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70 results on '"Evans, David M"'

1. A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans

Author

Moksnes, Marta R., primary, Hansen, Ailin F., additional, Wolford, Brooke N., additional, Thomas, Laurent F., additional, Rasheed, Humaira, additional, Simić, Anica, additional, Bhatta, Laxmi, additional, Brantsæter, Anne Lise, additional, Surakka, Ida, additional, Zhou, Wei, additional, Magnus, Per, additional, Njølstad, Pål R., additional, Andreassen, Ole A., additional, Syversen, Tore, additional, Zheng, Jie, additional, Fritsche, Lars G., additional, Evans, David M., additional, Warrington, Nicole M., additional, Nøst, Therese H., additional, Åsvold, Bjørn Olav, additional, Flaten, Trond Peder, additional, Willer, Cristen J., additional, Hveem, Kristian, additional, and Brumpton, Ben M., additional

Published
2024
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2. Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Author

Medina-Gomez, Carolina, primary, Mullin, Benjamin H., additional, Chesi, Alessandra, additional, Prijatelj, Vid, additional, Kemp, John P., additional, Shochat-Carvalho, Chen, additional, Trajanoska, Katerina, additional, Wang, Carol, additional, Joro, Raimo, additional, Evans, Tavia E., additional, Schraut, Katharina E., additional, Li-Gao, Ruifang, additional, Ahluwalia, Tarunveer S., additional, Zillikens, M. Carola, additional, Zhu, Kun, additional, Mook-Kanamori, Dennis O., additional, Evans, Daniel S., additional, Nethander, Maria, additional, Knol, Maria J., additional, Thorleifsson, Gudmar, additional, Prokic, Ivana, additional, Zemel, Babette, additional, Broer, Linda, additional, McGuigan, Fiona E., additional, van Schoor, Natasja M., additional, Reppe, Sjur, additional, Pawlak, Mikolaj A., additional, Ralston, Stuart H., additional, van der Velde, Nathalie, additional, Lorentzon, Mattias, additional, Stefansson, Kari, additional, Adams, Hieab H. H., additional, Wilson, Scott G., additional, Ikram, M. Arfan, additional, Walsh, John P., additional, Lakka, Timo A., additional, Gautvik, Kaare M., additional, Wilson, James F., additional, Orwoll, Eric S., additional, van Duijn, Cornelia M., additional, Bønnelykke, Klaus, additional, Uitterlinden, Andre G., additional, Styrkársdóttir, Unnur, additional, Akesson, Kristina E., additional, Spector, Timothy D., additional, Tobias, Jonathan H., additional, Ohlsson, Claes, additional, Felix, Janine F., additional, Bisgaard, Hans, additional, Grant, Struan F. A., additional, Richards, J. Brent, additional, Evans, David M., additional, van der Eerden, Bram, additional, van de Peppel, Jeroen, additional, Ackert-Bicknell, Cheryl, additional, Karasik, David, additional, Kague, Erika, additional, and Rivadeneira, Fernando, additional

Published
2023
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3. Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Author

Jami, Eshim S., primary, Hammerschlag, Anke R., additional, Sallis, Hannah M., additional, Qiao, Zhen, additional, Andreassen, Ole A., additional, Magnus, Per M., additional, Njølstad, Pål R., additional, Havdahl, Alexandra, additional, Pingault, Jean-Baptiste, additional, Evans, David M., additional, Munafò, Marcus R., additional, Ystrom, Eivind, additional, Bartels, Meike, additional, and Middeldorp, Christel, additional

Published
2023
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4. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Author

Howe, Laurence J, Nivard, Michel G, Morris, Tim T, Hansen, Ailin F, Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A, Palviainen, Teemu, Van Der Zee, Matthijs D, Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M, Bielak, Lawrence F, Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A, Reynolds, Chandra A, Balbona, Jared V, Andreassen, Ole A, Ask, Helga, Baras, Aris, Bauer, Christopher R, Boomsma, Dorret I, Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C, Dokuru, Deepika R, Evans, Luke M, De Geus, Eco JC, Giddaluru, Sudheer, Gordon, Scott D, Harden, K Paige, Hill, W David, Hughes, Amanda, Kerr, Shona M, Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A, Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik KE, Mallard, Travis T, Martikainen, Pekka, Mills, Melinda C, Njølstad, Pål Rasmus, Overton, John D, Pedersen, Nancy L, Porteous, David J, Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C, Stoltenberg, Camilla, Tucker-Drob, Elliot M, Wright, Margaret J, Social Science Genetic Association Consortium, Within Family Consortium, Hewitt, John K, Keller, Matthew C, Stallings, Michael C, Lee, James J, Christensen, Kaare, Kardia, Sharon LR, Peyser, Patricia A, Smith, Jennifer A, Wilson, James F, Hopper, John L, Hägg, Sara, Spector, Tim D, Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G, Oskarsson, Sven, Justice, Anne E, Millwood, Iona Y, Hveem, Kristian, Naess, Øyvind, Willer, Cristen J, Åsvold, Bjørn Olav, Koellinger, Philipp D, Kaprio, Jaakko, Medland, Sarah E, Walters, Robin G, Benjamin, Daniel J, Turley, Patrick, Evans, David M, Davey Smith, George, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, Davies, Neil M, Howe, Laurence J [0000-0002-2819-9686], Nivard, Michel G [0000-0003-2015-1888], Morris, Tim T [0000-0001-8178-6815], Rasheed, Humaira [0000-0002-3331-5864], Cho, Yoonsu [0000-0001-6118-6652], Lind, Penelope A [0000-0002-3887-2598], Palviainen, Teemu [0000-0002-7847-8384], van der Zee, Matthijs D [0000-0003-4076-9167], Mangino, Massimo [0000-0002-2167-7470], Wang, Yunzhang [0000-0003-1165-3595], Klaric, Lucija [0000-0003-3105-8929], Bielak, Lawrence F [0000-0002-3443-8030], Nygaard, Marianne [0000-0003-0703-2665], Giannelis, Alexandros [0000-0003-4587-0336], Willoughby, Emily A [0000-0001-7559-1544], Reynolds, Chandra A [0000-0001-6502-7173], Balbona, Jared V [0000-0003-4466-248X], Andreassen, Ole A [0000-0002-4461-3568], Ask, Helga [0000-0003-0149-5319], Baras, Aris [0000-0002-6830-3396], Boomsma, Dorret I [0000-0002-7099-7972], Campbell, Archie [0000-0003-0198-5078], Chen, Zhengming [0000-0001-6423-105X], Corfield, Elizabeth [0000-0002-0119-157X], Evans, Luke M [0000-0002-7458-1720], Gordon, Scott D [0000-0001-7623-328X], Harden, K Paige [0000-0002-1557-6737], Hughes, Amanda [0000-0001-5896-7650], Kerr, Shona M [0000-0002-4137-1495], Kweon, Hyeokmoon [0000-0002-3649-0457], Lawlor, Deborah A [0000-0002-6793-2262], Magnusson, Patrik KE [0000-0002-7315-7899], Mallard, Travis T [0000-0002-3265-3001], Martikainen, Pekka [0000-0001-9374-1438], Njølstad, Pål Rasmus [0000-0003-0304-6728], Porteous, David J [0000-0003-1249-6106], Reid, Jeffrey [0000-0001-8645-4713], Southey, Melissa C [0000-0002-6313-9005], Stoltenberg, Camilla [0000-0002-8747-1985], Tucker-Drob, Elliot M [0000-0001-5599-6237], Wright, Margaret J [0000-0001-7133-4970], Keller, Matthew C [0000-0002-6075-9882], Lee, James J [0000-0001-6547-5128], Christensen, Kaare [0000-0002-5429-5292], Peyser, Patricia A [0000-0002-9717-8459], Smith, Jennifer A [0000-0002-3575-5468], Wilson, James F [0000-0001-5751-9178], Hägg, Sara [0000-0002-2452-1500], Spector, Tim D [0000-0002-9795-0365], Plomin, Robert [0000-0002-0756-3629], Havdahl, Alexandra [0000-0002-9268-0423], Bartels, Meike [0000-0002-9667-7555], Oskarsson, Sven [0000-0001-8698-2866], Willer, Cristen J [0000-0001-5645-4966], Åsvold, Bjørn Olav [0000-0003-3837-2101], Koellinger, Philipp D [0000-0001-7413-0412], Kaprio, Jaakko [0000-0002-3716-2455], Walters, Robin G [0000-0002-9179-0321], Benjamin, Daniel J [0000-0002-2642-5416], Evans, David M [0000-0003-0663-4621], Davey Smith, George [0000-0002-1407-8314], Hayward, Caroline [0000-0002-9405-9550], Brumpton, Ben [0000-0002-3058-1059], Hemani, Gibran [0000-0003-0920-1055], Davies, Neil M [0000-0002-2460-0508], and Apollo - University of Cambridge Repository

