8 results on '"Jin Hyun Park"'
Search Results
2. Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation
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Sang-Won Jeon, Jin-Hyun Park, Joo-Eun Kim, and Young-Joon Park
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Pharmaceutical Science ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) - Published
- 2023
3. Characteristics of Sweet syndrome in patients with or without malignancy
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Eun Hee, Jung, Jin Hyun, Park, Ki, Hwan Kim, Jin-Soo, Kim, In, Sil Choi, Ja Min, Byun, Youngil, Koh, Dong-Yeop, Shin, Junshik, Hong, Sung-Soo, Yoon, Hyunkyung, Park, and Inho, Kim
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Adult ,Aged, 80 and over ,Male ,Adolescent ,Anemia ,Leukopenia ,Hematology ,General Medicine ,Middle Aged ,Sweet Syndrome ,Thrombocytopenia ,Young Adult ,Myelodysplastic Syndromes ,Neoplasms ,Humans ,Female ,Longitudinal Studies ,Aged ,Retrospective Studies - Abstract
Sweet syndrome is a neutrophilic dermatosis occasionally associated with malignancies. Due to its rarity, the clinical features of Sweet syndrome are still unclear. Thus, we aimed to analyze clinical features, treatment, and outcomes of these patients according to associated disease. We conducted a retrospective, longitudinal cohort study from January 2000 to August 2020. We reviewed the medical records of 52 patients with Sweet syndrome. The median age of patients was 57.5 years old (range, 17-84), and 48.1% were female. Of the 52 patients analyzed, 27 patients (51.9%) had malignancy-associated Sweet syndrome. Sweet syndrome was diagnosed concurrently with (N = 8), before (N = 5), and after (N = 14) the diagnosis of malignancy. The idiopathic Sweet syndrome was most common in the non-malignancy group (56.0%). Myelodysplastic syndrome was the most common malignancy associated with Sweet syndrome (47.6%). Leukopenia (p = 0.005), anemia (p 0.001), and thrombocytopenia (p = 0.008) were significantly associated with malignancy. The majority of patients showed rapid improvement of symptoms after steroid administration. The symptoms of some patients with malignancy did not improve with steroid alone; however, their symptoms often improved when steroids were combined with a treatment for the associated malignancy. Relapse and aggravation of Sweet syndrome were common in the malignancy group. Sweet syndrome showed a broad spectrum of clinical features related to various diseases. Sweet syndrome often occurred as a paraneoplastic feature. Therefore, active systemic evaluation is needed in the first diagnosis of Sweet syndrome without clear etiology.
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- 2022
4. Efficient access to general α-tertiary amines via water-accelerated organocatalytic multicomponent allylation
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Prithwish Goswami, Sung Yeon Cho, Jin Hyun Park, Woo Hee Kim, Hyun Jin Kim, Myoung Hyeon Shin, and Han Yong Bae
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Multidisciplinary ,Molecular Structure ,Water ,General Physics and Astronomy ,Stereoisomerism ,General Chemistry ,Amines ,Carbon ,Catalysis ,General Biochemistry, Genetics and Molecular Biology - Abstract
A tetrasubstituted carbon atom connected by three sp3 or sp2-carbons with single nitrogen, i.e., the α-tertiary amine (ATA) functional group, is an essential structure of diverse naturally occurring alkaloids and pharmaceuticals. The synthetic approach toward ATA structures is intricate, therefore, a straightforward catalytic method has remained a substantial challenge. Here we show an efficient water-accelerated organocatalytic method to directly access ATA incorporating homoallylic amine structures by exploiting readily accessible general ketones as useful starting material. The synergistic action of a hydrophobic Brønsted acid in combination with a squaramide hydrogen-bonding donor under aqueous condition enabled the facile formation of the desired moiety. The developed exceptionally mild but powerful system facilitated a broad substrate scope, and enabled efficient multi-gram scalability.
