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Your search keyword '"Klein, Reinhild"' showing total 16 results
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16 results on '"Klein, Reinhild"'

2. TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification

Author

Hoenisch Gravel, Naomi, primary, Nelde, Annika, additional, Bauer, Jens, additional, Mühlenbruch, Lena, additional, Schroeder, Sarah M., additional, Neidert, Marian C., additional, Scheid, Jonas, additional, Lemke, Steffen, additional, Dubbelaar, Marissa L., additional, Wacker, Marcel, additional, Dengler, Anna, additional, Klein, Reinhild, additional, Mauz, Paul-Stefan, additional, Löwenheim, Hubert, additional, Hauri-Hohl, Mathias, additional, Martin, Roland, additional, Hennenlotter, Jörg, additional, Stenzl, Arnulf, additional, Heitmann, Jonas S., additional, Salih, Helmut R., additional, Rammensee, Hans-Georg, additional, and Walz, Juliane S., additional

Published
2023
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3. The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma

Author

Bauer, Jens, primary, Köhler, Natalie, additional, Maringer, Yacine, additional, Bucher, Philip, additional, Bilich, Tatjana, additional, Zwick, Melissa, additional, Dicks, Severin, additional, Nelde, Annika, additional, Dubbelaar, Marissa, additional, Scheid, Jonas, additional, Wacker, Marcel, additional, Heitmann, Jonas S., additional, Schroeder, Sarah, additional, Rieth, Jonas, additional, Denk, Monika, additional, Richter, Marion, additional, Klein, Reinhild, additional, Bonzheim, Irina, additional, Luibrand, Julia, additional, Holzer, Ursula, additional, Ebinger, Martin, additional, Brecht, Ines B., additional, Bitzer, Michael, additional, Boerries, Melanie, additional, Feucht, Judith, additional, Salih, Helmut R., additional, Rammensee, Hans-Georg, additional, Hailfinger, Stephan, additional, and Walz, Juliane S., additional

Published
2022
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4. A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity

Author

Heitmann, Jonas S., primary, Bilich, Tatjana, additional, Tandler, Claudia, additional, Nelde, Annika, additional, Maringer, Yacine, additional, Marconato, Maddalena, additional, Reusch, Julia, additional, Jäger, Simon, additional, Denk, Monika, additional, Richter, Marion, additional, Anton, Leonard, additional, Weber, Lisa Marie, additional, Roerden, Malte, additional, Bauer, Jens, additional, Rieth, Jonas, additional, Wacker, Marcel, additional, Hörber, Sebastian, additional, Peter, Andreas, additional, Meisner, Christoph, additional, Fischer, Imma, additional, Löffler, Markus W., additional, Karbach, Julia, additional, Jäger, Elke, additional, Klein, Reinhild, additional, Rammensee, Hans-Georg, additional, Salih, Helmut R., additional, and Walz, Juliane S., additional

Published
2021
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5. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Author

Nelde, Annika, primary, Bilich, Tatjana, additional, Heitmann, Jonas S., additional, Maringer, Yacine, additional, Salih, Helmut R., additional, Roerden, Malte, additional, Lübke, Maren, additional, Bauer, Jens, additional, Rieth, Jonas, additional, Wacker, Marcel, additional, Peter, Andreas, additional, Hörber, Sebastian, additional, Traenkle, Bjoern, additional, Kaiser, Philipp D., additional, Rothbauer, Ulrich, additional, Becker, Matthias, additional, Junker, Daniel, additional, Krause, Gérard, additional, Strengert, Monika, additional, Schneiderhan-Marra, Nicole, additional, Templin, Markus F., additional, Joos, Thomas O., additional, Kowalewski, Daniel J., additional, Stos-Zweifel, Vlatka, additional, Fehr, Michael, additional, Rabsteyn, Armin, additional, Mirakaj, Valbona, additional, Karbach, Julia, additional, Jäger, Elke, additional, Graf, Michael, additional, Gruber, Lena-Christin, additional, Rachfalski, David, additional, Preuß, Beate, additional, Hagelstein, Ilona, additional, Märklin, Melanie, additional, Bakchoul, Tamam, additional, Gouttefangeas, Cécile, additional, Kohlbacher, Oliver, additional, Klein, Reinhild, additional, Stevanović, Stefan, additional, Rammensee, Hans-Georg, additional, and Walz, Juliane S., additional