Subjects
Multifactorial Inheritance, Phenotype, 631/208/205/2138, article, Humans, 631/208/457, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Genome-Wide Association Study
Abstract

Funder: Jacobs Foundation; doi: https://doi.org/10.13039/501100003986, Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.

Published
2022
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8. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, de Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, van Duijn, Cornelia M, van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, Medland, Sarah E, Cuellar-Partida, Gabriel [0000-0001-7648-4097], Aliev, Fazil [0000-0001-8357-4699], Andreassen, Ole A [0000-0002-4461-3568], Barroso, Inês [0000-0001-5800-4520], Beckmann, Jacques S [0000-0002-9741-1900], Boks, Marco P [0000-0001-6163-7484], Boomsma, Dorret I [0000-0002-7099-7972], Boyd, Heather A [0000-0001-6849-9985], Breteler, Monique MB [0000-0002-0626-9305], Chasman, Daniel I [0000-0003-3357-0862], de Geus, Eco JC [0000-0001-6022-2666], Deary, Ian J [0000-0002-1733-263X], Deloukas, Panos [0000-0001-9251-070X], Dick, Danielle M [0000-0002-1636-893X], Feenstra, Bjarke [0000-0003-1478-649X], Geller, Frank [0000-0002-9238-3269], Gordon, Scott D [0000-0001-7623-328X], Hansen, Thomas F [0000-0001-6703-7762], Hayward, Caroline [0000-0002-9405-9550], Hicks, Andrew A [0000-0001-6320-0411], Hirschhorn, Joel N [0000-0002-1650-7901], Hottenga, Jouke-Jan [0000-0002-5668-2368], Huffman, Jennifer E [0000-0002-9672-2491], Hwang, Liang-Dar [0000-0002-5535-2199], Ikram, M Arfan [0000-0003-0372-8585], Kaprio, Jaakko [0000-0002-3716-2455], Kemp, John P [0000-0002-9105-2249], Konte, Bettina [0000-0001-5287-308X], Kutalik, Zoltan [0000-0001-8285-7523], Lahti, Jari [0000-0002-4310-5297], Li, Xin [0000-0002-0135-8800], Loos, Ruth JF [0000-0002-8532-5087], Luciano, Michelle [0000-0002-7306-3008], Magnusson, Sigurdur H [0000-0001-6669-3071], Mangino, Massimo [0000-0002-2167-7470], Marques-Vidal, Pedro [0000-0002-4548-8500], Martin, Nicholas G [0000-0003-4069-8020], McArdle, Wendy L [0000-0002-0605-5403], McCarthy, Mark I [0000-0002-4393-0510], Medina-Gomez, Carolina [0000-0001-7999-5538], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Milani, Lili [0000-0002-5323-3102], Nelis, Mari [0000-0001-9748-1020], Nyholt, Dale R [0000-0001-7159-3040], O'Connell, Kevin S [0000-0002-6865-8795], Ophoff, Roel A [0000-0002-8287-6457], Palviainen, Teemu [0000-0002-7847-8384], Pare, Guillaume [0000-0002-6795-4760], Paternoster, Lavinia [0000-0003-2514-0889], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Ripatti, Samuli [0000-0002-0504-1202], Rivadeneira, Fernando [0000-0001-9435-9441], Rudan, Igor [0000-0001-6993-6884], Smit, Johannes H [0000-0002-2062-8378], Smith, George Davey [0000-0002-1407-8314], Smoller, Jordan W [0000-0002-0381-6334], Spector, Tim D [0000-0002-9795-0365], Pourcain, Beate St [0000-0002-4680-3517], Stefánsson, Hreinn [0000-0002-9331-6666], Steinberg, Stacy [0000-0001-7726-5152], Teder-Laving, Maris [0000-0002-5872-1850], Stefánsson, Kári [0000-0003-1676-864X], Timpson, Nicholas J [0000-0002-7141-9189], Uitterlinden, André G [0000-0002-7276-3387], van Rooij, Frank JA [0000-0002-8600-9852], Vink, Jaqueline M [0000-0003-3910-3528], Waeber, Gérard [0000-0003-4193-788X], Warrington, Nicole [0000-0003-4195-775X], Werge, Thomas [0000-0003-1829-0766], Wright, Margaret J [0000-0001-7133-4970], Zhao, Jing Hua [0000-0002-1463-5870], Kraft, Peter [0000-0002-4472-8103], Hinds, David A [0000-0002-4911-803X], Lindgren, Cecilia M [0000-0002-4903-9374], Neale, Benjamin M [0000-0003-1513-6077], Evans, David M [0000-0003-0663-4621], Medland, Sarah E [0000-0003-1382-380X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide, Functional Laterality, Linkage Disequilibrium, Quantitative Trait, Heritable, Sex Factors, Gene Frequency, Genetic Loci, Humans, Female, Aged, Genome-Wide Association Study
Abstract

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P

Published
2021

9. Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores

Author

Bond, Tom A., primary, Richmond, Rebecca C., additional, Karhunen, Ville, additional, Cuellar-Partida, Gabriel, additional, Borges, Maria Carolina, additional, Zuber, Verena, additional, Couto Alves, Alexessander, additional, Mason, Dan, additional, Yang, Tiffany C., additional, Gunter, Marc J., additional, Dehghan, Abbas, additional, Tzoulaki, Ioanna, additional, Sebert, Sylvain, additional, Evans, David M., additional, Lewin, Alex M., additional, O’Reilly, Paul F., additional, Lawlor, Deborah A., additional, and Järvelin, Marjo-Riitta, additional

Published
2022
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10. Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile

Author

Thompson, William D., primary, Beaumont, Robin N., additional, Kuang, Alan, additional, Warrington, Nicole M., additional, Ji, Yingjie, additional, Tyrrell, Jessica, additional, Wood, Andrew R., additional, Scholtens, Denise M., additional, Knight, Bridget A., additional, Evans, David M., additional, Lowe, William L., additional, Santorelli, Gillian, additional, Azad, Rafaq, additional, Mason, Dan, additional, Hattersley, Andrew T., additional, Frayling, Timothy M., additional, Yaghootkar, Hanieh, additional, Borges, Maria Carolina, additional, Lawlor, Deborah A., additional, and Freathy, Rachel M., additional

Published
2021
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13. The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock

Author

Cohen, Jeremy, primary, Blumenthal, Antje, additional, Cuellar-Partida, Gabriel, additional, Evans, David M., additional, Finfer, Simon, additional, Li, Qiang, additional, Ljungberg, Johanna, additional, Myburgh, John, additional, Peach, Elizabeth, additional, Powell, Joseph, additional, Rajbhandari, Dorrilyn, additional, Rhodes, Andrew, additional, Senabouth, Anne, additional, and Venkatesh, Balasubramanian, additional

Published
2021
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14. An atlas of genetic influences on osteoporosis in humans and mice