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- 2022
5. Long-term prognostic effect of hormone receptor subtype on breast cancer
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Jongjin Kim, Sook Young Jeon, Jeong Hwan Park, Jiwoong Jung, Kyu Ri Hwang, Su jin Kim, Eun Youn Roh, Ki Tae Hwang, Jin Hyun Park, and Byoung Hyuck Kim
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Adult ,0301 basic medicine ,End results ,Cancer Research ,medicine.medical_specialty ,Prognostic factor ,Seer database ,Estrogen receptor ,Breast Neoplasms ,Favorable prognosis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Progesterone receptor ,medicine ,Humans ,Aged ,Aged, 80 and over ,Chemistry ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,030104 developmental biology ,Endocrinology ,Receptors, Estrogen ,Oncology ,Hormone receptor ,030220 oncology & carcinogenesis ,Female ,Receptors, Progesterone ,SEER Program - Abstract
To determine the long-term prognostic role of hormone receptor subtype in breast cancer using surveillance, epidemiology, and end results (SEER) database. Data of 810,587 female operable invasive breast cancer patients from SEER database with a mean follow-up period of 94.2 months (range, 0–311 months) were analyzed. Hormone receptor subtype was classified into four groups based on estrogen receptor (ER) and progesterone receptor (PR) statuses: ER(+)/PR(+), ER(+)/PR(−), ER(−)/PR(+), and ER(−)/PR(−). Numbers of subjects with ER(+)/PR(+), ER(+)/PR(−), ER(−)/PR(+), ER(−)/PR(−), and unknown were 496,279 (61.2%), 86,858 (10.7%), 11,545 (1.4%), 135,441 (16.7%), and 80,464 (9.9%), respectively. The ER(+)/PR(+) subtype showed the best breast-cancer-specific survival, followed by ER(+)/PR(−), ER(−)/PR(+), and ER(−)/PR(−) subtypes in the respective order (all p
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- 2019
6. Comparison of quality of life and health behaviors in survivors of acute leukemia and the general population
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Young Ho Yun, Jeong Ok Lee, Dong Yeop Shin, Ja Min Byun, Inho Kim, Young-Ae Kim, Jin Hyun Park, Sung-Soo Yoon, Koung Jin Suh, Soo Mee Bang, Sang Min Park, Youngil Koh, and Ki Hwan Kim
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Adult ,Male ,medicine.medical_specialty ,Health Behavior ,Population ,Pain ,03 medical and health sciences ,0302 clinical medicine ,Cancer Survivors ,Quality of life ,Sleep Initiation and Maintenance Disorders ,Surveys and Questionnaires ,Survivorship curve ,Internal medicine ,Cancer screening ,Humans ,Medicine ,education ,Fatigue ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,education.field_of_study ,Acute leukemia ,Depression ,business.industry ,Hematology ,General Medicine ,Middle Aged ,Allografts ,Transplantation ,Leukemia, Myeloid, Acute ,Dyspnea ,030220 oncology & carcinogenesis ,Quality of Life ,Anxiety ,Female ,medicine.symptom ,business ,Stem Cell Transplantation ,030215 immunology - Abstract
We aimed to compare the health-related quality of life and health behaviors of acute leukemia (AL) survivors with that of the general population from two cohorts. AL survivors (n = 149) completed a set of questionnaires to evaluate quality of life, mental status, and health behaviors. AL survivors had more physical and mental difficulties (problems with usual activities, 15% vs. 5%, p
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- 2019
7. Prediction of survival in terminally ill cancer patients at the time of terminal cancer diagnosis
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Keun Wook Lee, Won Suk Choi, Su Jung Kim, Hee Jun Kim, Se-Hoon Lee, Yung-Jue Bang, Dong Wan Kim, June Koo Lee, Jin Hyun Park, Jee Hyun Kim, Yu Jung Kim, Sung Hoon Sim, Jong Seok Lee, and Dae Seog Heo
