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Background To effectively conserve migratory species, the entire range encompassed by their annual life cycle needs to be considered. Most research on Nearctic-Neotropical migratory birds has focused on the breeding grounds resulting in a general lack of knowledge regarding the wintering and migratory periods. The Canada Warbler (Cardellina canadensis) has declined by 71% from 1970 to 2012, at a rate of 2.9% per year, and is listed as Threatened in Canada. As with most Nearctic-Neotropical migrants, conservation efforts outside the breeding range are limited by a poor understanding of migration routes and the connectivity between specific breeding and wintering populations. Results To determine migratory routes of multiple breeding populations of Canada Warblers, we directly-tracked individuals using light-level geolocators deployed at four sites across the breeding range, spanning approximately 43 degrees in longitude (Alberta, Manitoba and Québec, Canada, and New Hampshire, USA). Twenty-five geolocators with usable data were recovered from three sites and were analyzed using FlightR to determine fall migration routes (n = 18) and individual wintering sites (n = 25). Individuals from all breeding populations took a western fall migration route at the Gulf of Mexico; with 77.8% of birds funnelling into a narrow geographic space along the western side of the Gulf of Mexico (97°W-99°W). We found no evidence for population-specific, parallel migration routes. Most individuals (72%) overwintered in Colombia. The remaining individuals overwintered in Venezuela. Conclusions Our results demonstrate convergence of migratory routes around a migration barrier for individuals originating from widely distributed breeding areas. Further, we suggest the potential importance of habitat around the Gulf of Mexico during migration and Andean forest in Colombia as overwintering habitat for this threatened species. Future research should be directed at understanding how these areas are used by Canada Warblers.

In this work we study the relaxation of the system of strongly correlated electrons, at charge neutrality, when the chemical potential undergoes a local change. This setup is a model for for the X-ray absorbtion edge study in the half-filled graphene. We use holographic duality to describe the system as a classical Schwarzschild black hole in curved 4-dimensional AdS spacetime. Assuming the amplitude of the quench is small, we neglect the backreaction on the geometry. We numerically study the two relaxation regimes: the adiabatic relaxation when the quench is slow and the relaxation governed by the quasinormal modes of the system, when the quench is fast. We confirm the expectation that the scale of separation between the slow and fast regimes is set by the characteristic frequency of the quasinormal modes., Comment: 11 pages, 5 figures; v2: references updated, treatment of scales improved; v3: technical mistakes corrected, treatment of QNMs improved; v4: treatment of evolution equation improved, Bessel analysis added, journal accepted version

We study the charge density response in holographic models with explicit translation symmetry breaking which is relevant in IR. In particular, we focus on Q-lattices and the Bianchy VII helix. We show that the hydrodynamic sound mode is removed from the spectrum due to the strong momentum relaxation and therefore, the usual treatment of the plasmon as Coulomb-dressed zero sound does not apply. Furthermore, the dominant coherent modes in the longitudinal channel, which control the neutral density-density correlator, are diffusive. We show these modes are strongly suppressed when the boundary Coulomb interaction is turned on. This renders the low frequency charge density response spectrum completely incoherent and featureless. At intermediate frequencies, we observe a broad feature -- the fake plasmon -- in the dressed correlator, which could be confused with an overdamped plasmon. However, its gap is set by the scale of translation symmetry breaking instead of the plasma frequency. This broad feature originates from the non-hydrodynamic sector of the holographic spectrum, and therefore, its behaviour, typical of strongly correlated quantum critical systems with holographic duals, deviates from the standard Fermi-liquid paradigm., Published version, fake plasmons in insulating Q-lattice and Helix