Author

Morris, John A, Kemp, John P, Youlten, Scott E, Laurent, Laetitia, Logan, John G, Chai, Ryan C, Vulpescu, Nicholas A, Forgetta, Vincenzo, Kleinman, Aaron, Mohanty, Sindhu T, Sergio, C Marcelo, Quinn, Julian, Nguyen-Yamamoto, Loan, Luco, Aimee-Lee, Vijay, Jinchu, Simon, Marie-Michelle, Pramatarova, Albena, Medina-Gomez, Carolina, Trajanoska, Katerina, Ghirardello, Elena J, Butterfield, Natalie C, Curry, Katharine F, Leitch, Victoria D, Sparkes, Penny C, Adoum, Anne-Tounsia, Mannan, Naila S, Komla-Ebri, Davide SK, Pollard, Andrea S, Dewhurst, Hannah F, Hassall, Thomas AD, Beltejar, Michael-John G, 23andMe Research Team, Adams, Douglas J, Vaillancourt, Suzanne M, Kaptoge, Stephen, Baldock, Paul, Cooper, Cyrus, Reeve, Jonathan, Ntzani, Evangelia E, Evangelou, Evangelos, Ohlsson, Claes, Karasik, David, Rivadeneira, Fernando, Kiel, Douglas P, Tobias, Jonathan H, Gregson, Celia L, Harvey, Nicholas C, Grundberg, Elin, Goltzman, David, Adams, David J, Lelliott, Christopher J, Hinds, David A, Ackert-Bicknell, Cheryl L, Hsu, Yi-Hsiang, Maurano, Matthew T, Croucher, Peter I, Williams, Graham R, Bassett, JH Duncan, Evans, David M, Richards, J Brent, Morris, John A [0000-0003-2769-8202], Kemp, John P [0000-0002-9105-2249], Youlten, Scott E [0000-0001-9314-2945], Vulpescu, Nicholas A [0000-0003-1310-0257], Sergio, C Marcelo [0000-0002-5426-0583], Medina-Gomez, Carolina [0000-0001-7999-5538], Reeve, Jonathan [0000-0002-4364-2682], Ntzani, Evangelia E [0000-0003-3712-4181], Rivadeneira, Fernando [0000-0001-9435-9441], Kiel, Douglas P [0000-0001-8474-0310], Gregson, Celia L [0000-0001-6414-0529], Harvey, Nicholas C [0000-0002-8194-2512], Lelliott, Christopher J [0000-0001-8087-4530], Hinds, David A [0000-0002-4911-803X], Williams, Graham R [0000-0002-8555-8219], Bassett, JH Duncan [0000-0003-0817-0082], Evans, David M [0000-0003-0663-4621], Richards, J Brent [0000-0002-3746-9086], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Mice, Knockout, Middle Aged, Polymorphism, Single Nucleotide, Fractures, Bone, Mice, Phenotype, Bone Density, Animals, Humans, Osteoporosis, Female, Genetic Predisposition to Disease, Aged, Genome-Wide Association Study
Abstract

Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with estimated BMD (eBMD), in ~1.2 million individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds ratio (OR) = 58, P = 1 × 10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice with disruptions in predicted target genes and found an increased abnormal skeletal phenotype frequency compared to 526 unselected lines (P < 0.0001). In-depth analysis of one gene, DAAM2, showed a disproportionate decrease in bone strength relative to mineralization. This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.

Published
2019

16. Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Author

Youlten, Scott E., primary, Kemp, John P., additional, Logan, John G., additional, Ghirardello, Elena J., additional, Sergio, Claudio M., additional, Dack, Michael R. G., additional, Guilfoyle, Siobhan E., additional, Leitch, Victoria D., additional, Butterfield, Natalie C., additional, Komla-Ebri, Davide, additional, Chai, Ryan C., additional, Corr, Alexander P., additional, Smith, James T., additional, Mohanty, Sindhu T., additional, Morris, John A., additional, McDonald, Michelle M., additional, Quinn, Julian M. W., additional, McGlade, Amelia R., additional, Bartonicek, Nenad, additional, Jansson, Matt, additional, Hatzikotoulas, Konstantinos, additional, Irving, Melita D., additional, Beleza-Meireles, Ana, additional, Rivadeneira, Fernando, additional, Duncan, Emma, additional, Richards, J. Brent, additional, Adams, David J., additional, Lelliott, Christopher J., additional, Brink, Robert, additional, Phan, Tri Giang, additional, Eisman, John A., additional, Evans, David M., additional, Zeggini, Eleftheria, additional, Baldock, Paul A., additional, Bassett, J. H. Duncan, additional, Williams, Graham R., additional, and Croucher, Peter I., additional

Published
2021
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18. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, De Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, Van Duijn, Cornelia M, Van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, and Medland, Sarah E

Subjects
Adult, Male, Genetic Variation, Middle Aged, Polymorphism, Single Nucleotide, Functional Laterality, Linkage Disequilibrium, Quantitative Trait, Heritable, Sex Factors, Gene Frequency, Genetic Loci, Humans, Female, Aged, Genome-Wide Association Study
Abstract

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

Published
2020
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22. Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort

Author

Moen, Gunn-Helen, primary, Brumpton, Ben, additional, Willer, Cristen, additional, Åsvold, Bjørn Olav, additional, Birkeland, Kåre I., additional, Wang, Geng, additional, Neale, Michael C., additional, Freathy, Rachel M., additional, Smith, George Davey, additional, Lawlor, Deborah A., additional, Kirkpatrick, Robert M., additional, Warrington, Nicole M., additional, and Evans, David M., additional

Published
2020
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24. Genome-wide association study identifies 48 common genetic variants associated with handedness

Author

Cuellar-Partida, Gabriel, primary, Tung, Joyce Y., additional, Eriksson, Nicholas, additional, Albrecht, Eva, additional, Aliev, Fazil, additional, Andreassen, Ole A., additional, Barroso, Inês, additional, Beckmann, Jacques S., additional, Boks, Marco P., additional, Boomsma, Dorret I., additional, Boyd, Heather A., additional, Breteler, Monique M. B., additional, Campbell, Harry, additional, Chasman, Daniel I., additional, Cherkas, Lynn F., additional, Davies, Gail, additional, de Geus, Eco J. C., additional, Deary, Ian J., additional, Deloukas, Panos, additional, Dick, Danielle M., additional, Duffy, David L., additional, Eriksson, Johan G., additional, Esko, Tõnu, additional, Feenstra, Bjarke, additional, Geller, Frank, additional, Gieger, Christian, additional, Giegling, Ina, additional, Gordon, Scott D., additional, Han, Jiali, additional, Hansen, Thomas F., additional, Hartmann, Annette M., additional, Hayward, Caroline, additional, Heikkilä, Kauko, additional, Hicks, Andrew A., additional, Hirschhorn, Joel N., additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E., additional, Hwang, Liang-Dar, additional, Ikram, M. Arfan, additional, Kaprio, Jaakko, additional, Kemp, John P., additional, Khaw, Kay-Tee, additional, Klopp, Norman, additional, Konte, Bettina, additional, Kutalik, Zoltan, additional, Lahti, Jari, additional, Li, Xin, additional, Loos, Ruth J. F., additional, Luciano, Michelle, additional, Magnusson, Sigurdur H., additional, Mangino, Massimo, additional, Marques-Vidal, Pedro, additional, Martin, Nicholas G., additional, McArdle, Wendy L., additional, McCarthy, Mark I., additional, Medina-Gomez, Carolina, additional, Melbye, Mads, additional, Melville, Scott A., additional, Metspalu, Andres, additional, Milani, Lili, additional, Mooser, Vincent, additional, Nelis, Mari, additional, Nyholt, Dale R., additional, O’Connell, Kevin S., additional, Ophoff, Roel A., additional, Palmer, Cameron, additional, Palotie, Aarno, additional, Palviainen, Teemu, additional, Pare, Guillaume, additional, Paternoster, Lavinia, additional, Peltonen, Leena, additional, Penninx, Brenda W. J. H., additional, Polasek, Ozren, additional, Pramstaller, Peter P., additional, Prokopenko, Inga, additional, Raikkonen, Katri, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Rujescu, Dan, additional, Smit, Johannes H., additional, Smith, George Davey, additional, Smoller, Jordan W., additional, Soranzo, Nicole, additional, Spector, Tim D., additional, Pourcain, Beate St, additional, Starr, John M., additional, Stefánsson, Hreinn, additional, Steinberg, Stacy, additional, Teder-Laving, Maris, additional, Thorleifsson, Gudmar, additional, Stefánsson, Kári, additional, Timpson, Nicholas J., additional, Uitterlinden, André G., additional, van Duijn, Cornelia M., additional, van Rooij, Frank J. A., additional, Vink, Jaqueline M., additional, Vollenweider, Peter, additional, Vuoksimaa, Eero, additional, Waeber, Gérard, additional, Wareham, Nicholas J., additional, Warrington, Nicole, additional, Waterworth, Dawn, additional, Werge, Thomas, additional, Wichmann, H.-Erich, additional, Widen, Elisabeth, additional, Willemsen, Gonneke, additional, Wright, Alan F., additional, Wright, Margaret J., additional, Xu, Mousheng, additional, Zhao, Jing Hua, additional, Kraft, Peter, additional, Hinds, David A., additional, Lindgren, Cecilia M., additional, Mägi, Reedik, additional, Neale, Benjamin M., additional, Evans, David M., additional, and Medland, Sarah E., additional