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Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,genetic structures ,Neutrophils ,Young Adult ,Neoplasms ,Internal medicine ,Humans ,Terminally Ill ,Medicine ,Lymphocytes ,Prospective Studies ,Young adult ,Prospective cohort study ,Aged ,Aged, 80 and over ,Univariate analysis ,Hematology ,Performance status ,business.industry ,Cancer ,General Medicine ,Middle Aged ,Prognosis ,bacterial infections and mycoses ,medicine.disease ,Confidence interval ,Surgery ,Female ,business - Abstract
We aimed to investigate the prognostic factors that can predict terminal stage survival (TSS) at the time of terminal cancer diagnosis. We prospectively evaluated 141 patients immediately after the diagnosis of terminal cancer by their attending oncologists. A total of 32 factors, including performance status, clinical prediction of survival, time to terminal cancer (TTC), clinical symptoms, signs, and laboratory tests including the neutrophil–lymphocyte ratio (NLR), were analyzed. TSS was defined as the time from the diagnosis of terminal cancer to death. The mean age of the 141 patients studied was 58.7 years, and 53 were female (38 %). The median TSS was 1.7 months (95 % confidence interval [CI] 1.43–1.97). In the univariate analyses, the TSS was significantly associated with 16 of the 32 factors tested. In the multivariate analysis, a lower Karnofsky performance status (KPS), a shorter TTC (
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- 2014
8. Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients
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Yong Shin, Il-Jin Kim, Hio Chung Kang, Jae-Gahb Park, Ja-Lok Ku, Song Yee Han, Sang-Geun Jang, Kyong Ah Yoon, Hyewon Park, Jin Hyun Park, Soo-Jeong Lim, Young-Kyoung Shin, Woo Ho Kim, H. R. Shin, Seung-Yong Jeong, Jin Soo Lee, and Min Ro Lee
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Adult ,Male ,Proto-Oncogene Proteins B-raf ,Colorectal cancer ,DNA Mutational Analysis ,Loss of Heterozygosity ,Biology ,DNA Glycosylases ,Familial adenomatous polyposis ,Germline mutation ,MUTYH ,Odds Ratio ,Genetics ,medicine ,Carcinoma ,Humans ,Codon ,Germ-Line Mutation ,beta Catenin ,Genetics (clinical) ,Korea ,Polymorphism, Genetic ,Genetic Variation ,Cancer ,Microsatellite instability ,Exons ,Base excision repair ,Middle Aged ,Genes, p53 ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Phosphoric Monoester Hydrolases ,Cytoskeletal Proteins ,DNA Repair Enzymes ,Genes, ras ,Adenomatous Polyposis Coli ,Case-Control Studies ,Mutation ,Trans-Activators ,Cancer research ,Female ,Colorectal Neoplasms - Abstract
MYH, OGG1 and MTH1 are members of base excision repair (BER) families, and MYH germline mutations were recently identified in patients with multiple adenomas or familial adenomatous polyposis (FAP). A total of 20 APC-negative Korean FAP patients were analyzed for OGG1, MYH and MTH1 germline mutations. A total of 19 hereditary nonpolyposis colorectal cancer (HNPCC), 86 suspected HNPCC, and 246 sporadic colorectal cancer cases were investigated for OGG1 and MYH mutations. A total of 14 R154H OGG1 polymorphisms were identified in hereditary, sporadic colorectal cancers, and normal controls. For the case-control analysis of OGG1 R154H, a total of 625 hereditary or sporadic colorectal cancer patients and 527 normal controls were screened. R154H was a rare polymorphism associated with sporadic colorectal cancer patents (OR: 3.586, P= 0.053). R154H does not segregate with cancer phenotypes. Upon examining the possibility of recessive inheritance of R154H, we could not identify any complementary mutations in OGG1, MYH or MTH1. Samples with R154H were further screened for mutations of K-ras, beta-catenin, APC, p53, BRAF and the microsatellite instability (MSI) status. Eight somatic mutations were identified in these genes and G:C to T:A transversion mutations were not dominant in samples harboring R154H. This result raises the possibility that OGG1 R154H may function as a low/moderate-penetrance modifier for colorectal cancer development.
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- 2004
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