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Physical inactivity is associated with increased mortality. However, it is rarely emphasized by physicians as an essential component of health. Physicians place greater emphasis on medications that they are uniquely qualified to prescribe. This review outlines the historical and recent data supporting the importance of physical activity with the aim of inspiring physicians to prescribe physical activity to their patients. Recent meta-analyses pooling international population based data on physical activity show a dose-dependent reduction in mortality. A pooled cohort study found that those that exceed the recommended physical activity have a 31% decreased mortality risk. A study in elderly women published in 2018 revealed a greater than 50% reduction in all-cause mortality for those that participate in moderate-to-vigorous physical activity. We encourage physicians to promote physical activity as the potential mortality benefit is substantial. Specific populations, such as African-Americans and Hispanics, may substantially benefit from increased promotion as they are disproportionately affected by the chronic diseases associated with physical inactivity. Adherence to physical activity guidelines is challenging, so regular reminders from physicians may be beneficial. The built environment predicts physical activity on a local level, so efforts to modify the built environment can promote physical activity. Given the potential mortality benefit illustrated by recent data, we encourage primary care physicians to promote physical activity in addition to recommended medical therapies.