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2. CACNA1C risk variant is associated with increased amygdala volume

Author

Sonya Foley, Xavier Caseras, David Edmund Johannes Linden, Thomas M. Lancaster, and Katherine E. Tansey

Subjects
Male, Psychosis, Calcium Channels, L-Type, Single-nucleotide polymorphism, Amygdala, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Pharmacology (medical), Bipolar disorder, Alleles, Genetic Association Studies, Biological Psychiatry, Genetic association, Genetics, Organ Size, General Medicine, medicine.disease, Phenotype, 030227 psychiatry, Psychiatry and Mental health, medicine.anatomical_structure, Psychotic Disorders, Schizophrenia, Female, Psychology, Neuroscience, 030217 neurology & neurosurgery
Abstract

Genome-wide association studies suggest that genetic variation within L-type calcium channel subunits confer risk to psychosis. The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology. Amongst others, it has been implicated in alterations in amygdala structure and function. In the present study, we show that the risk allele (A) is associated with increased amygdala volume in healthy individuals (n = 258). This observation reinforces a hypothesis that genetic variation may confer risk to psychosis via alterations in limbic structures. Further study of CACNA1C using intermediate phenotypes for psychosis will determine the mechanisms by which variation in this gene confers risk.

Published
2015
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3. Towards online patient imaging during helical radiotherapy

Author

Liting Yu, Craig M. Lancaster, Christopher Poole, and Steven Sylvander

Subjects
Engineering, Photon, Phantoms, Imaging, business.industry, Biomedical Engineering, Biophysics, General Physics and Astronomy, Object (computer science), Interference (wave propagation), Radiotherapy, Computer-Assisted, Imaging phantom, Humans, Radiology, Nuclear Medicine and imaging, Computer vision, Artificial intelligence, Sensitivity (control systems), Tomography, Tomography, X-Ray Computed, business, Error detection and correction, Algorithms, Image-guided radiation therapy
Abstract

Exit-detector data from helical radiation therapy have been studied extensively for delivery verification and dose reconstruction. Since the same radiation source is used for both imaging and treatment, this work investigates the possibility of utilising exit-detector raw data for imaging purposes. This gives rise to potential clinical applications such as retrospective daily setup verification and inter-fractional setup error detection. The exit-detector raw data were acquired and independently analysed using Python programming language. The raw data were extracted from the treatment machine's onboard computer, and converted into 2D array files. The contours of objects (phantom or patient) were acquired by applying a logarithmic function to the ratio of two sinograms, one with the object in the beam and one without. The setup variation between any two treatment deliveries can be detected by applying the same function to their corresponding exit-detector sinograms. The contour of the object was well defined by the secondary radiation from the treatment beam and validated with the imaging beam, although no internal structures were discernible due to the interference from the primary radiation. The sensitivity of the setup variation detection was down to 2 mm, which was mainly limited by the resolution of the exit-detector itself. The exit-detector data from treatment procedures contain valuable photon exit fluence maps which can be utilised for contour definition and verification of patient alignment without reconstruction.

Published
2015
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4. The influence of the dwell time deviation constraint (DTDC) parameter on dosimetry with IPSA optimisation for HDR prostate brachytherapy

Author

Natasha J. Mason, Vanessa Panettieri, Rick Franich, Jeremy Millar, Ryan L. Smith, and Craig M. Lancaster

Subjects
Male, Dose-volume histogram, medicine.medical_treatment, Brachytherapy, Biomedical Engineering, Biophysics, Modulation index, General Physics and Astronomy, Cohort Studies, medicine, Humans, Dosimetry, Radiology, Nuclear Medicine and imaging, Radiation treatment planning, Simulation, Mathematics, business.industry, Radiotherapy Planning, Computer-Assisted, Prostatic Neoplasms, Radiotherapy Dosage, Dwell time, Dose rate, Nuclear medicine, business, Prostate brachytherapy
Abstract

To investigate how the dwell time deviation constraint (DTDC) parameter, applied to inverse planning by simulated annealing (IPSA) optimisation limits large dwell times from occurring in each catheter and to characterise the effect on the resulting dosimetry for prostate high dose rate (HDR) brachytherapy treatment plans. An unconstrained IPSA optimised treatment plan, using the Oncentra Brachytherapy treatment planning system (version 4.3, Nucletron an Elekta company, Elekta AB, Stockholm, Sweden), was generated for 20 consecutive HDR prostate brachytherapy patients, with the DTDC set to zero. Successive constrained optimisation plans were also created for each patient by increasing the DTDC parameter by 0.2, up to a maximum value of 1.0. We defined a "plan modulation index", to characterise the change of dwell time modulation as the DTDC parameter was increased. We calculated the dose volume histogram indices for the PTV (D90, V100, V150, V200%) and urethra (D10%) to characterise the effect on the resulting dosimetry. The average PTV D90% decreases as the DTDC is applied, on average by only 1.5 %, for a DTDC = 0.4. The measures of high dose regions in the PTV, V150 and V200%, increase on average by less than 5 and 2 % respectively. The net effect of DTDC on the modulation of dwell times has been characterised by the introduction of the plan modulation index. DTDC applied during IPSA optimisation of HDR prostate brachytherapy plans reduce the occurrence of large isolated dwell times within individual catheters. The mechanism by which DTDC works has been described and its effect on the modulation of dwell times has been characterised. The authors recommend using a DTDC parameter no greater than 0.4 to obtain a plan with dwell time modulation comparable to a geometric optimised plan. This yielded on average a 1.5 % decrease in PTV coverage and an acceptable increase in V150%, without compromising the urethral dose.

Published
2014
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5. Type-zero copper proteins

Author

John H. Richards, Keiko Yokoyama, Serena DeBeer George, Harry B. Gray, and Kyle M. Lancaster

Subjects
Copper protein, General Chemical Engineering, Analytical chemistry, chemistry.chemical_element, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Article, Spectral line, Absorption, law.invention, Electron Transport, Electron transfer, Azurin, law, Electrochemistry, Electron paramagnetic resonance, Hyperfine structure, Binding Sites, 010405 organic chemistry, Electron Spin Resonance Spectroscopy, General Chemistry, Copper, 0104 chemical sciences, Oxygen, Crystallography, chemistry, Absorption band, Pseudomonas aeruginosa, Absorption (chemistry)
Abstract

Many proteins contain copper in a range of coordination environments, where it has various biological roles, such as transferring electrons or activating dioxygen. These copper sites can be classified by their function or spectroscopic properties. Those with a single copper atom are either type 1, with an intense absorption band near 600 nm, or type 2, with weak absorption in the visible region. We have built a novel copper(ii) binding site within structurally modified Pseudomonas aeruginosa azurins that does not resemble either existing type, which we therefore call 'type zero'. X-ray crystallographic analysis shows that these sites adopt distorted tetrahedral geometries, with an unusually short Cu–O (G45 carbonyl) bond. Relatively weak absorption near 800 nm and narrow parallel hyperfine splittings in electron paramagnetic resonance spectra are the spectroscopic signatures of type zero copper. Cyclic voltammetric experiments demonstrate that the electron transfer reactivities of type-zero azurins are enhanced relative to that of the corresponding type 2 (C112D) protein.

Published
2009
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6. Biosequence Similarity Search on the Mercury System

Author

Praveen Krishnamurthy, Kwame Gyang, Arpith C. Jacob, Roger D. Chamberlain, Joseph M. Lancaster, Jeremy Buhler, and Mark A. Franklin

Subjects
Computer science, Nearest neighbor search, Biosequence, computer.software_genre, Article, DNA sequencing, Search algorithm, Signal Processing, Data mining, Electrical and Electronic Engineering, Mercury (programming language), computer, Information Systems, computer.programming_language
Abstract

Biosequence similarity search is an important application in modern molecular biology. Search algorithms aim to identify sets of sequences whose extensional similarity suggests a common evolutionary origin or function. The most widely used similarity search tool for biosequences is BLAST, a program designed to compare query sequences to a database. Here, we present the design of BLASTN, the version of BLAST that searches DNA sequences, on the Mercury system, an architecture that supports high-volume, high-throughput data movement off a data store and into reconfigurable hardware. An important component of application deployment on the Mercury system is the functional decomposition of the application onto both the reconfigurable hardware and the traditional processor. Both the Mercury BLASTN application design and its performance analysis are described.

