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8 results on '"Hallberg, E"'

3. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Author

Lei, J, Rudolph, A, Moysich, KB, Rafiq, S, Behrens, S, Goode, EL, Pharoah, PD, Seibold, P, Fasching, PA, Andrulis, IL, Kristensen, VN, Couch, FJ, Hamann, U, Hooning, MJ, Nevanlinna, H, Eilber, U, Bolla, MK, Dennis, J, Wang, Q, Lindblom, A, Mannermaa, A, Lambrechts, D, García-Closas, M, Hall, P, Chenevix-Trench, G, Shah, M, Luben, R, Haeberle, L, Ekici, AB, Beckmann, MW, Knight, JA, Glendon, G, Tchatchou, S, Alnæs, GI, Borresen-Dale, AL, Nord, S, Olson, JE, Hallberg, E, Vachon, C, Torres, D, Ulmer, HU, Rüdiger, T, Jager, A, Van Deurzen, CH, Tilanus-Linthorst, MM, Muranen, TA, Aittomäki, K, Blomqvist, C, Margolin, S, Kosma, VM, Hartikainen, JM, Kataja, V, Hatse, S, Wildiers, H, Smeets, A, Figueroa, J, Chanock, SJ, Lissowska, J, Li, J, Humphreys, K, Phillips, KA, KConFab Investigators, Linn, S, Cornelissen, S, Van Den Broek, SA, Kang, D, Choi, JY, Park, SK, Yoo, KY, Hsiung, CN, Wu, PE, Hou, MF, Shen, CY, Teo, SH, Taib, NA, Yip, CH, Ho, GF, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Dunning, AM, Benitez, J, Czene, K, Sucheston, LE, Maishman, T, Tapper, WJ, Eccles, D, Easton, DF, Schmidt, MK, and Chang-Claude, J

Subjects
Adult, 32 Biomedical and Clinical Sciences, Breast Neoplasms, Kaplan-Meier Estimate, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Immunomodulation, Breast Cancer, Antineoplastic Combined Chemotherapy Protocols, Genetics, Biomarkers, Tumor, 2.1 Biological and endogenous factors, Humans, Cancer, Neoplasm Staging, 2 Aetiology, Interleukin-12 Subunit p40, Receptor, Transforming Growth Factor-beta Type II, Genomics, Middle Aged, 3211 Oncology and Carcinogenesis, Prognosis, 3. Good health, Tumor Burden, 3204 Immunology, Treatment Outcome, Receptors, Estrogen, FOS: Biological sciences, Female, Neoplasm Grading, 4 Detection, screening and diagnosis, Receptors, Transforming Growth Factor beta, 4.2 Evaluation of markers and technologies, Signal Transduction
Abstract

Tumor lymphocyte infiltration has been associated with clinical response to chemotherapy in estrogen receptor (ER) negative breast cancer. To identify variants in immunosuppressive pathway genes associated with prognosis after adjuvant chemotherapy for ER-negative patients, we studied invasive breast cancer patients of European ancestry with stage I-III disease, including 9,334 ER-positive patients (3,151 treated with chemotherapy) and 2,334 ER-negative patients (1,499 treated with chemotherapy).

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