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47 results on '"Li, Nuo"'

25. A cortico-cerebellar loop for motor planning

Author

Gao, Zhenyu, primary, Davis, Courtney, additional, Thomas, Alyse M., additional, Economo, Michael N., additional, Abrego, Amada M., additional, Svoboda, Karel, additional, De Zeeuw, Chris I., additional, and Li, Nuo, additional

Published
2018
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26. Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson’s disease patients

Author

Dan Wang, Zhi Li, Li-Nuo Nie, Dong-Li Hu, Xin-Xiang Yan, Lan Fan, Hong-Hao Zhou, Wei Ji, Bei-Sha Tang, Ying-Zi Liu, Dong-Sheng Ouyang, and Jie Liu

Subjects
Male, medicine.medical_specialty, Parkinson's disease, Genotype, Gastroenterology, Dopamine agonist, Drug Administration Schedule, Central nervous system disease, Pramipexole, Asian People, Gene Frequency, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Pharmacology (medical), Benzothiazoles, Allele, Allele frequency, Alleles, Aged, Pharmacology, Polymorphism, Genetic, Receptors, Dopamine D2, business.industry, Therapeutic effect, Receptors, Dopamine D3, Parkinson Disease, DNA, General Medicine, Middle Aged, medicine.disease, Treatment Outcome, Endocrinology, Dopamine Agonists, Female, business, medicine.drug
Abstract

To evaluate the impact of the DRD2 TaqIA and DRD3 Ser9Gly polymorphisms on the efficacy of pramipexole in treating patients with Parkinson’s disease (PD). Thirty patients with PD prospectively received pramipexole 0.25 mg three times daily for 2 months. Unified Parkinson Disease Rating Scale (UPDRS) assessments were conducted at baseline and 2 months after treatment initiation. Improvement by 20% or more in the total score on the UPDRS was considered to indicate responsiveness. The PCR–restriction fragment length polymorphism analysis was used to analyze the DRD2 Taq1A and DRD3 Ser9Gly genotype. The DRD2 Taq1A allele frequencies were A141.7 (A1) and 58.3% (A2), and the DRD3 Ser9Gly allele frequencies were 68.3 (Ser) and 31.7% (Gly). When the subjects were grouped by the DRD3 Ser9Gly polymorphism, the response rates for pramipexole treatment were significantly higher in the Ser/Ser group (60%) than in the group containing the Gly allele (13%). There was a significant association between the DRD3 Ser9Gly polymorphism and response rate to pramipexole in PD patients (P = 0.024). When the subjects were grouped by the DRD2 Taq1A polymorphism, there were no significant differences among the three Taq1A genotypes. DRD3 Ser9Gly polymorphisms are significantly associated with the therapeutic efficacy of pramipexole in Chinese patients with PD. A large-scale and multi-dose group study in patients with PD is necessary for evaluating the impact of the genetic polymorphisms of the dopamine receptor on the therapeutic effects of pramipexole.

Published
2009

37. The metabolism of the ground water contaminant 2-hydroxybiphenyl under sulfate-reducing conditions

Author

Shi Liu, Li-nuo Liang, and Joseph M. Suflita

Subjects
chemistry.chemical_classification, Chemistry, Substrate (chemistry), General Medicine, Electron acceptor, Biodegradation, Applied Microbiology and Biotechnology, Microbiology, Anoxic waters, chemistry.chemical_compound, Nitrate, Biotransformation, Biochemistry, Environmental chemistry, Carbon dioxide, Sulfate
Abstract

The metabolic fate of 2-hydroxybiphenyl under different anaerobic conditions was tested with sediment slurries and enrichment cultures obtained from a shallow anoxic aquifer. 2-Hydroxybiphenyl was depleted in aquifer slurries over the course of incubation, but substrate loss in methanogenic slurries was not significantly different from either filter-sterilized or autoclaved controls. In contrast, the rate of substrate removal was significantly higher in non-sterile, sulfate-reducing aquifer slurries relative to abiotic control incubations. A 2-hydroxybiphenyl-degrading enrichment was established that was inhibited by molybdate but not by bromoethane-sulfonic acid. For every mole of substrate consumed by the bacterial consortium, 6.1±0.2 moles of sulfate were depleted from the enrichment medium. This represents about 87% of the theoretical amount of sulfate consumed and suggests that the 2-hydroxybiphenyl was largely mineralized. Oxygen, nitrate, or carbon dioxide could not replace sulfate as a terminal electron acceptor for the enrichment. Other hydroxybiphenyl isomers were not metabolized by these cultures. This study shows that aromatic substrates with multiple ring systems can undergo biotransformation by anaerobic microorganisms under some ecological conditions.

Published
1991

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