Published
2007
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7. Genomic signatures to guide the use of chemotherapeutics

Author

David H. Harpole, Holly K. Dressman, Robyn Sayer, Michael J. Kelley, Andrew Berchuck, Rebecca P. Petersen, Johnathan M. Lancaster, Joseph R. Nevins, Anil Potti, Janiel M. Cragun, Gina Chan, Phillip G. Febbo, Richard F. Riedel, Jeffrey R. Marks, Hope Cottrill, Andrea H. Bild, and Geoffrey S. Ginsburg

Subjects
Drug, Extramural, media_common.quotation_subject, Affymetrix microarray, General Medicine, Chemotherapeutic drugs, Available drugs, Biology, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Chemotherapy response, Pharmacogenetics, media_common
Abstract

Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of cell line studies. We further show that many of these signatures can accurately predict clinical response in individuals treated with these drugs. Notably, signatures developed to predict response to individual agents, when combined, could also predict response to multidrug regimens. Finally, we integrated the chemotherapy response signatures with signatures of oncogenic pathway deregulation to identify new therapeutic strategies that make use of all available drugs. The development of gene expression profiles that can predict response to commonly used cytotoxic agents provides opportunities to better use these drugs, including using them in combination with existing targeted therapies.

Published
2006
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8. Oncogenic pathway signatures in human cancers as a guide to targeted therapies

Author

Johnathan M. Lancaster, Joseph R. Nevins, Quanli Wang, David H. Harpole, Anil Potti, Andrew Berchuck, Mike West, Dawn Chasse, John A. Olson, Holly K. Dressman, Andrea Bild, Mary Beth Joshi, Jeffrey T. Chang, Guang Yao, and Jeffrey R. Marks

Subjects
Regulation of gene expression, Multidisciplinary, Cancer, Computational biology, Biology, Cell fate determination, medicine.disease_cause, Bioinformatics, medicine.disease, Phenotype, Gene expression profiling, medicine, Signal transduction, DNA microarray, Carcinogenesis
Abstract

The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell signalling pathways central to the control of cell growth and cell fate. The ability to define cancer subtypes, recurrence of disease and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Various studies have also demonstrated the potential for using gene expression profiles for the analysis of oncogenic pathways. Here we show that gene expression signatures can be identified that reflect the activation status of several oncogenic pathways. When evaluated in several large collections of human cancers, these gene expression signatures identify patterns of pathway deregulation in tumours and clinically relevant associations with disease outcomes. Combining signature-based predictions across several pathways identifies coordinated patterns of pathway deregulation that distinguish between specific cancers and tumour subtypes. Clustering tumours based on pathway signatures further defines prognosis in respective patient subsets, demonstrating that patterns of oncogenic pathway deregulation underlie the development of the oncogenic phenotype and reflect the biology and outcome of specific cancers. Predictions of pathway deregulation in cancer cell lines are also shown to predict the sensitivity to therapeutic agents that target components of the pathway. Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics.

Published
2005
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9. Effects of beta-adrenoceptor blockade on components of human decision-making

Author

M. Lancaster, J. Wakeley, Rd D. Rogers, and Zubin Bhagwagar

Subjects
Adult, Male, Cingulate cortex, medicine.medical_specialty, Adolescent, Punishment (psychology), Adrenergic beta-Antagonists, Decision Making, Propranolol, Audiology, Placebo, Arousal, Double-Blind Method, Receptors, Adrenergic, beta, medicine, Humans, Pharmacology, Analysis of Variance, Chi-Square Distribution, Middle Aged, Mood, Female, Orbitofrontal cortex, Analysis of variance, Psychology, Neuroscience, medicine.drug
Abstract

Rationale: Converging evidence from studies with neurological patients and brain imaging studies with healthy volunteers suggests that the capacity to make choices between actions associated with probabilistic rewards and punishments depends upon a network of cortico-limbic systems including the orbitofrontal cortex, cingulate cortex, amygdala and striatum. The involvement of such structures highlights the emotional aspects of decision-making and suggests that decision-making may be sensitive to manipulations of the catecholamine systems that innervate these structures. In this study, we investigated the possible role of noradrenaline (NA). Objective: We examined the effects of a single oral 80 mg dose of the beta-adrenoceptor blocker, propranolol, on the decision-making of healthy volunteers in a double-blind, placebo-controlled, between-subjects design. Meth- ods: Seventeen volunteers ingested a placebo while 15 volunteers ingested propranolol. Visual analogue scales, and self-reported positive and negative ratings, were used to assess subjective changes and mood. Vital signs were also monitored. Seventy-five minutes after treatment, volunteers were asked to make a series of choices between two simultaneously presented gambles, differing in the magnitude of possible gains (i.e. reward), the magnitude of possible losses (i.e. punishment), and the probabilities with which these outcomes were delivered. Volunteers also chose between gambles probing identi- fied non-cognitive biases in human decision-making, namely, risk-aversion when choosing between gains and risk-seeking when choosing between losses. Results: Pro- pranolol treatment did not result in gross changes in subjective state or mood in comparison to placebo, but did slow heart rate significantly. Propranolol produced a selective change in volunteers' decision-making; namely, it significantly reduced the discrimination between large and small possible losses when the probability of winning was relatively low and the probability of losing was high. Conclusions: These results suggest that NA modulates the processing of punishment signals when choosing between probabilistic rewards and punishments under conditions of increased arousal.

Published
2004
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10. Might makes right: Using force to align the mitotic spindle

Author

Buzz Baum and Oscar M. Lancaster

Subjects
Physics, Cell polarity, Cell Biology, Cell shape, Mitosis, Multipolar spindles, Spindle pole body, Spindle apparatus, Cell biology
Abstract

Both symmetric and asymmetric divisions rely on alignment of the mitotic spindle with cues from the environment. A study now shows that mitotic spindles find their position by reading the map of forces that load-bearing retraction fibres exert on the cell body.

Published
2011
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11. [Untitled]

Author

Geoff A. Otto, Joseph D. Puglisi, Peter Sarnow, Peter J. Lukavsky, and Alissa M. Lancaster

Subjects
fungi, 5.8S ribosomal RNA, Shine-Dalgarno sequence, RNA-dependent RNA polymerase, RNA, Biochemistry, Virology, Cell biology, Hepatitis C virus internal ribosome entry site, chemistry.chemical_compound, Internal ribosome entry site, chemistry, Start codon, Structural Biology, Genetics, Eukaryotic Small Ribosomal Subunit
Abstract

Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.

Published
2000
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12. Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers☆

Author

Johnathan M. Lancaster, Michael E. Carney, P. Andrew Futreal, Andrew Berchuck, Jeffrey R. Marks, Curtis Gumbs, and G. Larry Maxwell

Subjects
Tumor suppressor gene, RNA Splicing, Breast Neoplasms, Ovary, Biology, Breast cancer, medicine, Humans, RNA, Messenger, Northern blot, Deoxyribonucleases, Type II Site-Specific, Southern blot, Ovarian Neoplasms, Leucine Zippers, Base Sequence, Endosomal Sorting Complexes Required for Transport, TSG101 Gene, Reverse Transcriptase Polymerase Chain Reaction, Obstetrics and Gynecology, DNA, Neoplasm, Blotting, Northern, medicine.disease, DNA-Binding Proteins, Blot, Blotting, Southern, medicine.anatomical_structure, Cancer research, Female, Ovarian cancer, Gene Deletion, Transcription Factors
Abstract

Objective To determine whether large deletions or other alterations in the putative tumor suppressor gene TSG101 play a role in the molecular pathogenesis of breast and ovarian cancers. Methods Expression of TSG101 transcripts was examined in breast and ovarian cancers using the reverse transcriptase-polymerase chain reaction (RT-PCR), and selected transcripts were sequenced. Southern blot analysis was performed to determine whether there were genomic deletions in the TSG101 gene, and Northern blot analysis was used to examine the relative abundance of various transcripts. Results All the cancerous and normal breast tissue examined expressed full length 1145 base pair (bp) TSG101 transcripts. Additional truncated transcripts were seen using the RT-PCR in 57 (64%) of 89 primary breast cancers, 1 (20%) of 5 breast cancer cell lines, 3 (50%) of 6 normal breast tissues, 16 (64%) of 25 primary ovarian cancers and 1 (33%) of 3 ovarian cancer cell lines. Only the primary breast (21%) and ovarian (24%) cancers had three or more truncated transcripts. None of the normal tissues or cell lines examined had more than two aberrant transcripts. DNA sequencing revealed that the most commonly expressed truncated transcript arises because of loss of 902 bp between codons 153 and 1055. Only full length TSG101 transcripts were seen on Northern blot analysis of breast cancer cell lines, however. There was no evidence of genomic deletions in the TSG101 gene on Southern blot analysis. Conclusion Truncated TSG101 transcripts that probably represent splice variants are present in some breast and ovarian cancers, but there is no evidence to suggest that loss of this putative tumor suppressor gene plays a role in the molecular pathogenesis of these cancers.