Published
2020
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25. RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

Author

Loh, Nellie Y., primary, Minchin, James E. N., additional, Pinnick, Katherine E., additional, Verma, Manu, additional, Todorčević, Marijana, additional, Denton, Nathan, additional, Moustafa, Julia El-Sayed, additional, Kemp, John P., additional, Gregson, Celia L., additional, Evans, David M., additional, Neville, Matt J., additional, Small, Kerrin S., additional, McCarthy, Mark I., additional, Mahajan, Anubha, additional, Rawls, John F., additional, Karpe, Fredrik, additional, and Christodoulides, Constantinos, additional

Published
2020
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28. Exposure time versus cytotoxicity for anticancer agents

Author

Evans, David M., primary, Fang, Jianwen, additional, Silvers, Thomas, additional, Delosh, Rene, additional, Laudeman, Julie, additional, Ogle, Chad, additional, Reinhart, Russell, additional, Selby, Michael, additional, Bowles, Lori, additional, Connelly, John, additional, Harris, Erik, additional, Krushkal, Julia, additional, Rubinstein, Larry, additional, Doroshow, James H., additional, and Teicher, Beverly A., additional

Published
2019
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32. Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Author

Corbin, Laura J., primary, Tan, Vanessa Y., additional, Hughes, David A., additional, Wade, Kaitlin H., additional, Paul, Dirk S., additional, Tansey, Katherine E., additional, Butcher, Frances, additional, Dudbridge, Frank, additional, Howson, Joanna M., additional, Jallow, Momodou W., additional, John, Catherine, additional, Kingston, Nathalie, additional, Lindgren, Cecilia M., additional, O’Donavan, Michael, additional, O’Rahilly, Stephen, additional, Owen, Michael J., additional, Palmer, Colin N. A., additional, Pearson, Ewan R., additional, Scott, Robert A., additional, van Heel, David A., additional, Whittaker, John, additional, Frayling, Tim, additional, Tobin, Martin D., additional, Wain, Louise V., additional, Smith, George Davey, additional, Evans, David M., additional, Karpe, Fredrik, additional, McCarthy, Mark I., additional, Danesh, John, additional, Franks, Paul W., additional, and Timpson, Nicholas J., additional

Published
2018
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33. Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium

Author

Fan, Qiao, Guo, Xiaobo, Tideman, J Willem L, Williams, Katie M, Yazar, Seyhan, Hosseini, S Mohsen, Howe, Laura D, Pourcain, Beaté St, Evans, David M, Timpson, Nicholas J, McMahon, George, Hysi, Pirro G, Krapohl, Eva, Wang, Ya Xing, Jonas, Jost B, Baird, Paul Nigel, Wang, Jie Jin, Cheng, Ching-Yu, Teo, Yik-Ying, Wong, Tien-Yin, Ding, Xiaohu, Wojciechowski, Robert, Young, Terri L, Pärssinen, Olavi, Oexle, Konrad, Pfeiffer, Norbert, Bailey-Wilson, Joan E, Paterson, Andrew D, Klaver, Caroline CW, Plomin, Robert, Hammond, Christopher J, Mackey, David A, He, Mingguang, Saw, Seang-Mei, Williams, Cathy, Guggenheim, Jeremy A, CREAM Consortium, Hosseini, S Mohsen [0000-0003-3626-9928], and Apollo - University of Cambridge Repository

Subjects
Male, Adolescent, Refractive Errors, Polymorphism, Single Nucleotide, Article, White People, Asian People, Myopia, Humans, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Longitudinal Studies, Age of Onset, Child, Genome-Wide Association Study
Abstract

Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7-15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E-08) and 2.3% (P = 6.9E-21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4; P = 6.3E-04).

Published
2016

36. Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

Author

Kemp, John P, primary, Morris, John A, additional, Medina-Gomez, Carolina, additional, Forgetta, Vincenzo, additional, Warrington, Nicole M, additional, Youlten, Scott E, additional, Zheng, Jie, additional, Gregson, Celia L, additional, Grundberg, Elin, additional, Trajanoska, Katerina, additional, Logan, John G, additional, Pollard, Andrea S, additional, Sparkes, Penny C, additional, Ghirardello, Elena J, additional, Allen, Rebecca, additional, Leitch, Victoria D, additional, Butterfield, Natalie C, additional, Komla-Ebri, Davide, additional, Adoum, Anne-Tounsia, additional, Curry, Katharine F, additional, White, Jacqueline K, additional, Kussy, Fiona, additional, Greenlaw, Keelin M, additional, Xu, Changjiang, additional, Harvey, Nicholas C, additional, Cooper, Cyrus, additional, Adams, David J, additional, Greenwood, Celia M T, additional, Maurano, Matthew T, additional, Kaptoge, Stephen, additional, Rivadeneira, Fernando, additional, Tobias, Jonathan H, additional, Croucher, Peter I, additional, Ackert-Bicknell, Cheryl L, additional, Bassett, J H Duncan, additional, Williams, Graham R, additional, Richards, J Brent, additional, and Evans, David M, additional

Published
2017
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37. Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Author

Medina-Gomez, Carolina, primary, Kemp, John P., additional, Dimou, Niki L., additional, Kreiner, Eskil, additional, Chesi, Alessandra, additional, Zemel, Babette S., additional, Bønnelykke, Klaus, additional, Boer, Cindy G., additional, Ahluwalia, Tarunveer S., additional, Bisgaard, Hans, additional, Evangelou, Evangelos, additional, Heppe, Denise H. M., additional, Bonewald, Lynda F., additional, Gorski, Jeffrey P., additional, Ghanbari, Mohsen, additional, Demissie, Serkalem, additional, Duque, Gustavo, additional, Maurano, Matthew T., additional, Kiel, Douglas P., additional, Hsu, Yi-Hsiang, additional, C.J. van der Eerden, Bram, additional, Ackert-Bicknell, Cheryl, additional, Reppe, Sjur, additional, Gautvik, Kaare M., additional, Raastad, Truls, additional, Karasik, David, additional, van de Peppel, Jeroen, additional, Jaddoe, Vincent W. V., additional, Uitterlinden, André G., additional, Tobias, Jonathan H., additional, Grant, Struan F.A., additional, Bagos, Pantelis G., additional, Evans, David M., additional, and Rivadeneira, Fernando, additional

Published
2017
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39. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Author

