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A 60-year-old female with a ten-month history of acute myelogenous leukemia, now in hematologic remission, presented with severe dizziness, unsteady gait, nausea and vomiting. She had recently received two courses of chemotherapy, including daunorubicin and ARA-C. She was admitted to Brigham and Women's Hospital. Cranial CT (Figs. 1 and 2) showed a high-density mass in the left cerebellar hemisphere, with central lucency and dense peripheral enhancement. There was osteolytic bone destruction of the inner table of occipital bone on both sides, confirmed on plain films and very dense tentorial enhancement as well as obstructive hydrocephalus. A left vertebral angiogram demonstrated a relatively avascular mass in the left cerebellar hemisphere without venous occlusion. Biopsies of the left cerebellar mass and left occipital bone proved to be chloroma. A follow-up cranial CT two months after the completion of radiation therapy (900 rad delivered to the whole brain and 2600 rad to the posterior fossa) showed complete resolution of the posterior fossa lesions.