1. Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents
- Author
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A. Muralidharan, Koti Reddy Eeda, Rathnasamy Rishikesan, Ranjith P. Karuvalam, Rajeesh Pakkath, Nibin Joy Muthipeedika, Ayyiliath M. Sajith, Karickal R. Haridas, Vaishnav Bhaskar, and Kereyagalahally H. Narasimhamurthy
- Subjects
Antifungal ,010405 organic chemistry ,Chemistry ,medicine.drug_class ,Biological activity ,General Chemistry ,010402 general chemistry ,Antimicrobial ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,Lipophilicity ,Mycobacterium tuberculosis H37Rv ,medicine ,Piperidine - Abstract
A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazole-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a–k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain.
- Published
- 2021