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29 results on '"Golebiewska, A"'

1. Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

Author

Yabo, Yahaya A., primary, Moreno-Sanchez, Pilar M., additional, Pires-Afonso, Yolanda, additional, Kaoma, Tony, additional, Nosirov, Bakhtiyor, additional, Scafidi, Andrea, additional, Ermini, Luca, additional, Lipsa, Anuja, additional, Oudin, Anaïs, additional, Kyriakis, Dimitrios, additional, Grzyb, Kamil, additional, Poovathingal, Suresh K., additional, Poli, Aurélie, additional, Muller, Arnaud, additional, Toth, Reka, additional, Klink, Barbara, additional, Berchem, Guy, additional, Berthold, Christophe, additional, Hertel, Frank, additional, Mittelbronn, Michel, additional, Heiland, Dieter H., additional, Skupin, Alexander, additional, Nazarov, Petr V., additional, Niclou, Simone P., additional, Michelucci, Alessandro, additional, and Golebiewska, Anna, additional

Published
2024
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3. Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors

Author

Biswas, Archita, primary, Salvucci, Manuela, additional, Connor, Kate, additional, Düssmann, Heiko, additional, Carberry, Steven, additional, Fichtner, Michael, additional, King, Ellen, additional, Murphy, Brona, additional, O’Farrell, Alice C., additional, Cryan, Jane, additional, Beausang, Alan, additional, Heffernan, Josephine, additional, Cremona, Mattia, additional, Hennessy, Bryan T., additional, Clerkin, James, additional, Sweeney, Kieron J., additional, MacNally, Steve, additional, Brett, Francesca, additional, O’Halloran, Philip, additional, Bacon, Orna, additional, Furney, Simon, additional, Verreault, Maite, additional, Quissac, Emie, additional, Bielle, Franck, additional, Ahmed, Mohammed H., additional, Idbaih, Ahmed, additional, Leenstra, Sieger, additional, Ntafoulis, Ioannis, additional, Fabro, Federica, additional, Lamfers, Martine, additional, Golebiewska, Anna, additional, Hertel, Frank, additional, Niclou, Simone P., additional, Yen, Romain Tching Chi, additional, Kremer, Andreas, additional, Dilcan, Gonca, additional, Lodi, Francesca, additional, Arijs, Ingrid, additional, Lambrechts, Diether, additional, Purushothama, Manasa Kalya, additional, Kel, Alexander, additional, Byrne, Annette T., additional, and Prehn, Jochen H.M., additional

Published
2023
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5. Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors

Author

Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, A.C O’Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, F Brett, P O’Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya P, Alexander Kel, Annette T Byrne, and Jochen H.M Prehn

Subjects
Long term survivors, Cancer Research, Cilium, Neurology, Oncology, RNA-sequencing, Apoptosis, Neurology (clinical), Cell cycle, Glioblastoma, Transcriptomics, Short term survivors, Reverse phase protein array
Abstract

Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (≥ 36 months, Long term survivors, LTS). Methods Patients were selected from an in-house cohort (GLIOTRAIN-cohort), using defined inclusion criteria (Karnofsky score > 70; age Results Transcriptomic analysis of tumour samples identified cilium gene signatures as enriched in LTS. Moreover, Immunohistochemical analysis confirmed the presence of cilia in the tumours of LTS. Notably, reverse phase protein array analysis (RPPA) demonstrated increased phosphorylated GAB1 (Y627), SRC (Y527), BCL2 (S70) and RAF (S338) protein expression in STS compared to LTS. Next, we identified 25 unique master regulators (MR) and 13 transcription factors (TFs) belonging to ontologies of integrin signalling and cell cycle to be upregulated in STS. Conclusion Overall, comparison of STS and LTS GBM patients, identifies novel biomarkers and potential actionable therapeutic targets for the management of GBM. Graphical abstract

Published
2023

8. Advancing preclinical cancer models to assess clinically relevant outcomes

Author

Anna Golebiewska and Ryan C. Fields

Subjects
Cancer Research, Oncology, Genetics
Abstract

Cancer models are indispensable research tools for elucidating the mechanisms involved in tumor onset, progression and treatment resistance. They are key in evaluating therapeutics prior clinical trials. In this editorial, we invite contributions for a BMC Cancer’s Collection of articles addressing ‘Advances in pre-clinical cancer models’ towards relivable outcomes at the preclinical stage.