Zheng, Hou-Feng, Forgetta, Vincenzo, Hsu, Yi-Hsiang, Estrada, Karol, Rosello-Diez, Alberto, Leo, Paul J, Dahia, Chitra L, Park-Min, Kyung Hyun, Tobias, Jonathan H, Kooperberg, Charles, Kleinman, Aaron, Styrkarsdottir, Unnur, Liu, Ching-Ti, Uggla, Charlotta, Evans, Daniel S, Nielson, Carrie M, Walter, Klaudia, Pettersson-Kymmer, Ulrika, McCarthy, Shane, Eriksson, Joel, Kwan, Tony, Jhamai, Mila, Trajanoska, Katerina, Memari, Yasin, Min, Josine, Huang, Jie, Danecek, Petr, Wilmot, Beth, Li, Rui, Chou, Wen-Chi, Mokry, Lauren E, Moayyeri, Alireza, Claussnitzer, Melina, Cheng, Chia-Ho, Cheung, Warren, Medina-Gómez, Carolina, Ge, Bing, Chen, Shu-Huang, Choi, Kwangbom, Oei, Ling, Fraser, James, Kraaij, Robert, Hibbs, Matthew A, Gregson, Celia L, Paquette, Denis, Hofman, Albert, Wibom, Carl, Tranah, Gregory J, Marshall, Mhairi, Gardiner, Brooke B, Cremin, Katie, Auer, Paul, Hsu, Li, Ring, Sue, Tung, Joyce Y, Thorleifsson, Gudmar, Enneman, Anke W, Van Schoor, Natasja M, De Groot, Lisette CPGM, Van Der Velde, Nathalie, Melin, Beatrice, Kemp, John P, Christiansen, Claus, Sayers, Adrian, Zhou, Yanhua, Calderari, Sophie, Van Rooij, Jeroen, Carlson, Chris, Peters, Ulrike, Berlivet, Soizik, Dostie, Josée, Uitterlinden, Andre G, Williams, Stephen R, Farber, Charles, Grinberg, Daniel, LaCroix, Andrea Z, Haessler, Jeff, Chasman, Daniel I, Giulianini, Franco, Rose, Lynda M, Ridker, Paul M, Eisman, John A, Nguyen, Tuan V, Center, Jacqueline R, Nogues, Xavier, Garcia-Giralt, Natalia, Launer, Lenore L, Gudnason, Vilmunder, Mellström, Dan, Vandenput, Liesbeth, Amin, Najaf, Van Duijn, Cornelia M, Karlsson, Magnus K, Ljunggren, Östen, Svensson, Olle, Hallmans, Göran, Rousseau, François, Giroux, Sylvie, Bussière, Johanne, Arp, Pascal P, Koromani, Fjorda, Prince, Richard L, Lewis, Joshua R, Langdahl, Bente L, Hermann, A Pernille, Jensen, Jens-Erik B, Kaptoge, Stephen, Khaw, Kay-Tee, Reeve, Jonathan, Formosa, Melissa M, Xuereb-Anastasi, Angela, Åkesson, Kristina, McGuigan, Fiona E, Garg, Gaurav, Olmos, Jose M, Zarrabeitia, Maria T, Riancho, Jose A, Ralston, Stuart H, Alonso, Nerea, Jiang, Xi, Goltzman, David, Pastinen, Tomi, Grundberg, Elin, Gauguier, Dominique, Orwoll, Eric S, Karasik, David, Davey-Smith, George, AOGC Consortium, Smith, Albert V, Siggeirsdottir, Kristin, Harris, Tamara B, Zillikens, M Carola, Van Meurs, Joyce BJ, Thorsteinsdottir, Unnur, Maurano, Matthew T, Timpson, Nicholas J, Soranzo, Nicole, Durbin, Richard, Wilson, Scott G, Ntzani, Evangelia E, Brown, Matthew A, Stefansson, Kari, Hinds, David A, Spector, Tim, Cupples, L Adrienne, Ohlsson, Claes, Greenwood, Celia MT, UK10K Consortium, Jackson, Rebecca D, Rowe, David W, Loomis, Cynthia A, Evans, David M, Ackert-Bicknell, Cheryl L, Joyner, Alexandra L, Duncan, Emma L, Kiel, Douglas P, Rivadeneira, Fernando, Richards, J Brent, Rosello-Diez, Alberto [0000-0002-5550-9846], Kaptoge, Stephen [0000-0002-1155-4872], Khaw, Kay-Tee [0000-0002-8802-2903], Soranzo, Nicole [0000-0003-1095-3852], and Apollo - University of Cambridge Repository

Subjects
Homeodomain Proteins, Genotype, Genome, Human, Genetic Variation, Genomics, Sequence Analysis, DNA, Bone and Bones, White People, Europe, Wnt Proteins, Disease Models, Animal, Fractures, Bone, Mice, Gene Frequency, Bone Density, Animals, Humans, Exome, Female, Genetic Predisposition to Disease
Abstract

The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF ≤ 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants, as well as rare, population-specific, coding variants. Here we identify novel non-coding genetic variants with large effects on BMD (ntotal = 53,236) and fracture (ntotal = 508,253) in individuals of European ancestry from the general population. Associations for BMD were derived from whole-genome sequencing (n = 2,882 from UK10K (ref. 10); a population-based genome sequencing consortium), whole-exome sequencing (n = 3,549), deep imputation of genotyped samples using a combined UK10K/1000 Genomes reference panel (n = 26,534), and de novo replication genotyping (n = 20,271). We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD (rs11692564(T), MAF = 1.6%, replication effect size = +0.20 s.d., Pmeta = 2 × 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 × 10(-11); ncases = 98,742 and ncontrols = 409,511). Using an En1(cre/flox) mouse model, we observed that conditional loss of En1 results in low bone mass, probably as a consequence of high bone turnover. We also identified a novel low-frequency non-coding variant with large effects on BMD near WNT16 (rs148771817(T), MAF = 1.2%, replication effect size = +0.41 s.d., Pmeta = 1 × 10(-11)). In general, there was an excess of association signals arising from deleterious coding and conserved non-coding variants. These findings provide evidence that low-frequency non-coding variants have large effects on BMD and fracture, thereby providing rationale for whole-genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.

Published
2015

40. Erratum to: Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

Author

Pourcain, Beate St, primary, Haworth, C. M. A., additional, Davis, O. S. P., additional, Wang, Kai, additional, Timpson, Nicholas J., additional, Evans, David M., additional, Kemp, John P., additional, Ronald, Angelica, additional, Price, Tom, additional, Meaburn, Emma, additional, Ring, Susan M., additional, Golding, Jean, additional, Hakonarson, Hakon, additional, Plomin, R., additional, and Smith, George Davey, additional

Published
2016
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41. Genome-wide association study identifies 74 loci associated with educational attainment

