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Your search keyword '"Mancuso, Mariateresa"' showing total 7 results
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7 results on '"Mancuso, Mariateresa"'

1. Exposure of the SH-SY5Y Human Neuroblastoma Cells to 50-Hz Magnetic Field: Comparison Between Two-Dimensional (2D) and Three-Dimensional (3D) In Vitro Cultures

Author

Consales, Claudia, primary, Butera, Alessio, additional, Merla, Caterina, additional, Pasquali, Emanuela, additional, Lopresto, Vanni, additional, Pinto, Rosanna, additional, Pierdomenico, Maria, additional, Mancuso, Mariateresa, additional, Marino, Carmela, additional, and Benassi, Barbara, additional

Published
2020
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2. A combined ANXA2-NDRG1-STAT1 gene signature predicts response to chemoradiotherapy in cervical cancer

Author

Buttarelli, Marianna, primary, Babini, Gabriele, additional, Raspaglio, Giuseppina, additional, Filippetti, Flavia, additional, Battaglia, Alessandra, additional, Ciucci, Alessandra, additional, Ferrandina, Gabriella, additional, Petrillo, Marco, additional, Marino, Carmela, additional, Mancuso, Mariateresa, additional, Saran, Anna, additional, Villani, Maria Elena, additional, Desiderio, Angiola, additional, D’Ambrosio, Chiara, additional, Scaloni, Andrea, additional, Scambia, Giovanni, additional, and Gallo, Daniela, additional

Published
2019
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5. Loss of tyrosinase activity confers increased skin tumor susceptibility in mice

Author

Saran, Anna, primary, Spinola, Monica, additional, Pazzaglia, Simonetta, additional, Peissel, Bernard, additional, Tiveron, Cecilia, additional, Tatangelo, Laura, additional, Mancuso, Mariateresa, additional, Covelli, Vincenzo, additional, Giovannelli, Lisa, additional, Pitozzi, Vanessa, additional, Pignatiello, Carmen, additional, Milani, Silvano, additional, Dolara, Piero, additional, and Dragani, Tommaso A, additional

Published
2004
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7. Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1 +/− granule cell precursors after radiation injury

Author

Barbara Tanno, Ilaria De Stefano, Anna Saran, Paola Giardullo, Mariateresa Mancuso, Simona Leonardi, Emanuela Pasquali, Gabriele Babini, Mancuso, M., Saran, A., Pasquali, E., Leonardi, S., Tanno, B., Tanno, Barbara, Leonardi, Simona, Babini, Gabriele, Giardullo, Paola, De Stefano, Ilaria, Pasquali, Emanuela, Saran, Anna, and Mancuso, Mariateresa

Subjects
0301 basic medicine, Homeobox protein NANOG, Carcinogenesis, Cellular differentiation, lcsh:Medicine, Apoptosis, medicine.disease_cause, Article, Gene Knockout Techniques, Mice, 03 medical and health sciences, Cell Line, Tumor, Radioresistance, medicine, Animals, Cell Self Renewal, Sonic hedgehog, lcsh:Science, Clonogenic assay, Medulloblastoma, Multidisciplinary, biology, lcsh:R, Nanog Homeobox Protein, Cell Differentiation, Dose-Response Relationship, Radiation, Cellular Reprogramming, medicine.disease, 3. Good health, Patched-1 Receptor, 030104 developmental biology, embryonic structures, Neoplastic Stem Cells, Cancer research, biology.protein, lcsh:Q, DNA Damage
Abstract

Medulloblastoma (MB) is the most common pediatric brain tumor, comprising four distinct molecular variants, one of which characterized by activation of the Sonic Hedgehog (SHH) pathway, driving 25–30% of sporadic MB. SHH-dependent MBs arise from granule cell precursors (GCPs), are fatal in 40–70% of cases and radioresistance strongly contributes to poor prognosis and tumor recurrence. Patched1 heterozygous (Ptch1+/−) mice, carrying a germ-line heterozygous inactivating mutation in the Ptch1 gene, the Shh receptor and negative regulator of the pathway, are uniquely susceptible to MB development after radiation damage in neonatal cerebellum. Here, we irradiated ex-vivo GCPs isolated from cerebella of neonatal WT and Ptch1+/− mice. Our results highlight a less differentiated status of Ptch1-mutated cells after irradiation, influencing DNA damage response. Increased expression levels of pluripotency genes Nanog, Oct4 and Sal4, together with greater clonogenic potential, clearly suggest that radiation induces expansion of the stem-like cell compartment through cell-reprogramming and self-renewal maintenance, and that this mechanism is strongly dependent on Nanog. These results contribute to clarify the molecular mechanisms that control radiation-induced Shh-mediated tumorigenesis and may suggest Nanog as a potential target to inhibit for adjuvant radiotherapy in treatment of SHH-dependent MB.

Published
2017

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