Published
2023

9. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Author

Woo, X.Y., Giordano, J., Srivastava, A., Zhao, Z.-., Lloyd, M.W., de Bruijn, R., Suh, Y.-., Patidar, R., Chen, L., Scherer, S., Bailey, M.H., Yang, C.-., Cortes-Sanchez, E., Xi, Y., Wang, J., Wickramasinghe, J., Kossenkov, A.V., Rebecca, V.W., Sun, H., Mashl, R.J., Davies, S.R., Jeon, R., Frech, C., Randjelovic, J., Rosains, J., Galimi, F., Bertotti, A., Lafferty, A., O'Farrell, A.C., Modave, E., Lambrechts, D., ter Brugge, P., Marangoni, E., El Botty, R., Kim, H., Kim, J.-., Yang, H.-., Lee, C., Dean, D.A., Davis-Dusenbery, B., Evrard, Y.A., Doroshow, J.H., Welm, A.L., Welm, B.E., Lewis, M.T., Fang, B., Roth, J.A., Meric-Bernstam, F., Herlyn, M., Davies, M.A., Ding, L., Li, S., Govindan, R., Isella, C., Moscow, J.A., Trusolino, L., Byrne, A.T., Jonkers, J., Bult, C.J., Medico, E., Chuang, J.H., Robinson, P.N., Sanderson, B.J., Neuhauser, S.B., Dobrolecki, L.E., Zheng, X., Majidi, M., Zhang, R., Zhang, X., Akcakanat, A., Evans, K.W., Yap, T.A., Li, D., Yucan, E., Lanier, C.D., Saridogan, T., Kirby, B.P., M. J., H., Chen, H., Kopetz, S., Menter, D.G., Zhang, J., Westin, S.N., Kim, M.P., Dai, B., Gibbons, D.L., Tapia, C., Jensen, V.B., Boning, G., Minna, J.D., Park, H., Timmons, B.C., Girard, L., Fingerman, D., Liu, Q., Somasundaram, R., Xiao, M., Yennu-Nanda, V.G., Tetzlaff, M.T., Xu, X., Nathanson, K.L., Cao, S., Chen, F., Dipersio, J.F., Lim, K.H., C. X., M., Rodriguez, F.M., Van Tine, B.A., Wang-Gillam, A., Wendl, M.C., Wu, Y., Wyczalkowski, M.A., Yao, L., Jayasinghe, R., Aft, R.L., Fields, R.C., Luo, J., Fuh, K.C., Chin, V., Digiovanna, J., Grover, J., Koc, S., Seepo, S., Wallace, T., Pan, C.-., Chen, M.S., Carvajal-Carmona, L.G., Kirane, A.R., Cho, M., Gandara, D.R., Riess, J.W., Le, T., deVere White, R.W., Tepper, C.G., Zhang, H., Coggins, N.B., Lott, P., Estrada, A., Toal, T., Arana, A.M., Polanco-Echeverry, G., Rocha, S., A. -H., M., Mitsiades, N., Kaochar, S., O'Malley, B.W., Ellis, M.J., Hilsenbeck, S.G., Ittmann, M., Corso, S., Fiori, A., Giordano, S., van de Ven, M., Peeper, D.S., Miller, I., Bernado, C., Morancho, B., Ramirez, L., Arribas, J., Palmer, H.G., Piris-Gimenez, A., Soucek, L., Dahmani, A., Montaudon, E., Nemati, F., Dangles-Marie, V., Decaudin, D., Roman-Roman, S., Alferez, D.G., Spence, K., Clarke, R.B., Bentires-Alj, M., Chang, D.K., Biankin, A.V., Bruna, A., O'Reilly, M., Caldas, C., Casanovas, O., Gonzalez-Suarez, E., Munoz, P., Villanueva, A., Conte, N., Mason, J., Thorne, R., Meehan, T.F., Parkinson, H., Dudova, Z., Krenek, A., Stuchlik, D., Elemento, O., Inghirami, G., Golebiewska, A., Niclou, S.P., Wisman, G.B.A., de Jong, S., Kralova, P., Sedlacek, R., Claeys, E., Leucci, E., Borsani, M., Lanfrancone, L., Pelicci, P.G., Maelandsmo, G.M., Norum, J.H., Vinolo, E., Serra, V., and Leucci, Eleonora

