4 results on '"Elina, Sillanpää"'
Search Results
2. Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning
- Author
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Aini Paavilainen, Kirsi H. Pietiläinen, Tuija Tammelin, Jaakko Kaprio, Vuokko Kovanen, Elina Sillanpää, Anna Kankaanpää, Urho M. Kujala, Miina Ollikainen, Sarianna Sipilä, Aino Heikkinen, Eija K. Laakkonen, Institute for Molecular Medicine Finland, Department of Public Health, HUS Abdominal Center, Department of Medicine, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, and Endokrinologian yksikkö
- Subjects
Epigenomics ,Male ,0301 basic medicine ,Aging ,maximal oxygen consumption ,biological ageing ,Monozygotic twin ,Physiology ,Epigenesis, Genetic ,Cohort Studies ,0302 clinical medicine ,twin study ,Genetics (clinical) ,Whole blood ,0303 health sciences ,DNA methylation ,Dual-energy X-ray absorptiometry ,Twin study ,Middle Aged ,DNA-metylaatio ,medicine.anatomical_structure ,muscle mass ,epigenetiikka ,Female ,dual-energy X-ray absorptiometry ,Adult ,Muscle tissue ,Biology ,Young Adult ,03 medical and health sciences ,Maximal oxygen consumption ,maksimaalinen hapenotto ,Genetics ,medicine ,Humans ,Epigenetics ,Muscle, Skeletal ,Exercise ,Molecular Biology ,Aged ,030304 developmental biology ,kaksostutkimus ,Muscle strength ,Research ,Skeletal muscle ,Muscle mass ,Cardiorespiratory fitness ,Biological ageing ,ikääntyminen ,030104 developmental biology ,lihasmassa ,Ageing ,3121 General medicine, internal medicine and other clinical medicine ,muscle strength ,030217 neurology & neurosurgery ,lihasvoima ,Developmental Biology - Abstract
The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function and body composition. Two independent cohorts (N = 139 and N = 47) were included, whose age span covered adulthood (23–69 years). Whole blood and m. vastus lateralis samples were collected, and DNA methylation was analysed. Four different DNA methylation age (DNAmAge) estimates were calculated using genome-wide methylation data and publicly available online tools. A novel muscle-specific methylation age was estimated using the R-package ‘MEAT’. PA was measured with questionnaires and accelerometers. Several tests were conducted to estimate cardiorespiratory fitness and muscle strength. Body composition was estimated by dual-energy X-ray absorptiometry. DNAmAge estimates from blood and muscle were highly correlated with chronological age, but different age acceleration estimates were weakly associated with each other. The monozygotic twin within-pair similarity of ageing pace was higher in blood (r = 0.617–0.824) than in muscle (r = 0.523–0.585). Associations of age acceleration estimates with PA, physical function and body composition were weak in both tissues and mostly explained by smoking and sex. The muscle-specific epigenetic clock MEAT was developed to predict chronological age, which may explain why it did not associate with functional phenotypes. The Horvath’s clock and GrimAge were weakly associated with PA and related phenotypes, suggesting that higher PA would be linked to accelerated biological ageing in muscle. This may, however, be more reflective of the low capacity of epigenetic clock algorithms to measure functional muscle ageing than of actual age acceleration. Based on our results, the investigated epigenetic clocks have rather low value in estimating muscle ageing with respect to the physiological adaptations that typically occur due to ageing or PA. Thus, further development of methods is needed to gain insight into muscle tissue-specific ageing and the underlying biological pathways.