The mechanisms that lead to the altered uterine gene expression in women with endometriosis are poorly understood. Are these changes in gene expression mediated by proximity to endometriotic lesions or is endometriosis a systemic disease where the effect is independent of proximity to the uterus? To answer this question, we created endometriosis in a murine model either in the peritoneal cavity (proximal) or at a subcutaneous remote site (distal). The expression of several genes that are involved in endometrial receptivity (homeobox A10 [Hoxa10], homeobox A11 [Hoxa11], insulin-like growth factor binding protein 1 [Igfbp1], Kruppel-like factor 9 [Klf9], and progesterone receptor [Pgr]) was measured in the eutopic endometrium of mice transplanted with either proximal or distal endometriosis lesions. Decreased expression of Hoxa10, Igfbp1, Klf9, and total Pgr genes was observed in the eutopic endometrium of mice with peritoneal endometriosis. In the mice with distal lesions, overall expression of these genes was not as severely affected, however, Igfbp1 expression was similarly decreased and the effect on Pgr was more pronounced. Endometriosis does have a systemic effect that varies with distance to the end organ. However, even remote disease selectively and profoundly alters the expression of genes such as Pgr. This is the first controlled experiment demonstrating that endometriosis is not simply a local peritoneal disease. Selective alteration of genes critical for endometrial receptivity and endometriosis propagation may be systemic. Similarly, systemic effects of endometriosis on other organs may also be responsible for the widespread manifestations of the disease.

Endometriosis has been associated with aberrant methylation in the eutopic endometrium. Using a genome-wide methylation array, we identified differentially methylated genes in the endometrium from women with or without endometriosis. One hundred and twenty genes were significantly altered by >1.5-fold. In all, 59 genes were significantly hypermethylated and 61 genes were significantly hypomethylated. Changes in gene expression associated with the altered methylation status were validated using quantitative real-time polymerase chain reaction. A limited number of candidate genes are selectively methylated in the endometrium of women with endometriosis. Several genes not previously associated with endometriosis are aberrantly methylated and expressed. These include O-6-methylguanine-DNA methyltransferase, dual specificity phosphatase 22, cell division cycle associated 2, inhibitor of DNA binding 2, retinoblastoma binding protein 7, bone morphogenetic protein receptor, type 1B, tumor necrosis factor receptor 1B, zinc finger protein receptor 681, immunoglobulin superfamily, member 21, and tumor protein 73. Aberrant DNA methylation and gene expression of these genes may contribute to abnormal regulation of endometrial cell proliferation and function in women.

A comparative evaluation is made of the thermal stability and radiation resistance of VVER-1000 vessel materials and new compositions of 15Kh2MFA-A steel of modifications A and B with low nickel content 0.2–0.8%. For this, complex structural studies and mechanical tests were performed on samples of materials in the following states: the initial state; after isothermal soaking at 330°C up to 7500 h, provoking grainboundary embrittlement of heat treatment in the interval of maximum development of reversible temper brittleness; and, accelerated irradiation to fluence corresponding to the service life of a reactor vessel to 60 or more years. The advantages of reducing the nickel content of steel with the new compositions, which is expressed in their improved radiation resistance and thermal stability, are shown.

Tributyltin (TBT) is a common environmental contaminant used as the active ingredient in many products such as a biocides, wood preservatives, disinfecting agents, and antifouling paints. The TBT is a known endocrine disruptor. The aim of the current investigation was to determine the toxicity of TBT in the reproductive tract of adult male Syrian hamsters and to ascertain whether this compound results in untoward effects on apolipoprotein E (ApoE), a lipoprotein central to sex hormone synthesis. The TBT was administered orally to male Syrian hamsters at doses of 50, 100, and 150 ppm/kg for 65 days of treatment. We determined body weight, testis weight, sperm count, sperm morphology, testis histology, ApoE expression, serum lipid profile, testosterone level, follicle-stimulating hormone receptor (FSHR), and steroid hormone receptor expression compared to vehicle-treated controls. High doses of TBT significantly affected each of these parameters in Syrian hamsters. Weight and morphology of the testis were altered as well as sperm production. Real-time reverse-transcriptase polymerase chain reaction analysis revealed that expression of ApoE messenger RNA was upregulated in testes from TBT-treated groups compared with controls while the expression of androgen receptor, FSHR, estrogen receptor α (ESR1), and estrogen receptor β (ESR2) was decreased. We posit that exposure to TBT hinders intracellular cholesterol transport resulting in abnormal sex steroid biosynthesis and subsequent spermatogenic defects. Importantly, these effects may account for the decreased level of normal sperm observed in hamsters exposed to TBT.

