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Your search keyword '"Jin, Jiabin"' showing total 10 results
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10 results on '"Jin, Jiabin"'

1. Robotic versus open pancreaticoduodenectomy with vascular resection for pancreatic ductal adenocarcinoma: surgical and oncological outcomes from pilot experience

Author

Jin, Jiabin, primary, Yin, Shih-min, additional, Weng, Yuanchi, additional, Chen, Mengmin, additional, Shi, Yusheng, additional, Ying, Xiayang, additional, Gemenetzis, Georgios, additional, Qin, Kai, additional, Zhang, Jun, additional, Deng, Xiaxing, additional, Peng, Chenghong, additional, and Shen, Baiyong, additional

Published
2022
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2. Robotic versus Open Pancreatoduodenectomy for Pancreatic and Periampullary Tumors (PORTAL): a study protocol for a multicenter phase III non-inferiority randomized controlled trial

Author

Jin, Jiabin, primary, Shi, Yusheng, additional, Chen, Mengmin, additional, Qian, Jianfeng, additional, Qin, Kai, additional, Wang, Zhen, additional, Chen, Wei, additional, Jin, Weiwei, additional, Lu, Fengchun, additional, Li, Zheyong, additional, Wu, Zehua, additional, Jian, Li, additional, Han, Bing, additional, Liang, Xiao, additional, Sun, Chuandong, additional, Wu, Zheng, additional, Mou, Yiping, additional, Yin, Xiaoyu, additional, Huang, Heguang, additional, Chen, Hao, additional, Gemenetzis, Georgios, additional, Deng, Xiaxing, additional, Peng, Chenghong, additional, and Shen, Baiyong, additional

Published
2021
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7. Up-Regulation of Toll-Like Receptors 2 and 4 on Peripheral Monocytes After Major Abdominal Surgical Operation

Author

Chen Hao, Shen Baiyong, Xie Junjie, Jin Jiabin, Deng Xiaxing, Zhan Xi, Li Jianfang, and Shi Mingming

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Physiology, Lipopolysaccharide Receptors, Peripheral blood mononuclear cell, Monocytes, Downregulation and upregulation, Internal medicine, medicine, Humans, RNA, Messenger, Receptor, Digestive System Surgical Procedures, Toll-like receptor, business.industry, Gastroenterology, HLA-DR Antigens, Middle Aged, Hepatology, Immunity, Innate, Toll-Like Receptor 2, Up-Regulation, Peripheral, Toll-Like Receptor 4, TLR2, Immunology, TLR4, Cytokines, Female, business
Abstract

This study is to investigate the time-course expression of TLR2 and TLR4 on peripheral monocytes in patients receiving major abdominal surgical operation.Blood samples were obtained from peripheral vein before and after an operation in 30 patients with gastrointestinal or pancreatic surgery. The mRNA expression of TLR2, TLR4, TNF-α and IL-6 on peripheral blood mononuclear cells (PBMC) was analyzed by real-time PCR. The expressions of TLR2, TLR4, HLA-DR, CD80, and CD86 on monocytes were analyzed by flow cytometry. The expressions of TLR2 and TLR4 on monocytes responding to each agonist (zymosan and lipopolysaccharide) were also measured by flow cytometry.TLR2 and TLR4 mRNA showed significant up-regulation after the completion of the operation when compared with those before the operation. TLR2 expression reached its peak level on day 1 and TLR4 on days 1 and 3. There was no significant difference between pre- and post-operation in the expressions of HLA-DR, CD80 and CD86. Stimulation with zymosan, increased the expression of TLR2 significantly after the operation and reached its highest value on day 3. Similarly, after stimulation with lipopolysaccharide, the expression of TLR4 was also increased and the highest level was observed on day 1. The expression of TNF-α and IL-6 mRNA decreased after completion of the operation and gradually returned to basal level.The expressions of TLR2 and TLR4 on monocytes were up-regulated during the early period after a major abdominal surgical operation in patients, which might be related to the activation of innate immunity.

