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Lipid nanoparticles are a successful carrier system for dermal drug delivery. They possess various beneficial properties, i.e., increased chemical stability for chemically labile compounds, increased dermal penetration of active compounds, or skin carrying properties after dermal application due to the formation of a so-called “invisible patch.” Despite manifold studies showing these properties individually, a study that investigates if one lipid nanoparticle formulation can really combine all the above-mentioned benefits at once is not yet available. In the present study, lipid nanoparticles (NLC) were produced and characterized regarding their physico-chemical properties. The chemical stability of the incorporated active ingredient (AI) was determined, as well as the dermal penetration efficacy of the AI, and the skin carrying properties of the NLC after dermal penetration. The properties of the NLC were compared to classical formulations, i.e., AI dissolved in pure oil, an o/w cream base and a nanoemulsion. All formulations contained similar lipids and emulsifiers, which allowed for a direct comparison of the different properties. NLC were shown to provide most efficient chemical stabilization and most efficient dermal penetration for the AI. The formation of the invisible patch was shown for the NLC but not for the other formulations. Skin hydration and skin carrying properties were also most pronounced for the NLC. Results provide evidence that NLC can combine all beneficial effects that were previously described in one formulation. Thus, providing evidence that NLC are a holistically superior formulation principle when compared to other formulation principles. Graphical abstract

Abstract Poor aqueous solubility of drug substances is associated with poor bioavailability and thus hampers the effective use of many potent active pharmaceutical ingredients. Various strategies to overcome poor solubility are available, whereby drug nanocrystals represent one of the most powerful formulation strategies to enhance the kinetic solubility and dissolution rate of poorly soluble drugs. Nanocrystals are simply obtained by milling large-sized drug powders to sizes Graphical abstract "Image missing"

We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its $$\alpha$$ α - crystalline form and the amount of A-IM in the smartFilms reduces. Both, $$\alpha$$ α - and A-IM are preferred over the more common $$\gamma$$ γ - crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug.

A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was qualitatively analysed using blood agar test. Subsequently, quantitative analyses were performed on germ carrier tests using the MRSA strain DSM11822, the MSSA strain DSM799, S. epidermidis DSM1798 with various soil loads. Additionally, the compatibility of the germicidal radiation doses on excised human skin and reconstructed human epidermis was proved. Cell viability, DNA damage and production of radicals were assessed in comparison to typical UVC radiation from discharge lamps (222 nm, 254 nm) and UVB (280–380 nm) radiation for clinical assessment. At a dose of 40 mJ/cm2, the 233 nm light source reduced the viable microorganisms by a log10 reduction (LR) of 5 log10 levels if no soil load was present. Mucin and protein containing soil loads diminished the effect to an LR of 1.5–3.3. A salt solution representing artificial sweat (pH 8.4) had only minor effects on the reduction. The viability of the skin models was not reduced and the DNA damage was far below the damage evoked by 0.1 UVB minimal erythema dose, which can be regarded as safe. Furthermore, the induced damage vanished after 24 h. Irradiation on four consecutive days also did not evoke DNA damage. The radical formation was far lower than 20 min outdoor visible light would cause, which is classified as low radical load and can be compensated by the antioxidant defence system.

ZusammenfassungDie Pflege und Gesunderhaltung der Haut ist nicht nur für ein gutes Aussehen, sondern auch für das allgemeine Wohlbefinden essenziell. Viele Menschen investieren daher für die Hautpflege nicht nur viel Zeit, sondern auch viel Geld. Oft stellt sich jedoch die Frage, welche Produkte aus der Vielfalt an Angeboten nun besonders effektiv und empfehlenswert sind. Der Artikel gibt darüber Auskunft. Er erläutert die Grundlagen und aktuellen Erkenntnisse der Corneobiologie und zeigt, wie eine präzise, effektive und nachhaltige Hautpflege heute aussehen sollte.

Effektive Anti-Aging-Wirkstoffe konnen nur dann entwickeltwerden, wenn der Alterungsprozess vollstandig verstanden ist. Da dies bis heute noch nicht vollstandig der Fall ist, sind derzeit nur solche Wirkstoffe verfugbar, die in bereits verstandene Teilbereiche des Alterungsprozesses eingreifen konnen. Der Beitrag umreist die wesentlichen heute bekannten Anti-Aging-Strategien und erlautert, basierend darauf, neue und innovative Konzepte fur die Entwicklung von Anti-Aging-Dermokosmetika.

Effektive Anti-Aging-Wirkstoffe konnen nur dann entwickelt werden, wenn der Alterungsprozess vollstandig verstanden ist. Da dies bis heute noch nicht vollstandig der Fall ist, sind derzeit nur solche Wirkstoffe verfugbar, die in bereits verstandene Teilbereiche des Alterungsprozesses eingreifen konnen. Der Beitrag umreist die wesentlichen heute bekannten Anti-Aging-Strategien und erlautert, basierend darauf, neue und innovative Konzepte fur die Entwicklung von Anti-Aging-Dermokosmetika.