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7 results on '"GE Yifan"'

1. Mechanical activation opens a lipid-lined pore in OSCA ion channels

Author

Han, Yaoyao, primary, Zhou, Zijing, additional, Jin, Ruitao, additional, Dai, Fei, additional, Ge, Yifan, additional, Ju, Xisan, additional, Ma, Xiaonuo, additional, He, Sitong, additional, Yuan, Ling, additional, Wang, Yingying, additional, Yang, Wei, additional, Yue, Xiaomin, additional, Chen, Zhongwen, additional, Sun, Yadong, additional, Corry, Ben, additional, Cox, Charles D., additional, and Zhang, Yixiao, additional

Published
2024
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2. In situ architecture of Opa1-dependent mitochondrial cristae remodeling

Author

Fry, Michelle Y, primary, Navarro, Paula P, additional, Hakim, Pusparanee, additional, Ananda, Virly Y, additional, Qin, Xingping, additional, Landoni, Juan C, additional, Rath, Sneha, additional, Inde, Zintis, additional, Lugo, Camila Makhlouta, additional, Luce, Bridget E, additional, Ge, Yifan, additional, McDonald, Julie L, additional, Ali, Ilzat, additional, Ha, Leillani L, additional, Kleinstiver, Benjamin P, additional, Chan, David C, additional, Sarosiek, Kristopher A, additional, and Chao, Luke H, additional

Published
2024
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5. Introgressing the Aegilops tauschii genome into wheat as a basis for cereal improvement

Author

Zhou, Yun, primary, Bai, Shenglong, additional, Li, Hao, additional, Sun, Guiling, additional, Zhang, Dale, additional, Ma, Feifei, additional, Zhao, Xinpeng, additional, Nie, Fang, additional, Li, Jingyao, additional, Chen, Liyang, additional, Lv, Linlin, additional, Zhu, Lele, additional, Fan, Ruixiao, additional, Ge, Yifan, additional, Shaheen, Aaqib, additional, Guo, Guanghui, additional, Zhang, Zhen, additional, Ma, Jianchao, additional, Liang, Huihui, additional, Qiu, Xiaolong, additional, Hu, Jiamin, additional, Sun, Ting, additional, Hou, Jingyi, additional, Xu, Hongxing, additional, Xue, Shulin, additional, Jiang, Wenkai, additional, Huang, Jinling, additional, Li, Suoping, additional, Zou, Changsong, additional, and Song, Chun-Peng, additional

Published
2021
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6. Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

Author

Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard University--MIT Division of Health Sciences and Technology, Miao, Lei, Lin, Jiaqi, Huang, Yuxuan, Li, Linxian, Delcassian, Derfogail, Ge, Yifan, Shi, Yunhua, Anderson, Daniel G, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard University--MIT Division of Health Sciences and Technology, Miao, Lei, Lin, Jiaqi, Huang, Yuxuan, Li, Linxian, Delcassian, Derfogail, Ge, Yifan, Shi, Yunhua, and Anderson, Daniel G

Abstract

© 2020, The Author(s). Lipid-like nanoparticles (LNPs) have potential as non-viral delivery systems for mRNA therapies. However, repeated administrations of LNPs may lead to accumulation of delivery materials and associated toxicity. To address this challenge, we have developed biodegradable lipids which improve LNPs clearance and reduce toxicity. We modify the backbone structure of Dlin-MC3-DMA by introducing alkyne and ester groups into the lipid tails. We evaluate the performance of these lipids when co-formulated with other amine containing lipid-like materials. We demonstrate that these formulations synergistically facilitate robust mRNA delivery with improved tolerability after single and repeated administrations. We further identify albumin-associated macropinocytosis and endocytosis as an ApoE-independent LNP cellular uptake pathway in the liver. Separately, the inclusion of alkyne lipids significantly increases membrane fusion to enhance mRNA release, leading to synergistic improvement of mRNA delivery. We believe that the rational design of LNPs with multiple amine-lipids increases the material space for mRNA delivery.

Published
2021

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