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30 results on '"Juma, Elizabeth"'

1. Post introduction evaluation of the malaria vaccine implementation programme in Ghana, 2021

Author

Adjei, Michael Rockson, primary, Amponsa-Achiano, Kwame, additional, Okine, Rafiq, additional, Tweneboah, Peter Ofori, additional, Sally, Emmanuel Tettey, additional, Dadzie, John Frederick, additional, Osei-Sarpong, Fred, additional, Adjabeng, Michael Jeroen, additional, Bawa, John Tanko, additional, Bonsu, George, additional, Antwi-Agyei, Kwadwo Odei, additional, Kaburi, Basil Benduri, additional, Owusu-Antwi, Felicia, additional, Juma, Elizabeth, additional, Kasolo, Francis Chisaka, additional, Asiedu-Bekoe, Franklin, additional, and Kuma-Aboagye, Patrick, additional

Published
2023
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2. Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Author

Dahal, Prabin, Simpson, Julie Anne, Abdulla, Salim, Achan, Jane, Adam, Ishag, Agarwal, Aarti, Allan, Richard, Anvikar, Anupkumar R., Ashley, Elizabeth A., Bassat, Quique, Borrmann, Steffen, Bousema, Teun, Bukirwa, Hasifa, Carrara, Verena, I, Corsi, Marco, D'Alessandro, Umberto, Davis, Timothy M. E., Deloron, Philippe, Desai, Meghna, Dimbu, Pedro Rafael, Djalle, Djibrine, Djimde, Abdoulaye, Dorsey, Grant, Drakeley, Chris J., Duparc, Stephan, Edstein, Michael D., Espie, Emmanuelle, Faiz, Abul, Falade, Catherine, Fanello, Caterina, Faucher, Jean-Francois, Faye, Babacar, Fortes, Filomeno de Jesus, Gadalla, Nahla B., Gaye, Oumar, Gil, J. Pedro, Gilayeneh, Julius, Greenwood, Brian, Grivoyannis, Anastasia, Hien, Tran Tinh, Hwang, Jimee, Janssens, Bart, Juma, Elizabeth, Kamugisha, Erasmus, Karema, Corine, Karunajeewa, Harin A., Kiechel, Jean R., Kironde, Fred, Kofoed, Poul-Erik, Kremsner, Peter G., Lee, Sue J., Marsh, Kevin, Mårtensson, Andreas, Mayxay, Mayfong, Menan, Herve, Mens, Petra, Mutabingwa, Theonest K., Ndiaye, Jean-Louis, Ngasala, Billy, Noedl, Harald, Nosten, Francois, Offianan, Andre Toure, Ogutu, Bernhards R., Olliaro, Piero L., Ouedraogo, Jean Bosco, Piola, Patrice, Plowe, Christopher, V, Plucinski, Mateusz M., Pratt, Oliver James, Premji, Zulfikarali, Ramharter, Michael, Rogier, Christophe, Vitare, Primum, Rombo, Lars, Rosenthal, Philip J., Sibley, Carol, Sirima, Sodiomon, Smithuis, Frank, Staedke, Sarah G., Sutanto, Inge, Talisuna, Ambrose Otau, Tarning, Joel, Taylor, Walter R. J., Temu, Emmanuel, Thriemer, Kamala, Thuy-Nhien, Nguyen, Udhayakumar, Venkatachalam, Ursing, Johan D., van Herp, Michel, van Lenthe, Marit, van Vugt, Michele, William, Yavo, Winnips, Cornelis, Zaloumis, Sophie, Zongo, Issaka, White, Nick J., Guerin, Philippe J., Stepniewska, Kasia, Price, Ric N., Arinaitwe, Emmanuel, and Group, WorldWide Antimalarial Resistance Network Methodology Study

Subjects
Infectious Medicine, Efficacy, Follow-up, Recrudescence, Artemether, Lumefantrine Drug Combination, Plasmodium falciparum, Infektionsmedicin, Distribution, Artemisinins, Malaria, Antimalarials, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, Recurrence, Child, Preschool, Humans, Parasitology, Artemether, Child
Abstract