The results of investigations of the structure and uniformity of the Y2O3 distribution in reactor EP-450 (12Kh13M2BFR) dispersion-strengthened ferrite-martensite steel are presented. It is found that electricpulse plasma sintering of powders of matrix steel and dispersion-strengthening oxides can be one of the methods for fabricating reactor steel. Optical and transmission electron microscopy investigations show that quite uniform grains are formed in a compact and no appreciable porosity is seen visually. Steel with structure in the form of flakes with mechanical alloying time 15 h possesses the best chemical composition with quite uniform Y2O3 distribution.

The human endometrium follows a predictable pattern of development during the proliferative phase. Endometrial thickness increases after day 3 and then plateaus at days 9 to 10 of the menstrual cycle despite continued high serum levels of estrogen. We hypothesized that proliferative phase endometrium undergoes more than simple estrogen responsive growth, rather it is characterized by complex time-dependent functional activities reflected in differential gene expression. Nine endometrial RNA samples from healthy participants were subjected to microarray analysis and 15 samples were used for quantitative real-time polymerase chain reaction. The samples were divided into early, mid, or late proliferative phase. The early proliferative phase showed higher expression of genes including transforming growth factor β2, chemokine (C-C motif) ligand 18 (CCL18), and metallothionein 2A. The mid-proliferative phase was characterized by higher expression of heat shock proteins and implantation-associated genes including Indian hedgehog, secreted frizzled protein 4, and progesterone receptor. In the late proliferative phase, we identified increased angiotensin II receptor, type 2 and large decrease in expression of genes related to natural killer (NK) cell function. We demonstrate a unique gene expression signature at distinct time points within the proliferative phase. The early proliferative phase is characterized by tissue remodeling, angiogenesis, and modulation of inflammation; the mid-proliferative phase is characterized not only by proliferation in response to estrogens but also marks the onset of expression of genes required for endometrial receptivity and a dampening of estrogen responsiveness. In the late proliferative phase, changes in immune function and NK cells predominate. The proliferative phase is not simply a uniform period of estrogen responsive endometrial growth that can be considered as a single experimental time point when evaluating endometrial development; rather the proliferative phase is complex with differing functions and patterns of gene expression.

The ferromagnetic Ising model without external field on an infinite Lorentzian triangulation sampled from the uniform distribution is considered. We prove uniqueness of the Gibbs measure in the high temperature region and coexistence of at least two Gibbs measures at low temperature. The proofs are based on the disagreement percolation method and on a variant of the Peierls contour method. The critical temperature is shown to be constant a.s.

Factor VII binds trans-membrane tissue factor to initiate hemostasis by forming thrombin. Tissue factor expression is enhanced in decidualized human endometrial stromal cells during the luteal phase. Long-term progestin only contraceptives elicit: 1) abnormal uterine bleeding from fragile vessels at focal bleeding sites, 2) paradoxically high tissue factor expression at bleeding sites; 3) reduced endometrial blood flow promoting local hypoxia and enhancing reactive oxygen species levels; and 4) aberrant angiogenesis reflecting increased stromal cell-expressed vascular endothelial growth factor, decreased Angiopoietin-1 and increased endothelial cell-expressed Angiopoietin-2. Aberrantly high local vascular permeability enhances circulating factor VII to decidualized stromal cell-expressed tissue factor to generate excess thrombin. Hypoxia-thrombin interactions augment expression of vascular endothelial growth factor and interleukin-8 by stromal cells. Thrombin, vascular endothelial growth factor and interlerukin-8 synergis-tically augment angiogenesis in a milieu of reactive oxygen species-induced endothelial cell activation. The resulting enhanced vessel fragility promotes abnormal uterine bleeding.

Simple stochastic models for phylogenetic trees on species have been well studied. But much paleontology data concerns time series or trees on higher-order taxa, and any broad picture of relationships between extant groups requires use of higher-order taxa. A coherent model for trees on (say) genera should involve both a species-level model and a model for the classification scheme by which species are assigned to genera. We present a general framework for such models, and describe three alternate classification schemes. Combining with the species-level model of Aldous and Popovic (Adv Appl Probab 37:1094-1115, 2005), one gets models for higher-order trees, and we initiate analytic study of such models. In particular we derive formulas for the lifetime of genera, for the distribution of number of species per genus, and for the offspring structure of the tree on genera.

