1. Avastin Exhibits Therapeutic Effects on Collagen-Induced Arthritis in Rat Model
- Author
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Gula Da, Yi Zheng, Hongbin Li, and Yong Wang
- Subjects
Vascular Endothelial Growth Factor A ,musculoskeletal diseases ,medicine.medical_specialty ,genetic structures ,medicine.drug_class ,Immunology ,Arthritis ,Angiogenesis Inhibitors ,Pharmacology ,Antibodies, Monoclonal, Humanized ,Monoclonal antibody ,Receptors, Tumor Necrosis Factor ,Etanercept ,Arthritis, Rheumatoid ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Immunology and Allergy ,Rats, Wistar ,Tumor Necrosis Factor-alpha ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Therapeutic effect ,medicine.disease ,Arthritis, Experimental ,eye diseases ,Rheumatology ,Rats ,Bevacizumab ,Vascular endothelial growth factor ,chemistry ,Immunoglobulin G ,Rheumatoid arthritis ,Female ,Joints ,Tumor necrosis factor alpha ,Collagen ,business ,medicine.drug - Abstract
Avastin is the monoclonal antibody for vascular endothelial growth factor (VEGF). This study aimed to investigate therapeutic effect of Avastin on type II collagen-induced arthritis. Type II chicken collagen was injected into the tails of Wistar rats, and 60 modeled female rats were randomly divided into three groups (n = 20): Avastin group, Etanercept group, and control group. Arthritis index and joint pad thickness were scored, and the pathology of back metapedes was analyzed. The results showed that compared to control group, the arthritis index, target-to-non-target ratio, synovial pathological injury index, serum levels of VEGF and tumor necrosis factor alpha, and VEGF staining were decreased significantly 14 days after Avastin or Etanercept treatment, but there were no significant differences between Avastin group and Etanercept group. These data provide evidence that Avastin exhibits similar effects to Etanercept to relieve rheumatoid arthritis in rat model and suggest that Avastin is a promising therapeutic agent for rheumatoid arthritis.
- Published
- 2013
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