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Start Over Author "De Luise, Monica" Publisher springer science and business media llc
4 results on '"De Luise, Monica"'

1. Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer

Author

De Luise, Monica, primary, Sollazzo, Manuela, additional, Lama, Eleonora, additional, Coadă, Camelia Alexandra, additional, Bressi, Licia, additional, Iorio, Maria, additional, Cavina, Beatrice, additional, D’Angelo, Luigi, additional, Milioni, Sara, additional, Marchio, Lorena, additional, Miglietta, Stefano, additional, Coluccelli, Sara, additional, Tedesco, Greta, additional, Ghelli, Anna, additional, Lemma, Silvia, additional, Perrone, Anna Myriam, additional, Kurelac, Ivana, additional, Iommarini, Luisa, additional, Porcelli, Anna Maria, additional, and Gasparre, Giuseppe, additional

Published
2022
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2. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Author

Kurelac, Ivana, primary, Iommarini, Luisa, additional, Vatrinet, Renaud, additional, Amato, Laura Benedetta, additional, De Luise, Monica, additional, Leone, Giulia, additional, Girolimetti, Giulia, additional, Umesh Ganesh, Nikkitha, additional, Bridgeman, Victoria Louise, additional, Ombrato, Luigi, additional, Columbaro, Marta, additional, Ragazzi, Moira, additional, Gibellini, Lara, additional, Sollazzo, Manuela, additional, Feichtinger, Rene Gunther, additional, Vidali, Silvia, additional, Baldassarre, Maurizio, additional, Foriel, Sarah, additional, Vidone, Michele, additional, Cossarizza, Andrea, additional, Grifoni, Daniela, additional, Kofler, Barbara, additional, Malanchi, Ilaria, additional, Porcelli, Anna Maria, additional, and Gasparre, Giuseppe, additional

Published
2019
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4. The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity

Author

Anna Maria Porcelli, Michele Vidone, Renaud Vatrinet, Monica De Luise, Giuseppe Gasparre, Giulia Girolimetti, Giulia Leone, Vatrinet, Renaud, Leone, Giulia, De Luise, Monica, Girolimetti, Giulia, Vidone, Michele, Gasparre, Giuseppe, and Porcelli, Anna Maria

Subjects
0301 basic medicine, Cell signaling, α-Ketoglutarate dehydrogenase complex, Dehydrogenase, Review, Biology, 03 medical and health sciences, medicine, chemistry.chemical_classification, Cancer plasticity, α-Ketoglutarate dehydrogenase complex, α-Ketoglutarate, Mitochondrial function, Metabolic stresses, Cancer plasticity, Cell signaling, Oncometabolite, Epigenetics, Cancer, Metabolism, medicine.disease, Cell biology, Citric acid cycle, Psychiatry and Mental health, Metabolic pathway, α-Ketoglutarate, 030104 developmental biology, Enzyme, Biochemistry, chemistry, Oncometabolite, Cancer cell, Metabolic stresses, Epigenetics, Mitochondrial function, Flux (metabolism)
Abstract

Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell’s change in bioenergetic requirements. By contributing to the control of α-ketoglutarate levels, dynamics, and oxidation state, the α-ketoglutarate dehydrogenase is also essential in modulating the epigenetic landscape of cancer cells. In this review, we will discuss the manifold roles that this TCA enzyme and its substrate play in cancer.

Published
2017
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