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Your search keyword '"Chen, Zhineng"' showing total 16 results
Start Over Author "Chen, Zhineng" Publisher springer science and business media llc
16 results on '"Chen, Zhineng"'

3. Developing an artificial intelligence method for screening hepatotoxic compounds in traditional Chinese medicine and Western medicine combination

Author

Chen, Zhao, primary, Zhao, Mengzhu, additional, You, Liangzhen, additional, Zheng, Rui, additional, Jiang, Yin, additional, Zhang, Xiaoyu, additional, Qiu, Ruijin, additional, Sun, Yang, additional, Pan, Haie, additional, He, Tianmai, additional, Wei, Xuxu, additional, Chen, Zhineng, additional, Zhao, Chen, additional, and Shang, Hongcai, additional

Published
2022
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4. Quantitative proteomics reveals the effect of Yigu decoction (YGD) on protein expression in bone tissue

Author

Wu Yulun, Xinmiao Yao, Ruikun Zhang, Chen Zhineng, Kun Yan, Guijin Li, and Ge Linpu

Subjects
Bone mineral, medicine.medical_specialty, Bone disease, Bone metabolism, business.industry, Research, Clinical Biochemistry, Osteoporosis, Quantitative proteomics, General Medicine, Proteomics, medicine.disease, Bone tissue, Bone remodeling, TMT proteomics, Endocrinology, medicine.anatomical_structure, Downregulation and upregulation, Internal medicine, Yigu decoction, medicine, Molecular Medicine, business, Molecular Biology
Abstract

Background Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, destruction of the bone tissue microstructure, increased bone brittleness and an increased risk of fracture. OP has a high incidence rate and long disease course and is associated with serious complications. Yigu decoction (YGD) is a compound prescription in traditional Chinese medicine that is used to treat OP. However, its mechanism in OP is not clear. This study used a tandem mass tag (TMT)quantitative proteomics method to explore the potential bone-protective mechanism of YGD in an osteoporotic rat model. Materials and methods A rat model of OP was established by ovariectomy. Eighteen 12-week-old specific-pathogen-free female Wistar rats weighing 220 ± 10 g were selected. The eighteen rats were randomly divided into 3 groups (n = 6 in each group): the normal, model and YGD groups. The right femurs from each group were subjected to quantitative biological analysis. TMT quantitative proteomics was used to analyze the proteins extracted from the bone tissue of rats in the model and YGD groups, and the differentially expressed proteins after intervention with YGD were identified as biologically relevant proteins of interest. Functional annotation correlation analysis was also performed to explore the biological function and mechanism of YGD. Result Compared with the model group, the YGD group showed significant upregulation of 26 proteins (FC > 1.2, P Conclusions YGD can significantly increase the bone mineral density (BMD) of osteoporotic rats and may play a therapeutic role by regulating target proteins involved in multiple signaling pathways. Therefore, these results improve the understanding of the OP mechanism and provide an experimental basis for the clinical application of YGD in OP treatment.

Published
2021

16. Web video retagging

Author

Chen, Zhineng, primary, Cao, Juan, additional, Xia, Tian, additional, Song, Yicheng, additional, Zhang, Yongdong, additional, and Li, Jintao, additional

Published
2010
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