Search

Your search keyword '"Liu, Ruilin"' showing total 18 results
Start Over Author "Liu, Ruilin" Publisher springer science and business media llc
18 results on '"Liu, Ruilin"'

2. Supramolecular self-assembly synthesis of hemoglobin-like amorphous CoP@N, P-doped carbon composites enable ultralong stable cycling under high-current density for lithium-ion battery anodes

Author

Mu, Qin, primary, Liu, Ruilin, additional, Kimura, Hideo, additional, Li, Jincheng, additional, Jiang, Huiyu, additional, Zhang, Xiaoyu, additional, Yu, Zhipeng, additional, Sun, Xueqin, additional, Algadi, Hassan, additional, Guo, Zhanhu, additional, Du, Wei, additional, and Hou, Chuanxin, additional

Published
2022
Full Text
View/download PDF

6. PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer

Author

Liu Ruilin, Wang Zhichao, Yuzheng He, Wang Baohua, Shi Yantao, Helin Zhang, and Shujun Li

Subjects
0301 basic medicine, Cell viability, Lung Neoplasms, Ubiquitin-Protein Ligases, Down-Regulation, Tetrazolium Salts, Antineoplastic Agents, Biology, 03 medical and health sciences, 0302 clinical medicine, Non-small cell lung cancer, Western blot, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Animals, Humans, MTT assay, Viability assay, Coloring Agents, Lung cancer, lcsh:QH301-705.5, medicine.diagnostic_test, Cell growth, miR-365a-5p, medicine.disease, PELI3, Disease Models, Animal, MicroRNAs, Thiazoles, 030104 developmental biology, lcsh:Biology (General), 030220 oncology & carcinogenesis, Cancer research, Immunohistochemistry, Ectopic expression, Research Article
Abstract

Background: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSCLC). Methods: PELI3 expression in NSCLC tissue samples was determined by the immunohistochemistry. The transcripts abundance of PELI3 was measured with real-time PCR. The protein intensity was analyzed by western blot. The overall survival in respect to PELI3 or miR-365a-5p expression was plotted by the Kaplan–Meier's analysis. Cell growth was determined by colony formation assay. Cell viability was measured by MTT assay. The migration and invasion were evaluated by wound healing and transwell assay respectively. The regulatory effect of miR-365a-5p on PELI3 was interrogated with luciferase reporter assay. The direct binding between miR-365a-5p and PELI3 was analyzed by pulldown assay. Results: PELI3 was aberrantly up-regulated in NSCLC both in vivo and in vitro. High level of PELI3 associated with poor prognosis. PELI3-deficiency significantly inhibited cell viability, colony formation, migration and invasion. We further identified that miR-365a-5p negatively regulated PELI3 in this disease. Ectopic expression of miR-365a-5p in both A549 and H1299 phenocopied PELI3-deficiency. Meanwhile, PELI3-silencing significantly abolished the pro-tumoral effect elicited by miR-365a-5p inhibition. Conclusion: Our results highlighted the importance of dysregulated miR-365a-5p-PELI3 signaling axis in NSCLC.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results