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Your search keyword '"Dobrynin IaV"' showing total 2 results
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2 results on '"Dobrynin IaV"'

1. Cytostatic effect of L-lysine-?-oxidase fromTrichoderma harzianum Rifai andTrichoderma viride

Author

Berezov Tt, Dobrynin IaV, Zhukova Os, Khaduev SKh, and Soda K

Subjects
chemistry.chemical_classification, DNA synthesis, biology, Trichoderma viride, Deamination, RNA, Trichoderma harzianum, General Medicine, biology.organism_classification, complex mixtures, Molecular biology, General Biochemistry, Genetics and Molecular Biology, In vitro, chemistry.chemical_compound, Enzyme, chemistry, Biochemistry, bacteria, DNA
Abstract

L-lysine-alpha-oxidase, a new fungal enzyme catalyzing oxidative L-lysine deamination, was shown to have an inhibitory effect on the in vitro synthesis of DNA, RNA and proteins in human carcinoma ovarian (CaOv) cells.

Published
1987
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2. Comparison of the effect of L-lysine-?-oxidase fromTrichodern, harzianum Rifai andTrichoderma viride on nucleic acid synthesis in human tumor cellsin vitro

Author

Dobrynin IaV, Zhukova Os, Khaduev SKh, Soda K, and Berezov Tt

Subjects
DNA synthesis, biology, Trichoderma viride, RNA, Trichoderma harzianum, General Medicine, biology.organism_classification, Molecular biology, General Biochemistry, Genetics and Molecular Biology, Enzyme assay, chemistry.chemical_compound, Biochemistry, chemistry, Trichoderma, Nucleic acid, biology.protein, DNA
Abstract

This paper gives comparative data on the effect of the new antitumor enzyme LO from a Soviet strain Trichoderma harzianum Rifai and from Trichoderma viride from Japan, on DNA and RNA synthesis in human ovarian carcinoma cells (CaOv strain) in culture, and also the results of the action of LO from T. harzianum Rifai on protein synthesis. Specific precursors were added before the end of the incubation time to the samples; /sup 3/H-thymidine as precursor for DNA synthesis, /sup 3/H-uridine as RNA precursor, and /sup 3/H-leucine as protein precursor. The final values of inhibition of DNA and RNA synthesis in the presence of enzyme from both sources are shown to depend in a virtually linear manner on enzyme concentration.

Published
1986
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