Published
1998
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13. Study of charged—currentep interactions atQ 2>200 GeV2 with the ZEUS detector at HERA

Author

WN Cottingham, D.D. Reeder, M. Wodarczyk, H. Park, P. B. Kaziewicz, H. Uijterwaal, U. Wollmer, Roberto Sacchi, Ulf Behrens, H.G.J.M. Tiecke, B. Surrow, F. Benard, M.A.J. Botje, Fernando Barreiro, S. Mengel, J. Mainusch, J.B. Lane, Gy. Wolf, Yasunori Yamazaki, D. Simmons, Avto Kharchilava, W. Schott, Cd Catterall, Federico Cindolo, R. R. McNeil, W. Bogusz, Cristiana Peroni, Aharon Levy, Thomas Trefzger, K.F. Johnson, J. N. Lim, Mauro Morandin, Z. Jakubowski, Ricardo Graciani, Samuel Silverstein, H.-P. Jakob, John Hart, P. Nylander, K. K. Joo, A. Bruni, L. W. Hung, F. Palmonari, R. Sinkus, O. Mańczak, G. F. Hartner, R. J. Cashmore, Miriam Lucio Martinez, S. B. Lee, Andrea Contin, A. Kruse, S. Wölfle, Laurel E. Sinclair, M. Löwe, Katsuo Tokushuku, L. Hagge, Antonino Zichichi, Aleksander Filip Żarnecki, Silvia Maselli, R. Cross, M. Derrick, T. Tymieniecka, U. Kötz, R. L. Saunders, M. de Kamps, H. J. Kim, Giovanni Maccarrone, D. Hochman, C. Rembser, T. Ishii, F. J. Sciulli, T. Monteiro, S. Polenz, S. Schlenstedt, Amedeo Staiano, U. F. Katz, M. Pfeiffer, D. Filges, R. J. Tapper, D. Revel, Z. Duliński, J. Gilmore, Lucia Votano, Enrico Tassi, J. J. Whitmore, Giancarlo Susinno, Masami Chiba, R. Brugnera, S.H. An, P. J. Bussey, N. A. McCubbin, Marcella Capua, A. Meyer, K. Umemori, Mariusz Przybycien, D. Horstmann, N. H. Brook, V. L. Harris, V. K. Nadendla, M. Corradi, C. Nath, S. Yang, H. Heßling, J. F. Martin, I. Gialas, R. J. Nowak, F. Selonke, E. Hilger, Matthias Kasemann, V. A. Kuzmin, S. Campbell-Robson, H.J. Grabosch, J. P. Fernandez, Umberto Dosselli, Rosario Nania, Sung Keun Park, Cg Matthews, M. Roco, M. Rohde, Danuta Kisielewska, Marcel Vreeswijk, D Piccioni, N. Cartiglia, T. Tsurugai, O. Deppe, W. N. Murray, D. C. Bailey, J. Del Peso, M. De Giorgi, C. Youngman, A. M. Cooper-Sarkar, S. Dagan, D. Notz, G. Cases, A. Nigro, T. Massam, A.S. Proskuryakov, T. Yip, M. Inuzuka, R. van Woudenberg, A. Seiden, R. Stanek, W. Liu, K. Desler, R. J. Seifert, Leszek Adamczyk, I. A. Korzhavina, M. Khakzad, Janusz Chwastowski, M. L. Cardy, K. Homma, James Crittenden, Yu. A. Golubkov, M. Krzyżanowski, J. Ciborowski, M.I. Ferrero, M. St-Laurent, C. Coldewey, D.C. Williams, B. D. Burow, R. Loveless, ME Hayes, Luca Stanco, J.H. Vossebeld, E. Barberis, C.-P. Fagerstroem, A. Eskreys, A. T. Doyle, Y. Zamora Garcia, T. Voß, R. Ullmann, M. Nakao, P. Borzemski, R. G. Feild, M. Geerts, M. Posocco, T. W. Jones, A. N. Solomin, A. H. Walenta, DG Roff, L. Labarga, E. A. De Wolf, J. K. Sedgbeer, M. Eckert, L. Bellagamba, A.S. Wilson, L. Lamberti, Wouter Verkerke, C.R. Sampson, U. Mallik, Greg P Heath, J. R. Okrasinski, Jeffrey T. Rahn, L. M. Shcheglova, M. Grothe, P. Giusti, Gm Levman, B.Y. Oh, G. Zacek, G. L. Bashindzhagyan, A. Pesci, W.B. Schmidke, G. Drews, R. J. Teuscher, P. M. Patel, L. Heinz, J. A. Parsons, P. Joos, J. Stamm, A.F. Whitfield, S. W. Nam, B. A. Dolgoshein, Stefano Maria Mari, A. Quadt, D. S. Bailey, O. Schwarzer, Helen F Heath, J. Große-Knetter, V.A. Noyes, J.J. Engelen, Giuseppe Iacobucci, N. Pavel, J. R. Tickner, B. Foster, D. S. Waters, D. Krakauer, Jens Hartmann, G. Bruni, W. Hain, Z. Jing, M. Dardo, P.M. Kooijman, A. Dannemann, B. Lu, M. Brkic, J. Shulman, S. Ritz, D. S. Hanna, Vladimir Bashkirov, C. Amelung, M. L. Utley, N. Wulff, M. Riveline, M. Lancaster, J.T. Wu, Juan Terron, M. Kasprzak, K. Yamauchi, Y. Iga, J. Zając, H. Kowalski, A. Frey, M. Flasiński, N. Dyce, C. Voci, B. H. Y. Hung, J. K. Bienlein, Anselmo Margotti, L.W. Wiggers, E. Rulikowska-Zarebska, C. Li, P. Antonioli, A.I. van Sighem, K. Wick, G. Abbiendi, J.D. McFall, Marco Schioppa, G. Grzelak, T. C. Bacon, D. Hasell, G. D'Agostini, S. Mattingly, D. Schramm, C. A. Heusch, Luisa Cifarelli, L. K. Gladilin, Neville Harnew, D. Mikunas, G. Howell, J. Bulmahn, J. I. Fleck, D. Lüke, A. Polini, P.F. Ermolov, P. Bruni, P. G. Pelfer, T.P. Shah, Mark Sutton, T. Doeker, G. Briskin, Q. Zhu, S. M. Wang, D. H. Saxon, Costas Foudas, L.W. Mo, J. A. Zakrzewski, D. Westphal, F. Zuin, T. Y. Ling, S. Kartik, L. Lindemann, S. De Pasquale, M.C.K. Mattingly, U. Karshon, L. S. Durkin, E. Lohrmann, D. Zer-Zion, C. Glasman, P. Göttlicher, R. Hamatsu, Luis Hervas, I. Suzuki, S. Mine, D. Boscherini, R. Yoshida, J. Puga, Robert Klanner, A. Vaiciulis, R. S. Orr, A. Caldwell, G. Castellini, William S. Lockman, Michele Arneodo, H. F.W. Sadrozinski, J.S.T. Ng, Y. Eisenberg, D.J. Gilkinson, R. Walczak, J. M. Pawlak, P. B. Straub, Kenneth Long, R. Deffner, M. Adamus, A. Bornheim, K. Heinloth, A. Garfagnini, G. Bari, Giuseppe Barbagli, A. Ladage, J. Roldán, Hao Zhang, S. Magill, W. Schulz, G. Marini, Francois Corriveau, M. Van Hook, A. Kotański, K. Muchorowski, B. Bednarek, Np Zotov, I. H. Park, Wolfram Dietrich Zeuner, A.K. Wróblewski, A. Bamberger, Ben Bylsma, J. Milewski, O. Yu. Lukina, G. Sartorelli, R. Wedemeyer, M. Przybycien, B. J. Ko, H. Hartmann, L.A.T. Bauerdick, Giuseppe Levi, F. Zetsche, A. A. Savin, L. Suszycki, K. Jelen, S. Eisenhardt, Roberto Carlin, W.R. Frisken, Sridhara Dasu, D. Chapin, Halina Abramowicz, A. Bertolin, U. Schneekloth, J. F. de Trocóniz, I. Butterworth, F. Dal Corso, L. Zawiejski, Roberto Cirio, A. Cassidy, W.F. Badgett, Ta Romanowski, B. Musgrave, E. Paul, A. Stifutkin, F. F. Wilson, Jonathan Butterworth, B. Löhr, R. L. Talaga, S. Kitamura, Ada Solano, S. Limentani, M. Z. Wang, S. Bhadra, M. Zachara, Shoichi Yamada, R.C.E. Devenish, G. Laurenti, L. Iannotti, A. Prinias, Elisabetta Gallo, W. Koch, H. Beier, Tadeusz Kowalski, G. Poelz, Lutz Feld, J.T. Bromley, W. Metcalf, U. Holm, D. Acosta, Dg Stairs, Krzysztof Piotrzkowski, D. Sideris, D. B. Miller, Jose Repond, K. Ohrenberg, J. Gajewski, W. H. Smith, Mário Costa, G. H. Cho, J. Labs, F.S. Chlebana, M. Basile, T. Haas, V. D. Kobrin, T. Dubbs, J. Biltzinger, P. Cloth, R. Ayad, J. Breitweg, J. M. Hernandez, G. Cara Romeo, N. Brümmer, Simon George, Tachishige Hirose, M. Kuze, T. Matsushita, L. Wai, and R. Stroili

