Search

Your search keyword '"Crawley, Charles"' showing total 14 results
Start Over Author "Crawley, Charles" Publisher springer science and business media llc
14 results on '"Crawley, Charles"'

1. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesús, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Kim, Orchard, additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew, additional, Wilson, Keith M. O., additional, Gadisseur, Alain, additional, Protheroe, Rachel, additional, Wagner-Drouet, Eva Maria, additional, Savani, Bipin N., additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2023
Full Text
View/download PDF

2. Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT

Author

Drozd-Sokołowska, Joanna, primary, Gras, Luuk, additional, Zinger, Nienke, additional, Snowden, John A., additional, Arat, Mutlu, additional, Basak, Grzegorz, additional, Pouli, Anastasia, additional, Crawley, Charles, additional, Wilson, Keith M. O., additional, Tilly, Herve, additional, Byrne, Jennifer, additional, Bulabois, Claude Eric, additional, Passweg, Jakob, additional, Ozkurt, Zubeyde Nur, additional, Schroyens, Wilfried, additional, Lioure, Bruno, additional, Colorado Araujo, Mercedes, additional, Poiré, Xavier, additional, Van Gorkom, Gwendolyn, additional, Gurman, Gunhan, additional, de Wreede, Liesbeth C., additional, Hayden, Patrick J., additional, Beksac, Meral, additional, Schönland, Stefan O., additional, and Yakoub-Agha, Ibrahim, additional

Published
2022
Full Text
View/download PDF

3. Influence of pretransplant inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis study from the Transplant Complications Working Party (TCWP) of the EBMT

Author

Peric, Zinaida, primary, Peczynski, Christophe, additional, Polge, Emmanuelle, additional, Kröger, Nicolaus, additional, Sengeloev, Henrik, additional, Radujkovic, Aleksandar, additional, Helbig, Grzegorz, additional, Russell, Nigel, additional, Bunjes, Donald, additional, Socié, Gerard, additional, Potter, Victoria, additional, Beelen, Dietrich, additional, Crawley, Charles, additional, Bloor, Adrian, additional, Finke, Jürgen, additional, Schoemans, Helene, additional, Penack, Olaf, additional, Snowden, John A., additional, Koenecke, Christian, additional, and Basak, Grzegorz W., additional

Published
2021
Full Text
View/download PDF

4. Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance

Author

Gouliouris, Theodore, Coll, Francesc, Ludden, Catherine, Blane, Beth, Raven, Kathy E, Naydenova, Plamena, Crawley, Charles, Török, Mili Estée, Enoch, David A, Brown, Nicholas M, Harrison, Ewan M, Parkhill, Julian, Peacock, Sharon J, Gouliouris, Theodore [0000-0002-2011-1205], Coll, Francesc [0000-0002-7882-2325], Blane, Beth [0000-0002-0996-9091], Török, Mili Estée [0000-0001-9098-8590], Peacock, Sharon J [0000-0002-1718-2782], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Cross Infection, Infection Control, Whole Genome Sequencing, Chlorhexidine, Enterococcus faecium, Microbial Sensitivity Tests, Middle Aged, Anti-Bacterial Agents, Disease Outbreaks, Vancomycin-Resistant Enterococci, Young Adult, Vancomycin, Alcohols, Humans, Prospective Studies, Genome, Bacterial, Gram-Positive Bacterial Infections, Aged, Disinfectants
Abstract

Nosocomial acquisition and transmission of vancomycin-resistant Enterococcus faecium (VREfm) is the driver for E. faecium carriage in hospitalized patients, which, in turn, is a risk factor for invasive infection in immunocompromised patients. In the present study, we provide a comprehensive picture of E. faecium transmission in an entire sampled patient population using a sequence-driven approach. We prospectively identified and followed 149 haematology patients admitted to a hospital in England for 6 months. Patient stools (n = 376) and environmental swabs (n = 922) were taken at intervals and cultured for E. faecium. We sequenced 1,560 isolates (1,001 stool, 559 environment) and focused our genomic analyses on 1,477 isolates (95%) in the hospital-adapted clade A1. Of 101 patients who provided two or more stool samples, 40 (40%) developed E. faecium carriage after admission based on culture, compared with 64 patients (63%) based on genomic analysis (73% VREfm). Half of 922 environmental swabs (447, 48%) were positive for VREfm. Network analysis showed that, of 111 patients positive for the A1 clade, 67 had strong epidemiological and genomic links with at least one other patient and/or their direct environment, supporting nosocomial transmission. Six patients (3.4%) developed an invasive E. faecium infection from their own gut-colonizing strain, which was preceded by nosocomial acquisition of the infecting isolate in half of these. Two informatics approaches (subtype categorization to define phylogenetic clusters and the development of an SNP cut-off for transmission) were central to our analyses, both of which will inform the future translation of E. faecium sequencing into routine outbreak detection and investigation. In conclusion, we showed that carriage and environmental contamination by the hospital-adapted E. faecium lineage were hyperendemic in our study population and that improved infection control measures will be needed to reduce hospital acquisition rates.

