juha, additional, Kivimaki, Mika, additional, Jorde, Rolf, additional, Brenner, Hermann, additional, Kumari, Meena, additional, Power, Chris, additional, Llewellyn, David J., additional, and Hyppönen, Elina, additional

Published
2017
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20. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Author

Warrington, Nicole M, Beaumont, Robin N, Horikoshi, Momoko, Day, Felix R, Helgeland, Øyvind, Laurin, Charles, Bacelis, Jonas, Peng, Shouneng, Hao, Ke, Feenstra, Bjarke, Wood, Andrew R, Mahajan, Anubha, Tyrrell, Jessica, Robertson, Neil R, Rayner, N William, Qiao, Zhen, Moen, Gunn-Helen, Vaudel, Marc, Marsit, Carmen J, Chen, Jia, Nodzenski, Michael, Schnurr, Theresia M, Zafarmand, Mohammad H, Bradfield, Jonathan P, Grarup, Niels, Kooijman, Marjolein N, Li-Gao, Ruifang, Geller, Frank, Ahluwalia, Tarunveer S, Paternoster, Lavinia, Rueedi, Rico, Huikari, Ville, Hottenga, Jouke-Jan, Lyytikäinen, Leo-Pekka, Cavadino, Alana, Metrustry, Sarah, Cousminer, Diana L, Wu, Ying, Thiering, Elisabeth, Wang, Carol A, Have, Christian T, Vilor-Tejedor, Natalia, Joshi, Peter K, Painter, Jodie N, Ntalla, Ioanna, Myhre, Ronny, Pitkänen, Niina, Van Leeuwen, Elisabeth M, Joro, Raimo, Lagou, Vasiliki, Richmond, Rebecca C, Espinosa, Ana, Barton, Sheila J, Inskip, Hazel M, Holloway, John W, Santa-Marina, Loreto, Estivill, Xavier, Ang, Wei, Marsh, Julie A, Reichetzeder, Christoph, Marullo, Letizia, Hocher, Berthold, Lunetta, Kathryn L, Murabito, Joanne M, Relton, Caroline L, Kogevinas, Manolis, Chatzi, Leda, Allard, Catherine, Bouchard, Luigi, Hivert, Marie-France, Zhang, Ge, Muglia, Louis J, Heikkinen, Jani, EGG Consortium, Morgen, Camilla S, Van Kampen, Antoine HC, Van Schaik, Barbera DC, Mentch, Frank D, Langenberg, Claudia, Luan, Jian'an, Scott, Robert A, Zhao, Jing Hua, Hemani, Gibran, Ring, Susan M, Bennett, Amanda J, Gaulton, Kyle J, Fernandez-Tajes, Juan, Van Zuydam, Natalie R, Medina-Gomez, Carolina, De Haan, Hugoline G, Rosendaal, Frits R, Kutalik, Zoltán, Marques-Vidal, Pedro, Das, Shikta, Willemsen, Gonneke, Mbarek, Hamdi, Müller-Nurasyid, Martina, Standl, Marie, Appel, Emil VR, Fonvig, Cilius E, Trier, Caecilie, Van Beijsterveldt, Catharina EM, Murcia, Mario, Bustamante, Mariona, Bonas-Guarch, Sílvia, Hougaard, David M, Mercader, Josep M, Linneberg, Allan, Schraut, Katharina E, Lind, Penelope A, Medland, Sarah E, Shields, Beverley M, Knight, Bridget A, Chai, Jin-Fang, Panoutsopoulou, Kalliope, Bartels, Meike, Sánchez, Friman, Stokholm, Jakob, Torrents, David, Vinding, Rebecca K, Willems, Sara M, Atalay, Mustafa, Chawes, Bo L, Kovacs, Peter, Prokopenko, Inga, Tuke, Marcus A, Yaghootkar, Hanieh, Ruth, Katherine S, Jones, Samuel E, Loh, Po-Ru, Murray, Anna, Weedon, Michael N, Tönjes, Anke, Stumvoll, Michael, Michaelsen, Kim F, Eloranta, Aino-Maija, Lakka, Timo A, Van Duijn, Cornelia M, Kiess, Wieland, Körner, Antje, Niinikoski, Harri, Pahkala, Katja, Raitakari, Olli T, Jacobsson, Bo, Zeggini, Eleftheria, Dedoussis, George V, Teo, Yik-Ying, Saw, Seang-Mei, Montgomery, Grant W, Campbell, Harry, Wilson, James F, Vrijkotte, Tanja GM, Vrijheid, Martine, De Geus, Eco JCN, Hayes, M Geoffrey, Kadarmideen, Haja N, Holm, Jens-Christian, Beilin, Lawrence J, Pennell, Craig E, Heinrich, Joachim, Adair, Linda S, Borja, Judith B, Mohlke, Karen L, Eriksson, Johan G, Widén, Elisabeth E, Hattersley, Andrew T, Spector, Tim D, Kähönen, Mika, Viikari, Jorma S, Lehtimäki, Terho, Boomsma, Dorret I, Sebert, Sylvain, Vollenweider, Peter, Sørensen, Thorkild IA, Bisgaard, Hans, Bønnelykke, Klaus, Murray, Jeffrey C, Melbye, Mads, Nohr, Ellen A, Mook-Kanamori, Dennis O, Rivadeneira, Fernando, Hofman, Albert, Felix, Janine F, Jaddoe, Vincent WV, Hansen, Torben, Pisinger, Charlotta, Vaag, Allan A, Pedersen, Oluf, Uitterlinden, André G, Järvelin, Marjo-Riitta, Power, Christine, Hyppönen, Elina, Scholtens, Denise M, Lowe, William L, Davey Smith, George, Timpson, Nicholas J, Morris, Andrew P, Wareham, Nicholas J, Hakonarson, Hakon, Grant, Struan FA, Frayling, Timothy M, Lawlor, Debbie A, Njølstad, Pål R, Johansson, Stefan, Ong, Ken K, McCarthy, Mark I, Perry, John RB, Evans, David M, and Freathy, Rachel M

Subjects
Adult, Male, Heart Diseases, Models, Genetic, Infant, Newborn, Blood Pressure, Polymorphism, Single Nucleotide, Body Height, 3. Good health, Fetal Development, Diabetes Mellitus, Type 2, Metabolic Diseases, Pregnancy, Risk Factors, Birth Weight, Humans, Female, Genetic Predisposition to Disease, Maternal Inheritance, Maternal-Fetal Exchange, Genome-Wide Association Study
Abstract

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.

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