1. Repeatability of Radiomic Features in Non-Small-Cell Lung Cancer [18F]FDG-PET/CT Studies: Impact of Reconstruction and Delineation
- Author
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Egbert F. Smit, Floris H. P. van Velden, Otto S. Hoekstra, Virginie Frings, Ronald Boellaard, E. Mulder, Ida A. Nissen, Adrianus J. de Langen, Gerbrand M. Kramer, Radiology and nuclear medicine, Pulmonary medicine, CCA - Imaging, MOVE Research Institute, Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)
- Subjects
Male ,Cancer Research ,Lung Neoplasms ,UPTAKE VALUES ,non-small cell lung cancer (NSCLC) ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Positron Emission Tomography Computed Tomography ,Image Processing, Computer-Assisted ,F-18-FDG PET ,Repeatability ,Positron emission ,Medicine(all) ,Middle Aged ,Reconstruction method ,Oncology ,030220 oncology & carcinogenesis ,Female ,Fdg pet ct ,Radiology ,Non small cell ,TUMOR TEXTURE ANALYSIS ,Research Article ,medicine.medical_specialty ,PET/CT ,IMAGES ,TEST-RETEST ,CHEMORADIOTHERAPY ,03 medical and health sciences ,QUANTITATIVE FDG-PET ,Fluorodeoxyglucose F18 ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Lung cancer ,Aged ,Demography ,Non-small-cell lung cancer (NSCLC) ,PET-CT ,Radiomics ,business.industry ,Reproducibility of Results ,medicine.disease ,UPTAKE HETEROGENEITY ,VOLUME ,Tracer uptake heterogeneity ,business ,Nuclear medicine ,FRACTAL ANALYSIS - Abstract
Purpose To assess (1) the repeatability and (2) the impact of reconstruction methods and delineation on the repeatability of 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies. Procedures Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using the point spread function (PSF) and once complying with the European Association for Nuclear Medicine (EANM) guidelines for tumor PET imaging. Volumes of interest (n = 19) were delineated twice, once on PET and once on CT images. Results Sixty-three features showed an intraclass correlation coefficient ≥ 0.90 independent of delineation or reconstruction. More features were sensitive to a change in delineation than to a change in reconstruction (25 and 3 features, respectively). Conclusions The majority of features in NSCLC [18F]FDG-PET/CT studies show a high level of repeatability that is similar or better compared to simple standardized uptake value measures. Electronic supplementary material The online version of this article (doi:10.1007/s11307-016-0940-2) contains supplementary material, which is available to authorized users.
- Published
- 2016
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