Subjects
Nuclear physics, Physics, Particle physics, Physics and Astronomy (miscellaneous), Rapidity, Center of mass, HERA, Zeus (malware), Energy (signal processing), Boson, Bar (unit)
Abstract

Deep inelastic charged-current reactions have been studied ine+p ande−p collisions at a center of mass energy of about 300GeV in the kinematic regionQ2>200GeV2 andx>0.006 using the ZEUS detector at HERA. The integrated cross sections forQ2>200GeV2 are found to be \(\sigma _{e^ + p \to \bar \nu X} = 30.3_{ - 4.2 - 2.6}^{ + 5.5 + 1.6} pb\) and \(\sigma _{e^ - p \to \nu X} = 54.7_{ - 9.8 - 3.4}^{ + 15.9 + 2.8} pb\). Differential cross sections have been measured as functions of the variablesx, y andQ2. From the measured differential cross sectionsdσ/dQ2, theW boson mass is determined to be \(M_W = 79_{ - 7 - 4}^{ + 8 + 4} GeV\). Measured jet rates and transverse energy profiles agree with model predictions. A search for charged-current interactions with a large rapidity gap yielded one candidate event, corresponding to a cross section of \(\sigma _{e^ + p \to \bar \nu X} (Q^2 > 200 GeV^2 ; \eta _{\max }< 2.5) = 0.8_{ - 0.7}^{ + 1.8} \pm 0.1 pb\)

Published
1996
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14. Measurement of elasticρ 0 photoproduction at HERA

Author

D.D. Reeder, A. Bertolin, B. Diekmann, M. Wodarczyk, M. Lancaster, J.T. Wu, J. Zając, J. F. de Trocóniz, L. Zawiejski, Roberto Cirio, S.H. An, D. Mikunas, H.-P. Jakob, P. Morawitz, Rosario Nania, Sung Keun Park, R. L. Saunders, B. Musgrave, M. St.Laurent, G. Briskin, P. B. Kaziewicz, D. Krakauer, L. Lamberti, Simon George, Detlef Filges, Q. Zhu, R. Brugnera, P.M. Kooijman, Miguel Molina Martínez, H. Uijterwaal, E. Gallo, M. Roco, E. McCliment, V. A. Kuzmin, D. C. Bailey, Tachishige Hirose, M.C.K. Mattingly, L. S. Durkin, A. Dannemann, A. Stifutkin, M. De Giorgi, M. L. Utley, J. Shulman, T. Tsurugai, Aleksander Filip Żarnecki, Silvia Maselli, R. Hamatsu, A. Seiden, J. Puga, B. Surrow, Gm Levman, Giuseppe Barbagli, J. Bulmahn, D. S. Waters, Juan Terron, M. Kasprzak, M. Kuze, E. Rulikowska-Zarebska, J. I. Fleck, Y. Nagasawa, R. S. Orr, G. Zech, M. Flasiński, Vladimir Bashkirov, S.S. Wilson, A. Nigro, P. B. Straub, Kenneth Long, K. Yamauchi, S. Mengel, J. Mainusch, A. Eskreys, A. T. Doyle, A. Byrne, J. A. Zakrzewski, B. Bargende, L. Wai, B. Behrens, D. Horstmann, A. Dake, N. H. Brook, K. Wick, A. Prinias, L. Labarga, Wouter Verkerke, G. Bari, C.J.S. Morgado, M. Adamus, G. Marini, V. L. Harris, Michele Arneodo, D. C. Williams, R. Stroili, L. M. Shcheglova, T.L. Short, B. A. Dolgoshein, N. Bruemmer, Cg Matthews, M. de Kamps, H. J. Kim, Giovanni Maccarrone, S. Schlenstedt, P. J. Bussey, Giovanna Bruni, M. Van Hook, B. Bednarek, R. Yoshida, Np Zotov, Wolfram Dietrich Zeuner, A.K. Wróblewski, A. Bamberger, Avto Kharchilava, W. Schott, Cd Catterall, W. Koch, M. Eckert, L. Bellagamba, A.F. Whitfield, S. W. Nam, L. Köpke, C. Fordham, R. Loveless, Giuseppe Iacobucci, M. Rohde, A. M. Cooper-Sarkar, S. Dagan, M. Khakzad, M. L. Cardy, Roberto Sacchi, J.J. Engelen, J. M. Pawlak, A. Garfagnini, N. Pavel, I. Suzuki, William S. Lockman, J. F. Martin, Jose Repond, K. Ohrenberg, F. Zetsche, H. Beier, D. J. P. Norman, K. Honscheid, Aharon Levy, Y. Nakamitsu, Katsuo Tokushuku, T. Yip, F. J. Sciulli, I. H. Park, G. Grzelak, H.G.J.M. Tiecke, F. Benard, Roberto Carlin, Yu. A. Golubkov, E. Paul, M. Geerts, K. Blankenship, C.R. Sampson, P. Giusti, G. Zacek, G. Drews, J. A. Parsons, J. N. Lim, Cristiana Peroni, R. Sinkus, A. Freidhof, R. J. Tapper, G. F. Susinno, R. J. Cashmore, A. A. Savin, M. Derrick, M. Posocco, Geoffrey Smith, S. Ritz, D. S. Hanna, Anselmo Margotti, L.W. Wiggers, T. Tymieniecka, L. Suszycki, Jeffrey T. Rahn, Umberto Dosselli, P. M. Patel, Janusz Chwastowski, J. A. O'Mara, A. Bernstein, Y. Zamora Garcia, T. Voß, C. Youngman, V.A. Noyes, Tadeusz Kowalski, D. Acosta, S. Nickel, D. B. Miller, B. D. Burow, Ben Bylsma, J. Milewski, W.N. Murray, G. Anzivino, W. H. Smith, Mário Costa, H. Hartmann, Dg Stairs, U. Kötz, T. C. Bacon, J.B. Lane, J. Mollen, G. Poelz, Masashi Hazumi, E. A. De Wolf, J. Gajewski, A. Frey, M. Nakao, P. Borzemski, Giuseppe Levi, Gy. Wolf, Rr Rau, K. Jelen, J. R. Tickner, J. Ciborowski, S. Polenz, C. Rembser, Marcel Vreeswijk, R. Ullmann, P. Nylander, F.S. Chlebana, N. A. McCubbin, K. K. Joo, V. K. Nadendla, Masami Chiba, Klaus Kurt Desch, James Crittenden, O. Mańczak, T.P. Shah, S. M. Wang, D. H. Saxon, R. J. Nowak, M. Grothe, F. Selonke, E. Hilger, W.R. Frisken, J. Labs, G. F. Hartner, Ulf Behrens, Federico Cindolo, W. Bogusz, H. Kowalski, J. P. Fernandez, M. Dardo, C. Coldewey, Lutz Feld, M. Basile, A. B. Meyer, T. Haas, V. D. Kobrin, T. Dubbs, Samuel Silverstein, A.S. Wilson, Antonino Zichichi, P. Göttlicher, E. Stiliaris, D. Lüke, J. Del Peso, J. Biltzinger, A. Polini, K. Prytz, U. Schneekloth, W. Metcalf, M. Krzyżanowski, I. A. Korzhavina, S. De Pasquale, R. Ayad, I. Butterworth, M. H. Suh, U. Holm, B. Lu, L.E. Sinclair, D. Westphal, L. Hagge, Marco Schioppa, R. J. Seifert, P. G. Pelfer, Sridhara Dasu, B.Y. Oh, U. Karshon, A.S. Proskuryakov, R. Seidlein, Stefano Maria Mari, G. Cara Romeo, T. Ishii, K. Homma, Luis Hervas, D. Boscherini, R. van Woudenberg, A. Quadt, J. M. Hernandez, M. Zachara, Krzysztof Piotrzkowski, Ta Romanowski, G. Castellini, Shoichi Yamada, Fernando Barreiro, C. Li, J.S.T. Ng, R.C.E. Devenish, B. Y. H. Hung, F. Dal Corso, Halina Abramowicz, T. Hasegawa, H. F.W. Sadrozinski, A. Leich, W.F. Badgett, F. F. Wilson, M. Chiarini, G. Cases, Mauro Morandin, Danuta Kisielewska, G. Laurenti, Debades Bandyopadhyay, T. Massam, L. W. Hung, Jonathan Butterworth, T. J. Llewellyn, I. Ali, D. S. Bailey, D. Schramm, O. Schwarzer, S. M. Hong, Helen F Heath, R. L. Talaga, E. Tassi, Matthias Kasemann, I. Gialas, Jens Hartmann, L. Iannotti, K. M. Furutani, E. Lohrmann, D. Revel, Mariusz Przybycien, D. Notz, M. Corradi, S. Yang, J. Schroeder, A. H. Walenta, S. Campbell-Robson, R.S. Gilmore, W. Schulz, H.J. Grabosch, E. Barberis, J. K. Bienlein, O. Deppe, A. N. Solomin, S. H. Yon, U. Mallik, T. W. Jones, Anna Goussiou, Leszek Adamczyk, Yasunori Yamazaki, G. L. Bashindzhagyan, B. Gutjahr, Greg P Heath, John Hart, W.B. Schmidke, R. J. Teuscher, M.I. Ferrero, J. Große-Knetter, Douglas Gingrich, R. G. Feild, R. R. McNeil, K. Charchuła, A. Bruni, M. Löwe, S. Kartik, J.D. McFall, K. Muchorowski, R. Wedemeyer, J. J. Whitmore, Francois Corriveau, C. A. Heusch, J.F. Zhou, P.F. Ermolov, W. Hain, A. Kotański, P. Bruni, Costas Foudas, L.W. Mo, A. Caldwell, Christian Nemoz, L.A.T. Bauerdick, M.A.J. Botje, D. Zer-Zion, K.W. McLean, Ricardo Graciani, Y. Iga, A. Ladage, S. Söldner-Rembold, C. P. Fagerstroem, N. Dyce, Amedeo Staiano, O. Yu. Lukina, U. F. Katz, M. Pfeiffer, P. Cloth, R. Imlay, Ada Solano, C. Voci, S. Limentani, S. Magill, T. Doeker, M. Z. Wang, S. Bhadra, J. Gilmore, T. Timellini, A. Cassidy, R. Stanek, E. Badura, M. Nakahata, Luca Stanco, J. K. Sedgbeer, T. Neumann, B. Löhr, K. Desler, S. Kitamura, Thomas Trefzger, K.F. Johnson, Hao Zhang, Andrea Contin, A. Kruse, T. Monteiro, S. Eisenhardt, Marcella Capua, N. Cartiglia, C. Glasman, S. Mine, A. Bornheim, F. Palmonari, P. Joos, J. Stamm, B. Foster, Luisa Cifarelli, L. K. Gladilin, Neville Harnew, Y. Eisenberg, D.J. Gilkinson, R. Walczak, K. Heinloth, J. Roldán, G. Sartorelli, M. Brkic, N. Wulff, D. Hasell, G. D'Agostini, T. Y. Ling, L. Lindemann, Giovanni Abbiendi, Robert Klanner, A. Vaiciulis, Lucia Votano, C. Nath, and H. Heßling