Background The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria. Methods Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites. Fractional polynomials were used to capture non-linear instantaneous hazard. The area under the density curve (AUC) of the constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify the absolute overestimation in efficacy due to sub-optimal follow-up. Results Overall, 3703 recurrent infections were detected in 60 studies conducted in Africa (15,512 children aged 48 mg/kg total piperaquine (PIP) dose and 9% [95% CI 0–22%] in those treated with ≤ 48 mg/kg PIP dose. In absolute terms, the simulation study found that trials limited to 28 days follow-up following AL underestimated the risk of recrudescence by a median of 2.8 percentage points compared to day 63 estimates and those limited to 42 days following DP underestimated the risk of recrudescence by a median of 2.0 percentage points compared to day 42 estimates. The analysis was limited by few clinical trials following patients for longer than 42 days (9 out of 83 trials) and the imprecision of PCR genotyping which overcalls recrudescence in areas of higher transmission biasing the later distribution. Conclusions Restricting follow-up of clinical efficacy trials to day 28 for AL and day 42 for DP will miss a proportion of late recrudescent treatment failures but will have a modest impact in derived efficacy. The results highlight that as genotyping methods improve consideration should be given for trials with longer duration of follow-up to detect early indications of emerging drug resistance.

Published
2022
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4. Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Author

Saito, Makoto, primary, Mansoor, Rashid, additional, Kennon, Kalynn, additional, Anvikar, Anupkumar R., additional, Ashley, Elizabeth A., additional, Chandramohan, Daniel, additional, Cohee, Lauren M., additional, D’Alessandro, Umberto, additional, Genton, Blaise, additional, Gilder, Mary Ellen, additional, Juma, Elizabeth, additional, Kalilani-Phiri, Linda, additional, Kuepfer, Irene, additional, Laufer, Miriam K., additional, Lwin, Khin Maung, additional, Meshnick, Steven R., additional, Mosha, Dominic, additional, Muehlenbachs, Atis, additional, Mwapasa, Victor, additional, Mwebaza, Norah, additional, Nambozi, Michael, additional, Ndiaye, Jean-Louis A., additional, Nosten, François, additional, Nyunt, Myaing, additional, Ogutu, Bernhards, additional, Parikh, Sunil, additional, Paw, Moo Kho, additional, Phyo, Aung Pyae, additional, Pimanpanarak, Mupawjay, additional, Piola, Patrice, additional, Rijken, Marcus J., additional, Sriprawat, Kanlaya, additional, Tagbor, Harry K., additional, Tarning, Joel, additional, Tinto, Halidou, additional, Valéa, Innocent, additional, Valecha, Neena, additional, White, Nicholas J., additional, Wiladphaingern, Jacher, additional, Stepniewska, Kasia, additional, McGready, Rose, additional, and Guérin, Philippe J., additional

Published
2020
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5. The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Author

Bretscher, Michael T., primary, Dahal, Prabin, additional, Griffin, Jamie, additional, Stepniewska, Kasia, additional, Bassat, Quique, additional, Baudin, Elisabeth, additional, D’Alessandro, Umberto, additional, Djimde, Abdoulaye A., additional, Dorsey, Grant, additional, Espié, Emmanuelle, additional, Fofana, Bakary, additional, González, Raquel, additional, Juma, Elizabeth, additional, Karema, Corine, additional, Lasry, Estrella, additional, Lell, Bertrand, additional, Lima, Nines, additional, Menéndez, Clara, additional, Mombo-Ngoma, Ghyslain, additional, Moreira, Clarissa, additional, Nikiema, Frederic, additional, Ouédraogo, Jean B., additional, Staedke, Sarah G., additional, Tinto, Halidou, additional, Valea, Innocent, additional, Yeka, Adoke, additional, Ghani, Azra C., additional, Guerin, Philippe J., additional, and Okell, Lucy C., additional

Published
2020
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7. Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure

Author

Abdi, Abdirahman I., primary, Hodgson, Susanne H., additional, Muthui, Michelle K., additional, Kivisi, Cheryl A., additional, Kamuyu, Gathoni, additional, Kimani, Domtila, additional, Hoffman, Stephen L., additional, Juma, Elizabeth, additional, Ogutu, Bernhards, additional, Draper, Simon J., additional, Osier, Faith, additional, Bejon, Philip, additional, Marsh, Kevin, additional, and Bull, Peter C., additional

Published
2017
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8. Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

