1. Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenström macroglobulinemia and IgM monoclonal gammopathy
- Author
-
Serena Yen Shan Tan, Sharina Belani, Leonid Yankulin, Richard K. Sibley, John P. Higgins, Tracy Jonelis, Sumie Iwasaki, Neeraja Kambham, and Megan L. Troxell
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Thrombotic microangiopathy ,Glomerulonephritis, Membranoproliferative ,Biopsy ,Kidney Glomerulus ,Paraproteinemias ,030232 urology & nephrology ,Fluorescent Antibody Technique ,030204 cardiovascular system & hematology ,Nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Cryoglobulin ,immune system diseases ,hemic and lymphatic diseases ,Membranoproliferative glomerulonephritis ,medicine ,Humans ,Aged ,Thrombotic Microangiopathies ,business.industry ,Waldenstrom macroglobulinemia ,Middle Aged ,medicine.disease ,Capillaries ,IgM Monoclonal Gammopathy ,Microscopy, Electron ,Immunoglobulin M ,Renal pathology ,Nephrology ,Female ,Waldenstrom Macroglobulinemia ,business ,Biomarkers ,Monoclonal Immunoglobulin Deposition Disease - Abstract
IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.
- Published
- 2018