Subjects
endocrine system diseases, Microarray, gene amplification, Whole Exome Sequencing, Mice, 0302 clinical medicine, Gene expression, Databases, Genetic, Gene duplication, Neoplasm Metastasis, Exome sequencing, Cancer, Regulation of gene expression, 0303 health sciences, Manchester Cancer Research Centre, adult, adult, animal experiment, animal model, animal tissue, breast cancer, microarray, DNA sequencing engraftment, gene amplification, tumor, xenograft, tumor-related gene, Polymorphism, Single Nucleotide/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, microarray, hormones, hormone substitutes, and hormone antagonists, tumor, endocrine system, DNA sequencing engraftment, animal experiment, DNA Copy Number Variations/genetics, Biology, digestive system, DNA sequencing, Article, animal tissue, 03 medical and health sciences, breast cancer, Breast cancer, Genetics, medicine, Animals, Humans, xenograft, Gene, 030304 developmental biology, Settore MED/04 - Patologia Generale, Microarray analysis techniques, animal model, ResearchInstitutes_Networks_Beacons/mcrc, tumor-related gene, medicine.disease, Xenograft Model Antitumor Assays, Computational biology and bioinformatics, Cancer research, Human cancer
Abstract

Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting the accuracy of PDX modeling of human cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 PDX and matched patient tumor (PT) samples from 509 PDX models. CNA inferences based on DNA sequencing and microarray data displayed substantially higher resolution and dynamic range than gene expression-based inferences, and they also showed strong CNA conservation from PTs through late-passage PDXs. CNA recurrence analysis of 130 colorectal and breast PT/PDX-early/PDX-late trios confirmed high-resolution CNA retention. We observed no significant enrichment of cancer-related genes in PDX-specific CNAs across models. Moreover, CNA differences between patient and PDX tumors were comparable to variations in multiregion samples within patients. Our study demonstrates the lack of systematic copy number evolution driven by the PDX mouse host., Analysis of copy number alterations in 1,451 patient-derived xenografts (PDXs) and matched patient tumor samples shows strong conservation from patient tumors through late-passage PDXs and a lack of systematic copy number evolution driven by the mouse host.

Published
2021

10. Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry

Author

Kulkarni, Amit, primary, Ferreira, Tiago, additional, Bretscher, Clemens, additional, Grewenig, Annabel, additional, El-Andaloussi, Nazim, additional, Bonifati, Serena, additional, Marttila, Tiina, additional, Palissot, Valérie, additional, Hossain, Jubayer A., additional, Azuaje, Francisco, additional, Miletic, Hrvoje, additional, Ystaas, Lars A. R., additional, Golebiewska, Anna, additional, Niclou, Simone P., additional, Roeth, Ralf, additional, Niesler, Beate, additional, Weiss, Amélie, additional, Brino, Laurent, additional, and Marchini, Antonio, additional

Published
2021
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11. A rare large duplication of MLH1 identified in Lynch syndrome

Author

Kumar, Abhishek, primary, Paramasivam, Nagarajan, additional, Bandapalli, Obul Reddy, additional, Schlesner, Matthias, additional, Chen, Tianhui, additional, Sijmons, Rolf, additional, Dymerska, Dagmara, additional, Golebiewska, Katarzyna, additional, Kuswik, Magdalena, additional, Lubinski, Jan, additional, Hemminki, Kari, additional, and Försti, Asta, additional

Published
2021
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12. AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion

Author

Schuster, Anne, primary, Klein, Eliane, additional, Neirinckx, Virginie, additional, Knudsen, Arnon Møldrup, additional, Fabian, Carina, additional, Hau, Ann-Christin, additional, Dieterle, Monika, additional, Oudin, Anais, additional, Nazarov, Petr V., additional, Golebiewska, Anna, additional, Muller, Arnaud, additional, Perez-Hernandez, Daniel, additional, Rodius, Sophie, additional, Dittmar, Gunnar, additional, Bjerkvig, Rolf, additional, Herold-Mende, Christel, additional, Klink, Barbara, additional, Kristensen, Bjarne Winther, additional, and Niclou, Simone P., additional

Published
2020
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13. Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Author

Golebiewska, Anna, primary, Hau, Ann-Christin, additional, Oudin, Anaïs, additional, Stieber, Daniel, additional, Yabo, Yahaya A., additional, Baus, Virginie, additional, Barthelemy, Vanessa, additional, Klein, Eliane, additional, Bougnaud, Sébastien, additional, Keunen, Olivier, additional, Wantz, May, additional, Michelucci, Alessandro, additional, Neirinckx, Virginie, additional, Muller, Arnaud, additional, Kaoma, Tony, additional, Nazarov, Petr V., additional, Azuaje, Francisco, additional, De Falco, Alfonso, additional, Flies, Ben, additional, Richart, Lorraine, additional, Poovathingal, Suresh, additional, Arns, Thais, additional, Grzyb, Kamil, additional, Mock, Andreas, additional, Herold-Mende, Christel, additional, Steino, Anne, additional, Brown, Dennis, additional, May, Patrick, additional, Miletic, Hrvoje, additional, Malta, Tathiane M., additional, Noushmehr, Houtan, additional, Kwon, Yong-Jun, additional, Jahn, Winnie, additional, Klink, Barbara, additional, Tanner, Georgette, additional, Stead, Lucy F., additional, Mittelbronn, Michel, additional, Skupin, Alexander, additional, Hertel, Frank, additional, Bjerkvig, Rolf, additional, and Niclou, Simone P., additional

Published
2020
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15. Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Author

Dirkse, Anne, primary, Golebiewska, Anna, additional, Buder, Thomas, additional, Nazarov, Petr V., additional, Muller, Arnaud, additional, Poovathingal, Suresh, additional, Brons, Nicolaas H. C., additional, Leite, Sonia, additional, Sauvageot, Nicolas, additional, Sarkisjan, Dzjemma, additional, Seyfrid, Mathieu, additional, Fritah, Sabrina, additional, Stieber, Daniel, additional, Michelucci, Alessandro, additional, Hertel, Frank, additional, Herold-Mende, Christel, additional, Azuaje, Francisco, additional, Skupin, Alexander, additional, Bjerkvig, Rolf, additional, Deutsch, Andreas, additional, Voss-Böhme, Anja, additional, and Niclou, Simone P., additional

Published
2019
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17. Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A

Author

Abdul Rahim, Siti Aminah, primary, Dirkse, Anne, additional, Oudin, Anais, additional, Schuster, Anne, additional, Bohler, Jill, additional, Barthelemy, Vanessa, additional, Muller, Arnaud, additional, Vallar, Laurent, additional, Janji, Bassam, additional, Golebiewska, Anna, additional, and Niclou, Simone P, additional

Published
2017
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18. Prophage-mediated defence against viral attack and viral counter-defence