Author

Hodgson, Susanne H, primary, Juma, Elizabeth, additional, Salim, Amina, additional, Magiri, Charles, additional, Njenga, Daniel, additional, Molyneux, Sassy, additional, Njuguna, Patricia, additional, Awuondo, Ken, additional, Lowe, Brett, additional, Billingsley, Peter F, additional, Cole, Andrew O, additional, Ogwang, Caroline, additional, Osier, Faith, additional, Chilengi, Roma, additional, Hoffman, Stephen L, additional, Draper, Simon J, additional, Ogutu, Bernhards, additional, and Marsh, Kevin, additional

Published
2015
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9. Patient adherence to prescribed artemisinin-based combination therapy in Garissa County, Kenya, after three years of health care in a conflict setting

Author

Gore-Langton, Georgia R, primary, Alenwi, Nfornuh, additional, Mungai, James, additional, Erupe, Nahashon I, additional, Eves, Katie, additional, Kimwana, Francis Njoroge, additional, Soti, David, additional, Akhwale, Willis, additional, Hassan, Farah A, additional, Juma, Elizabeth, additional, and Allan, Richard, additional

Published
2015
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10. Investigating the acceptability of non-mesh, long-lasting insecticidal nets amongst nomadic communities in Garissa County, Kenya using a prospective, longitudinal study design and cross-sectional household surveys

Author

Gore-Langton, Georgia R, primary, Mungai, James, additional, Alenwi, Nfornuh, additional, Abagira, Abdulla, additional, Bicknell, Owen M, additional, Harrison, Rebecca, additional, Hassan, Farah A, additional, Munga, Stephen, additional, Njoroge, Francis, additional, Juma, Elizabeth, additional, and Allan, Richard, additional

Published
2015
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11. Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

Author

Hodgson, Susanne H, primary, Douglas, Alexander D, additional, Edwards, Nick J, additional, Kimani, Domtila, additional, Elias, Sean C, additional, Chang, Ming, additional, Daza, Glenda, additional, Seilie, Annette M, additional, Magiri, Charles, additional, Muia, Alfred, additional, Juma, Elizabeth A, additional, Cole, Andrew O, additional, Rampling, Thomas W, additional, Anagnostou, Nicholas A, additional, Gilbert, Sarah C, additional, Hoffman, Stephen L, additional, Draper, Simon J, additional, Bejon, Philip, additional, Ogutu, Bernhards, additional, Marsh, Kevin, additional, Hill, Adrian VS, additional, and Murphy, Sean C, additional

Published
2015
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13. Perceptions of malaria and acceptance of rapid diagnostic tests and related treatment practises among community members and health care providers in Greater Garissa, North Eastern Province, Kenya

Author

Diggle, Emma, primary, Asgary, Ramin, additional, Gore-Langton, Georgia, additional, Nahashon, Erupe, additional, Mungai, James, additional, Harrison, Rebecca, additional, Abagira, Abdullahi, additional, Eves, Katie, additional, Grigoryan, Zoya, additional, Soti, David, additional, Juma, Elizabeth, additional, and Allan, Richard, additional

Published
2014
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14. Controlled human malaria infection in Kenyan adults: A safe model that could accelerate assessment of novel drugs and vaccines in malaria endemic populations

Author

Hodgson, Susanne, primary, Juma, Elizabeth, additional, Salim, Amina, additional, Magiri, Charles, additional, Kimani, Domtila, additional, Njenga, Daniel, additional, Muia, Alfred, additional, Cole, Andrew, additional, Ogwang, Caroline, additional, Billingsley, Peter, additional, James, Eric, additional, Sim, Kim Lee, additional, Rampling, Thomas, additional, Hill, Adrian, additional, Osier, Faith, additional, Draper, Simon, additional, Bejon, Philip, additional, Hoffman, Stephen, additional, Ogutu, Bernhards, additional, and Marsh, Kevin, additional

Published
2014
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15. Controlled human malaria infections using aseptic, purified cryopreserved Plasmodium falciparum sporozoites administered by needle and syringe

