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Start Over Author "Fu, Jiyang" Publisher springer science and business media llc
9 results on '"Fu, Jiyang"'

2. Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection

Author

Xu, Bojie, Yang, Ruicheng, Yang, Bo, Li, Liang, Chen, Jiaqi, Fu, Jiyang, Qu, Xinyi, Huo, Dong, Tan, Chen, Chen, Huanchun, Peng, Zhong, and Wang, Xiangru

Subjects
Research, NF-kappa B, Endothelial Cells, Meningitic Escherichia coli, Meningitis, Bacterial, Blood–brain barrier, Brain microvascular endothelial cells, Cellular and Molecular Neuroscience, LncC11orf54-1, Neuroinflammation, NF-κB signaling, Escherichia coli, Humans, RNA, Long Noncoding, Neurology. Diseases of the nervous system, RC346-429, Molecular Biology, Escherichia coli Infections
Abstract

Escherichia coli is the most common gram-negative pathogenic bacterium causing meningitis. It penetrates the blood–brain barrier (BBB) and activates nuclear factor kappa B (NF-κB) signaling, which are vital events leading to the development of meningitis. Long non-coding RNAs (lncRNAs) have been implicated in regulating neuroinflammatory signaling, and our previous study showed that E. coli can induce differential expression of lncRNAs, including lncC11orf54-1, in human brain microvascular endothelial cells (hBMECs). The hBMECs constitute the structural and functional basis for the BBB, however, it is unclear whether lncRNAs are involved in the regulation of inflammatory responses of hBMECs during meningitic E. coli infection. In this study, we characterized an abundantly expressed lncRNA, lncC11orf54-1, which was degraded by translocated coilin to produce mgU2-19 and mgU2-30 in hBMECs during E. coli infection. Functionally, lncC11orf54-1-originated non-coding RNA mgU2-30 interacted with interleukin-1 receptor-associated kinase 1 (IRAK1) to induce its oligomerization and autophosphorylation, thus promoting the activation of NF-κB signaling and facilitating the production of pro-inflammatory cytokines. In summary, our study uncovers the involvement of lncC11orf54-1 in IRAK1–NF-κB signaling, and it functions as a positive regulator of inflammatory responses in meningitic E. coli-induced neuroinflammation, which may be a valuable therapeutic and diagnostic target for bacterial meningitis.

Published
2022

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