Author

Dedrick, Rebekah M., primary, Jacobs-Sera, Deborah, additional, Bustamante, Carlos A. Guerrero, additional, Garlena, Rebecca A., additional, Mavrich, Travis N., additional, Pope, Welkin H., additional, Reyes, Juan C. Cervantes, additional, Russell, Daniel A., additional, Adair, Tamarah, additional, Alvey, Richard, additional, Bonilla, J. Alfred, additional, Bricker, Jerald S., additional, Brown, Bryony R., additional, Byrnes, Deanna, additional, Cresawn, Steven G., additional, Davis, William B., additional, Dickson, Leon A., additional, Edgington, Nicholas P., additional, Findley, Ann M., additional, Golebiewska, Urszula, additional, Grose, Julianne H., additional, Hayes, Cory F., additional, Hughes, Lee E., additional, Hutchison, Keith W., additional, Isern, Sharon, additional, Johnson, Allison A., additional, Kenna, Margaret A., additional, Klyczek, Karen K., additional, Mageeney, Catherine M., additional, Michael, Scott F., additional, Molloy, Sally D., additional, Montgomery, Matthew T., additional, Neitzel, James, additional, Page, Shallee T., additional, Pizzorno, Marie C., additional, Poxleitner, Marianne K., additional, Rinehart, Claire A., additional, Robinson, Courtney J., additional, Rubin, Michael R., additional, Teyim, Joseph N., additional, Vazquez, Edwin, additional, Ware, Vassie C., additional, Washington, Jacqueline, additional, and Hatfull, Graham F., additional

Published
2017
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19. The Relative Motion of Earth Orbiting Satellites

Author

Edwin Wnuk and Justyna Golebiewska

Subjects
Physics, Orbital elements, Geopotential, Applied Mathematics, Numerical analysis, Motion (geometry), Astronomy and Astrophysics, Geodesy, Computational Mathematics, Transverse plane, Space and Planetary Science, Unit vector, Modeling and Simulation, Physics::Space Physics, Satellite, Astrophysics::Earth and Planetary Astrophysics, Physics::Atmospheric and Oceanic Physics, Mathematical Physics, Reference frame
Abstract

Relative motion of objects moving in a close satellite formation is studied. The relative motion is expressed in the satellite reference frame R Λ B defined by orthogonal unit vectors in the radial, transverse and normal directions. Differential perturbations in orbital elements, satellite positions as well as in the radial, transverse and normal components of the radius vector are defined. Differential perturbations due to geopotential coefficients and luni-solar attraction are analysed for some exemplary satellites orbits. Results of a numerical analysis of motion have shown that the geopotential coefficients up to high degree and order as well as lunisolar effects have to be included into the applied force model to save the meter or centimeter level of accuracy in the description of the relative satellite motion.

Published
2005

20. Cyclin D1 and CHEK2 polymorphic variants as low risk susceptibility alleles in DTC patients

Author

Hryhorowicz, Szymon, primary, Ziemnicka, Katarzyna, additional, Kaczmarek-Rys, Marta, additional, Hoppe-Golebiewska, Justyna, additional, Plawski, Andrzej, additional, Skrzypczak-Zielinska, Marzena, additional, Golab, Monika, additional, Szkudlarek, Malgorzata, additional, Budny, Batlomiej, additional, Ruchala, Marek, additional, and Slomsk, Ryszard, additional

Published
2015
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23. Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

Author

Fack, Fred, primary, Espedal, Heidi, additional, Keunen, Olivier, additional, Golebiewska, Anna, additional, Obad, Nina, additional, Harter, Patrick N., additional, Mittelbronn, Michel, additional, Bähr, Oliver, additional, Weyerbrock, Astrid, additional, Stuhr, Linda, additional, Miletic, Hrvoje, additional, Sakariassen, Per Ø., additional, Stieber, Daniel, additional, Rygh, Cecilie B., additional, Lund-Johansen, Morten, additional, Zheng, Liang, additional, Gottlieb, Eyal, additional, Niclou, Simone P., additional, and Bjerkvig, Rolf, additional

Published
2014
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27. Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes

Author

Stieber, Daniel, primary, Golebiewska, Anna, additional, Evers, Lisa, additional, Lenkiewicz, Elizabeth, additional, Brons, Nicolaas H. C., additional, Nicot, Nathalie, additional, Oudin, Anaïs, additional, Bougnaud, Sébastien, additional, Hertel, Frank, additional, Bjerkvig, Rolf, additional, Vallar, Laurent, additional, Barrett, Michael T., additional, and Niclou, Simone P., additional

Published
2013
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