Author

Billingsley, Peter, primary, Sim, B Kim Lee, additional, Bijker, Else, additional, Roestenberg, Meta, additional, Lyke, Kirsten, additional, Laurens, Matthew, additional, Mordmueller, Benjamin, additional, Gomez, Patricia, additional, Shekalaghe, Seif, additional, Hodgson, Susanne, additional, Hill, Adrian, additional, Juma, Elizabeth, additional, Ogutu, Bernhards, additional, Lell, Bertrand, additional, Alonso, Pedro, additional, Abdullah, Salim, additional, Kremsner, Peter, additional, Tanner, Marcel, additional, Sauerwein, Robert, additional, and Hoffman, Stephen, additional

Published
2014
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16. Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study

Author

Ogutu, Bernhards R, primary, Onyango, Kevin O, additional, Koskei, Nelly, additional, Omondi, Edgar K, additional, Ongecha, John M, additional, Otieno, Godfrey A, additional, Obonyo, Charles, additional, Otieno, Lucas, additional, Eyase, Fredrick, additional, Johnson, Jacob D, additional, Omollo, Raymond, additional, Perkins, Douglas J, additional, Akhwale, Willis, additional, and Juma, Elizabeth, additional

Published
2014
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17. The affordable medicines facility-malaria—A success in peril

Author

Talisuna, Ambrose O, primary, Adibaku, Seraphine, additional, Amojah, Chioma N, additional, Amofah, George K, additional, Aubyn, Vivian, additional, Dodoo, Alex, additional, Juma, Elizabeth, additional, Jackou, Djermakoye H, additional, Mkude, Sigsbert, additional, Okui, Albert P, additional, Ramarosandratana, Benjamin, additional, and Shija, Shija J, additional

Published
2012
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26. The risks of malaria infection in Kenya in 2009

Author

Noor, Abdisalan M, primary, Gething, Peter W, additional, Alegana, Victor A, additional, Patil, Anand P, additional, Hay, Simon I, additional, Muchiri, Eric, additional, Juma, Elizabeth, additional, and Snow, Robert W, additional

Published
2009
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30. Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure

Author

Abdi, Abdirahman I, Hodgson, Susanne H, Muthui, Michelle K, Kivisi, Cheryl A, Kamuyu, Gathoni, Kimani, Domtila, Hoffman, Stephen L, Juma, Elizabeth, Ogutu, Bernhards, Draper, Simon J, Osier, Faith, Bejon, Philip, Marsh, Kevin, and Bull, Peter C

Subjects
Adult, Erythrocytes, Sporozoite, Plasmodium falciparum, Immunity, Protozoan Proteins, Antibodies, Protozoan, Gene Expression, Antigens, Protozoan, P. falciparum, Real-Time Polymerase Chain Reaction, Kenya, Antibodies, 3. Good health, PfEMP1, parasitic diseases, Host-Pathogen Interactions, Animals, Humans, Longitudinal Studies, Malaria, Falciparum, Controlled human malaria infection (CHMI)
Abstract

BACKGROUND: The PfEMP1 family of Plasmodium falciparum antigens play a key role in pathogenesis of severe malaria through their insertion into the surface of parasite infected erythrocytes, and adhesion to host cells. Previous studies have suggested that parasites expressing PfEMP1 subclasses group A and DC8, associated with severe malaria, may have a growth advantage in immunologically naïve individuals. However, this idea has not been tested in longitudinal studies. METHODS: Here we assessed expression of the var genes encoding PfEMP1, in parasites sampled from volunteers with varying prior exposure to malaria, following experimental infection by sporozoites (PfSPZ). Using qPCR, we tested for associations between the expression of various var subgroups in surviving parasite populations from each volunteer and 1) the levels of participants' antibodies to infected erythrocytes before challenge infection and 2) the apparent in vivo parasite multiplication rate. RESULTS: We show that 1) expression of var genes encoding for group A and DC8-like PfEMP1 were associated with low levels of antibodies to infected erythrocytes (αIE) before challenge, and 2) expression of a DC8-like CIDRα1.1 domain was associated with higher apparent parasite multiplication rate in a manner that was independent of levels of prior antibodies to infected erythrocytes. CONCLUSIONS: This study provides insight into the role of antibodies to infected erythrocytes surface antigens in the development of naturally acquired immunity and may help explain why specific PfEMP1 variants may be associated with severe malaria. TRIAL REGISTRATION: Pan African Clinical Trial Registry: PACTR201211000433272 . Date of registration: 10th October 2012.

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