1. Auswertung von Histonmodifikations-ChIP-Seq-Datensätzen
- Author
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Ho-Ryun Chung and Johannes Helmuth
- Subjects
0301 basic medicine ,Genetics ,Histone-modifying enzymes ,biology ,Computational biology ,03 medical and health sciences ,030104 developmental biology ,Histone ,Histone H1 ,Histone methylation ,Histone H2A ,biology.protein ,Nucleosome ,Histone code ,Histone octamer ,Molecular Biology ,Biotechnology - Abstract
The basic repeating unit of chromatin is the nucleosome, which is made of two copies each of the core histones H2A, H2B, H3 and H4. Histones are frequently post-translationally modified. These histone modifications correlate with functional elements, such as promoters and enhancers, and the activity status of the DNA in a cell-type-specific manner. Here we describe how to determine the localization of histone modifications by the analysis of ChIP-seq data.
- Published
- 2016
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