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Start Over Author "Li, Qingmei" Publisher springer science and business media llc
19 results on '"Li, Qingmei"'

11. Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods

Author

Wenying Wang, Xie Juan, Bing Qi, Li Qingmei, Di Zhang, Xiaoqing Wu, Yong Liu, Feng Kong, Yinghui Ling, Xinyan Cao, Wenyong Li, Fengrui Wu, Rong Wang, Wu Qiaoqin, Zhang Shengnan, Xin Jing, Jiang Xin, and Xiaorong Zhang

Subjects
0301 basic medicine, lcsh:QH426-470, lcsh:Biotechnology, Ovary, Luteal Phase, Luteal phase, Biology, Oogenesis, Genome, Follicular phase, 03 medical and health sciences, lcsh:TP248.13-248.65, Genetics, medicine, Animals, Genome-wide, KEGG, Goat ovary, Gene, Progesterone, Sequence Analysis, RNA, Goats, Oocyte, LncRNA, Cell biology, lcsh:Genetics, 030104 developmental biology, medicine.anatomical_structure, RNA, Female, RNA, Long Noncoding, Transcriptome, Research Article, Genome-Wide Association Study, Biotechnology
Abstract

Background The goat is an important farm animal. Reproduction is an important process of goat farming. The ovary is the most important reproductive organ for goats. In recent years, an increasing number of long non-coding RNAs (lncRNAs) have been implicated in the regulation of mammal reproduction. However, there are few studies on the function of lncRNAs in reproduction, particularly lncRNAs in the ovary. Results The sequencing of goat ovaries generated 1,122,014,112 clean reads, and 4926 lncRNAs and 1454 TUCPs (transcripts of uncertain coding potential) were identified for further analysis by using the coding potential analysis software, CNCI, CPC and Pfam-sca. There were 115 /22 differential lncRNAs /TUCPs transcripts between the ovaries of the luteal phase and the follicular phase. We predicted the related genes of lncRNA /TUCP based on co-expression and co-localization methods. In total, 2584 /904 genes were predicted by co-expression, and 326/73 genes were predicted by co-localization. The functions of these genes were further analyzed with GO and KEGG analysis. The results showed that lncRNAs /TUCPs, which are highly expressed in goat ovaries in the luteal phase, are mainly associated with the synthesis of progesterone, and we filtered the lncRNAs /TUCPs, such as XR_001918177.1 and TUCP_001362, which may regulate the synthesis of progesterone; lncRNAs /TUCPs, which are highly expressed in goat ovaries in the follicular phase, are mainly associated with oogenesis and the maturation of oocytes, and we filtered the lncRNAs /TUCPs that may regulate the oogenesis and maturation of oocyte, such as XR_001917388.1 and TUCP_000849. Conclusion The present study provided the genome expression profile of lncRNAs /TUCPs in goat ovaries at different estrus periods and filtered the potential lncRNAs /TUCPs associated with goat reproduction. These results are helpful to further study the molecular mechanisms of goat reproduction. Electronic supplementary material The online version of this article (10.1186/s12864-018-5268-7) contains supplementary material, which is available to authorized users.

Published
2018

12. Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods

Author

Liu, Yong, primary, Qi, Bing, additional, Xie, Juan, additional, Wu, Xiaoqing, additional, Ling, Yinghui, additional, Cao, Xinyan, additional, Kong, Feng, additional, Xin, Jing, additional, Jiang, Xin, additional, Wu, Qiaoqin, additional, Wang, Wenying, additional, Li, Qingmei, additional, Zhang, Shengnan, additional, Wu, Fengrui, additional, Zhang, Di, additional, Wang, Rong, additional, Zhang, Xiaorong, additional, and Li, Wenyong, additional

Published
2018
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