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12 results on '"Hu, Wanming"'

3. Screening and verification of antiviral compounds against HSV-1 using a method based on a plaque inhibition assay

Author

Yin, Yingxian, primary, Li, Jiahui, additional, Su, Ling, additional, Ou, Zhiying, additional, Lv, Qingqun, additional, Xiao, Misi, additional, Wang, Changbing, additional, Zeng, Dan, additional, Gu, Yiling, additional, Yang, Fengxia, additional, Chen, Minxia, additional, Feng, Shaojuan, additional, Hu, Wanming, additional, Bu, Fengling, additional, Zhu, Bing, additional, and Xu, Yi, additional

Published
2023
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4. Multimodal data analysis reveals that pancreatobiliary-type ampullary adenocarcinoma resembles pancreatic adenocarcinoma and differs from cholangiocarcinoma

Author

Cheng, Jun, primary, Mao, Yize, additional, Hong, Wenhui, additional, Hu, Wanming, additional, Shu, Peng, additional, Huang, Kun, additional, Yu, Jingjing, additional, Jiang, Maofen, additional, Li, Liqin, additional, Wang, Wei, additional, Ni, Dong, additional, and Li, Shengping, additional

Published
2022
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5. Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells

Author

Chen, Zhijie, primary, Zhong, Yingqian, additional, Chen, Jiehong, additional, Sun, Shuxin, additional, Liu, Wenfeng, additional, Han, Yu, additional, Liu, Xincheng, additional, Guo, Cui, additional, Li, Depei, additional, Hu, Wanming, additional, Zhang, Peiyu, additional, Chen, Zhuopeng, additional, Chen, Zhongping, additional, Mou, Yonggao, additional, Yan, Guangmei, additional, Zhu, Wenbo, additional, Yin, Wei, additional, and Sai, Ke, additional

Published
2022
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6. The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study

Author

Cai, Qian, primary, Mao, Yize, additional, Dai, Siqi, additional, Gao, Feng, additional, Xiao, Qian, additional, Hu, Wanming, additional, Qin, Tao, additional, Yang, Qiuxia, additional, Li, Zhaozhou, additional, Cai, Du, additional, Zhong, Min-Er, additional, Ding, Kefeng, additional, Wu, Xiao-Jian, additional, and Zhang, Rong, additional

Published
2022
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7. High frequency of PDGFRA and MUC family gene mutations in diffuse hemispheric glioma, H3 G34-mutant: a glimmer of hope?

Author

Yonggao Mou, Hao Duan, Hu Wanming, Sheng Zhong, and Jing Zeng

Subjects
Survival, Mutant, PDGFRA, Gene mutation, Biology, General Biochemistry, Genetics and Molecular Biology, Histones, H3K27M, Glioma, Exome Sequencing, H3G34R/V, MUC, medicine, Humans, Child, Diffuse hemispheric glioma, Brain Neoplasms, Research, General Medicine, medicine.disease, Immune infiltration, Mutation, Cancer research, Medicine
Abstract

Background Diffuse hemispheric glioma H3 G34-mutant (G34-DHG) is a new type of pediatric-type diffuse high-grade glioma in the fifth edition of the WHO Classification of Tumors of the Central Nervous System. The current treatment for G34-DHG involves a combination of surgery and conventional radiotherapy or chemotherapy; however, the therapeutic efficacy of this approach is not satisfactory. In recent years, molecular targeted therapy and immunotherapy have achieved significant benefits in a variety of tumors. In-depth understanding of molecular changes and immune infiltration in G34-DHGs will help to establish personalized tumor treatment strategies. Here, we report the clinicopathological, molecular and immune infiltration characteristics of G34-DHG cases from our center along with cases from the HERBY Trial and the Chinese Glioma Genome Atlas database (CGGA). Methods Hematoxylin–eosin (HE) and immunohistochemistry (IHC) staining were used to present the clinicopathological characteristics of 10 Chinese G34-DHG patients treated at our institution. To address the molecular characteristics of G34-DHG, we performed whole-exome sequencing (WES) and RNA sequencing (RNA-seq) analyses of 5 patients from our center and 3 Chinese patients from the Chinese Glioma Genome Atlas (CGGA) database. Additionally, 7 European G34-DHG patients from the HERBY Trail were also subjected to analyses, with 7 cases of WES data and 2 cases of RNA-seq data. Six G34-DHG patients from another organization were used as external validation. Results WES showed a high frequency of PDGFRA mutation in G34-DHGs (12/15). We further identified frequent mutations in MUC family genes in G34-DHGs, including MUC16 (8/15) and MUC17 (8/15). Although no statistical difference was found, PDGFRA mutation tended to be an indicator for worse prognosis whereas MUC16/MUC17 mutation indicated a favorable prognosis in G34-DHGs. RNA sequencing results revealed that most G34-DHG are considered to be immune cold tumors. However, one patient in our cohort with MUC16 mutation showed significant immune infiltration, and the total overall survival of this patient reached 75 months. Conclusions Our results demonstrate that G34-DHG is a new high-grade glioma with high frequency of PDGFRA and MUC gene family mutations. PDGFRA may serve as an indicator of poor prognosis and an effective therapeutic target. Moreover, MUC16 tends to be a favorable prognostic factor and indicates high immune infiltration in certain patients, and these findings may provide a new direction for targeted therapy and immunotherapy of patients with G34-DHGs.

Published
2022

9. CMTM6 expression in M2 macrophages is a potential predictor of PD-1/PD-L1 inhibitor response in colorectal cancer

Author

Wu, Xuehui, primary, Lan, Xiaoliang, additional, Hu, Wanming, additional, Zhang, Wanning, additional, Lai, Xiangmeng, additional, Xu, Shaowan, additional, Li, Jiaoying, additional, Qiu, Weihao, additional, Wang, Wei, additional, Xiao, Jianbiao, additional, Wang, Feifei, additional, Ding, Yanqing, additional, and Liang, Li, additional

Published
2021
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