Published
2021

5. Legionellosis after hematopoietic stem cell transplantation

Author

Mikulska, Malgorzata, primary, Tridello, Gloria, additional, Hoek, Jennifer, additional, Gil, Lidia, additional, Yañez, Lucrecia, additional, Labussière-Wallet, Hélène, additional, Passweg, Jakob, additional, Xhaard, Aliénor, additional, Pioltelli, Pietro, additional, Caillot, Denis, additional, Michel, Gerard, additional, Veelken, Hendrik, additional, Blaise, Didier, additional, Bruno, Benedetto, additional, Garcia, Carmen Botella, additional, Itälä-Remes, Maija, additional, Crawley, Charles, additional, Bourhis, Jean Henri, additional, Kaare, Ain, additional, Arcese, William, additional, Parody, Rocio, additional, and Styczynski, Jan, additional

Published
2021
Full Text
View/download PDF

6. Autologous stem cell transplantation for post-transplant lymphoproliferative disorders after solid organ transplantation: a retrospective analysis from the Lymphoma Working Party of the EBMT

Author

Eyre, Toby A., primary, Caillard, Sophie, additional, Finel, Herve, additional, Boumendil, Ariane, additional, Kothari, Jaimal, additional, Zimmermann, Heiner, additional, Trappe, Ralf Ulrich, additional, De Wilde, Virginie, additional, Tholouli, Eleni, additional, Kanfer, Edward, additional, Broom, Angus, additional, Damaj, Gandhi, additional, Bargetzi, Mario, additional, Kozák, Tomáš, additional, Hilgendorf, Inken, additional, Crawley, Charles, additional, Kerre, Tessa, additional, Trněný, Marek, additional, Bachy, Emmanuel, additional, Robinson, Stephen, additional, and Montoto, Silvia, additional

Published
2021
Full Text
View/download PDF

7. Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance

Author

Gouliouris, Theodore, primary, Coll, Francesc, additional, Ludden, Catherine, additional, Blane, Beth, additional, Raven, Kathy E., additional, Naydenova, Plamena, additional, Crawley, Charles, additional, Török, Mili Estée, additional, Enoch, David A., additional, Brown, Nicholas M., additional, Harrison, Ewan M., additional, Parkhill, Julian, additional, and Peacock, Sharon J., additional

Published
2020
Full Text
View/download PDF

8. Reducing the diversity of allogeneic transplant protocols in the UK through a BSBMT Anthony Nolan Protocol Harmonization Initiative

Author

Anthias, Chloe, primary, Apperley, Jane, additional, Bloor, Adrian, additional, Byrne, Jennifer, additional, Collin, Matthew, additional, Crawley, Charles, additional, Craddock, Charles, additional, Finnegan, Damian, additional, Gilleece, Maria, additional, Gribben, John, additional, Hunter, Ann, additional, Hunter, Hannah, additional, Koh, Mickey, additional, Mackinnon, Stephen, additional, Malladi, Ram, additional, Marks, David, additional, McQuaker, Grant, additional, Nikolousis, Manos, additional, Orchard, Kim, additional, Pavlu, Jiri, additional, Peniket, Andrew, additional, Potter, Mike, additional, Potter, Victoria, additional, Robinson, Stephen, additional, Russell, Nigel, additional, Salim, Rahuman, additional, Snowden, John, additional, Thomson, Kirsty, additional, Tholouli, Eleni, additional, and Wilson, Keith, additional

Published
2020
Full Text
View/download PDF

9. Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT

Author

Gilleece, Maria H., primary, Labopin, Myriam, additional, Savani, Bipin N., additional, Yakoub-Agha, Ibrahim, additional, Socié, Gerard, additional, Gedde-Dahl, Tobias, additional, Blaise, Didier, additional, Byrne, Jennifer L., additional, Craddock, Charles, additional, Cornelissen, Jan J., additional, Arcese, William, additional, Forcade, Edouard, additional, Crawley, Charles, additional, Polge, Emmanuelle, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2019
Full Text
View/download PDF

10. Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients

Author

Moradigaravand, Danesh, primary, Gouliouris, Theodore, additional, Blane, Beth, additional, Naydenova, Plamena, additional, Ludden, Catherine, additional, Crawley, Charles, additional, Brown, Nicholas M., additional, Török, M. Estée, additional, Parkhill, Julian, additional, and Peacock, Sharon J., additional

Published
2017
Full Text
View/download PDF

12. The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

Author

Connick, Peter, primary, Kolappan, Madhan, additional, Patani, Rickie, additional, Scott, Michael A, additional, Crawley, Charles, additional, He, Xiao-Ling, additional, Richardson, Karen, additional, Barber, Kelly, additional, Webber, Daniel J, additional, Wheeler-Kingshott, Claudia AM, additional, Tozer, Daniel J, additional, Samson, Rebecca S, additional, Thomas, David L, additional, Du, Ming-Qing, additional, Luan, Shi L, additional, Michell, Andrew W, additional, Altmann, Daniel R, additional, Thompson, Alan J, additional, Miller, David H, additional, Compston, Alastair, additional, and Chandran, Siddharthan, additional

Published
2011
Full Text
View/download PDF

13. Factors which predict unsuccessful mobilisation of peripheral blood progenitor cells following G-CSF alone in patients with non-Hodgkin's lymphoma

Author

Micallef, Ivana NM, primary, Apostolidis, John, additional, Rohatiner, Ama ZS, additional, Wiggins, Claire, additional, Crawley, Charles R, additional, Foran, James M, additional, Leonhardt, Marcus, additional, Bradburn, Mike, additional, Okukenu, Emily, additional, Salam, Ashiq, additional, Matthews, Janet, additional, Cavenagh, Jamie D, additional, Gupta, Rajnish K, additional, and Lister, T Andrew, additional

Published
2000
Full Text
View/download PDF

14. Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance

Author

Gouliouris, Theodore, Coll, Francesc, Ludden, Catherine, Blane, Beth, Raven, Kathy E, Naydenova, Plamena, Crawley, Charles, Török, Mili Estée, Enoch, David A, Brown, Nicholas M, Harrison, Ewan M, Parkhill, Julian, and Peacock, Sharon J

Subjects
Adult, Aged, 80 and over, Cross Infection, Infection Control, Whole Genome Sequencing, Chlorhexidine, Enterococcus faecium, Microbial Sensitivity Tests, Middle Aged, 3. Good health, Anti-Bacterial Agents, Disease Outbreaks, Vancomycin-Resistant Enterococci, Young Adult, Vancomycin, Alcohols, Humans, Prospective Studies, Genome, Bacterial, Gram-Positive Bacterial Infections, Aged, Disinfectants
Abstract

Nosocomial acquisition and transmission of vancomycin-resistant Enterococcus faecium (VREfm) is the driver for E. faecium carriage in hospitalized patients, which, in turn, is a risk factor for invasive infection in immunocompromised patients. In the present study, we provide a comprehensive picture of E. faecium transmission in an entire sampled patient population using a sequence-driven approach. We prospectively identified and followed 149 haematology patients admitted to a hospital in England for 6 months. Patient stools (n = 376) and environmental swabs (n = 922) were taken at intervals and cultured for E. faecium. We sequenced 1,560 isolates (1,001 stool, 559 environment) and focused our genomic analyses on 1,477 isolates (95%) in the hospital-adapted clade A1. Of 101 patients who provided two or more stool samples, 40 (40%) developed E. faecium carriage after admission based on culture, compared with 64 patients (63%) based on genomic analysis (73% VREfm). Half of 922 environmental swabs (447, 48%) were positive for VREfm. Network analysis showed that, of 111 patients positive for the A1 clade, 67 had strong epidemiological and genomic links with at least one other patient and/or their direct environment, supporting nosocomial transmission. Six patients (3.4%) developed an invasive E. faecium infection from their own gut-colonizing strain, which was preceded by nosocomial acquisition of the infecting isolate in half of these. Two informatics approaches (subtype categorization to define phylogenetic clusters and the development of an SNP cut-off for transmission) were central to our analyses, both of which will inform the future translation of E. faecium sequencing into routine outbreak detection and investigation. In conclusion, we showed that carriage and environmental contamination by the hospital-adapted E. faecium lineage were hyperendemic in our study population and that improved infection control measures will be needed to reduce hospital acquisition rates.

Catalog

Books, media, physical & digital resources
See catalog results