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Facial fracture repair is time-dependent. Early reduction and fixation after trauma help with later repair. Abnormal healing caused by delayed repair increases not only the difficulty of reconstruction, but also the risk of aesthetic or functional defects. Digital technology was used to model local trauma in three dimensions. The fracture fragments were reset, and the facial shape was reconstructed on the reset model. After resampling, 3D printing was used to construct a personalised external fixation helmet. Combined with the posterior nasal passage lift reduction technique, early reduction of the mid-face fractures was performed. Through the early application of a 3D-printed personalised external fixation helmet to a patient with a comprehensive fracture, the helmet manufacturing process and application methods were introduced, and the effect of this application was investigated. In the treatment of facial fractures, the early application of a 3D-printed personalised external fixation helmet is conducive to fracture reduction and fixation and reduces the difficulty of later reconstruction.

Inflammation in impaired diabetic wound healing has been described as caught in a persistent inflammatory state. Accumulation of advanced glycation end products (AGEs) is closely relevant to impaired diabetic wound. Recent studies identified that blockade of AGEs-RAGE increased neovascularization and granulation tissue formation to improving diabetic wound healing. This study aimed to evaluate the correlation among the pathogenic effects of AGEs-RAGE, persistent abnormal inflammatory inflammation stage, and impaired wound healing on diabetes. Authors examined the levels of inflammatory factor secretion and inflammatory leukocytes infiltration and the connection with AGEs-RAGE interaction on diabetic mice. Blockade of AGEs-RAGE improved essential secretion of inflammatory factors and infiltration of inflammatory leukocytes in the early inflammatory stage. Furthermore, it also improved the clean of neutrophils by macrophages. In summary, these findings suggest that rather than a hyper-inflammatory state, diabetic wounds are lack of an essential inflammatory response in the early phase, thus may induce a paradoxical and persistent inflammation state, and AGEs-RAGE play a vital role in these pathogenic progresses.