- Published
- 2021
3. Body composition changes by DXA, BIA and skinfolds during exercise training in women
- Author
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Elina Sillanpää, Keijo Häkkinen, and Arja Häkkinen
- Subjects
Adult ,medicine.medical_specialty ,Physiology ,Strength training ,Body Mass Index ,Education ,Fat mass ,Fats ,Absorptiometry, Photon ,Animal science ,Endurance training ,Physiology (medical) ,Electric Impedance ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Exercise physiology ,Exercise ,Dual-energy X-ray absorptiometry ,medicine.diagnostic_test ,business.industry ,Public Health, Environmental and Occupational Health ,General Medicine ,Middle Aged ,Skinfold Thickness ,Cross-Sectional Studies ,Skinfold thickness ,Body Composition ,Lean body mass ,Physical therapy ,Female ,business ,human activities ,Body mass index - Abstract
Few studies have examined responsiveness of bioimpedance (BIA) to detect changes over time in body composition using a longitudinal design. Accuracy of BIA and skinfold thickness in estimating body composition among 39–64 year-old women was investigated using dual-energy X-ray absorptiometry (DXA) as a criterion method both cross-sectionally and during a training intervention. 97 women had percentage of fat assessed using DXA, skinfolds and eight-polar BIA using multi-frequency current. Fat mass and lean mass were estimated by DXA and BIA. Measurements were performed before and after the 21-week training intervention. At baseline relative to DXA, BIA under predicted percentage of fat (−6.50 %) and fat mass (−3.42 kg) and overestimated lean mass (3.18 kg) considerably. Also skinfold measurement under predicted percentage of fat compared to DXA, but the difference was smaller (−1.69 % units). Skinfold measurement overestimated percentage of fat at low values and underestimated at high values (r 2 = 0.535). A significant bias was detected between DXA and BIA’s estimate of change in percentage of fat, fat mass and lean mass. Compared to DXA, BIA and skinfolds underestimated the training-induced positive changes in body composition. BIA and skinfold methods compared to DXA are not interchangeable to quantify the percentage of fat, fat mass and lean mass at the cross-sectional design in middle-aged women. Moreover, exercise training-induced small changes in body composition cannot be detected with BIA or skinfold method, even though DXA was able to measure statistically significant within-group changes in body composition after training.
- Published
- 2013
4. Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages
- Author
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Jussi Mikkola, Heli Valkeinen, Laura Karavirta, Antti A. Mero, Keijo Häkkinen, Juha J. Hulmi, Elina Sillanpää, Janne Sallinen, J. Holviala, Simon Walker, Heikki Peltonen, and Juha P. Ahtiainen
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Adult ,Male ,Gerontology ,Aging ,Time Factors ,Muscle size ,Physiology ,Age and sex ,Article ,Muscle hypertrophy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Muscle Strength ,Young adult ,Muscle, Skeletal ,Aged ,Retrospective Studies ,Metabolic health ,business.industry ,Resistance training ,Resistance Training ,Retrospective cohort study ,030229 sport sciences ,General Medicine ,Middle Aged ,Healthy Volunteers ,Muscle strength ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Physical activity recommendations for public health include typically muscle-strengthening activities for a minimum of 2 days a week. The range of inter-individual variation in responses to resistance training (RT) aiming to improve health and well-being requires to be investigated. The purpose of this study was to quantify high and low responders for RT-induced changes in muscle size and strength and to examine possible effects of age and sex on these responses. Previously collected data of untrained healthy men and women (age 19 to 78 years, n = 287 with 72 controls) were pooled for the present study. Muscle size and strength changed during RT are 4.8 ± 6.1 % (range from −11 to 30 %) and 21.1 ± 11.5 % (range from −8 to 60 %) compared to pre-RT, respectively. Age and sex did not affect to the RT responses. Fourteen percent and 12 % of the subjects were defined as high responders (>1 standard deviation (SD) from the group mean) for the RT-induced changes in muscle size and strength, respectively. When taking into account the results of non-training controls (upper 95 % CI), 29 and 7 % of the subjects were defined as low responders for the RT-induced changes in muscle size and strength, respectively. The muscle size and strength responses varied extensively between the subjects regardless of subject’s age and sex. Whether these changes are associated with, e.g., functional capacity and metabolic health improvements due to RT requires further studies.
- Published
- 2016
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