1. [Untitled]
- Author
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Kumiko Ohtsuka, Hiroyuki Ohuchi, Kiyoko Mori, Hirokazu Okamoto, and Hiroaki Ishii
- Subjects
Pharmacology ,Aqueous solution ,Chromatography ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,Prodrug ,Micelle ,Medicinal chemistry ,chemistry.chemical_compound ,Hydrolysis ,Methylprednisolone ,Ionic strength ,Critical micelle concentration ,medicine ,Molecular Medicine ,Pharmacology (medical) ,Acyl group ,Biotechnology ,medicine.drug - Abstract
Purpose. PNU-67590A is a water-soluble micellar prodrug of methyl-prednisolone (MP). The major products of degradation of PNU-67590A are MP by hydrolysis and methylprednisolone 17-suleptanate (17-E) by 21 โ 17 acyl migration. The effect of ionic strength on micelle formation and stability of PNU-67590A in aqueous solution was examined.
- Published
- 1997
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