1. The K121Q polymorphism in the plasma cell membrane glycoprotein 1 gene predisposes to early myocardial infarction
- Author
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Elisabeth Raiger, Freja Kunz, Raute Sunder-Plassmann, Kurt Huber, Markus Exner, Martin Schillinger, Susanne Meier, Oswald Wagner, Heike Sunder-Plassmann, Georg Endler, Sonja Kapiotis, Christine Mannhalter, and Alexandra Klimesch
- Subjects
Adult ,Male ,medicine.medical_specialty ,Arteriosclerosis ,Myocardial Infarction ,Polymerase Chain Reaction ,Insulin resistance ,Internal medicine ,Drug Discovery ,Odds Ratio ,medicine ,Humans ,Genetic Predisposition to Disease ,Myocardial infarction ,Age of Onset ,Pyrophosphatases ,Allele ,Endothelial dysfunction ,Family history ,Alleles ,Genetics (clinical) ,Aged ,Aged, 80 and over ,Polymorphism, Genetic ,Phosphoric Diester Hydrolases ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Molecular medicine ,Endocrinology ,Multivariate Analysis ,Mutation ,Cardiology ,Molecular Medicine ,Female ,Age of onset ,business - Abstract
Elevated plasma cell membrane glycoprotein 1 (PC-1) expression and the frequent PC-1 K121Q polymorphism have recently been associated with insulin resistance. Since insulin resistance represents an important risk factor for atherosclerotic vascular disease and myocardial infarction, we investigated the involvement of the PC-1 K121Q polymorphism in the development of myocardial infarction. We analyzed two independent series of cardiovascular patients at a defined end-point of atherosclerotic vascular disease (those having suffered myocardial infarction) for the PC-1 K121Q mutation by a newly developed mutagenic separated PCR assay. In both patient groups the presence of the Q allele was significantly associated with younger age at the time of first myocardial infarction, suggesting a more rapid progression of endothelial dysfunction. In a multivariate analysis carriers of the 121Q allele from Vienna and from Central Germany exhibited a 2.6- and a 4.2-increased odds, respectively, for suffering myocardial infarction within the first tertile of age (
- Published
- 2002
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