Subjects
Nuclear physics, Physics, Cross section (physics), ZEUS (particle detector), Pion, Physics and Astronomy (miscellaneous), Proton, Vertex (curve), High Energy Physics::Experiment, Invariant mass, HERA, Nuclear Experiment, Helicity
Abstract

Elasticρ0 photoproduction has been measured using the ZEUS detector at HERA. Untagged photoproduction events fromep interactions were used to measure the reactionγp→ρ0p(ρ0)→π+π−) at photon-proton centre-of-mass energies between 60 and 80 GeV and |t

Published
1995
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15. Measurement of the proton structure functionF 2 at lowx and lowQ 2 at HERA

Author

D. Krakauer, M. L. Utley, J. Mollen, J. I. Fleck, Y. Nagasawa, P. Nylander, K. K. Joo, O. Mańczak, G. F. Hartner, R. Yoshida, J. A. Zakrzewski, Thomas Trefzger, F. J. Sciulli, K.F. Johnson, P. Bruni, Costas Foudas, A. M. Cooper-Sarkar, S. Dagan, M. Khakzad, M. L. Cardy, K. Honscheid, Yu. A. Golubkov, Vladimir Bashkirov, H. Tiecke, M. Posocco, Geoffrey Smith, L.W. Mo, Andrea Contin, C. Händel-Pikielny, J. F. Martin, N. Bruemmer, Christian Nemoz, A. Caldwell, A. Frey, F. Selonke, L. Köpke, Ulf Behrens, Federico Cindolo, W. Bogusz, A. Cassidy, Y. Iga, N. Dyce, J. Ciborowski, A. Kruse, D. Schramm, C. A. Heusch, E. Hilger, G. Grzelak, R. Ullmann, C. Voci, T. Monteiro, J. M. Pawlak, T. C. Bacon, T. Yip, Mariusz Przybycien, M. Corradi, A. Bernstein, Y. Zamora Garcia, T. Voß, M. Nakahata, Cg Matthews, M.A.J. Botje, Marcella Capua, W. Metcalf, U. Holm, A. Garfagnini, Fernando Barreiro, Mauro Morandin, Hao Zhang, M. Dardo, C. Coldewey, S. Yang, Jens Hartmann, P. Cloth, N. Pavel, I. Suzuki, William S. Lockman, K.W. McLean, S. Nickel, D. B. Miller, J. Gajewski, A. Ladage, Ricardo Graciani, S. Söldner-Rembold, K. Prytz, N. Cartiglia, K. Muchorowski, P. Kooijman, L. W. Hung, T. Neumann, Lucia Votano, T.P. Shah, E. Lohrmann, B. Löhr, C. Nath, C. P. Fagerstroem, H. Heßling, F. Palmonari, M. Krzyżanowski, W. N. Murray, S. M. Wang, S. De Pasquale, D. H. Saxon, I. H. Park, O. Yu. Lukina, Ben Bylsma, D. Lüke, A. Polini, S. Campbell-Robson, S. Kitamura, Amedeo Staiano, U. F. Katz, R. Wedemeyer, M. Basile, Rosario Nania, Sung Keun Park, J. K. Bienlein, T. Doeker, J. Milewski, S. Eisenhardt, Y. Eisenberg, H.J. Grabosch, S. Kartik, P. Göttlicher, J. Gilmore, M. Pfeiffer, T. Haas, V. D. Kobrin, T. Dubbs, Antonino Zichichi, ME Hayes, E. Tassi, A. Nigro, D.J. Gilkinson, B. Lu, S. W. Nam, R. Ayad, R. Walczak, J. Biltzinger, B.Y. Oh, M. H. Suh, M. Zachara, Krzysztof Piotrzkowski, K. Heinloth, Giuseppe Barbagli, D. Filges, J. Roldán, M. Eckert, L. Bellagamba, Shoichi Yamada, R.C.E. Devenish, Francois Corriveau, H. Hartmann, E. McCliment, D. Revel, G. Cara Romeo, A. Dannemann, H.-P. Jakob, P. Joos, R. L. Saunders, O. Deppe, J. Stamm, A.F. Whitfield, A. Kotański, A. Meyer, A. Seiden, G. Laurenti, L.A.T. Bauerdick, B. Foster, M. Lancaster, J. M. Hernandez, R. Brugnera, C. Li, G. Sartorelli, J.T. Wu, J.R. Okrasiński, J. Bulmahn, J. Zając, Yasunori Yamazaki, G. Cases, D. C. Bailey, B. Gutjahr, V. A. Kuzmin, R. Stanek, M. De Giorgi, C. Youngman, A. Eskreys, A. T. Doyle, L. Labarga, Wouter Verkerke, R. R. McNeil, E. Badura, D. Mikunas, W. N. Cottingham, C. Fordham, Luisa Cifarelli, L. K. Gladilin, Neville Harnew, P. Morawitz, B. Y. H. Hung, Sridhara Dasu, Marcel Vreeswijk, T.L. Short, D Piccioni, B. A. Dolgoshein, John Hart, W. Schulz, Luca Stanco, K. Desler, L. Iannotti, Ada Solano, Gm Levman, S. Ritz, D. S. Hanna, Halina Abramowicz, D. C. Williams, D. S. Waters, S. Limentani, J. Del Peso, Aleksander Filip Żarnecki, Silvia Maselli, G. Briskin, E. Rulikowska-Zarcebska, Roberto Carlin, M. de Kamps, K. Charchuła, K. Yamauchi, Q. Zhu, M. Brkic, L.E. Sinclair, K. Homma, H. J. Kim, C. Glasman, N. Wulff, Cristiana Peroni, R. J. Cashmore, Roberto Sacchi, H. Kowalski, M. Z. Wang, D. Hasell, G. D'Agostini, Giovanni Maccarrone, J. K. Sedgbeer, Anselmo Margotti, Simon George, S. Mine, S. Schlenstedt, S. Bhadra, A. Bruni, T. Y. Ling, L. Lindemann, L.W. Wiggers, P. J. Bussey, M. Löwe, Tachishige Hirose, J.D. McFall, D. Horstmann, R. Timellini, A. Dake, N. H. Brook, V. L. Harris, B. D. Burow, Giovanni Abbiendi, Robert Klanner, A. Vaiciulis, G. Bruni, M. Derrick, A. Prinias, Elisabetta Gallo, T. Tymieniecka, A. Bornheim, E. Barberis, J. A. O'Mara, P.F. Ermolov, Jose Repond, G. Anzivino, K. Ohrenberg, Giuseppe Levi, W. Koch, M. Rohde, Danuta Kisielewska, A. N. Solomin, U. Kötz, U. Mallik, Aharon Levy, D. Westphal, P. Giusti, J. T. Rahn, M. Nakao, P. Borzemski, M. Kuze, T. Massam, J. N. Lim, A. Bertolin, Greg P Heath, K. Jelen, J. Engelen, G. Zacek, G. Drews, J. A. Parsons, U. Karshon, H. Beier, A.S. Wilson, J. J. Whitmore, W. Hain, R. Sinkus, Luis Hervas, D. Zer-Zion, J. F. de