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19 results on '"De Vathaire F"'

2. Increased risk of second cancers following breast cancer: Role of the initial treatment

Author

de Vathaire F, Carole Rubino, A Shamsaldin, Ibrahima Diallo, and M. G. Lê

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Neoplasms, Radiation-Induced, Time Factors, medicine.medical_treatment, Breast Neoplasms, Cohort Studies, Breast cancer, Risk Factors, Internal medicine, medicine, Humans, Risk factor, Survival analysis, Aged, Aged, 80 and over, Gynecology, Radiotherapy, business.industry, Incidence, Incidence (epidemiology), Neoplasms, Second Primary, Middle Aged, medicine.disease, Survival Analysis, Menopause, Radiation therapy, Relative risk, Female, France, Skin cancer, business, Follow-Up Studies
Abstract

Objectives and methods.The risk of second primary malignancies (SMN) was studied in a cohort of 4,416 one-year survivors of a breast cancer. The role of the menopausal status and of the initial treatment modalities (surgery, radiotherapy, and chemotherapy) was investigated. Results.Excluding second primary breast cancer and non-melanoma skin cancer, a total of 193 (4.4%) patients developed a SMN between 1973 and 1992, compared with 136 expected (Standardised Incidence Ratio, SIR = 1.4, 95% CI (1.2–1.6)). No trend towards either an increase or a decrease was noted in the SIR with time after treatment (p = 0.2). The greatest increase in the relative risk concerned soft tissue cancers (SIR = 13.0, 95% CI: 6.8–22.3), followed by leukaemia (SIR = 3.1, 95% CI: 1.7–5.0), melanoma (SIR = 2.7, 95% CI: 1.4–4.8), kidney (SIR = 2.5, 95% CI: 1.2–4.5), ovary (SIR = 2.0, 95% CI: 1.2–3.1) and uterine tumours (SIR = 1.9, 95% CI: 1.4–2.5). The SIR was 3.0 (95% CI 1.8–4.7) in women under 40 at the time of the breast cancer, 1.9 (95% CI : 1.4 – 2.4) in those aged 40–49 and 1.2 (95% CI 1.0–1.4) in those aged 50 or more. In the 2,514 women who had received radiotherapy as initial treatment without chemotherapy, the SIR for all SMN was 1.6 (95% CI: 1.1–2.3) fold higher than in those who had not received radiotherapy as initial treatment. Conclusion.In conclusion, this study confirms the increased risk of second malignancies in women treated for a breast cancer, and particularly in those who were younger at the time of treatment for breast cancer. Our results also suggest that radiotherapy may play a role in the onset of these second lesions.

Published
2000
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3. [Untitled]

Author

de Vathaire F, Le Vu B, and Vathaire Cc

Subjects
Cancer Research, education.field_of_study, business.industry, common, Incidence (epidemiology), Thyroid, Population, Environmental exposure, medicine.disease, medicine.disease_cause, Cancer registry, medicine.anatomical_structure, Polynesians, Oncology, common.group, medicine, education, Nuclear medicine, business, Thyroid cancer, Thyroid neoplasm, Demography
Abstract

Background: Between 1966 and 1974, France performed 41 atmospheric nuclear weapon tests in the Mururoa and Fangataufa atolls in French Polynesia. Methods: We performed a geographic analysis of thyroid cancer incidence, using data from the cancer registry of French Polynesia, medical evacuation files, insurance records and hospital and pathology laboratory files. Results: A total of 153 thyroid cancers were diagnosed between 1985 and 1995 in the population born before 1976 and residing in French Polynesia. The incidence of thyroid cancer was 2–3 times larger in French Polynesia than in Maoris of New Zealand and Hawaiians of Hawaii. Based on few cases, a nonsignificant (p = 0.1) increase with decreasing distance between Mururoa and the birth place was observed in women born between 1950 and 1975 for thyroid cancer. Conclusion: Because the difference between Polynesian and reference populations was not larger for Polynesians who were children during the tests than for Polynesians born earlier, as would be expected in the case of radioiodine contamination, the high thyroid cancer rates in French Polynesia could hardly be attributed to radioiodine fallout. Nevertheless, a surveillance of the population born close to Mururoa is necessary to confirm or deny the existence of a higher risk of thyroid cancer in this population.

Published
2000
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5. Thyroid cancer following nuclear tests in French Polynesia

Author

de Vathaire, F, primary, Drozdovitch, V, additional, Brindel, P, additional, Rachedi, F, additional, Boissin, J-L, additional, Sebbag, J, additional, Shan, L, additional, Bost-Bezeaud, F, additional, Petitdidier, P, additional, Paoaafaite, J, additional, Teuri, J, additional, Iltis, J, additional, Bouville, A, additional, Cardis, E, additional, Hill, C, additional, and Doyon, F, additional

Published
2010
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8. Second primary malignancies in thyroid cancer patients

Author

Rubino, C, primary, de Vathaire, F, additional, Dottorini, M E, additional, Hall, P, additional, Schvartz, C, additional, Couette, J E, additional, Dondon, M G, additional, Abbas, M T, additional, Langlois, C, additional, and Schlumberger, M, additional

Published
2003
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