Author

Okbay, Aysu, primary, Beauchamp, Jonathan P., additional, Fontana, Mark Alan, additional, Lee, James J., additional, Pers, Tune H., additional, Rietveld, Cornelius A., additional, Turley, Patrick, additional, Chen, Guo-Bo, additional, Emilsson, Valur, additional, Meddens, S. Fleur W., additional, Oskarsson, Sven, additional, Pickrell, Joseph K., additional, Thom, Kevin, additional, Timshel, Pascal, additional, de Vlaming, Ronald, additional, Abdellaoui, Abdel, additional, Ahluwalia, Tarunveer S., additional, Bacelis, Jonas, additional, Baumbach, Clemens, additional, Bjornsdottir, Gyda, additional, Brandsma, Johannes H., additional, Pina Concas, Maria, additional, Derringer, Jaime, additional, Furlotte, Nicholas A., additional, Galesloot, Tessel E., additional, Girotto, Giorgia, additional, Gupta, Richa, additional, Hall, Leanne M., additional, Harris, Sarah E., additional, Hofer, Edith, additional, Horikoshi, Momoko, additional, Huffman, Jennifer E., additional, Kaasik, Kadri, additional, Kalafati, Ioanna P., additional, Karlsson, Robert, additional, Kong, Augustine, additional, Lahti, Jari, additional, Lee, Sven J. van der, additional, deLeeuw, Christiaan, additional, Lind, Penelope A., additional, Lindgren, Karl-Oskar, additional, Liu, Tian, additional, Mangino, Massimo, additional, Marten, Jonathan, additional, Mihailov, Evelin, additional, Miller, Michael B., additional, van der Most, Peter J., additional, Oldmeadow, Christopher, additional, Payton, Antony, additional, Pervjakova, Natalia, additional, Peyrot, Wouter J., additional, Qian, Yong, additional, Raitakari, Olli, additional, Rueedi, Rico, additional, Salvi, Erika, additional, Schmidt, Börge, additional, Schraut, Katharina E., additional, Shi, Jianxin, additional, Smith, Albert V., additional, Poot, Raymond A., additional, St Pourcain, Beate, additional, Teumer, Alexander, additional, Thorleifsson, Gudmar, additional, Verweij, Niek, additional, Vuckovic, Dragana, additional, Wellmann, Juergen, additional, Westra, Harm-Jan, additional, Yang, Jingyun, additional, Zhao, Wei, additional, Zhu, Zhihong, additional, Alizadeh, Behrooz Z., additional, Amin, Najaf, additional, Bakshi, Andrew, additional, Baumeister, Sebastian E., additional, Biino, Ginevra, additional, Bønnelykke, Klaus, additional, Boyle, Patricia A., additional, Campbell, Harry, additional, Cappuccio, Francesco P., additional, Davies, Gail, additional, De Neve, Jan-Emmanuel, additional, Deloukas, Panos, additional, Demuth, Ilja, additional, Ding, Jun, additional, Eibich, Peter, additional, Eisele, Lewin, additional, Eklund, Niina, additional, Evans, David M., additional, Faul, Jessica D., additional, Feitosa, Mary F., additional, Forstner, Andreas J., additional, Gandin, Ilaria, additional, Gunnarsson, Bjarni, additional, Halldórsson, Bjarni V., additional, Harris, Tamara B., additional, Heath, Andrew C., additional, Hocking, Lynne J., additional, Holliday, Elizabeth G., additional, Homuth, Georg, additional, Horan, Michael A., additional, Hottenga, Jouke-Jan, additional, de Jager, Philip L., additional, Joshi, Peter K., additional, Jugessur, Astanand, additional, Kaakinen, Marika A., additional, Kähönen, Mika, additional, Kanoni, Stavroula, additional, Keltigangas-Järvinen, Liisa, additional, Kiemeney, Lambertus A. L. M., additional, Kolcic, Ivana, additional, Koskinen, Seppo, additional, Kraja, Aldi T., additional, Kroh, Martin, additional, Kutalik, Zoltan, additional, Latvala, Antti, additional, Launer, Lenore J., additional, Lebreton, Maël P., additional, Levinson, Douglas F., additional, Lichtenstein, Paul, additional, Lichtner, Peter, additional, Liewald, David C. M., additional, Cohort Study, LifeLines, additional, Loukola, Anu, additional, Madden, Pamela A., additional, Mägi, Reedik, additional, Mäki-Opas, Tomi, additional, Marioni, Riccardo E., additional, Marques-Vidal, Pedro, additional, Meddens, Gerardus A., additional, McMahon, George, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Milaneschi, Yusplitri, additional, Milani, Lili, additional, Montgomery, Grant W., additional, Myhre, Ronny, additional, Nelson, Christopher P., additional, Nyholt, Dale R., additional, Ollier, William E. R., additional, Palotie, Aarno, additional, Paternoster, Lavinia, additional, Pedersen, Nancy L., additional, Petrovic, Katja E., additional, Porteous, David J., additional, Räikkönen, Katri, additional, Ring, Susan M., additional, Robino, Antonietta, additional, Rostapshova, Olga, additional, Rudan, Igor, additional, Rustichini, Aldo, additional, Salomaa, Veikko, additional, Sanders, Alan R., additional, Sarin, Antti-Pekka, additional, Schmidt, Helena, additional, Scott, Rodney J., additional, Smith, Blair H., additional, Smith, Jennifer A., additional, Staessen, Jan A., additional, Steinhagen-Thiessen, Elisabeth, additional, Strauch, Konstantin, additional, Terracciano, Antonio, additional, Tobin, Martin D., additional, Ulivi, Sheila, additional, Vaccargiu, Simona, additional, Quaye, Lydia, additional, van Rooij, Frank J. A., additional, Venturini, Cristina, additional, Vinkhuyzen, Anna A. E., additional, Völker, Uwe, additional, Völzke, Henry, additional, Vonk, Judith M., additional, Vozzi, Diego, additional, Waage, Johannes, additional, Ware, Erin B., additional, Willemsen, Gonneke, additional, Attia, John R., additional, Bennett, David A., additional, Berger, Klaus, additional, Bertram, Lars, additional, Bisgaard, Hans, additional, Boomsma, Dorret I., additional, Borecki, Ingrid B., additional, Bültmann, Ute, additional, Chabris, Christopher F., additional, Cucca, Francesco, additional, Cusi, Daniele, additional, Deary, Ian J., additional, Dedoussis, George V., additional, van Duijn, Cornelia M., additional, Eriksson, Johan G., additional, Franke, Barbara, additional, Franke, Lude, additional, Gasparini, Paolo, additional, Gejman, Pablo V., additional, Gieger, Christian, additional, Grabe, Hans-Jörgen, additional, Gratten, Jacob, additional, Groenen, Patrick J. F., additional, Gudnason, Vilmundur, additional, van der Harst, Pim, additional, Hayward, Caroline, additional, Hinds, David A., additional, Hoffmann, Wolfgang, additional, Hyppönen, Elina, additional, Iacono, William G., additional, Jacobsson, Bo, additional, Järvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Lehtimäki, Terho, additional, Lehrer, Steven F., additional, Magnusson, Patrik K. E., additional, Martin, Nicholas G., additional, McGue, Matt, additional, Metspalu, Andres, additional, Pendleton, Neil, additional, Penninx, Brenda W. J. H., additional, Perola, Markus, additional, Pirastu, Nicola, additional, Pirastu, Mario, additional, Polasek, Ozren, additional, Posthuma, Danielle, additional, Power, Christine, additional, Province, Michael A., additional, Samani, Nilesh J., additional, Schlessinger, David, additional, Schmidt, Reinhold, additional, Sørensen, Thorkild I. A., additional, Spector, Tim D., additional, Stefansson, Kari, additional, Thorsteinsdottir, Unnur, additional, Thurik, A. Roy, additional, Timpson, Nicholas J., additional, Tiemeier, Henning, additional, Tung, Joyce Y., additional, Uitterlinden, André G., additional, Vitart, Veronique, additional, Vollenweider, Peter, additional, Weir, David R., additional, Wilson, James F., additional, Wright, Alan F., additional, Conley, Dalton C., additional, Krueger, Robert F., additional, Davey Smith, George, additional, Hofman, Albert, additional, Laibson, David I., additional, Medland, Sarah E., additional, Meyer, Michelle N., additional, Yang, Jian, additional, Johannesson, Magnus, additional, Visscher, Peter M., additional, Esko, Tõnu, additional, Koellinger, Philipp D., additional, Cesarini, David, additional, and Benjamin, Daniel J., additional

Published
2016
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42. Systematic identification of genetic influences on methylation across the human life course

Author

Gaunt, Tom R., primary, Shihab, Hashem A., additional, Hemani, Gibran, additional, Min, Josine L., additional, Woodward, Geoff, additional, Lyttleton, Oliver, additional, Zheng, Jie, additional, Duggirala, Aparna, additional, McArdle, Wendy L., additional, Ho, Karen, additional, Ring, Susan M., additional, Evans, David M., additional, Davey Smith, George, additional, and Relton, Caroline L., additional