Trocóniz, L. Zawiejski, W.R. Frisken, I. Ali, D. Boscherini, Tadeusz Kowalski, V. K. Nadendla, R. J. Nowak, W. H. Smith, J. Große-Knetter, Roberto Cirio, D. S. Bailey, O. Schwarzer, Helen F Heath, G. Poelz, J.F. Zhou, G. Castellini, L. Wai, Mário Costa, A. H. Walenta, DG Roff, Lutz Feld, M.C.K. Mattingly, L. S. Durkin, Douglas Gingrich, Giancarlo Susinno, B. Musgrave, M. St.Laurent, J.S.T. Ng, R. Stroili, R. Hamatsu, R. Imlay, K. Wick, E. Paul, J. Puga, F.S. Chlebana, U. Schneekloth, A. Stifutkin, I. Gialas, I. Butterworth, S. Magill, M. Adamus, J. Schroeder, S. Polenz, Ta Romanowski, G. Marini, Np Zotov, Wolfram Dietrich Zeuner, A.K. Wróblewski, A. Bamberger, Masami Chiba, Klaus Kurt Desch, Matthias Kasemann, K. M. Furutani, F. F. Wilson, M. Chiarini, Leszek Adamczyk, Jonathan Butterworth, J. P. Fernandez, D. Notz, I. A. Korzhavina, M.I. Ferrero, S. H. Yon, D. Acosta, T. W. Jones, Anna Goussiou, Dg Stairs, G. L. Bashindzhagyan, W.B. Schmidke, R. J. Teuscher, R. G. Feild, J. Labs, A. Freidhof, James Crittenden, M. Grothe, L. Heinz, R. S. Orr, P. B. Straub, Kenneth Long, F. Dal Corso, Marco Schioppa, P. G. Pelfer, B. Behrens, G. Bari, R. Seidlein, T. Hasegawa, M. Van Hook, B. Bednarek, A. Leich, W.F. Badgett, H. F.W. Sadrozinski, F. Zetsche, Y. Nakamitsu, Katsuo Tokushuku, R. J. Tapper, J. Shulman, Umberto Dosselli, Debades Bandyopadhyay, Janusz Chwastowski, E. A. De Wolf, J. R. Tickner, D.D. Reeder, Juan Terron, M. Kasprzak, B. Diekmann, G. Zech, M. Flasiński, M. Wodarczyk, S. M. Hong, Masashi Hazumi, R. L. Talaga, C. Rembser, N. A. McCubbin, Samuel Silverstein, E. Stiliaris, L. Hagge, P. B. Kaziewicz, T. Ishii, R. J. Seifert, L. Lamberti, Stefano Maria Mari, A. Quadt, H. Uijterwaal, L. M. Shcheglova, A.S. Proskuryakov, C.J.S. Morgado, Michele Arneodo, R. van Woudenberg, F. Benard, M. Martinez, A. A. Savin, L. Suszycki, Giuseppe Iacobucci, R. Loveless, M. Geerts, K. Blankenship, C.R. Sampson, J.B. Lane, P. M. Patel, Gy. Wolf, Rr Rau, B. Surrow, S.H. An, V.A. Noyes, M. Roco, T. Tsurugai, S. Mengel, J. Mainusch, A. Byrne, Avto Kharchilava, W. Schott, and Cd Catterall

Subjects
Nuclear physics, Physics, Range (particle radiation), Physics and Astronomy (miscellaneous), Proton, law, Structure (category theory), Perturbative QCD, HERA, Collider, Deep inelastic scattering, law.invention, Positron energy
Abstract

We report on a measurement of the proton structure function F 2 in the range 3.5×10-5≤x≤4×10-3 and 1.5 GeV2≤Q 2≤15GeV2 at the ep collider HERA operating at a centre-of-mass energy of √s=300GeV. The rise of F 2 with decreasing x observed in the previous HERA measurements persists in this lower x and Q 2 range. The Q 2 evolution of F 2, even at the lowest Q 2 and x measured, is consistent with perturbative QCD. © 1996 Springer-Verlag.

Published
1995
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16. Cancer education curriculum at the Louisiana state university school of Dentistry

Author

Diana M. Lancaster, James E. Cade, and Luis R. Guerra

Subjects
Male, Biopsy, medicine.medical_treatment, education, Students, Dental, Early detection, Dentistry, Education, Dental, Graduate, Medical Oncology, Education curriculum, Experiential learning, Patient Care Planning, Pathology, medicine, Humans, Oral Diagnosis, Education, Dental, Patient Care Team, Medical education, Rehabilitation, Oral cancer screening, business.industry, Diagnosis, Oral, Public Health, Environmental and Occupational Health, Cancer, Community Dentistry, Middle Aged, Louisiana, medicine.disease, Cancer treatment, stomatognathic diseases, Oncology, Preventive Dentistry, Pathology, Oral, Schools, Dental, Female, Mouth Neoplasms, Curriculum, Dental Hygienists, business, Program Evaluation
Abstract

The cancer education curriculum at Louisiana State University School of Dentistry provides students didactic and experiential learning throughout their dental training. Freshman are presented concepts of early detection of cancer in an oral diagnosis course. Later courses in oral diagnosis, medicine, and pathology include diagnostic and treatment decision making and rehabilitative information. Junior students attend a head-and-neck-tumor board composed of dentists and physicians that decides cancer treatment and rehabilitation. Juniors also participate in a biopsy service that includes observing or performing the biopsy, examining the tissue microscopically, and reporting their findings. Additionally, a required, medical and dental, multidisciplinary course in oral oncology provides instruction in diagnosis, treatment, and rehabilitation of cancer patients. Seniors participate in an oral cancer screening service as part of their community dentistry rotation. The postgraduate dental programs and the dental hygiene programs also participate in this curriculum.