Published
2012

8. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Author

Liu, Ruixin, primary, Hong, Jie, additional, Xu, Xiaoqiang, additional, Feng, Qiang, additional, Zhang, Dongya, additional, Gu, Yanyun, additional, Shi, Juan, additional, Zhao, Shaoqian, additional, Liu, Wen, additional, Wang, Xiaokai, additional, Xia, Huihua, additional, Liu, Zhipeng, additional, Cui, Bin, additional, Liang, Peiwen, additional, Xi, Liuqing, additional, Jin, Jiabin, additional, Ying, Xiayang, additional, Wang, Xiaolin, additional, Zhao, Xinjie, additional, Li, Wanyu, additional, Jia, Huijue, additional, Lan, Zhou, additional, Li, Fengyu, additional, Wang, Rui, additional, Sun, Yingkai, additional, Yang, Minglan, additional, Shen, Yuxin, additional, Jie, Zhuye, additional, Li, Junhua, additional, Chen, Xiaomin, additional, Zhong, Huanzi, additional, Xie, Hailiang, additional, Zhang, Yifei, additional, Gu, Weiqiong, additional, Deng, Xiaxing, additional, Shen, Baiyong, additional, Xu, Xun, additional, Yang, Huanming, additional, Xu, Guowang, additional, Bi, Yufang, additional, Lai, Shenghan, additional, Wang, Jian, additional, Qi, Lu, additional, Madsen, Lise, additional, Wang, Jiqiu, additional, Ning, Guang, additional, Kristiansen, Karsten, additional, and Wang, Weiqing, additional

Published
2017
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9. The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

Author

Deng Xiaxing, Shi Minmin, Jin Jiabin, Xie Junjie, Jiang Songyao, Chen Hao, Shen Baiyong, Song Yanyan, and Zhan Xi

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Linkage disequilibrium, Carcinoma, Hepatocellular, Adolescent, Single-nucleotide polymorphism, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, lcsh:RC254-282, Gastroenterology, Linkage Disequilibrium, Young Adult, Internal medicine, Genotype, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, Aged, Aged, 80 and over, business.industry, Liver Neoplasms, Haplotype, Case-control study, Odds ratio, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Toll-Like Receptor 2, digestive system diseases, Haplotypes, Oncology, Case-Control Studies, Hepatocellular carcinoma, Immunology, Female, business, Research Article
Abstract

Background Toll-like receptors (TLR) are key innate immunity receptors participating in an immune response. Growing evidence suggests that mutations of TLR2/TLR9 gene are associated with the progress of cancers. The present study aimed to investigate the temporal relationship of single nucleotide polymorphisms (SNP) of TLR2/TLR9 and the risk of hepatocellular carcinoma (HCC). Methods In this single center-based case-control study, SNaPshot method was used to genotype sequence variants of TLR2 and TLR9 in 211 patients with HCC and 232 subjects as controls. Results Two synonymous SNPs in the exon of TLR2 were closely associated with risk of HCC. Compared with those carrying wild-type homozygous genotypes (T/T), risk of HCC decreased significantly in individuals carrying the heterozygous genotypes (C/T) of the rs3804099 (adjusted odds ratio (OR), 0.493, 95% CI 0.331 - 0.736, P < 0.01) and rs3804100 (adjusted OR, 0.509, 95% CI 0.342 - 0.759, P < 0.01). There was no significant association found in two TLR9 SNPs concerning the risk of HCC. The haplotype TT for TLR2 was associated significantly with the decreased risk of HCC (OR 0.524, 95% CI 0.394 - 0.697, P = 0.000). Inversely, the risk of HCC increased significantly in patients with the haplotype CC (OR 2.743, 95% CI 1.915 - 3.930, P = 0.000). Conclusions These results suggested that TLR2 rs3804099 C/T and rs3804100 C/T polymorphisms were closely associated with HCC. In addition, the haplotypes composed of these two TLR2 synonymous SNPs have stronger effects on the susceptibility of HCC.

Published
2012

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