Published
2016
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43. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Author

Lu, Yingchang, primary, Day, Felix R., additional, Gustafsson, Stefan, additional, Buchkovich, Martin L., additional, Na, Jianbo, additional, Bataille, Veronique, additional, Cousminer, Diana L., additional, Dastani, Zari, additional, Drong, Alexander W., additional, Esko, Tõnu, additional, Evans, David M., additional, Falchi, Mario, additional, Feitosa, Mary F., additional, Ferreira, Teresa, additional, Hedman, Åsa K., additional, Haring, Robin, additional, Hysi, Pirro G., additional, Iles, Mark M., additional, Justice, Anne E., additional, Kanoni, Stavroula, additional, Lagou, Vasiliki, additional, Li, Rui, additional, Li, Xin, additional, Locke, Adam, additional, Lu, Chen, additional, Mägi, Reedik, additional, Perry, John R. B., additional, Pers, Tune H., additional, Qi, Qibin, additional, Sanna, Marianna, additional, Schmidt, Ellen M., additional, Scott, William R., additional, Shungin, Dmitry, additional, Teumer, Alexander, additional, Vinkhuyzen, Anna A. E., additional, Walker, Ryan W., additional, Westra, Harm-Jan, additional, Zhang, Mingfeng, additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Zhu, Zhihong, additional, Afzal, Uzma, additional, Ahluwalia, Tarunveer Singh, additional, Bakker, Stephan J. L., additional, Bellis, Claire, additional, Bonnefond, Amélie, additional, Borodulin, Katja, additional, Buchman, Aron S., additional, Cederholm, Tommy, additional, Choh, Audrey C., additional, Choi, Hyung Jin, additional, Curran, Joanne E., additional, de Groot, Lisette C. P. G. M., additional, De Jager, Philip L., additional, Dhonukshe-Rutten, Rosalie A. M., additional, Enneman, Anke W., additional, Eury, Elodie, additional, Evans, Daniel S., additional, Forsen, Tom, additional, Friedrich, Nele, additional, Fumeron, Frédéric, additional, Garcia, Melissa E., additional, Gärtner, Simone, additional, Han, Bok-Ghee, additional, Havulinna, Aki S., additional, Hayward, Caroline, additional, Hernandez, Dena, additional, Hillege, Hans, additional, Ittermann, Till, additional, Kent, Jack W., additional, Kolcic, Ivana, additional, Laatikainen, Tiina, additional, Lahti, Jari, additional, Leach, Irene Mateo, additional, Lee, Christine G., additional, Lee, Jong-Young, additional, Liu, Tian, additional, Liu, Youfang, additional, Lobbens, Stéphane, additional, Loh, Marie, additional, Lyytikäinen, Leo-Pekka, additional, Medina-Gomez, Carolina, additional, Michaëlsson, Karl, additional, Nalls, Mike A., additional, Nielson, Carrie M., additional, Oozageer, Laticia, additional, Pascoe, Laura, additional, Paternoster, Lavinia, additional, Polašek, Ozren, additional, Ripatti, Samuli, additional, Sarzynski, Mark A., additional, Shin, Chan Soo, additional, Narančić, Nina Smolej, additional, Spira, Dominik, additional, Srikanth, Priya, additional, Steinhagen-Thiessen, Elisabeth, additional, Sung, Yun Ju, additional, Swart, Karin M. A., additional, Taittonen, Leena, additional, Tanaka, Toshiko, additional, Tikkanen, Emmi, additional, van der Velde, Nathalie, additional, van Schoor, Natasja M., additional, Verweij, Niek, additional, Wright, Alan F., additional, Yu, Lei, additional, Zmuda, Joseph M., additional, Eklund, Niina, additional, Forrester, Terrence, additional, Grarup, Niels, additional, Jackson, Anne U., additional, Kristiansson, Kati, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Lichtner, Peter, additional, Luan, Jian'an, additional, Mahajan, Anubha, additional, Männistö, Satu, additional, Palmer, Cameron D., additional, Ried, Janina S., additional, Scott, Robert A., additional, Stancáková, Alena, additional, Wagner, Peter J., additional, Demirkan, Ayse, additional, Döring, Angela, additional, Gudnason, Vilmundur, additional, Kiel, Douglas P., additional, Kühnel, Brigitte, additional, Mangino, Massimo, additional, Mcknight, Barbara, additional, Menni, Cristina, additional, O'Connell, Jeffrey R., additional, Oostra, Ben A., additional, Shuldiner, Alan R., additional, Song, Kijoung, additional, Vandenput, Liesbeth, additional, van Duijn, Cornelia M., additional, Vollenweider, Peter, additional, White, Charles C., additional, Boehnke, Michael, additional, Boettcher, Yvonne, additional, Cooper, Richard S., additional, Forouhi, Nita G., additional, Gieger, Christian, additional, Grallert, Harald, additional, Hingorani, Aroon, additional, Jørgensen, Torben, additional, Jousilahti, Pekka, additional, Kivimaki, Mika, additional, Kumari, Meena, additional, Laakso, Markku, additional, Langenberg, Claudia, additional, Linneberg, Allan, additional, Luke, Amy, additional, Mckenzie, Colin A., additional, Palotie, Aarno, additional, Pedersen, Oluf, additional, Peters, Annette, additional, Strauch, Konstantin, additional, Tayo, Bamidele O., additional, Wareham, Nicholas J., additional, Bennett, David A., additional, Bertram, Lars, additional, Blangero, John, additional, Blüher, Matthias, additional, Bouchard, Claude, additional, Campbell, Harry, additional, Cho, Nam H., additional, Cummings, Steven R., additional, Czerwinski, Stefan A., additional, Demuth, Ilja, additional, Eckardt, Rahel, additional, Eriksson, Johan G., additional, Ferrucci, Luigi, additional, Franco, Oscar H., additional, Froguel, Philippe, additional, Gansevoort, Ron T., additional, Hansen, Torben, additional, Harris, Tamara B., additional, Hastie, Nicholas, additional, Heliövaara, Markku, additional, Hofman, Albert, additional, Jordan, Joanne M., additional, Jula, Antti, additional, Kähönen, Mika, additional, Kajantie, Eero, additional, Knekt, Paul B., additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Lehtimäki, Terho, additional, Lind, Lars, additional, Liu, Yongmei, additional, Orwoll, Eric S., additional, Osmond, Clive, additional, Perola, Markus, additional, Pérusse, Louis, additional, Raitakari, Olli T., additional, Rankinen, Tuomo, additional, Rao, D. C., additional, Rice, Treva K., additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Sørensen, Thorkild I. A., additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, Towne, Bradford, additional, Tranah, Gregory J., additional, Tremblay, Angelo, additional, Uitterlinden, André G., additional, van der Harst, Pim, additional, Vartiainen, Erkki, additional, Viikari, Jorma S., additional, Vitart, Veronique, additional, Vohl, Marie-Claude, additional, Völzke, Henry, additional, Walker, Mark, additional, Wallaschofski, Henri, additional, Wild, Sarah, additional, Wilson, James F., additional, Yengo, Loïc, additional, Bishop, D. Timothy, additional, Borecki, Ingrid B., additional, Chambers, John C., additional, Cupples, L. Adrienne, additional, Dehghan, Abbas, additional, Deloukas, Panos, additional, Fatemifar, Ghazaleh, additional, Fox, Caroline, additional, Furey, Terrence S., additional, Franke, Lude, additional, Han, Jiali, additional, Hunter, David J., additional, Karjalainen, Juha, additional, Karpe, Fredrik, additional, Kaplan, Robert C., additional, Kooner, Jaspal S., additional, McCarthy, Mark I., additional, Murabito, Joanne M., additional, Morris, Andrew P., additional, Bishop, Julia A. N., additional, North, Kari E., additional, Ohlsson, Claes, additional, Ong, Ken K., additional, Prokopenko, Inga, additional, Richards, J. Brent, additional, Schadt, Eric E., additional, Spector, Tim D., additional, Widén, Elisabeth, additional, Willer, Cristen J., additional, Yang, Jian, additional, Ingelsson, Erik, additional, Mohlke, Karen L., additional, Hirschhorn, Joel N., additional, Pospisilik, John Andrew, additional, Zillikens, M. Carola, additional, Lindgren, Cecilia, additional, Kilpeläinen, Tuomas Oskari, additional, and Loos, Ruth J. F., additional

