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16 results on '"Davies, Jessica"'

2. Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS

Author

Pallett, Laura J., primary, Swadling, Leo, additional, Diniz, Mariana, additional, Maini, Alexander A., additional, Schwabenland, Marius, additional, Gasull, Adrià Dalmau, additional, Davies, Jessica, additional, Kucykowicz, Stephanie, additional, Skelton, Jessica K., additional, Thomas, Niclas, additional, Schmidt, Nathalie M., additional, Amin, Oliver E., additional, Gill, Upkar S., additional, Stegmann, Kerstin A., additional, Burton, Alice R., additional, Stephenson, Emily, additional, Reynolds, Gary, additional, Whelan, Matt, additional, Sanchez, Jenifer, additional, de Maeyer, Roel, additional, Thakker, Clare, additional, Suveizdyte, Kornelija, additional, Uddin, Imran, additional, Ortega-Prieto, Ana M., additional, Grant, Charlotte, additional, Froghi, Farid, additional, Fusai, Giuseppe, additional, Lens, Sabela, additional, Pérez-del-Pulgar, Sofia, additional, Al-Akkad, Walid, additional, Mazza, Giuseppe, additional, Noursadeghi, Mahdad, additional, Akbar, Arne, additional, Kennedy, Patrick T. F., additional, Davidson, Brian R., additional, Prinz, Marco, additional, Chain, Benjamin M., additional, Haniffa, Muzlifah, additional, Gilroy, Derek W., additional, Dorner, Marcus, additional, Bengsch, Bertram, additional, Schurich, Anna, additional, and Maini, Mala K., additional

Published
2023
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3. Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Author

Kaur, Gurman, primary, Porter, Caroline B. M., additional, Ashenberg, Orr, additional, Lee, Jack, additional, Riesenfeld, Samantha J., additional, Hofree, Matan, additional, Aggelakopoulou, Maria, additional, Subramanian, Ayshwarya, additional, Kuttikkatte, Subita Balaram, additional, Attfield, Kathrine E., additional, Desel, Christiane A. E., additional, Davies, Jessica L., additional, Evans, Hayley G., additional, Avraham-Davidi, Inbal, additional, Nguyen, Lan T., additional, Dionne, Danielle A., additional, Neumann, Anna E., additional, Jensen, Lise Torp, additional, Barber, Thomas R., additional, Soilleux, Elizabeth, additional, Carrington, Mary, additional, McVean, Gil, additional, Rozenblatt-Rosen, Orit, additional, Regev, Aviv, additional, and Fugger, Lars, additional

Published
2022
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4. Evidence of partner similarity for autistic traits, systemizing, and theory of mind via facial expressions

Author

Richards, Gareth, Baron-Cohen, Simon, Warrier, Varun, Mellor, Ben, Davies, Jessica, Gee, Laura, Galvin, John, Baron-Cohen, Simon [0000-0001-9217-2544], and Apollo - University of Cambridge Repository

Subjects
Facial Expression, 631/477/2811, Multidisciplinary, mental disorders, article, Theory of Mind, Humans, 631/477, Autistic Disorder, Empathy, behavioral disciplines and activities, health care economics and organizations
Abstract

Funder: Autism Research Trust, Funder: Autistica; doi: http://dx.doi.org/10.13039/501100008161, Funder: Medical Research Council; doi: http://dx.doi.org/10.13039/501100000265, Funder: Cambridge Biomedical Research Centre; doi: http://dx.doi.org/10.13039/501100018956, Funder: National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care East of England at Cambridgeshire and Peterborough NHS Foundation Trust, Funder: Templeton World Charity Foundation; doi: http://dx.doi.org/10.13039/501100011730, It has been hypothesised that romantic partners are more similar than chance in relation to autistic traits. To test this theory, we recruited n = 105 heterosexual couples and examined within-couple correlations for autistic traits [measured using the Autism Spectrum Quotient (AQ)], empathizing [measured using the Empathy Quotient (EQ)], and systemizing [measured using the Systemizing Quotient-Revised (SQ-R)]. For a subsample that attended the lab (n = 58 couples), we also investigated theory of mind via facial expressions using the Reading the Mind in the Eyes Test (RMET) and attention to detail, a component within systemizing, using the Embedded Figures Task (EFT). Variable-centred analyses revealed positive within-couple correlations for all measures except EQ, although these effects were only statistically significant for unmarried couples and not for married/engaged couples. Follow-up analyses indicated that the observed couple similarity effects are likely consistent with people pairing with those more similar than chance (initial assortment) rather than becoming alike over time (convergence), and to seeking out self-resembling partners (active assortment) rather than pairing in this manner via social stratification processes (social homogamy). Additionally, a significant within-couple correlation for autistic traits was observed at the meta-analytic level. However, it should be noted that the meta-analytic effect size estimate was small (r = 0.153) and indicates that only ~ 2% of variance in a person’s score on a phenotypic measure of autistic traits can be predicted by that of their partner.

Published
2022
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8. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Jarvis, Lorna B., primary, Rainbow, Daniel B., additional, Coppard, Valerie, additional, Howlett, Sarah K., additional, Georgieva, Zoya, additional, Davies, Jessica L., additional, Mullay, Harpreet Kaur, additional, Hester, Joanna, additional, Ashmore, Tom, additional, Van Den Bosch, Aletta, additional, Grist, James T., additional, Coles, Alasdair J., additional, Mousa, Hani S., additional, Pluchino, Stefano, additional, Mahbubani, Krishnaa T., additional, Griffin, Julian L., additional, Saeb-Parsy, Kourosh, additional, Issa, Fadi, additional, Peruzzotti-Jametti, Luca, additional, Wicker, Linda S., additional, and Jones, Joanne L., additional

Published
2021
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12. Disseminated Mycobacterium malmoense and Salmonella Infections Associated with a Novel Variant in NFKBIA

Author

Staples, Emily, primary, Morillo-Gutierrez, Beatriz, additional, Davies, Jessica, additional, Petersheim, Daniel, additional, Massaad, Michel, additional, Slatter, Mary, additional, Dimou, Dimitra, additional, Doffinger, Rainer, additional, Hackett, Scott, additional, Kumararatne, Dinkantha, additional, Hadfield, James, additional, Eldridge, Matthew D., additional, Geha, Raif S., additional, Abinun, Mario, additional, and Thaventhiran, James E. D., additional

Published
2017
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16. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Jarvis, Lorna B, Rainbow, Daniel B, Coppard, Valerie, Howlett, Sarah K, Georgieva, Zoya, Davies, Jessica L, Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T, Coles, Alasdair J, Mousa, Hani S, Pluchino, Stefano, Mahbubani, Krishnaa T, Griffin, Julian L, Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S, and Jones, Joanne L

Subjects
Male, Gene Expression Regulation, Humans, hemic and immune systems, chemical and pharmacologic phenomena, Female, GPI-Linked Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, 5'-Nucleotidase, T-Lymphocytes, Regulatory, 3. Good health
Abstract

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression. In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine. We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression.

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