1. Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes
- Author
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Jin Hyoung Kim, Dong Hyun Jo, Jin Gyeong Son, Yuanze Piao, Tae Geol Lee, and Jeong Hun Kim
- Subjects
Materials science ,biology ,Angiogenesis ,VEGF receptors ,Nanoparticle ,Nanotechnology ,Condensed Matter Physics ,Inhibitory postsynaptic potential ,medicine.disease_cause ,Atomic and Molecular Physics, and Optics ,Vascular endothelial growth factor ,chemistry.chemical_compound ,chemistry ,Apoptosis ,In vivo ,medicine ,biology.protein ,Biophysics ,General Materials Science ,Electrical and Electronic Engineering ,Oxidative stress - Abstract
Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis. more...
- Published
- 2014
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