Published
2016
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44. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Author

Cortes, Adrian, primary, Pulit, Sara L., additional, Leo, Paul J., additional, Pointon, Jenny J., additional, Robinson, Philip C., additional, Weisman, Michael H., additional, Ward, Michael, additional, Gensler, Lianne S., additional, Zhou, Xiaodong, additional, Garchon, Henri-Jean, additional, Chiocchia, Gilles, additional, Nossent, Johannes, additional, Lie, Benedicte A., additional, Førre, Øystein, additional, Tuomilehto, Jaakko, additional, Laiho, Kari, additional, Bradbury, Linda A., additional, Elewaut, Dirk, additional, Burgos-Vargas, Ruben, additional, Stebbings, Simon, additional, Appleton, Louise, additional, Farrah, Claire, additional, Lau, Jonathan, additional, Haroon, Nigil, additional, Mulero, Juan, additional, Blanco, Francisco J., additional, Gonzalez-Gay, Miguel A., additional, Lopez-Larrea, C, additional, Bowness, Paul, additional, Gaffney, Karl, additional, Gaston, Hill, additional, Gladman, Dafna D., additional, Rahman, Proton, additional, Maksymowych, Walter P., additional, Crusius, J. Bart A., additional, van der Horst-Bruinsma, Irene E., additional, Valle-Oñate, Raphael, additional, Romero-Sánchez, Consuelo, additional, Hansen, Inger Myrnes, additional, Pimentel-Santos, Fernando M., additional, Inman, Robert D., additional, Martin, Javier, additional, Breban, Maxime, additional, Wordsworth, Bryan Paul, additional, Reveille, John D., additional, Evans, David M., additional, de Bakker, Paul I.W., additional, and Brown, Matthew A., additional

Published
2015
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45. Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

Author

St Pourcain, Beate, primary, Haworth, C. M. A., additional, Davis, O. S. P., additional, Wang, Kai, additional, Timpson, Nicholas J., additional, Evans, David M., additional, Kemp, John P., additional, Ronald, Angelica, additional, Price, Tom, additional, Meaburn, Emma, additional, Ring, Susan M., additional, Golding, Jean, additional, Hakonarson, Hakon, additional, Plomin, R., additional, and Davey Smith, George, additional

Published
2014
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46. Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study

Author

Gilbert, Rebecca, primary, Bonilla, Carolina, additional, Metcalfe, Chris, additional, Lewis, Sarah, additional, Evans, David M., additional, Fraser, William D., additional, Kemp, John P., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Neal, David E., additional, Lane, J. Athene, additional, Smith, George Davey, additional, Lathrop, Mark, additional, and Martin, Richard M., additional

Published
2014
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47. Common variation near ROBO2 is associated with expressive vocabulary in infancy

Author

St Pourcain, Beate, primary, Cents, Rolieke A.M., additional, Whitehouse, Andrew J.O., additional, Haworth, Claire M.A., additional, Davis, Oliver S.P., additional, O’Reilly, Paul F., additional, Roulstone, Susan, additional, Wren, Yvonne, additional, Ang, Qi W., additional, Velders, Fleur P., additional, Evans, David M., additional, Kemp, John P., additional, Warrington, Nicole M., additional, Miller, Laura, additional, Timpson, Nicholas J., additional, Ring, Susan M., additional, Verhulst, Frank C., additional, Hofman, Albert, additional, Rivadeneira, Fernando, additional, Meaburn, Emma L., additional, Price, Thomas S., additional, Dale, Philip S., additional, Pillas, Demetris, additional, Yliherva, Anneli, additional, Rodriguez, Alina, additional, Golding, Jean, additional, Jaddoe, Vincent W.V., additional, Jarvelin, Marjo-Riitta, additional, Plomin, Robert, additional, Pennell, Craig E., additional, Tiemeier, Henning, additional, and Davey Smith, George, additional

Published
2014
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49. Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

Author

van den Berg, Stéphanie M., primary, de Moor, Marleen H. M., additional, McGue, Matt, additional, Pettersson, Erik, additional, Terracciano, Antonio, additional, Verweij, Karin J. H., additional, Amin, Najaf, additional, Derringer, Jaime, additional, Esko, Tõnu, additional, van Grootheest, Gerard, additional, Hansell, Narelle K., additional, Huffman, Jennifer, additional, Konte, Bettina, additional, Lahti, Jari, additional, Luciano, Michelle, additional, Matteson, Lindsay K., additional, Viktorin, Alexander, additional, Wouda, Jasper, additional, Agrawal, Arpana, additional, Allik, Jüri, additional, Bierut, Laura, additional, Broms, Ulla, additional, Campbell, Harry, additional, Smith, George Davey, additional, Eriksson, Johan G., additional, Ferrucci, Luigi, additional, Franke, Barbera, additional, Fox, Jean-Paul, additional, de Geus, Eco J. C., additional, Giegling, Ina, additional, Gow, Alan J., additional, Grucza, Richard, additional, Hartmann, Annette M., additional, Heath, Andrew C., additional, Heikkilä, Kauko, additional, Iacono, William G., additional, Janzing, Joost, additional, Jokela, Markus, additional, Kiemeney, Lambertus, additional, Lehtimäki, Terho, additional, Madden, Pamela A. F., additional, Magnusson, Patrik K. E., additional, Northstone, Kate, additional, Nutile, Teresa, additional, Ouwens, Klaasjan G., additional, Palotie, Aarno, additional, Pattie, Alison, additional, Pesonen, Anu-Katriina, additional, Polasek, Ozren, additional, Pulkkinen, Lea, additional, Pulkki-Råback, Laura, additional, Raitakari, Olli T., additional, Realo, Anu, additional, Rose, Richard J., additional, Ruggiero, Daniela, additional, Seppälä, Ilkka, additional, Slutske, Wendy S., additional, Smyth, David C., additional, Sorice, Rossella, additional, Starr, John M., additional, Sutin, Angelina R., additional, Tanaka, Toshiko, additional, Verhagen, Josine, additional, Vermeulen, Sita, additional, Vuoksimaa, Eero, additional, Widen, Elisabeth, additional, Willemsen, Gonneke, additional, Wright, Margaret J., additional, Zgaga, Lina, additional, Rujescu, Dan, additional, Metspalu, Andres, additional, Wilson, James F., additional, Ciullo, Marina, additional, Hayward, Caroline, additional, Rudan, Igor, additional, Deary, Ian J., additional, Räikkönen, Katri, additional, Arias Vasquez, Alejandro, additional, Costa, Paul T., additional, Keltikangas-Järvinen, Liisa, additional, van Duijn, Cornelia M., additional, Penninx, Brenda W. J. H., additional, Krueger, Robert F., additional, Evans, David M., additional, Kaprio, Jaakko, additional, Pedersen, Nancy L., additional, Martin, Nicholas G., additional, and Boomsma, Dorret I., additional

Published
2014
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50. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence

Author

St Pourcain, Beate, primary, Skuse, David H, additional, Mandy, William P, additional, Wang, Kai, additional, Hakonarson, Hakon, additional, Timpson, Nicholas J, additional, Evans, David M, additional, Kemp, John P, additional, Ring, Susan M, additional, McArdle, Wendy L, additional, Golding, Jean, additional, and Smith, George Davey, additional

Published
2014
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