Published
1994
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17. [Untitled]

Author

Jean-Paul Scalart, Philip L. Smith, Panayiotis P. Constantinides, Cindy M. Lancaster, Joseph Marcello, Gary J. Marks, and Harma Ellens

Subjects
Pharmacology, Absorption (pharmacology), Aqueous solution, Chromatography, Organic Chemistry, Pharmaceutical Science, Intestinal absorption, Dosage form, Bioavailability, Calcein, chemistry.chemical_compound, chemistry, Molecular Medicine, Platelet aggregation inhibitor, Pharmacology (medical), Microemulsion, Biotechnology
Abstract

We developed self-emulsifying water-in-oil (w/o) microemulsions incorporating medium-chain glycerides and measured their conductance, viscosity, refractive index and particle size. Formulation of Calcein (a water-soluble marker molecule, MW = 623), or SK&F 106760 (a water-soluble RGD peptide, MW = 634) in a w/o microemulsion having a composition of Captex 355/Capmul MCM/Tween 80/Aqueous (65/22/10/3, % w/w), resulted in significant bioavailability enhancement in rats relative to their aqueous formulations. Upon intraduodenal administration the bioavailability was enhanced from 2% for Calcein in isotonic Tris, pH 7.4 to 45% in the microemulsion and from 0.5% for SK&F 106760 in physiological saline to 27% in the microemulsion formulation. The microemulsion did not induce gross changes in GI mucosa at a dosing volume of 3.3 ml/kg. These results suggest that water-in-oil microemulsion systems may be utilized for enhancement of intestinal drug absorption.

Published
1994
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18. Improved determination of the sample composition of dimuon events produced in $p\bar{p}$ collisions at $\sqrt{s}=1.96$ TeV

Author

D. Torretta, C. Mesropian, S. Donati, Kenichi Hatakeyama, A. Anastassov, Gervasio Gomez, A. Semenov, D. Mietlicki, C. Paus, M. Franklin, G. L. Strycker, A. Eppig, M. Binkley, M. J. Shochet, D. Krop, D. Amidei, L. Demortier, J. C. Freeman, A. T. Goshaw, S. Tkaczyk, A. Ruiz, Stephan Lammel, P. N. Dong, N. Moggi, Lucio Cerrito, A. Scribano, G. A. Thompson, F. Ptohos, Shalhout Shalhout, J. D. Lewis, G. P. Yeh, S. Torre, S. B. Kim, M. Gold, L. Sartori, A. Savoy-Navarro, D. Beecher, M. M. Deninno, A. Napier, R. McNulty, M. Hare, M. Tecchio, Teresa Rodrigo, A. Varganov, Z. Gunay-Unalan, Y. Funakoshi, T. J. Phillips, M. Trovato, E. Rogers, S. Behari, J. Boudreau, A. Mitra, E. J. Jeon, Chuan-Ming Liu, G. Punzi, K. Yi, S. R. Hou, A. Sukhanov, S. Errede, Yasuyoshi Nagai, Francesco Crescioli, A. N. Sissakian, D. Hare, Maxim Goncharov, Alberto Annovi, G. Piacentino, R. Madrak, G. Latino, Matteo Bauce, V. Khotilovich, M. E. Mattson, B. Whitehouse, S. Y. Jun, I. Bizjak, J. Naganoma, Koji Yamamoto, Tara Shears, T. Tomura, D. Goldin, S. Pagan Griso, Jason Nielsen, B. Casal, S. W. Lee, Azeddine Kasmi, Markus Frank, M. Campbell, A. Manousakis-Katsikakis, S. Shiraishi, S. Kwang, D. H. Kim, M. Hurwitz, H. S. Budd, J. Asaadi, P. Barria, Naoki Kimura, G. Velev, Ivan-Kresimir Furic, Y. Seiya, P. Ttito-Guzmán, T. Riddick, J. Deng, Fabrizio Margaroli, P. K. Teng, B Alvarez-Gonzalez, W. Ashmanskas, S. Lockwitz, Sudhir Malik, M. Vidal, J. E. Kim, R. E. Hughes, Vyacheslav Krutelyov, H. Gerberich, Sally Seidel, S. R. Hahn, A. Zanetti, Y. S. Chung, Amitabh Lath, Anna Sfyrla, Paola Giannetti, B. A. Barnett, P. Totaro, Giorgio Apollinari, J. Strologas, Eva Halkiadakis, I. Shreyber, P. Sinervo, W. Badgett, A. Boveia, Christopher Clarke, M. Dorigo, Pavol Bartos, Antonio Limosani, A. Mukherjee, L. Brigliadori, C. Pagliarone, Keunchang Cho, M. Shimojima, Teruki Kamon, R. Forrest, O. Poukhov, Robin Erbacher, M. Datta, D. Waters, W. Johnson, A. Simonenko, Francesco Rubbo, Dean Hidas, S. Amerio, J. Patrick, W-M. Yao, V. Papadimitriou, Andrea Bocci, V. V. Glagolev, D. J. Cox, Mark Neubauer, P. Garosi, Virgil E Barnes, A. Elagin, D. Cauz, R. L. Wagner, Kaori Maeshima, Jay Dittmann, Andreas Warburton, Emily Nurse, A. Di Canto, Tommaso Dorigo, R. Orava, J. Yamaoka, F. D. Snider, M. N. Mondragon, K. Goulianos, E. Pueschel, Giovanni Bellettini, T. Miao, D. Chokheli, V. A. Giakoumopoulou, R. Vilar, B. Jayatilaka, S. S. Yu, A. Artikov, T. Wright, H. S. Lee, J. Y. Han, Paolo Mastrandrea, T. Aaltonen, D. E. Pellett, Stanislav Tokár, Adrian Buzatu, Y. C. Yang, C. Cuenca Almenar, Y. Zeng, M. Kirby, M. J. Kim, K. Gibson, S. Wolbers, A. Menzione, C. S. Moon, P. Wilson, Luca Scodellaro, M. E. Convery, Xin Wu, J. E. Garcia, G. Lungu, E. Palencia, Andrew Beretvas, P. de Barbaro, M. Bucciantonio, M. Cordelli, G. Busetto, Brian L Winer, Franco Bedeschi, Michele Gallinaro, Marcelo Vogel, Peter Wittich, F. Canelli, Aron Soha, K. Ebina, M. Rossi, Matteo Cavalli-Sforza, D. Toback, R. D. Field, M. Iori, J. N. Bellinger, P. Giromini, Koji Sato, Andrea Castro, T. Wakisaka, C. Plager, Matthew Herndon, A. Hamaguchi, Kazuhiko Hara, M. K. Jha, P. Mehtala, M. Giunta, M. Rescigno, Justin Pilot, D. Lucchesi, Bernd Stelzer, A. Brisuda, J. Nett, Stefano Giagu, M. Hussein, T. A. Schwarz, Monica D'Onofrio, P. Movilla Fernandez, J. P. Chou, C. M. Ginsburg, Y. Takeuchi, A. G. Clark, A. Penzo, Kevin Burkett, A. Sedov, E. Gerchtein, S. Lami, S. Somalwar, Fedor Prokoshin, T. Okusawa, S. Rolli, Benjamin Kilminster, P. Mazzanti, U. Husemann, P. F. Shepard, S. H. Oh, I. Oksuzian, A. Hocker, B. Di Ruzza, S. Leo, N. Krumnack, K. S. McFarland, T. R. Junk, K. R. Bland, Barry Blumenfeld, Michael Schmitt, Y. D. Oh, V. Saveliev, G. De Lorenzo, J. Huston, Mark Kruse, Alison Lister, Roger Moore, Y. Sakurai, Alexei Safonov, J. Yoh, D. O. Litvintsev, T. Yang, K. Makhoul, Manuela Campanelli, G. Flanagan, C. I. Ciobanu, W. Ketchum, R. Martínez-Ballarín, S. Zucchelli, F. Rimondi, Frank Chlebana, C. Deluca, Guido Volpi, E. Lee, M. Stanitzki, Chi Lin, Viviana Cavaliere, Sebastian Grinstein, S. Uozumi, K. K. Joo, J. S. H. Lee, O. González, J. Galyardt, Itsuo Nakano, M. Kurata, I. Suslov, Fabrizio Scuri, S. Hewamanage, S. Moed, J. C. Yun, Andrew Ivanov, Daniela Bortoletto, J. R. Smith, G. B. Yu, Oliver Stelzer-Chilton, Alan Garfinkel, P. McIntyre, Yongsun Kim, A. Bodek, M. Stancari, F. Devoto, S. Carron, A. T. Laasanen, A. Golossanov, Alessandro Cerri, M. Corbo, Y. C. Chen, C. Ferrazza, Jian Tang, Andrew Mehta, Jacobo Konigsberg, Kevin Lannon, S. H. Kim, Javier Cuevas, G. Chlachidze, Duncan Carlsmith, Giorgio Chiarelli, Sandra Leone, L. Oakes, Jane Nachtman, K. Sliwa, S. Klimenko, Guillelmo Gomez-Ceballos, J. Antos, W. K. Sakumoto, N. Hussain, L. Ortolan, Ignacio Redondo, K. T. Pitts, M. Mussini, N. Ershaidat, Q. Liu, C. Grosso-Pilcher, N. Goldschmidt, Song-Ming Wang, F. Azfar, J. P. Fernandez, Ricardo Eusebi, Tetsuo Arisawa, C. Neu, Stefano Camarda, R. F. Harr, M. Jones, Julia Thom, A. Apresyan, F. Ruffini, P. J. Bussey, V. Ramakrishnan, Fumihiko Ukegawa, M. Weinberger, A. Aurisano, A. Loginov, A. B. Wicklund, J. S. Wilson, N. Giokaris, G. Compostella, Maria Agnese Ciocci, Erik Brücken, G. Introzzi, K. Potamianos, Sergo Jindariani, L. Santi, E. E. Schmidt, J. Budagov, D. Stentz, Aidan Robson, D. P. Benjamin, R. L. Lander, B. Brau, D. Dagenhart, D. Errede, D. J. Kong, Rainer Wallny, B. Carls, V. Sorin, P. Lukens, J. Vizán, Mauro Dell'Orso, M. Martinez, C. Haber, Y. Kato, Y. Sudo, G. Giurgiu, J. Guimaraes Da Costa, S. De Cecco, P. Squillacioti, V. Rusu, M. Lancaster, H. Wolfe, J. Pursley, I. V. Gorelov, Zhenbin Wu, K. Tollefson, B. Auerbach, Federico Sforza, K. Takemasa, F. Vázquez, N. Ranjan, H. C. Fang, M. Lindgren, M. J. Morello, Tomoko Yoshida, K. Kondo, Nicola D'Ascenzo, G. Pauletta, D. W. Jang, M. D'Errico, S. Budd, Paul Lujan, M. P. Schmidt, A. Rahaman, I. Yu, P. Catastini, C. Bromberg, W. H. Chung, Luciano Ristori, A. Barbaro-Galtieri, Tiehui Liu, Rodolfo Carosi, U. K. Yang, H. Miyake, G. Manca, F. Happacher, Dario Bisello, A. Bhatti, Massimo Casarsa, W. H. Hopkins, C. Calancha, P. Schlabach, O. Norniella, C. A. Cox, H. S. Kim, J. Linacre, James Russ, Kohei Yorita, D. Glenzinski, J. Thome, Roman Lysak, S. Wilbur, H. W. Kim, A. Pronko, J. Lys, R. Roser, Ivan Vila, R. St. Denis, S. Carrillo, C. Vellidis, L. Pondrom, and E. Wicklund

