6 results on '"Guanfeng Lin"'
Search Results
2. Cross-sectional analysis of associated anomalies and vertebral anomaly location in 1289 surgical congenital scoliosis
- Author
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Zhe Su, You Du, Shengru Wang, Xiran Chai, Xiaolin Xu, Xiaohan Ye, Jianguo Zhang, Jianxiong Shen, Yang Yang, and Guanfeng Lin
- Subjects
medicine.medical_specialty ,Lumbar Vertebrae ,medicine.diagnostic_test ,business.industry ,Cross-sectional study ,Genitourinary system ,Physical examination ,Musculoskeletal Abnormalities ,Cross-Sectional Studies ,Lumbar ,Scoliosis ,Humans ,Outpatient clinic ,Medicine ,Orthopedics and Sports Medicine ,Surgery ,Radiology ,Neurosurgery ,Risk factor ,Abnormality ,business ,Retrospective Studies - Abstract
This study systematically analyzed and assessed the interrelationships among vertebral anomaly location, congenital scoliosis (CS) type and associated abnormality prevalence. We retrospectively extracted medical records of 1289 CS inpatients surgically treated in our institute from January 2010–December 2019. All patients underwent spinal X-ray, CT, MRI, echocardiogram, urogenital ultrasound and systemic physical examination. We analyzed information on demographics, CS type, associated anomalies and vertebral anomaly location. Cervical, thoracic and lumbar vertebral anomalies were found in 5.7%, 78.1% and 33.6% of patients, respectively. 82.7% had one region involved. 59.5% with cervical malformations had mixed defects and 61.1% with lumbar malformations exhibited failure of formation. The musculoskeletal defect prevalence was 28.4%, 19.1% and 9.0% in patients with cervical, thoracic and lumbar anomalies. The intraspinal defect prevalence was 33.4% and 20.7% for thoracic and lumbar anomalies. 86.5% of patients with cervical anomalies had more than one region involved, while 78.1% and 62.2% with thoracic and lumbar anomalies, respectively, had only one region involved. Cervical malformations had higher prevalence of mixed defects, musculoskeletal and intraspinal defects and multi-region involved. Thoracic malformations had higher prevalence of intraspinal and musculoskeletal defects and more involvement of only one vertebral region. Lumbar vertebral malformation patients had much lower prevalence of intraspinal and musculoskeletal defects and more involvement of only one vertebral region. Cervical malformation was a risk factor for more associated anomalies and more severe vertebral anomalies, which deserves more attention from surgeons in outpatient clinic.
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- 2021
3. Cross-sectional analysis and trend of vertebral and associated anomalies in Chinese congenital scoliosis population: a retrospective study of one thousand, two hundred and eighty nine surgical cases from 2010 to 2019
- Author
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Shengru Wang, Xiran Chai, Yang Yang, Guanfeng Lin, Jianguo Zhang, and Jianxiong Shen
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030203 arthritis & rheumatology ,030222 orthopedics ,medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,Cross-sectional study ,business.industry ,Genitourinary system ,Medical record ,Population ,Physical examination ,Retrospective cohort study ,03 medical and health sciences ,0302 clinical medicine ,Orthopedic surgery ,Cohort ,medicine ,Orthopedics and Sports Medicine ,Surgery ,Radiology ,education ,business - Abstract
The objective of this article is to report associated anomaly incidences of a large CS cohort and analyze interrelationships among vertebral anomaly types and associated abnormalities. We retrospectively searched and extracted medical records of 1289 CS inpatients surgically treated in our institute from January 2010 to December 2019. All patients have taken spine X-ray, CT, MRI, echocardiogram, urogenital ultrasound, and systemic physical examination. We analyzed information on demographics, CS types, and associated anomalies. CS type was found to be 49.1% for failure of formation (FF), 19.5% for failure of segmentation (FS), and 31.4% for mixed defects (MD). Intraspinal defects were found in 29.4% patients (16.0% for FF, 45.4% for FS, 40.5% for MD), cardiac in 13.7% (12.3% for FF, 14.3% for FS, 15.6% for MD), genitourinary in 5.8% (4.1% for FF, 6.0% for FS, 8.4% for MD), gastrointestinal in 3.6% (4.7% for FF, 1.6% for FS, 3.0% for MD), and musculoskeletal in 16.4% (10.3% for FF, 19.9% for FS, 23.7% for MD). The intraspinal and musculoskeletal defect incidences were significantly higher in patients with failure of segmentation and mixed defects. We also observed a decreasing trend for intraspinal and musculoskeletal defect incidences as well as a tendency for more failure of formation and less failure of segmentation from 2010 to 2019. The intraspinal and musculoskeletal defect incidences were higher in patients with failure of segmentation and mixed defects. Strong interrelationships were found between intraspinal and musculoskeletal defects and among cardiovascular, genitourinary, and gastrointestinal defects. From 2010 to 2019, the proportion of patients with failure of formation increased significantly, causing a decrease in the intraspinal and musculoskeletal defect incidences over time. Female sex, failure of segmentation, and mixed defects could be considered risk factors for more associated anomalies in CS individuals, which would help surgeons in medical management and prenatal consultation.