Published
2020
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6. Inhibition of effector B cells by ibrutinib in systemic sclerosis

Author

Einhaus, Jakob, primary, Pecher, Ann-Christin, additional, Asteriti, Elisa, additional, Schmid, Hannes, additional, Secker, Kathy-Ann, additional, Duerr-Stoerzer, Silke, additional, Keppeler, Hildegard, additional, Klein, Reinhild, additional, Schneidawind, Corina, additional, Henes, Joerg, additional, and Schneidawind, Dominik, additional

Published
2020
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7. Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis

Author

Pecher, Ann-Christin, primary, Kettemann, Felix, additional, Asteriti, Elisa, additional, Schmid, Hannes, additional, Duerr-Stoerzer, Silke, additional, Keppeler, Hildegard, additional, Henes, Joerg Christoph, additional, Klein, Reinhild, additional, Hinterleitner, Clemens, additional, Secker, Kathy-Ann, additional, Schneidawind, Corina, additional, Kanz, Lothar, additional, and Schneidawind, Dominik, additional

Published
2019
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9. High incidence of antibodies to lens proteins in sera from patients with uveitis

Author

Deshka, Doycheva, Doycheva, Deshka, Beate, Preuss, Preuss, Beate, Reinhild, Klein, Klein, Reinhild, Manfred, Zierhut, and Zierhut, Manfred

Subjects
Pathology, medicine.medical_specialty, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Autoantigens, Uveitis, Lens protein, Cellular and Molecular Neuroscience, medicine, Humans, alpha-Crystallins, Autoantibodies, biology, business.industry, Retinal vasculitis, Incidence, Autoantibody, Episcleritis, medicine.disease, Crystallins, beta-Crystallins, Sensory Systems, Ophthalmology, Immunology, biology.protein, Intermediate uveitis, Antibody, business, Scleritis
Abstract

Uveitis is an intraocular inflammatory disease in which autoimmune reactions have been discussed in playing an important role. Many data in this respect derived from the animal model of "experimental autoimmune uveitis", where several organ-specific autoantigens have been described such as the retinal S-antigen and the interphotoreceptor retinoid-binding protein. However, their diagnostic and pathogenic role in humans has been controversially discussed. In recent studies, the possible relevance of betaB1-crystallin, present in lens and ciliary body, has been outlined. We, therefore, wanted to analyse whether sera from patients with uveitis might contain antibodies to lens proteinsHuman lenses from cadaveric eyes were shock frozen, homogenized, and resuspended. The resulting suspension (human lens protein fraction--HLPF) was analyzed for antigenicity by ELISA and Western blotting with patients' sera. A total of 165 patients with uveitis, 54 patients with scleritis and episcleritis, 56 patients with other eye diseases, and 112 healthy blood donors were studied.Twenty-six (49%) of the 53 patients with anterior uveitis, 17 (32%) of the 53 patients with intermediate uveitis and 7 (22%) of 32 patients with posterior uveitis reacted in the ELISA with the HLPF. Antibodies to lens antigens were detected in one-third of patients with panuveitis and retinal vasculitis. In contrast, only 12% of the healthy blood donors were positive in the ELISA. The number of patients with an autoimmune response to alpha-crystallins in Western blot predominated in all investigated groups.These data indicate that antibodies to lens proteins occur in a high incidence in sera from patients with uveitis. Forty-nine percent of the patients with anterior uveitis and only 12% of healthy controls were positive in the ELISA. In our groups of patients and controls the autoantibodies reacted in the Western blot predominantly with alpha-crystallin. Further studies are required to analyze in more detail the clinical and etiopathogenetic relevance of the antilens antibodies in uveitis.

Published
2006

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