Subjects
Nuclear physics, Physics, Pion, Muon, Physics and Astronomy (miscellaneous), Sample composition, 010308 nuclear & particles physics, 0103 physical sciences, Hadron, Drell–Yan process, 010306 general physics, 01 natural sciences, Engineering (miscellaneous)
Abstract

We use a new method to estimate with 5% accuracy the contribution of pion and kaon in-flight-decays to the dimuon data set acquired with the CDF detector. Based on this improved estimate, we show that the total number and the properties of the collected dimuon events are not yet accounted for by ordinary sources of dimuons which also include the contributions, as measured in the data, of heavy flavor, Υ{hooked}, and Drell-Yan production in addition to muons mimicked by hadronic punchthrough. The number of unaccounted events corresponds to (12.8±3.2)% of the bb production. We find that (23±6)% of the unaccounted events contain additional muon candidates. For comparison, this fraction is (6.9±0.4)% for events due to bb production. © 2011 The Author(s).

Published
2011
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19. Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families

Author

Patricia N. Tonin, Paul E. Goss, Johnathan M. Lancaster, William D. Foulkes, Ronald F. Carter, Charles Cochran, Ellen Warner, F. Dion, Catherine M. Phelan, Catharina Larsson, Chantal Perret, H Lounis, Roxana Moslehi, Sepideh Karimi, Parviz Ghadirian, P. A. Futreal, K Dole, M C Faucher, Steven A. Narod, Curtis Gumbs, and David E. Anderson

Subjects
Genetics, Mutation, Point mutation, Nonsense mutation, Biology, BRCA2 Protein, medicine.disease, medicine.disease_cause, Breast cancer, Pancreatic cancer, Male breast cancer, medicine, Family history, skin and connective tissue diseases
Abstract

The hereditary breast cancer gene BRCA2 was recently cloned and is believed to account for almost half of site-specific breast cancer families and the majority of male breast cancer families. We screened 49 site-specific breast cancer families for mutations in the BRCA2 gene using single strand conformation analysis (SSCA) followed by direct sequencing. We found mutations in eight families, including all four families with male breast cancer. The eight mutations were small deletions with the exception of a single nonsense mutation, an all were predicted to interrupt the BRCA2 coding sequence and to lead to a truncated protein product. Other factors which predicted the presence of a BRCA2 mutation included a case of breast cancer diagnosed at age 35 or below (P = 0.01) and a family history of pancreatic cancer (P = 0.03). Two mutations were seen twice, including a 8535delAG, which was detected in two French Canadian families. Our results suggest the possibility that the proportion of site-specific breast cancer families attributable to BRCA2 may be overestimated.

Published
1996
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20. Retraction Note: Genomic signatures to guide the use of chemotherapeutics

Author

Hope Cottrill, Phillip G. Febbo, Joseph R. Nevins, Robyn Sayer, Michael J. Kelley, Gina Chan, Richard F. Riedel, Holly K. Dressman, David H. Harpole, Johnathan M. Lancaster, Rebecca P. Petersen, Geoffrey S. Ginsburg, Janiel M. Cragun, Jeffrey R. Marks, Anil Potti, Andrea H. Bild, and Andrew Berchuck

Subjects
endocrine system diseases, business.industry, Computer science, digestive, oral, and skin physiology, General Medicine, humanities, General Biochemistry, Genetics and Molecular Biology, Biotechnology, Docetaxel, medicine, Cancer research, Topotecan, business, medicine.drug
Abstract

The authors wish to retract this article because they have been unable to reproduce certain crucial experiments showing validation of signatures for predicting response to chemotherapies, including docetaxel and topotecan.

Published
2011
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21. Erratum: Corrigendum: Genomic signatures to guide the use of chemotherapeutics

Author

Janiel M. Cragun, Johnathan M. Lancaster, Anil Potti, David H. Harpole, Phillip G. Febbo, Joseph R. Nevins, Rebecca P. Petersen, Hope Cottrill, Andrew Berchuck, Holly K. Dressman, Jeffrey R. Marks, Gina Chan, Richard F. Riedel, Robyn Sayer, Michael J. Kelley, Geoffrey S. Ginsburg, and Andrea H. Bild

Subjects
Gene expression omnibus, Nat, Daunorubicin, medicine, General Medicine, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, medicine.drug
Abstract

Nat. Med. 12, 1294–1300 (2006); published online 22 October 2006; corrected after print 10 May and 10 October 2007 and 18 July 2008 In the version of this article initially published, of the 122 samples assayed for sensitivity to daunorubicin for which the authors applied a predictor of adriamycin sensitivity, 27 samples were replicated owing to the fact that the same samples were included in several separate series files in the Gene Expression Omnibus generated in 2004 and 2005, which were the source of the data provided for the study.

Published
2008
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22. Erratum: Corrigenda: Genomic signatures to guide the use of chemotherapeutics

Author

Jeffrey R. Marks, Phillip G. Febbo, Gina Chan, Richard F. Riedel, Geoffrey S. Ginsburg, Holly K. Dressman, Rebecca P. Petersen, Hope Cottrill, Andrea H. Bild, Johnathan M. Lancaster, Anil Potti, Joseph R. Nevins, Robyn Sayer, Michael J. Kelley, Janiel M. Cragun, David H. Harpole, and Andrew Berchuck

Subjects
General Medicine, General Biochemistry, Genetics and Molecular Biology
Published
2007
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23. Looking After Animals

Author

M. Lancaster

Subjects
Multidisciplinary, Sociology, Management
Abstract

The UFAW Handbook on the Care and Management of Laboratory Animals Edited by the Staff of UFAW with the assistance of W. Lane Petter, A. N. Worden, Berton F. Hill, J. S. Paterson and H. G. Vevers. Third edition. Pp. xvi + 1015. (Edinburgh and London: E. and S. Livingstone, Ltd., in collaboration with UFAW, 1967.) 120s. net.

Published
1967
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