- Published
- 2021
4. The influence of early thoracic fusion on the pulmonary function of patients with idiopathic scoliosis in the early period of the second growth peak with different Risser signs
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Shengru Wang, Guanfeng Lin, Jianguo Zhang, You Du, Yang Yang, and Xiaolin Xu
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Vital capacity ,medicine.medical_specialty ,Pulmonary function ,Risser sign ,medicine.medical_treatment ,Vital Capacity ,Diseases of the musculoskeletal system ,Scoliosis ,Second growth peak ,Thoracic Vertebrae ,Pulmonary function testing ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,Forced Expiratory Volume ,Idiopathic scoliosis ,medicine ,Humans ,Orthopedics and Sports Medicine ,Respiratory function ,030212 general & internal medicine ,Retrospective Studies ,Orthopedic surgery ,030222 orthopedics ,business.industry ,medicine.disease ,Early thoracic fusion ,Surgery ,Spinal Fusion ,RC925-935 ,Spinal fusion ,business ,RD701-811 ,Research Article - Abstract
Background Previous reports confirmed early spinal fusion may compromise pulmonary function and thoracic development in skeletal immature patients with scoliosis. However, the different effects in patients with various Risser signs remain unknown. This study aimed to compare the influence of early thoracic fusion on pulmonary function and thoracic growth in patients with idiopathic scoliosis (IS) with closed triangular cartilage (TRC) and different Risser signs. Methods Thirty-six patients with IS and a closed TRC were retrospectively selected and divided into the low Risser (LR, Risser sign ≤2, 22 patients) and high Risser (HR, 2 Results There were no differences in patients’ general characteristics between two groups. The preoperative forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were 2.06±0.43 L and 2.50±0.49 L, respectively, in the LR group, and 2.31±0.49 L (p = 0.067) and 2.74±0.56 L (p = 0.122), respectively, in the HR group. While these values significantly increased postoperatively, to 2.62±0.46 L (p < 0.001) and 3.09±0.69 L (p < 0.001), in the LR group, they remained unchanged in the HR group [2.53±0.56 L (p = 0.093) and 2.70±0.98 L (p = 0.386), respectively]. The FEV1/FVC in both groups was >80% before and after surgery. The T1-T12 and anteroposterior thoracic diameter significantly increased after surgery in both groups, while the maximum inner chest diameter only increased in the LR group at the final follow-up. However, there were no significant differences in respiratory function and thoracic data between both groups. Conclusion For patients with IS, early fusion did not deteriorate pulmonary function or thoracic development in TRC-closed patients whose Risser sign was ≤2 compared with those with a Risser sign >2.
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- 2021
5. In situ polymerization approach to cellulose–polyacrylamide interpenetrating network hydrogel with high strength and pH-responsive properties
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Wang Zi, Biao Huang, Beili Lu, Guanfeng Lin, Xiangchao Lu, Qilin Lu, and Fengcai Lin
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Materials science ,Polymers and Plastics ,Hydrogen bond ,Polyacrylamide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Compressive strength ,chemistry ,Chemical engineering ,Rheology ,Self-healing hydrogels ,Interpenetrating polymer network ,Cellulose ,In situ polymerization ,0210 nano-technology - Abstract
Cellulose hydrogels usually have poor mechanical properties which seriously limit their applications in biomedical or industrial fields. Herein, an interpenetrating polymer network strategy was proposed to construct double network hydrogels composed of cellulose and polyacrylamide with high mechanical strength and pH responsive properties. The synergistic interactions and strong hydrogen bonds between two networks contributed to the dissipation of mechanical energy, as evidenced by the compressive stress–strain and rheology analyses. The compressive strength and compressive modulus for cellulose–polyacrylamide interpenetrating network (C–PAM IPN) hydrogels could reach up to 5.62 and 22.47 MPa, which is nearly 18 and 23 times higher than that of cellulose hydrogels. Moreover, these tough C–PAM IPN hydrogels exhibit pH sensitive properties in various pH solutions. Therefore, this paper provides a general strategy to enhance the mechanical and physical properties of cellulose-based hydrogels, which are potentially useful in developing novel cellulose-based hydrogels and expanding their applications.
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- 2018
6. A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency
- Author
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Qiaoting Deng, Tian-Cai Liu, Xin-Xin Guo, Rong-Liang Liang, Junyu Liang, Ying-Song Wu, Shaolang Chen, Baihong Chen, Zhenhua Chen, Guanfeng Lin, and Hui Zhao
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0301 basic medicine ,Rabies ,medicine.drug_class ,Science ,Fluoroimmunoassay ,Enzyme-Linked Immunosorbent Assay ,Antibodies, Viral ,Monoclonal antibody ,medicine.disease_cause ,Sensitivity and Specificity ,01 natural sciences ,Article ,Cell Line ,Mice ,Viral Proteins ,03 medical and health sciences ,Rabies vaccine ,In vivo ,medicine ,Animals ,Humans ,Potency ,Antigens, Viral ,Vaccine Potency ,Glycoproteins ,chemistry.chemical_classification ,Multidisciplinary ,business.industry ,010401 analytical chemistry ,Rabies virus ,Antibodies, Monoclonal ,Virology ,0104 chemical sciences ,Disease Models, Animal ,030104 developmental biology ,Rabies Vaccines ,chemistry ,Immunology ,Medicine ,Female ,business ,Glycoprotein ,medicine.drug - Abstract
Replacement of the in vivo rabies vaccine potency test (NIH test) by in vitro methods had been discussed by several researcher including WHO expert working groups. In this paper, a time-resolved fluoroimmunoassay (TRFIA) for the assay of rabies virus glycoprotein in rabies vaccine was first established to estimate the rabies vaccine potency by using specific monoclonal antibody that only recognized the native, trimeric and immunogenic form of rabies virus glycoprotein. Potency of the rabies virus glycoprotein was assayed with satisfactory performance under optimal conditions, and the method demonstrated satisfactory results when applied in practical samples. The correlation coefficient of potency values obtained from the present TRFIA and ELISA was 0.912, and 0.903 for those from the present TRFIA and NIH test. These preliminary results confirmed that this TRFIA can replace ELISA with higher performance, and could be a promising replacement of the NIH test. Based upon these results, the present TRFIA seemed to be a convenient tool for evaluating rabies vaccine potency and its products at different stages accordingly.
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- 2017
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