1. Total synthesis of 1-oxomiltirone via Suzuki coupling
- Author
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Gang Xu, Hui-Chun Geng, Ming-Ming Li, Hong-Bo Qin, Tie-Jun Ling, and Chun-Miao Li
- Subjects
Pharmacology ,Chemistry ,Short Communication ,Organic Chemistry ,Pharmacology toxicology ,Total synthesis ,Plant Science ,Toxicology ,Biochemistry ,Combinatorial chemistry ,Analytical Chemistry ,abietane diterpenes ,chemistry.chemical_compound ,Suzuki reaction ,Yield (chemistry) ,versatile intermediate ,Plant biochemistry ,1-oxomiltirone ,Suzuki coupling ,total synthesis ,Food Science ,Abietane - Abstract
Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization, and total synthesis of 1-oxomiltirone (1) has been achieved. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-013-0034-7 and is accessible for authorized users.
- Published
- 2013
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