Corrosion-electrochemical behavior of tube stills of a 18–10 steel combined with the case component members from plain carbon steels in circulating water of petroleum refineries is investigated. It was ascertained that the reasons for accelerated corrosion of tube panels, as well as origination and development of pitting corrosion perforating the bundle tubes, are as follows: a high content of chlorine ions in the circulating water and its periodical acidification; the contact between the two highly different steels accepted when manufacturing the coolers; and precipitation of corrosion products on the inner surface of tubes during shutdowns of the process.

Endometrial gene expression can be regulated exquisitely by cyclical changes in ovarian steroid concentration. Although hormonal induction of many of these genes occurs through classical steroid response elements, other endometrial genes respond to steroids at the transcriptional level but do not contain steroid response elements. A family of transcription factors, namely the Sp1 family, has now been implicated as important mediators of steroid hormone action in the endometrium during the periimplantation and postimplantation periods. This review summarizes the current literature regarding the role of the Sp1 protein family in regulating the response to steroid hormones of genes for tissue factor, plasminogen activator inhibitor-1, insulin-like growth factor binding protein-1, uteroglobin, and uteroferrin in the endometrium.

We suggest the following methods for the corrosion protection of equipment under the conditions of its long-term service: comprehensive monitoring of equipment accompanied by its reconditioning (suppression of the causes of local corrosion) and electrochemical or complex electrochemical inhibitor protection. We also determined service conditions under which it is possible to use inexpensive carbos steels and cast irons.

The investigations of the properties of ultradispersed systems---a new class of materials which contain a microscopic composition of particles less than 0.1 micrometers in size---makes it possible to solve a number of problems which cannot be solved by traditional means. In contrast to the well-known Bormann effect in crystalline samples, when the Wolf-Bragg relation between the wavelength and the interplanar distance is satisfied, x-ray transmission increases, and in the case where ultradispersed systems are irradiated, both an anomalous increase and decrease of x-ray transmission are observed. In this paper, we present some experimental results that indicate an anomalous interaction of the x-rays with ultradispersed systems and the prospects for practical applications of such materials are discussed.

The effect of methyl bromide and P fertilization on the growth of four agricultural crops in a P-sorbing soil was studied. Harvestable yields and P tissue content were significantly lower for celery (Apium graveolens L.), onion (Allium cepa L.) and pepper (Capsicum annuum L.) following fumigation. P fertilization up to 330 kg P ha−1 as superphosphate could not reverse this effect. The highest P fertilizer treatment had 25.4 μg g−1 bicarbonate-extractable P and 0.26 μg g−1 water extractable P. This P level produced acceptable commercial yields when vesicular arbuscular mycorrhizae (VAM) were present (non-fumigated) and indicate the importance of the VAM association for these crops. In contrast, melon (Cucumis melo L.) growth was slightly greater following soil fumigation at all P fertilization rates. These findings indicate that crop VAM dependence and efficacy of VAM biotypes must be considered as essential components for P fertilization recommendations on fumigated P-sorbing soils.

Background Neutrophils infiltrate the endometrium pre-menstrually and after long-term progestin only-contraceptive (LTPOC) treatment. Trafficking of neutrophils involves endothelial cell-expressed intercellular adhesion molecule (ICAM-1). Previous studies observed that ICAM-1 was immunolocalized to the endothelium of endometrial specimens across the menstrual cycle, but disagreed as to whether extra-endothelial cell types express ICAM-1 and whether ICAM-1 expression varies across the menstrual cycle. Methods Endometrial biopsies were obtained from women across the menstrual cycle and from those on LTPOC treatment (either Mirena or Norplant). The biopsies were formalin-fixed and paraffin-embedded with subsequent immunohistochemical staining for ICAM-1. Results The current study found prominent ICAM-1 staining in the endometrial endothelium that was of equivalent intensity in different blood vessel types irrespective of the steroidal or inflammatory endometrial milieu across the menstrual cycle and during LTPOC therapy. Unlike the endothelial cells, the glands were negative and the stromal cells were weakly positive for ICAM immunostaining. Conclusion The results of the current study suggest that altered expression of ICAM-1 by endothelial cells does not account for the influx of neutrophils into the premenstrual and LTPOC-derived endometrium. Such neutrophil infiltration may depend on altered expression of neutrophil chemoattractants.